Cited by 50Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsSaffron Plant Research Studies

Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease

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Mirmosayyeb, Omid, Tanhaei, Amirpouya, Sohrabi, Hamid R., Martins, Ralph N., Tanhaei, Mana, Najafi, Mohammad Amin, Safaei, Ali, Meamar, Rokhsareh·2017·International Journal of Preventive Medicine

Abstract

For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon. Besides suppressing inflammatory pathways, these spices may act as antioxidant and inhibit acetyl cholinesterase and amyloid β aggregation. We summarized how spice-derived nutraceuticals mediate such different effects and what their molecular targets might be. Finally, some directions for future research are briefly discussed.

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Authors
Mirmosayyeb, O., Tanhaei, A., Sohrabi, H. R., Martins, R. N., Tanhaei, M., Najafi, M. A., Safaei, A., & Meamar, R.
Affiliations
  • Isfahan University of Medical Sciences (IR)
  • Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Edith Cowan University (AU)
  • Islamic Azad University, Isfahan (IR)
Corresponding author
Meamar, Rokhsareh
Venue
International Journal of Preventive Medicine
Published
2017-01
Volume
8
Issue
1
Pages
5-5
ISSN
  • 2008-7802 (ISSN-L)
  • 2008-8213
OpenAlex
W2587404563
Cited by
50
References
69
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 1
FWCI
1.00
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • International Journal of Preventive Medicine (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Murdoch University Research Portal (submittedVersion)
  • Australasian Journal of Paramedicine (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
Keywords
spices, Alzheimer's disease, neurodegenerative diseases, nutraceuticals, turmeric, saffron, black pepper, ginger, cinnamon, neuroinflammation, antioxidant activity, acetylcholinesterase inhibition, amyloid-beta aggregation, dietary prevention

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