The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Effect of high-dose Ascorbic acid on vasopressor′s requirement in septic shock
Open accessAbstract
OBJECTIVE: Effects of ascorbic acid on hemodynamic parameters of septic shock were evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the effect of high-dose ascorbic acid on vasopressor drug requirement was evaluated in surgical critically ill patients with septic shock. METHODS: Patients with septic shock who required a vasopressor drug to maintain mean arterial pressure >65 mmHg were assigned to receive either 25 mg/kg intravenous ascorbic acid every 6 h or matching placebo for 72 h. Vasopressor dose and duration were considered as the primary outcomes. Duration of Intensive Care Unit (ICU) stay and 28-day mortality has been defined as secondary outcomes. FINDINGS: During the study period, 28 patients (14 in each group) completed the trial. Mean dose of norepinephrine during the study period (7.44 ± 3.65 vs. 13.79 ± 6.48 mcg/min, P = 0.004) and duration of norepinephrine administration (49.64 ± 25.67 vs. 71.57 ± 1.60 h, P = 0.007) were significantly lower in the ascorbic acid than the placebo group. No statistically significant difference was detected between the groups regarding the length of ICU stay. However, 28-day mortality was significantly lower in the ascorbic acid than the placebo group (14.28% vs. 64.28%, respectively; P = 0.009). CONCLUSION: High-dose ascorbic acid may be considered as an effective and safe adjuvant therapy in surgical critically ill patients with septic shock. The most effective dose of ascorbic acid and the best time for its administration should be determined in future studies.
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The Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup*, Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,290
Severe Sepsis and Septic Shock
Angus, D. C., & van der Poll, T. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1208623 · Cited by 3,961
Dombrovskiy, V. Y., Martin, A. A., Sunderram, J., & Paz, H. L. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000261890.41311.e9 · Cited by 1,249
Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock
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Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940
Does vitamin C act as a pro‐oxidant under physiological conditions?
Carr, A., & Frei, B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9.1007 · Cited by 884
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
Petros, A., Bennett, D., & Vallance, P. (1991) · The Lancet · doi:10.1016/0140-6736(91)92376-d · Cited by 861
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.
Nursing, M. R. I. C. U., Fowler, A. A., Syed, A. A., Knowlson, S., Sculthorpe, R., Farthing, D., DeWilde, C., Farthing, C. A., Larus, T. L., Martin, E., et al. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-32 · Cited by 573
Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients
Nathens, A. B., Neff, M. J., Jurkovich, G. J., Klotz, P., Farver, K., Ruzinski, J. T., Radella, F., Garcia, I., & Maier, R. V. (2002) · Annals of Surgery · doi:10.1097/00000658-200212000-00014 · Cited by 536
Effects of a nitric oxide synthase inhibitor in humans with septic shock
Petros, A., Lamb, G., Leone, A., Moncada, S., Bennett, D., & Vallance, P. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.1.34 · Cited by 509
Cited by
Weiss, S. L., Peters, M. J., Alhazzani, W., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., et al. (2020) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002198 · Cited by 1,228
Weiss, S. L., Peters, M. J., Alhazzani, W., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05878-6 · Cited by 606
Sepsis and Septic Shock – Basics of diagnosis, pathophysiology and clinical decision making
Font, M. D., Thyagarajan, B., & Khanna, A. K. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2020.02.011 · Cited by 420
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
Hemilä, H., & Chalker, E. (2019) · Nutrients · doi:10.3390/nu11040708 · Cited by 257
The Emerging Role of Vitamin C as a Treatment for Sepsis
Kashiouris, M. G., L’Heureux, M., Cable, C. A., Fisher, B. J., Leichtle, S. W., & Fowler, A. A. (2020) · Nutrients · doi:10.3390/nu12020292 · Cited by 177
Metadata
- Authors
- Khalili, H., Zabet, M., Mohammadi, M., & Ramezani, M.
- Venue
- Journal of Research in Pharmacy Practice
- Publisher
- Medknow
- Published
- 2016
- Volume
- 5
- Issue
- 2
- Pages
- 94
- ISSN
- 2279-042X (ISSN-L)
- OpenAlex
- W2318294335
- Cited by
- 287
- References
- 49
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Khalili, H., Zabet, M., Mohammadi, M., & Ramezani, M. (2016). Effect of high-dose Ascorbic acid on vasopressor′s requirement in septic shock. Journal of Research in Pharmacy Practice. https://doi.org/10.4103/2279-042x.179569
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
