Treatment of Alzheimer’s disease by natural products
Open accessAbstract
Alzheimer’s disease is a neurological disorder that progressively affects the brain cells. It is sometimes accompanied with dementia and commonly seen in elderly people. It ultimately leads to impaired cognitive functions and loss of memory. Widely used drugs such as donepezil and galantamine successfully abate mild to moderate symptoms of the disease though they have profound side effects. Natural products have been a source of medicine for over thousands of years. Plant secondary metabolites such as alkaloids, flavonoids, terpenoids, etc. are major sources of such medicines. In recent times, the use of natural products to treat various diseases has gained a lot of popularity. Extensive research is being undertaken to identify and isolate various natural products that can be used to not only reduce the disease symptoms but also as a permanent cure. The review article aims to summarize the effects of various natural products and their neuroprotective mechanisms that can be helpful to cure Alzheimer’s disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aβ peptide production is regulated through enzyme inhibition associated with the amyloidogenic cascade, mainly β-secretase.
“Recent reports point to the Aβ peptides production regulation, through enzyme inhibition associated with the amyloidogenic cascade, mainly β-secretase [162,163,164].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [164]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Panche, A. N., Diwan, A. D., & Chandra, S. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.41 · Cited by 5,644 · see citing works
The Traditional Medicine and Modern Medicine from Natural Products
Yuan, H.-D., Ma, Q., Li, Y., & Piao, G. (2016) · Molecules · doi:10.3390/molecules21050559 · Cited by 2,451 · see citing works
Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
Aziz, N., Kim, M., & Cho, J. Y. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.05.019 · Cited by 654 · see citing works
Thymoquinone and its therapeutic potentials
Darakhshan, S., Pour, A. B., Colagar, A. H., & Sisakhtnezhad, S. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.03.011 · Cited by 508 · see citing works
Molecular Pathogenesis of Alzheimer's Disease: An Update
Sanabria‐Castro, A., Echeverría, I. A., & Bonilla, C. M. (2017) · Annals of Neurosciences · doi:10.1159/000464422 · Cited by 419 · see citing works
Zhao, L., Wang, J., Liu, R., Li, X., Li, J., & Zhang, L. (2013) · Molecules · doi:10.3390/molecules18089949 · Cited by 311 · see citing works
The Mechanisms of Action of Curcumin in Alzheimer’s Disease
Tang, M., & Taghibiglou, C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170188 · Cited by 311 · see citing works
Plant alkaloids as drug leads for Alzheimer's disease
Ng, Y. P., Or, T. C. T., & Ip, N. Y. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.018 · Cited by 236 · see citing works
Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease
Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234 · see citing works
Dey, A., Bhattacharya, R., Mukherjee, A., & Pandey, D. K. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.005 · Cited by 232 · see citing works
Apigenin as neuroprotective agent: Of mice and men
Nabavi, S. F., Khan, H. Z., D’Onofrio, G., Šamec, D., Shirooie, S., Dehpour, A. R., Argüelles, S., Habtemariam, S., & Sobarzo‐Sánchez, E. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.10.008 · Cited by 221 · see citing works
Benefits of curcumin in brain disorders
Bhat, A., Mahalakshmi, A. M., Ray, B., Tuladhar, S., Hediyal, T. A., Manthiannem, E., Jagadeeswari, P., Chandra, R., Chidambaram, S. B., & Sakharkar, M. K. (2019) · BioFactors · doi:10.1002/biof.1533 · Cited by 202 · see citing works
Jabir, N. R., Khan, F. R., & Tabrez, S. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12971 · Cited by 187 · see citing works
Resveratrol and Alzheimer’s Disease: Mechanistic Insights
Ahmed, T., Javed, S., Javed, S., Tariq, A., Šamec, D., Tejada, S., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9839-9 · Cited by 179 · see citing works
Bahar, E., Kim, J., & Yoon, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091989 · Cited by 163 · see citing works
The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain
Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.07.073 · Cited by 159 · see citing works
Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease
Arbo, B. D., André‐Miral, C., Nasre‐Nasser, R. G., Schimith, L. E., dos Santos, M. G., da Costa-Silva, D. G., Muccillo-Baisch, A. L., & Hort, M. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00103 · Cited by 156 · see citing works
Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders
Choi, J. G., Kim, S. Y., Jeong, M., & Oh, M. S. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.08.010 · Cited by 155 · see citing works
Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease
Dubey, T., & Chinnathambi, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108153 · Cited by 151 · see citing works
Natural product for the treatment of Alzheimer’s disease
Bui, T. T., & Nguyễn, T. H. (2017) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2016-0147 · Cited by 146 · see citing works
Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works
Habtemariam, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020458 · Cited by 110 · see citing works
Exploring the efficacy of natural products in alleviating Alzheimer’s disease
Singh, A., Deshpande, P., & Gogia, N. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.253509 · Cited by 108 · see citing works
A Review on Medicinal Properties of Centella Asiatica
Prakash, V., Jaiswal, N., & Srivastava, M. (2017) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v10i10.20760 · Cited by 107 · see citing works
Therapeutic potential of luteolin in transgenic Drosophila model of Alzheimer’s disease
Ali, F. R., Rahul, Jyoti, S., Naz, F., Ashafaq, M., Shahid, M., & Siddique, Y. H. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.053 · Cited by 99 · see citing works
Songjiang, Z., & Wu, L. (2009) · AAPS PharmSciTech · doi:10.1208/s12249-009-9279-1 · Cited by 94 · see citing works
Zeng, G., Zhang, Z., Lü, L., Xiao, D.-Q., Zong, S., & He, J.-M. (2013) · Rejuvenation Research · doi:10.1089/rej.2012.1389 · Cited by 94 · see citing works
Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease
Kwon, Y. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.05.014 · Cited by 94 · see citing works
Calfío, C., González, A., Singh, S. K., Rojo, L. E., & Maccioni, R. B. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200443 · Cited by 94 · see citing works
Hao, C., Wang, W., Wang, S., Zhang, L., & Guo, Y. (2017) · Marine Drugs · doi:10.3390/md15040089 · Cited by 88 · see citing works
Maleki, S. N., Aboutaleb, N., & Souri, F. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.04.008 · Cited by 82 · see citing works
Ouyang, Q., Zhao, S. X., Li, S., & Song, C. (2017) · Marine Drugs · doi:10.3390/md15110322 · Cited by 78 · see citing works
Fachel, F. N. S., Schuh, R. S., Veras, K. S., Bassani, V. L., Koester, L., Henriques, A. T., Braganhol, E., & Teixeira, H. F. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.11.003 · Cited by 68 · see citing works
Phytochemicals in the Treatment of Alzheimer's Disease: A Systematic Review
D’Onofrio, G., Sancarlo, D., Ruan, Q., Yu, Z., Panza, F., Daniele, A., Greco, A., & Seripa, D. (2016) · Current Drug Targets · doi:10.2174/1389450117666161102121553 · Cited by 59 · see citing works
Gao, J., Inagaki, Y., Li, X., Kokudo, N., & Tang, W. (2013) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2013.v7.2.46 · Cited by 52 · see citing works
Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease
Mirmosayyeb, O., Tanhaei, A., Sohrabi, H. R., Martins, R. N., Tanhaei, M., Najafi, M. A., Safaei, A., & Meamar, R. (2017) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.199640 · Cited by 50 · see citing works
Natural product medicines: A literature update
Dar, R. A., Shahnawaz, M., Rasool, S., & Qazi, P. H. (2017) · The Journal of Phytopharmacology · doi:10.31254/phyto.2017.6606 · Cited by 46 · see citing works
Iranshahy, M., & Javadi, B. (2019) · PubMed Central · doi:10.22038/ijbms.2019.36505.8694 · Cited by 34 · see citing works
Manap, A. S. A., Vijayabalan, S., Madhavan, P., Chia, Y. Y., Arya, A., Wong, E. H., Rizwan, F., Bindal, U., & Koshy, S. (2019) · Drug Target Insights · doi:10.33393/dti.2019.1417 · Cited by 30 · see citing works
Tundis, R., Loizzo, M. R., Nabavi, S. M., Orhan, İ. E., Skalicka‐Woźniak, K., D’Onofrio, G., & Aiello, F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809593-5.00003-3 · Cited by 19 · see citing works
Nutritional and bioactive characterization of unexplored food rich in phytonutrients
Memariani, Z., Farzaei, M. H., Ali, A., & Momtaz, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815354-3.00001-0 · Cited by 19 · see citing works
Self-citationPharmacogenetic studies in Alzheimer disease
Santamaría, T. Z., Gómez, P. Y., Fricke-Galindo, I., González, M. G., Ortega‐Vázquez, A., & López, M. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2018.03.022 · Cited by 19 · see citing works
Phenolic Acids and Their Health-Promoting Activity
Khatri, S., Paramanya, A., & Ali, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-03344-6_27 · Cited by 17 · see citing works
Self-citationCaffeine: A Potential Protective Agent Against Cognitive Decline in Alzheimer’s Disease
Hussain, A., Tabrez, E. S., Mavrych, V., Bolgova, O., & Peela, J. R. (2018) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2018021391 · Cited by 15 · see citing works
The Use of Polyphenols for the Treatment of Alzheimer’s Disease
Sathya, S., & Devi, K. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00015-8 · Cited by 15 · see citing works
Evaluation of the Effects of Chitosan Hemostasis Dressings on Hemorrhage Caused by Breast Biopsy
Chou, C., Wang, Y.-C., Chang, S. J., Liu, P., & Kuo, S. M. (2012) · Breast Care · doi:10.1159/000339687 · Cited by 9 · see citing works
Vazhayil, B. K., & Sundaram, R. S. (2013) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 9 · see citing works
Garlic and its Effects in Neurological Disorders
Farooqui, A. A., & Farooqui, T. (2017) · doi:10.1002/9781119155195.ch5 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 12
- Ali A. Herbs that heal: the philanthropic behavior of nature. Ann Phytomed. 2020; 9(1), 7-17.
- Ijaz H, Tulain UR, Qureshi J, Danish Z, Musayab S, Akhtar MF, et al. (prophetic medicine): a review. Pak J Pharm Sci. 2017; 30, 229-234.
- Chen CL, Tsai WH, Chen CJ, Pan TM. Centella asiatica extract protects against amyloid β1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. J Trad Complement Med. 2015; 6, 362-369.
- Taguchi R, Hatayama K, Takahashi T, Hayashi T, Sato Y, Sato D, et al Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties. Eur J Med Chem. 2017; 138, 1066-1075.
- Senol FS, Slusarczyk S, Matkowski A, Perez-Garrido A, Giron- Rodriguez F, Ceron-Carrasco JP, et al. Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth and Salvia glutinosa L Phytochemistry. 2017; 133, 33-44.
- Khodagholi F, Eftekharzadeh B, Maghsoudi N, Rezaei PF. Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB. Mol Cell Biochem. 2010; 337, 39-51.
- Grzanna R, Phan P, Polotsky A, Lindmark L, Frondoza CG. Ginger extract inhibits beta-amyloid peptide-induced cytokine and chemokine expression in cultured THP-1 monocytes. J Altern Complement Med. 2004; 10, 1009-1013.
- Sahardi NFNM, Makpol S. Ginger (Zingiber officinale Roscoe) in the prevention of ageing and degenerative diseases: review of current evidence. Evid Based Complement Alternat Med. 2019, 5054395.
- Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, et al. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther. 2010; 35, 581-588.
- Leone S, Recinella L, Chiavaroli A, Orlando G, Ferrante C, Leporini L, et al. Phytotherapic use of Crocus sativus L. (Saffron) and its potential applications: a brief review. Phytother Res. 2017; 32, 2364-2375.
- Kaur N, Sarkar B, Gill I, Kaur S, Mittal S, Dhiman M, et al. Indian herbs and their therapeutical potential against Alzheimer's disease and other neurological disorders. In Neuroprotective Effects of Phytochemicals in Neurological Disorders, First eds. John Wiley and Sons Inc. 2017; 79-112.
- Rather MA, Thenmohzi AJ, Manivasagam T, Bharathi MD, Essa M, Guillemin GJ. Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. Front Biosci. 2018; 10, 262-275.
Cited by
Sorted by citations
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Zakharova, L. Y., Maganova, F., Sinyashin, K. O., Gaynanova, G. A., Mirgorodskaya, A. B., Vasilieva, E. A., & Sinyashin, O. G. (2023) · Russian Journal of General Chemistry · doi:10.1134/s1070363223070253 · Cited by 28 · see citing works
Role of Polyphenols in Alleviating Alzheimer’s Disease: A Review
Raja, T. R. W., Duraipandiyan, V., Ignacimuthu, S., Janakiraman, U., & Packiam, S. M. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221202152540 · Cited by 26 · see citing works
Recent Nanoscale Carriers for Therapy of Alzheimer's Disease: Current Strategies and Perspectives
Zakharova, L. Y., Gaynanova, G. A., Vasilieva, E. A., Vasileva, L. A., Pavlov, R. V., Kashapov, R. R., Petrov, K. A., & Sinyashin, O. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221115103513 · Cited by 16 · see citing works
Multi‐Targeting Phytochemicals for Alzheimer's Disease
Bhattacharya, R. S., Singh, R., Panghal, A., Thakur, A., Singh, L., Verma, R. K., Singh, C., Goyal, M., & Kumar, J. (2025) · Phytotherapy Research · doi:10.1002/ptr.8435 · Cited by 17 · see citing works
Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works
Studi In Silico Potensi Piperine, Piperlongumine, dan Thymoquinone Sebagai Obat Alzheimer
Mutiara, Y. M., Wahjudi, M., & Kok, T. (2022) · Indonesian Journal of Biotechnology and Biodiversity · doi:10.47007/ijobb.v6i3.138
Protective effect of Bacopa monnieri against Methotrexate induced Hepatotoxicity in Wistar rats
Tummala, S., Banothu, A. K., Kumar, B., Lakshman, M., Ambica, G., & Ravikumar, Y. (2023) · Indian Journal of Animal Research · doi:10.18805/ijar.b-5148
- Authors
- CHOUGLE, S., KUMAR, D., KHAN, A., ZEHRA, S., & ALİ, A.
- Affiliations
- University of Mumbai (IN)
- Jazan University (SA)
- University of Windsor (CA)
- Venue
- Journal of Experimental and Clinical Medicine
- Published
- 2021-08-30
- Volume
- 38
- Issue
- 4
- Pages
- 634-644
- ISSN
- 1309-4483 (ISSN-L)
- 1309-5129
- OpenAlex
- W3198975966
- Cited by
- 8
- References
- 48
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 4
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Experimental and Clinical Medicine (publishedVersion)
- DergiPark (Istanbul University) (submittedVersion, cc-by-nc)
- Funders
- Research Society for the Study of Diabetes in India (2017/342, RSSDI/HQ/Grants/2017/342)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, natural products, plant secondary metabolites, neuroprotection, alkaloids, flavonoids, terpenoids, cognitive impairment, memory loss, dementia, donepezil, galantamine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
