Cinnamon extract inhibits tau aggregation associated with Alzheimer’s disease in vitro
Abstract
An aqueous extract of Ceylon cinnamon (C. zeylanicum) is found to inhibit tau aggregation and filament formation, hallmarks of Alzheimer's disease (AD). The extract can also promote complete disassembly of recombinant tau filaments and cause substantial alteration of the morphology of paired-helical filaments isolated from AD brain. Cinnamon extract (CE) was not deleterious to the normal cellular function of tau, namely the assembly of free tubulin into microtubules. An A-linked proanthocyanidin trimer molecule was purified from the extract and shown to contain a significant proportion of the inhibitory activity. Treatment with polyvinylpyrolidone effectively depleted all proanthocyanidins from the extract solution and removed the majority, but not all, of the inhibitory activity. The remainder inhibitory activity could be attributed to cinnamaldehyde. This work shows that compounds endogenous to cinnamon may be beneficial to AD themselves or may guide the discovery of other potential therapeutics if their mechanisms of action can be discerned.
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An aqueous extract of Ceylon cinnamon inhibits tau aggregation and filament formation.
“Inhibitory effect of an aqueous extract of Ceylon cinnamon (C. zeylanicum) on tau aggregation and filament formation has also been reported [19].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [19]
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“zeylanicum) on tau aggregation and filament formation has also been reported [19].”
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- Authors
- Peterson, D. W., George, R. C., Scaramozzino, F., LaPointe, N. E., Anderson, R. A., Graves, D. J., & Lew, J.
- Affiliations
- University of California, Santa Barbara (US)
- Beltsville Human Nutrition Research Center (US)
- Corresponding author
- Lew, John
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2009-07-01
- Volume
- 17
- Issue
- 3
- Pages
- 585-597
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1567694301
- Cited by
- 171
- References
- 64
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 21 · 2022: 15 · 2021: 15 · 2020: 16 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 6
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM058445)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- Cinnamomum zeylanicum
- MeSH terms
- Animals, Antioxidants, Cells, Cultured, Chromatography, High Pressure Liquid, Cinnamomum zeylanicum, Dose-Response Relationship, Drug, Embryo, Mammalian, Hippocampus, Humans, Microtubules, Neurons, Plant Extracts, Mass Spectrometry, Tubulin, tau Proteins, Rats, Sprague-Dawley, Proanthocyanidins, Microscopy, Electron, Transmission, Rats
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