Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease
Open accessAbstract
For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon. Besides suppressing inflammatory pathways, these spices may act as antioxidant and inhibit acetyl cholinesterase and amyloid β aggregation. We summarized how spice-derived nutraceuticals mediate such different effects and what their molecular targets might be. Finally, some directions for future research are briefly discussed.
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The theory of Shad Rasa in Ayurveda emphasizes the importance of phytoconstituents from spices in ameliorating neurological disease.
“The theory of Shad Rasa in Ayurveda has emphasized the importance of phytoconstituents from spices in ameliorating neurological disease (Aggarwal & Kunnumakkara, 2009;Mirmosayyeb et al., 2017).”
From Alpha-terpinyl acetate: A natural monoterpenoid from Elettaria cardamomum as multi-target directed ligand in Alzheimer’s disease (2020) · cites this paper as Mirmosayyeb et al., 2017
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- Authors
- Mirmosayyeb, O., Tanhaei, A., Sohrabi, H. R., Martins, R. N., Tanhaei, M., Najafi, M. A., Safaei, A., & Meamar, R.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
- Edith Cowan University (AU)
- Islamic Azad University, Isfahan (IR)
- Corresponding author
- Meamar, Rokhsareh
- Venue
- International Journal of Preventive Medicine
- Published
- 2017-01
- Volume
- 8
- Issue
- 1
- Pages
- 5-5
- ISSN
- 2008-7802 (ISSN-L)
- 2008-8213
- PMC
- PMC5320868
- OpenAlex
- W2587404563
- Cited by
- 50
- References
- 69
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- International Journal of Preventive Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Australasian Journal of Paramedicine (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
- Keywords
- spices, Alzheimer's disease, neurodegenerative diseases, nutraceuticals, turmeric, saffron, black pepper, ginger, cinnamon, neuroinflammation, antioxidant activity, acetylcholinesterase inhibition, amyloid-beta aggregation, dietary prevention
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