The Emerging Role of Vitamin C as a Treatment for Sepsis

The third international consensus definitions for sepsis and septic shock (Sepsis-3).

Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)

Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674 · see citing works

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

DNA methylation and its basic function

Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906 · see citing works

Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations.

Fleischmann, C., Scherag, A., Adhikari, N. K. J., Hartog, C. S., Tsaganos, T., Schlattmann, P., Angus, D. C., & Reinhart, K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0781oc · Cited by 3,548 · see citing works

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

Vitamin C and Immune Function

Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035 · see citing works

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

Kaukonen, K., Bailey, M., Suzuki, S., Pilcher, D. V., & Bellomo, R. (2014) · JAMA · doi:10.1001/jama.2014.2637 · Cited by 1,704 · see citing works

Hypoxia-Inducible Factor-1 (HIF-1)

Ke, Q., & Costa, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027029 · Cited by 1,638 · see citing works

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

Ziegler, E. J., Fisher, C. J., Sprung, C. L., Straube, R., SADOFF, J. C., Foulke, G. E., Wortel, C. H., Fink, M. P., Dellinger, R. P., Teng, N. N. H., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199102143240701 · Cited by 1,618 · see citing works

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

Saffarzadeh, M., Jünemann, C., Queisser, M. A., Lochnit, G., Barreto, G., Galuska, S. P., Lohmeyer, J., & Preissner, K. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032366 · Cited by 1,343 · see citing works

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325 · see citing works

Drotrecogin Alfa (Activated) in Adults with Septic Shock

Ranieri, V. M., Thompson, B., Barie, P. S., Dhainaut, J.-F., Douglas, I. S., Finfer, S. R., Gårdlund, B., Marshall, J. C., Rhodes, A., Artigas, A., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202290 · Cited by 1,312 · see citing works

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

Kaplan, M. J., & Radic, M. Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201719 · Cited by 1,168 · see citing works

Sepsis: a roadmap for future research

Cohen, J., Vincent, J., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S. G., Delaloye, J., Opal, S. M., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 996 · see citing works

Vitamin C pharmacokinetics: Implications for oral and intravenous use

Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

Marik, P. E., Khangoora, V., Rivera, R., Hooper, M. H., & Catravas, J. (2017) · Chest · doi:10.1016/j.chest.2016.11.036 · Cited by 887 · see citing works

A family of mammalian Na+-dependent L-ascorbic acid transporters

Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U. V., Chen, X.-Z., Wang, Y., Brubaker, R. F., & Hediger, M. A. (1999) · Nature · doi:10.1038/19986 · Cited by 882 · see citing works

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure

Fowler, A. A., Truwit, J. D., Hite, R. D., Morris, P. E., DeWilde, C., Priday, A., Fisher, B., Thacker, L. R., Natarajan, R., Brophy, D. F., et al. (2019) · JAMA · doi:10.1001/jama.2019.11825 · Cited by 836 · see citing works

Vitamin C: The known and the unknown and Goldilocks

Padayatty, S., & Levine, M. (2016) · Oral Diseases · doi:10.1111/odi.12446 · Cited by 753 · see citing works

Prolyl 4-hydroxylase

Gorres, K. L., & Raines, R. T. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409231003627991 · Cited by 611 · see citing works

Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals

Rhee, C., Jones, T. M., Hamad, Y., Pande, A., Varon, J., O’Brien, C. L., Anderson, D. J., Warren, D. K., Dantes, R., Epstein, L. H., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.7571 · Cited by 580 · see citing works

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.

Nursing, M. R. I. C. U., Fowler, A. A., Syed, A. A., Knowlson, S., Sculthorpe, R., Farthing, D., DeWilde, C., Farthing, C. A., Larus, T. L., Martin, E., et al. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-32 · Cited by 573 · see citing works

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature · doi:10.1038/nature23876 · Cited by 545 · see citing works

Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients

Nathens, A. B., Neff, M. J., Jurkovich, G. J., Klotz, P., Farver, K., RUZINSKI, J. T., Radella, F., Garcia, I. A., & Maier, R. V. (2002) · Annals of Surgery · doi:10.1097/00000658-200212000-00014 · Cited by 544 · see citing works

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis‐mediated cell death

Gupta, A. K., Joshi, M. B., Philippova, M., Erné, P., Hasler, P., Hahn, S., & Resink, T. J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.006 · Cited by 538 · see citing works

Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome

The National Heart, L. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401520 · Cited by 533 · see citing works

Neutrophil extracellular traps — the dark side of neutrophils

Sørensen, O. E., & Borregaard, N. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84538 · Cited by 532 · see citing works

Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury

Lefrançais, E., Mallavia, B., Zhuo, H., Calfee, C. S., & Looney, M. R. (2018) · JCI Insight · doi:10.1172/jci.insight.98178 · Cited by 472 · see citing works

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia

Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469 · see citing works

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

Nakahira, K., Kyung, S.-Y., Rogers, A. J., Gazourian, L., Youn, S., Massaro, A. F., Quintana, C., Osorio, J. C., Wang, Z., Zhao, Y., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001577 · Cited by 445 · see citing works

Reduction of Resuscitation Fluid Volumes in Severely Burned Patients Using Ascorbic Acid Administration: A Randomized, Prospective Study

Tanaka, H. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.3.326 · Cited by 438 · see citing works

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

Czaikoski, P. G., Mota, J. M., Nascimento, D. C., Sônego, F., Castanheira, F. V. S., Melo, P. H., Scortegagna, G. T., Silva, R. L., Barroso‐Sousa, R., Souto, F. O., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148142 · Cited by 400 · see citing works

Clinical manifestations of ascorbic acid deficiency in man

Hodges, R. E., Hood, J., Canham, J. E., Sauberlich, H. E., & Baker, E. M. (1971) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/24.4.432 · Cited by 392 · see citing works

The Genetics of Vitamin C Loss in Vertebrates

Drouin, G., Godin, J. R. P., & Pagé, B. (2011) · Current Genomics · doi:10.2174/138920211796429736 · Cited by 359 · see citing works

Role of Vitamin C in the Function of the Vascular Endothelium

May, J. M., & Harrison, F. E. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5205 · Cited by 358 · see citing works

Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk.

Borrelli, E., Roux-Lombard, P., Grau, G., Girardin, E., Ricou, B., Dayer, J., & Suter, P. (1996) · Critical Care Medicine · doi:10.1097/00003246-199603000-00006 · Cited by 354 · see citing works

Recycling of vitamin E in human low density lipoproteins.

Kagan, V. E., Serbinova, E. A., Forte, T. M., Scita, G., & Packer, L. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41529-9 · Cited by 322 · see citing works

Regulation of the epigenome by vitamin C

Young, J. I., Züchner, S., & Wang, G. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034228 · Cited by 319 · see citing works

Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients

Schorah, C., Downing, C. P., Piripitsi, A., Gallivan, L., Al-Hazaa, A., Sanderson, M., & Bodenham, A. R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.760 · Cited by 313 · see citing works

Vitamin C revisited

Oudemans-van Straaten, H. M., Man, A. M. S.-D., & de Waard, M. C. (2014) · Critical Care · doi:10.1186/s13054-014-0460-x · Cited by 299 · see citing works

Effect of high-dose Ascorbic acid on vasopressor′s requirement in septic shock

Khalili, H., Zabet, M., Mohammadi, M., & Ramezani, M. (2016) · Journal of Research in Pharmacy Practice · doi:10.4103/2279-042x.179569 · Cited by 298 · see citing works

Ascorbic acid recycling in human neutrophils

Washko, P., Wang, Y., & Levine, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82289-x · Cited by 289 · see citing works

Ascorbate: The Most Effective Antioxidant in Human Blood Plasma

Frei, B. B., Stocker, R., England, L. J., & Ames, B. N. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5730-8_24 · Cited by 287 · see citing works

Ascorbic acid and carnitine biosynthesis

Rebouche, C. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1147s · Cited by 276 · see citing works

Redox Regulation of the Caspases during Apoptosisa

Hampton, M. B., Fadeel, B., & Orrenius, S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09913.x · Cited by 274 · see citing works

Neutrophil extracellular traps (NETs) - formation and implications.

Zawrotniak, M., & Rąpała‐Kozik, M. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_1983 · Cited by 273 · see citing works

Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2

Daruwala, R., Song, J., Koh, W. S., Rumsey, S. C., & Levine, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01393-9 · Cited by 272 · see citing works

INCREASED LEVELS OF GLYCOSAMINOGLYCANS DURING SEPTIC SHOCK

Nelson, A., Berkestedt, I., Schmidtchen, A., Ljunggren, L., & Bodelsson, M. (2008) · Shock · doi:10.1097/shk.0b013e3181777da3 · Cited by 271 · see citing works

Antioxidant status in patients with acute respiratory distress syndrome

Metnitz, P., Bartens, C., Fischer, M., Fridrich, P., Steltzer, H., & Druml, W. (1999) · Intensive Care Medicine · doi:10.1007/s001340050813 · Cited by 263 · see citing works

Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS.

Sheu, C.-C., Gong, M. N., Zhai, R., Chen, F., Bajwa, E. K., Clardy, P. F., Gallagher, D. C., Thompson, B. T., & Christiani, D. C. (2010) · Chest · doi:10.1378/chest.09-2933 · Cited by 260 · see citing works

Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?

Carr, A. C., Shaw, G. M., Fowler, A. A., & Natarajan, R. (2015) · Critical Care · doi:10.1186/s13054-015-1131-2 · Cited by 258 · see citing works

Ascorbic acid dynamics in the seriously ill and injured

Long, C. L., Maull, K. I., Krishnan, R. S., Laws, H. L., Geiger, J. W., Borghesi, L., Franks, W., Lawson, T. C., & Sauberlich, H. E. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(02)00083-5 · Cited by 254 · see citing works

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

Liu, S., Su, X., Pan, P., Zhang, L., Hu, Y., Tan, H., Wu, D., Liu, B., Li, H., Li, H., et al. (2016) · Scientific Reports · doi:10.1038/srep37252 · Cited by 254 · see citing works

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.

Fisher, B. J., Kraskauskas, D., Martin, E. J., Farkas, D., Wegelin, J. A., Brophy, D., Ward, K. R., Voelkel, N. F., Fowler, A. A., & Natarajan, R. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2011 · Cited by 231 · see citing works

Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function

Brogdon, J. L., Xu, Y., Szabo, S. J., An, S., Buxton, F., Cohen, D., & Huang, Q. (2006) · Blood · doi:10.1182/blood-2006-04-019711 · Cited by 226 · see citing works

A Multicenter Randomized Trial of Atorvastatin Therapy in Intensive Care Patients with Severe Sepsis

Krüger, P., Bailey, M., Bellomo, R., Cooper, D. J., Harward, M. L., Higgins, A. M., Howe, B. D., Jones, D., Joyce, C., Kostner, K., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1718oc · Cited by 219 · see citing works

Dietary vitamin C in human health

Granger, M., & Eck, P. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.11.006 · Cited by 217 · see citing works

Antioxidant Vitamins and Trace Elements in Critical Illness

Koekkoek, W. A. C. (., & van Zanten, A. R. H. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616653832 · Cited by 203 · see citing works

Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients

Berger, M. M., Soguel, L., Shenkin, A., Revelly, J.-P., Pinget, C., Baines, M., & Chioléro, R. L. (2008) · Critical Care · doi:10.1186/cc6981 · Cited by 202 · see citing works

Oxidative stress in septic shock and disseminated intravascular coagulation

Salvemini, D., & Cuzzocrea, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00961-9 · Cited by 201 · see citing works

Ascorbyl radical formation in patients with sepsis: Effect of ascorbate loading

Galley, H. F., Davies, M. J., & Webster, N. R. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02022-5 · Cited by 199 · see citing works

Post‐Translational Processing of Procollagens

Kivirikko, K. I., & Myllylä, R. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb51167.x · Cited by 196 · see citing works

Vitamin C: a novel regulator of neutrophil extracellular trap formation.

Mohammed, B., Fisher, B., Kraskauskas, D., Farkas, D., Brophy, D., Fowler, A., & Natarajan, R. (2013) · Nutrients · doi:10.3390/nu5083131 · Cited by 187 · see citing works

Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury.

Fisher, B. J., Seropian, I. M., Kraskauskas, D., Thakkar, J. N., Voelkel, N. F., Fowler, A. A., & Natarajan, R. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182120cb8 · Cited by 178 · see citing works

Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium

Wilson, J. X. (2009) · BioFactors · doi:10.1002/biof.7 · Cited by 176 · see citing works

Vitamin C Promotes Maturation of T-Cells

Manning, J., Mitchell, B., Appadurai, D. A., Shakya, A., Pierce, L. J., Wang, H., Nganga, V. K., Swanson, P. C., May, J. M., Tantin, D. R., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4988 · Cited by 174 · see citing works

Evolution and the Need for Ascorbic Acid

Pauling, L. C. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.67.4.1643 · Cited by 174 · see citing works

The role of ascorbic acid in cell metabolism: between gene-directed functions and unpredictable chemical reactions

Arrigoni, O., & Tullio, M. C. D. (2000) · Journal of Plant Physiology · doi:10.1016/s0176-1617(00)80102-9 · Cited by 173 · see citing works

Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines

Hayashida, K., Parks, W. C., & Park, P. W. (2009) · Blood · doi:10.1182/blood-2009-02-204966 · Cited by 159 · see citing works

Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia

Mikacenic, C. R., Moore, R., Dmyterko, V., West, T. E., Altemeier, W. A., Liles, W. C., & Lood, C. (2018) · Critical Care · doi:10.1186/s13054-018-2290-8 · Cited by 153 · see citing works

Trends in Sepsis and Infection Sources in the United States. A Population-Based Study

Walkey, A. J., Lagu, T. C., & Lindenauer, P. K. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201411-498bc · Cited by 151 · see citing works

JMJD3 as an epigenetic regulator in development and disease

Burchfield, J. S., Li, Q., Wang, H. Y., & Wang, R. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.07.006 · Cited by 150 · see citing works

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M. H., Lane, S., Welters, I. D., Wang, G., & Toh, C. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201811-2111oc · Cited by 148 · see citing works

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

Chen, Y., Luo, G., Jiao, Y., Wang, Y., Yang, X., Wang, X., Li, G., Liu, Z., & Zhong, N. (2014) · Mediators of Inflammation · doi:10.1155/2014/426740 · Cited by 144 · see citing works

Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8

Corpe, C. P., Eck, P., Wang, J., Al‐Hasani, H., & Levine, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436790 · Cited by 140 · see citing works

Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock

Maruchi, Y., Tsuda, M., Mori, H., Takenaka, N., Gocho, T., Huq, M. A., & Takeyama, N. (2018) · Critical Care · doi:10.1186/s13054-018-2109-7 · Cited by 131 · see citing works

Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β

Cárcamo, J. M., Pedraza, A. M., Bórquez-Ojeda, O., Zhang, B., Sánchez, R., & Golde, D. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6645-6652.2004 · Cited by 129 · see citing works

Reprogramming the epigenome with vitamin C

Lee Chong, T., Ahearn, E. L., & Cimmino, L. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00128 · Cited by 120 · see citing works

Ascorbic acid inhibits ROS production, NF-?B activation and prevents ethanol-induced growth retardation and microencephaly

PENG, Y., KWOK, K., Yang, P., NG, S., LIU, J., WONG, O., He, M., Kung, H. H., & Lin, M.-S. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.10.018 · Cited by 117 · see citing works

Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

Hirose, T., Hamaguchi, S., Matsumoto, N., Irisawa, T., Seki, M., Tasaki, O., Hosotsubo, H., Yamamoto, N., Yamamoto, K., Akeda, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111755 · Cited by 115 · see citing works

Plasma syndecan-1 levels identify a cohort of patients with severe sepsis at high risk for intubation after large-volume intravenous fluid resuscitation

Puskarich, M. A., Cornelius, D. C., Tharp, J. G., Nandi, U., & Jones, A. E. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.06.027 · Cited by 115 · see citing works

Clinical trials of mediator-directed therapy in sepsis: what have we learned?

Marshall, J. C. (2000) · Intensive Care Medicine · doi:10.1007/s001340051122 · Cited by 112 · see citing works

Epidemiology of Sepsis in the Valencian Community (Spain), 1995–2004

Andreu‐Ballester, J. C., Ballester, F., Sánchez, A. G., Almela-Quilis, A., Colomer-Rubio, E., & Otero, C. P. (2008) · Infection Control and Hospital Epidemiology · doi:10.1086/589583 · Cited by 112 · see citing works

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts

Kishimoto, Y., Saito, N., Kurita, K., Shimokado, K., Maruyama, N., & Ishigami, A. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.110 · Cited by 111 · see citing works

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Murphy, L. S., Wickersham, N. E., McNeil, J. B., Shaver, C. M., May, A. K., Bastarache, J. A., & Ware, L. B. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0325-y · Cited by 111 · see citing works

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

Huijskens, M. J. A. J., Walczak, M., Koller, N., Briedé, J. J., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C. A., Bos, G. M. J., & Germeraad, W. T. V. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ta0214-121rr · Cited by 109 · see citing works

Evaluation of Vitamin C for Adjuvant Sepsis Therapy

Wilson, J. X. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5401 · Cited by 101 · see citing works

Vascular adhesion protein‐1 and syndecan‐1 in septic shock

Sallisalmi, M., Tenhunen, J. J., Yang, R., Oksala, N., & Pettilä, V. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02578.x · Cited by 100 · see citing works

Inactivation dates of the human and guinea pig vitamin C genes

Lachapelle, M. Y., & Drouin, G. (2010) · Genetica · doi:10.1007/s10709-010-9537-x · Cited by 98 · see citing works

Neutrophil Extracellular Traps Promote Hypercoagulability in Patients With Sepsis

Yang, S., Qi, H., Kan, K., Chen, J., Xie, H., Guo, X., & Zhang, L. (2016) · Shock · doi:10.1097/shk.0000000000000741 · Cited by 98 · see citing works

CD138 (syndecan 1) expression in health and disease

Palaiologou, M., Delladetsima, I. K., & TINIAKOS, D. G. (2014) · PubMed · doi:10.14670/hh-29.177 · Cited by 95 · see citing works

Soluble syndecans: biomarkers for diseases and therapeutic options

Bertrand, J., & Bollmann, M. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14397 · Cited by 89 · see citing works

Vitamin C Inhibits Staphylococcus aureus Growth and Enhances the Inhibitory Effect of Quercetin on Growth of Escherichia coli In Vitro

Kallio, J., Jaakkola, M., Mäki, M., Kilpeläinen, P., & Virtanen, V. T. (2012) · Planta Medica · doi:10.1055/s-0032-1315388 · Cited by 88 · see citing works

Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock

Winter, B., Fiskum, G., & Gallo, L. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.482 · Cited by 88 · see citing works

Neutrophil extracellular traps in physiology and pathology

Manda‐Handzlik, A., Pruchniak, M. P., Araźna, M., & Demkow, U. A. (2014) · Central European Journal of Immunology · doi:10.5114/ceji.2014.42136 · Cited by 83 · see citing works

Effect of Vitamin C Administration on Neutrophil Apoptosis in Septic Patients After Abdominal Surgery

Ferrón-Celma, I., Mansilla, A., Hassan, L., García‐Navarro, A., Comino, A.-M., Bueno, P., & Ferrón, J. A. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.04.024 · Cited by 80 · see citing works

Vitamin C is dispensable for oxygen sensing in vivo

Nytko, K. J., Maeda, N., Schläfli, P., Spielmann, P., Wenger, R. H., & Stiehl, D. P. (2011) · Blood · doi:10.1182/blood-2010-09-307637 · Cited by 77 · see citing works

Functional and Physiological Role of Vitamin C Transporters

Bürzle, M., & Hediger, M. A. (2012) · Current topics in membranes · doi:10.1016/b978-0-12-394316-3.00011-9 · Cited by 70 · see citing works

Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

Smart, L., Bosio, E., Macdonald, S. P. J., Dull, R. O., Fatovich, D. M., Neil, C., & Arendts, G. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.06.015 · Cited by 67 · see citing works

Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial

Wei, S., González, E. G., Chang, R., Holcomb, J. B., Kao, L. S., & Wade, C. E. (2018) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2018.09.003 · Cited by 65 · see citing works

The Role of Physiological Vitamin C Concentrations on Key Functions of Neutrophils Isolated from Healthy Individuals

Bozonet, S. M., & Carr, A. C. (2019) · Nutrients · doi:10.3390/nu11061363 · Cited by 63 · see citing works

2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: Design and Evaluation as a Novel Radical-Scavenging Antioxidant against Lipid Peroxidation

Noguchi, N., Iwaki, Y., Takahashi, M., Komuro, E., Kato, Y., Tamura, K., Cynshi, O., Kodama, T., & Niki, E. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.9994 · Cited by 61 · see citing works

Consequences of extracellular trap formation in sepsis

O’Brien, X. M., Girard, B., & Reichner, J. S. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000303 · Cited by 61 · see citing works

Functional Expression of Sodium-Dependent Vitamin C Transporter 2 in Human Endothelial Cells

Seno, T., Inoue, N., Matsui, K., Ejiri, J., Hirata, K., Kawashima, S., & Yokoyama, M. (2004) · Journal of Vascular Research · doi:10.1159/000080525 · Cited by 59 · see citing works

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Li, J. (2018) · Critical Care · doi:10.1186/s13054-018-2191-x · Cited by 59 · see citing works

Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro

Goldschmidt, M. C. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1214s · Cited by 56 · see citing works

Origin of Circulating Free DNA in Sepsis: Analysis of the CLP Mouse Model

Hamaguchi, S., Akeda, Y., Yamamoto, N., Seki, M., Yamamoto, K., Oishi, K., & Tomono, K. (2015) · Mediators of Inflammation · doi:10.1155/2015/614518 · Cited by 53 · see citing works

Effect of ascorbic acid deficiency on the in vivo synthesis of carnitine

Nelson, P. J., Pruitt, R. E., Henderson, L. L., Jenness, R., & Henderson, L. M. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90286-5 · Cited by 53 · see citing works

Neutrophil dysfunction and repeated infections: influence of levamisole and ascorbic acid

Rebora, A., Dallegri, F., & Patrone, F. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb05671.x · Cited by 52 · see citing works

Vitamin C inhibits platelet expression of CD40 ligand

Pignatelli, P., Sanguigni, V., Paola, S. G., Coco, E. L., Lenti, L., & Violi, F. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.032 · Cited by 50 · see citing works

The Effects of Intravenous Vitamin C on Point-of-Care Glucose Monitoring

Sartor, Z., Kesey, J. E., & Dissanaike, S. (2014) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000142 · Cited by 47 · see citing works

The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus.

Goldschmidt, M. C., Wj, M., Brown, L. R., & Wyde, P. R. (1988) · PubMed · Cited by 47 · see citing works

Loss of Syndecan-1 Abrogates the Pulmonary Protective Phenotype Induced by Plasma After Hemorrhagic Shock

Wu, F., Peng, Z., Park, P. W., & Kozar, R. A. (2017) · Shock · doi:10.1097/shk.0000000000000832 · Cited by 47 · see citing works

Cytokine–Ion Channel Interactions in Pulmonary Inflammation

Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M. G., Männel, D. N., Moehrlen, U., Lucas, R., & Stammberger, U. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01644 · Cited by 47 · see citing works

Effect of Ascorbic Acid Nutriture on Blood Histamine and Neutrophil Chemotaxis in Guinea Pigs

Johnston, C. S., & Huang, S. (1991) · Journal of Nutrition · doi:10.1093/jn/121.1.126 · Cited by 43 · see citing works

The role of ascorbate in the biosynthesis of neuroendocrine peptides

Eipper, B., & Mains, R. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1153s · Cited by 41 · see citing works

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P. P., Sangani, R., Chutkan, N. B., Hamrick, M. W., Bhattacharyya, M. H., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. M., et al. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.08.004 · Cited by 39 · see citing works

Glycolytic, Hexose Monophosphate Shunt and Bactericidal Activities of Leukocytes in Ascorbic Acid Deficient Guinea Pigs

Shilotri, P. G. (1977) · Journal of Nutrition · doi:10.1093/jn/107.8.1507 · Cited by 33 · see citing works

Protective Effects of Combined Ischemic Preconditioning and Ascorbic Acid on Mitochondrial Injury in Hepatic Ischemia/Reperfusion

Lee, W., Lee, J., & Lee, S. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.08.043 · Cited by 32 · see citing works

Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

Mikirova, N. A., Riordan, N. H., & Casciari, J. J. (2016) · Medical Science Monitor · doi:10.12659/msm.895368 · Cited by 32 · see citing works

Circulating syndecans during critical illness

Nelson, A., Johansson, J., Tydén, J., & Bodelsson, M. (2017) · Apmis · doi:10.1111/apm.12662 · Cited by 30 · see citing works

Ascorbic acid as a sensor of oxidative stress and a regulator of gene expression: The Yin and Yang of vitamin C

Grano, A., & Tullio, M. C. D. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.02.008 · Cited by 26 · see citing works

Impact of high dose vitamin C on platelet function

Mohammed, B. M., Sanford, K., Fisher, B. J., Martin, E. J., Contaifer, D., Warncke, U. O., Wijesinghe, D. S., Chalfant, C. E., Brophy, D. F., Fowler, A. A., et al. (2017) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v6.i1.37 · Cited by 26 · see citing works

How to Give Vitamin C a Cautious but Fair Chance in Severe Sepsis

Straaten, H. M. O., Elbers, P., & de Man, A. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.01.008 · Cited by 23 · see citing works

Bactericidal Action of Ascorbic Acid on Pseudomonas aeruginosa: Alteration of Cell Surface as a Possible Mechanism

Rawal, B. D. (2009) · Chemotherapy · doi:10.1159/000237777 · Cited by 22 · see citing works

Effects of the Antioxidants Lycium Barbarum and Ascorbic Acid on Reperfusion Liver Injury in Rats

Wang, N. T., Lin, H. I., Yeh, D. Y.-W., Chou, T., Chen, C. F., Leu, F.-C., Wang, D., & Hu, R. T. (2009) · Transplantation Proceedings · doi:10.1016/j.transproceed.2009.08.051 · Cited by 20 · see citing works

Ascorbic Acid and Prostaglandin Synthesis

Horrobin, D. F. (1996) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4613-0325-1_6 · Cited by 13 · see citing works

Relation of thrombomodulin, TFPI and plasma antioxidants in healthy individuals and patients with coronary heart disease

Huang, J., Fu, G., Yao, Q., & Cheng, G. (2008) · Acta Cardiologica · doi:10.2143/ac.63.3.1020311 · Cited by 12 · see citing works

Accuracy of Point‐of‐Care Blood Glucose Level Measurements in Critically Ill Patients with Sepsis Receiving High‐Dose Intravenous Vitamin C

Smith, K., Brown, C. S., Manning, B. M., May, T., Riker, R. R., Lerwick, P. A., Hayes, T. L., & Fraser, G. L. (2018) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2182 · Cited by 11 · see citing works

Glucometry When Using Vitamin C in Sepsis

Hager, D. N., Martin, G. S., Sevransky, J., & Hooper, M. H. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.03.018 · Cited by 10 · see citing works

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment

Cudjoe, E. K., Hassan, Z. H., Kang, L., Reynolds, P. S., Fisher, B. J., McCarter, J., Sweeney, C., Martin, E. J., Middleton, P., Ellenberg, M., et al. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14580 · Cited by 9 · see citing works

Effects of High Dose Intravenous Vitamin C (IVC) on Plasma Cell-Free DNA Levels in Patients with Sepsis-Associated ARDS

Qiao, X., Fisher, B., Kashiouris, M. G., Truwit, J. D., Hite, R. D., Morris, P. E., Martin, G. S., & Fowler, A. A. (2019) · doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2100 · Cited by 6 · see citing works

Ascorbate (1g/day) does not help the phagocyte killing defect of X-linked chronic granulomatous disease.

Foroozanfar, N., Lucas, C., Joss, D. V., Hugh-Jones, K., & Hobbs, J. R. (1983) · PubMed Central · Cited by 5 · see citing works

A Multicenter Parsimonious Biomarker Mortality Prediction Model for Sepsis-Induced ARDS

Kashiouris, M. G., Qiao, X., Fisher, B. J., Truwit, J. D., Hite, R. D., Morris, P. E., Martin, G. S., & Fowler, A. A. (2019) · doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2381 · Cited by 2 · see citing works

A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19)

Kakodkar, P., Kaka, N., & Baig, M. (2020) · Cureus · doi:10.7759/cureus.7560 · Cited by 533 · see citing works

Clinical trials on drug repositioning for COVID-19 treatment

Viveiros-Rosa, S. G., & Santos, W. C. (2020) · Revista Panamericana de Salud Pública · doi:10.26633/rpsp.2020.40 · Cited by 420 · see citing works

Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

Yang, J., Zhang, R., Zhao, H., Qi, H., Li, J., Li, J., Zhou, X., Wang, A., Fan, K., Yan, X., et al. (2022) · Exploration · doi:10.1002/exp.20210267 · Cited by 290 · see citing works

Could Vitamins Help in the Fight Against COVID-19?

Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020) · Nutrients · doi:10.3390/nu12092550 · Cited by 234 · see citing works

Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19

Holford, P., Carr, A. C., Jovic, T. H., Ali, S. R., Whitaker, I. S., Marik, P. E., & Smith, A. D. (2020) · Nutrients · doi:10.3390/nu12123760 · Cited by 201 · see citing works

Myth Busters: Dietary Supplements and COVID-19

Adams, K. K., Baker, W. L., & Sobieraj, D. M. (2020) · Annals of Pharmacotherapy · doi:10.1177/1060028020928052 · Cited by 171 · see citing works

Role of vitamins and minerals as immunity boosters in COVID-19

Kumar, P., Kumar, M., Bedi, O., Gupta, M., Kumar, S., Jaiswal, G., Rahi, V., Yedke, N. G., Bijalwan, A., Sharma, S., et al. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00826-7 · Cited by 174 · see citing works

A narrative literature review on traditional medicine options for treatment of corona virus disease 2019 (COVID-19)

Mirzaie, A., Halaji, M., Dehkordi, F. S., Ranjbar, R., & Noorbazargan, H. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101214 · Cited by 164 · see citing works

Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential

Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161 · see citing works

Overview of the possible role of vitamin C in management of COVID-19

Abobaker, A., Alzwi, A., & Alraied, A. H. A. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00176-1 · Cited by 158 · see citing works

The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19

Carr, A. C., & Rowe, S. (2020) · Nutrients · doi:10.3390/nu12113286 · Cited by 155 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C

Vollbracht, C., & Kraft, K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.899198 · Cited by 146 · see citing works

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

Alam, M. S., & Czajkowsky, D. M. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.11.001 · Cited by 101 · see citing works

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

Li, R., Guo, C., Li, Y., Qin, Z., & Huang, W. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa079 · Cited by 87 · see citing works

Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C

Lankadeva, Y. R., Peiris, R. M., Okazaki, N., Birchall, I. E., Trask-Marino, A. L., Dornom, A., Vale, T. A. M., Evans, R. G., Yanase, F., Bellomo, R., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004770 · Cited by 72 · see citing works

Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial

Rosengrave, P., Spencer, E. S., Williman, J. A., Mehrtens, J. E., Morgan, S., Doyle, T., Heyden, K. V. D., Morris, A., Shaw, G. M., & Carr, A. C. (2022) · Critical Care · doi:10.1186/s13054-022-03900-w · Cited by 70 · see citing works

SARS-CoV-2: A critical review of its history, pathogenesis, transmission, diagnosis and treatment

Sofi, M. S., Hamid, A., & Bhat, S. U. (2020) · Biosafety and Health · doi:10.1016/j.bsheal.2020.11.002 · Cited by 61 · see citing works

High-dose intravenous vitamin C treatment for COVID-19Preprint

Erol, A. (2020) · doi:10.31219/osf.io/p7ex8 · Cited by 61 · see citing works

Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes

Neyton, L. P. A., Sinha, P., Sarma, A. A., Mick, E., Kalantar, K., Chen, S., Wu, N., Delucchi, K., Zhuo, H., Bos, L. D. J., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202308-1328oc · Cited by 61 · see citing works

Hazards of the Cytokine Storm and Cytokine-Targeted Therapy in Patients With COVID-19: Review

Quirch, M., Lee, J., & Rehman, S. (2020) · Journal of Medical Internet Research · doi:10.2196/20193 · Cited by 57 · see citing works

Development of a colorimetric sensing assay for ascorbic acid and sarcosine utilizing the dual-class enzyme activity of Fe3O4@SiO2@NiCo2S4

Wang, X., Chen, M., & Zhao, L. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143612 · Cited by 52 · see citing works

The multiomics landscape of serum exosomes during the development of sepsis

Li, L., Huang, L., Huang, C., Xu, J., Huang, Y., Luo, H., Lu, X., He, S., Yuan, G., Chen, L., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.11.005 · Cited by 50 · see citing works

The prophylaxis and treatment potential of supplements for COVID-19

Sahebnasagh, A., Saghafi, F., Avan, R., Khoshi, A., Khataminia, M., Safdari, M., Habtemariam, S., Ghaleno, H. R., & Nabavi, S. M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173530 · Cited by 48 · see citing works

Role of vitamin C in preventing of COVID-19 infection, progression and severity

Shahbaz, U., Fatima, N., Basharat, S., Bibi, A., Yu, X., Hussain, M. I., & Nasrullah, M. (2022) · AIMS Microbiology · doi:10.3934/microbiol.2022010 · Cited by 46 · see citing works

Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection

Patterson, T., Isales, C. M., & Fulzele, S. (2021) · Aging and Disease · doi:10.14336/ad.2020.0918 · Cited by 44 · see citing works

Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients

Lavillegrand, J., Raia, L., Urbina, T., Hariri, G., Gabarre, P., Bonny, V., Bigé, N., Baudel, J.-L., Bruneel, A., Dupré, T., et al. (2022) · Critical Care · doi:10.1186/s13054-022-03891-8 · Cited by 43 · see citing works

A High-Performance Liquid Chromatography with Electrochemical Detection Method Developed for the Sensitive Determination of Ascorbic Acid: Validation, Application, and Comparison with Titration, Spectrophotometric, and High-Performance Liquid Chromatography with Diode-Array Detection Methods

Wu, F., Xu, F., Liu, W., Chen, S., Luo, H., Cheng, N., Zhao, H., & Cao, W. (2023) · Foods · doi:10.3390/foods12163100 · Cited by 42 · see citing works

The pharmacology of vitamin C

Lykkesfeldt, J., Carr, A. C., & Tveden‐Nyborg, P. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100043 · Cited by 44 · see citing works

Advances in Ascorbic Acid (Vitamin C) Manufacturing: Green Extraction Techniques from Natural Sources

Susa, F., & Pisano, R. (2023) · Processes · doi:10.3390/pr11113167 · Cited by 41 · see citing works

Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study

Chen, P., Reed, G. A., Jiang, J., Wang, Y., Sunega, J. M., Dong, R., Ma, Y., Esparham, A. E., Ferrell, R., Levine, M. N., et al. (2022) · Clinical Pharmacokinetics · doi:10.1007/s40262-022-01142-1 · Cited by 40 · see citing works

A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats

Üstündağ, H., Doğanay, S., Kalındemirtaş, F. D., Demir, Ö., Huyut, M. T., Kurt, N., Özgeriş, F. B., & Akbaba, Ö. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121875 · Cited by 40 · see citing works

Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF-κB signaling

Zhao, Z.-M., Su, M., Zheng, Q.-Y., Wang, J., Yin, Y.-R., Zhang, J., & Wang, X. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115481 · Cited by 37 · see citing works

Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19

Yamasaki, H. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.07.005 · Cited by 36 · see citing works

Molecular hydrogen is a potential protective agent in the management of acute lung injury

Zhang, Y., Zhang, J., & Fu, Z. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00455-y · Cited by 36 · see citing works

Decoding Sepsis-Induced Disseminated Intravascular Coagulation: A Comprehensive Review of Existing and Emerging Therapies

Unar, A., Bertolino, L., Patauner, F., Gallo, R., & Durante‐Mangoni, E. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196128 · Cited by 29 · see citing works

Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back

González‐Montero, J., Chichiarelli, S., Eufemi, M., Fabio Altieri, F., Saso, L., & Rodrigo, R. (2022) · Molecules · doi:10.3390/molecules27123818 · Cited by 27 · see citing works

A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19

Fogleman, C. D., Cohen, D., Mercier, A., Farrell, D., Rutz, J., Bresz, K. E., & Vernon, T. M. (2022) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2022.04.210529 · Cited by 27 · see citing works

The effect of neutrophil extracellular traps in venous thrombosis

Li, W., Wang, Z., Su, C., Liao, Z., Pei, Y., Wang, J., Li, Z., Fu, S., & Liu, J. (2023) · Thrombosis Journal · doi:10.1186/s12959-023-00512-4 · Cited by 30 · see citing works

Potential Antioxidant Multitherapy against Complications Occurring in Sepsis

Abelli, J., Méndez-Valdés, G., Gómez-Hevia, F., Bragato, M. C., Chichiarelli, S., Saso, L., & Rodrigo, R. (2022) · Biomedicines · doi:10.3390/biomedicines10123088 · Cited by 27 · see citing works

Vitamins C and D and COVID-19 Susceptibility, Severity and Progression: An Evidence Based Systematic Review

Migliorini, F., Vaishya, R., Eschweiler, J., Oliva, F., Hildebrand, F., & Maffulli, N. (2022) · Medicina · doi:10.3390/medicina58070941 · Cited by 26 · see citing works

Prolonged Reactive Oxygen Species Production following Septic Insult

Jensen, I. J., McGonagill, P. W., Berton, R. R., Wagner, B. A., Silva, E. E., Buettner, G. R., Griffith, T. S., & Badovinac, V. P. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100027 · Cited by 25 · see citing works

High-Dose Intravenous Ascorbate in Sepsis, a Pro-Oxidant Enhanced Microbicidal Activity and the Effect on Neutrophil Functions

Sae‐khow, K., Charoensappakit, A., Chiewchengchol, D., & Leelahavanichkul, A. (2022) · Biomedicines · doi:10.3390/biomedicines11010051 · Cited by 24 · see citing works

COVID-19 severity in relation to sociodemographics and vitamin D use

Abdulateef, D. S., Rahman, H. S., Salih, J. M., Osman, S. M., Mahmood, T. A., Omer, S. H. S., & Ahmed, R. A. (2021) · Open Medicine · doi:10.1515/med-2021-0273 · Cited by 21 · see citing works

Efficacy of intravenous vitamin C intervention for septic patients: A systematic review and meta-analysis based on randomized controlled trials

Li, T., Zeng, J., Li, D.-H., Yang, G., Wang, K., Deng, H., & Jiang, H. (2021) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2021.08.012 · Cited by 21 · see citing works

Efficacy and safety of perioperative vitamin C in patients undergoing noncardiac surgery: a systematic review and meta-analysis of randomised trials

Suter, M., Pinto, B. B., Belletti, A., & Putzu, A. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.11.039 · Cited by 21 · see citing works

SP1 Promotes HDAC4 Expression and Inhibits HMGB1 Expression to Reduce Intestinal Barrier Dysfunction, Oxidative Stress, and Inflammatory Response after Sepsis

Liu, Z.-M., Wang, X., Li, C., Liu, X., Guo, X., Li, Y., Chen, Y.-L., Ye, H.-X., & Chen, H. (2022) · Journal of Innate Immunity · doi:10.1159/000518277 · Cited by 21 · see citing works

Electroacupuncture at ST36 (Zusanli) Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice

Lv, Z.-Y., Shi, Y.-L., Bassi, G. S., Chen, Y., Yin, L.-M., Wang, Y., Ulloa, L., Yang, Y., & Xu, Y. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s361466 · Cited by 21 · see citing works

Recent advances in understanding oxidative stress in sepsis: pathogenic roles and antioxidant therapeutic prospects - a narrative review

Lin, Y., Alhaskawi, A., Chen, L., & Moqbel, S. A. A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1695992 · Cited by 21 · see citing works

Medical Nutrition Therapy in Hospitalized Patients With SARS-CoV-2 (COVID-19) Infection in a Non-critical Care Setting: Knowledge in Progress

Cervantes‐Pérez, E., Cervantes‐Guevara, G., Holguín, M. C. M.-S., Cervantes-Pérez, L. A., Cervantes-Pérez, G., Cervantes‐Cardona, G. A., González‐Ojeda, A., Fuentes‐Orozco, C., & Ramírez-Ochoa, S. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00337-x · Cited by 20 · see citing works

Compliance Indicators of COVID-19 Prevention and Vaccines Hesitancy in Kenya: A Random-Effects Endogenous Probit Model

Oyekale, A. S. (2021) · Vaccines · doi:10.3390/vaccines9111359 · Cited by 20 · see citing works

Insight into SARS-CoV-2 Omicron variant immune escape possibility and variant independent potential therapeutic opportunities

Alam, M. S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13285 · Cited by 22 · see citing works

A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status

Chowdhury, A., Sajid, M., Jahan, N., Adelusi, T. I., Maitra, P., Yin, G., Wu, X., Gao, Y., & Wang, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111956 · Cited by 19 · see citing works

COVID-19, Vascular Endothelial Growth Factor (VEGF) and IodidePreprint

Turkia, M. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3604987 · Cited by 19 · see citing works

Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock: a double-blind, randomized, placebo-controlled study

Belousovienė, E., Pranskūnienė, Ž., Vaitkaitienė, E., Pilvinis, V., & Pranskūnas, A. (2023) · BMC Anesthesiology · doi:10.1186/s12871-023-02265-z · Cited by 19 · see citing works

High-dose intravenous vitamin C decreases rates of mechanical ventilation and cardiac arrest in severe COVID-19

Hess, A. L., Halalau, A., Dokter, J., Paydawy, T. S., Karabon, P., Bastani, A., Baker, R. E., Balla, A. K., & Galens, S. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-02954-6 · Cited by 18 · see citing works

Clinical efficacy and safety of vitamin C in the treatment of septic shock patients: systematic review and meta-analysis

Cai, B., Lv, X., Lin, M., Feng, C., & Chen, C. (2022) · Annals of Palliative Medicine · doi:10.21037/apm-22-225 · Cited by 17 · see citing works

Vitamins, microelements and the immune system: current standpoint in the fight against coronavirus disease 2019

Djordjevic, B., Milenković, J., Stojanovic, D., Velickov, A., Djindjic, B., & Stoimenov, T. J. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522000083 · Cited by 17 · see citing works

Better Preventing and Mitigating the Effects of Covid-19

Maguire, G. (2020) · Future Science OA · doi:10.2144/fsoa-2020-0051 · Cited by 16 · see citing works

Biochemical Effects and Therapeutic Application of Vitamin C (C6H8O6) on COVID-19 Infection

Earar, K., Arbune, M., Dorobăț, C., Rusu-Negraia, M., Ștefănescu, V., Indrei, L. L., Harabor, V. R., Hărăbor, A., & Bratu, A. M. (2020) · Revista de Chimie · doi:10.37358/rc.20.5.8159 · Cited by 16 · see citing works

Role of ascorbic acid infusion in critically ill patients with transfusion‐related acute lung injury

Kassem, A. B., Ahmed, I., Omran, G. A., Megahed, M., & Habib, T. N. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15167 · Cited by 17 · see citing works

Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review

Singh, P., Rauda, R. H., & Peña‐Rodas, O. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3314 · Cited by 14 · see citing works

Polyvagal and Global Cytokine Theory of Safety and Threat Covid-19 Plan B

Hanscom, D. R., Clawson, D. R., Porges, S. W., Bunnage, R., Aria, L., Lederman, S., Taylor, J. M., & Carter, C. S. (2020) · SciMedicine Journal · doi:10.28991/scimedj-2020-02-si-2 · Cited by 14 · see citing works

Implications of Vitamins in COVID-19 Prevention and Treatment through Immunomodulatory and Anti-Oxidative Mechanisms

Toledano, J. M., Moreno‐Fernández, J., Puche-Juárez, M., Ochoa, J. J., & Díaz‐Castro, J. (2021) · Antioxidants · doi:10.3390/antiox11010005 · Cited by 14 · see citing works

Point of care blood glucose devices in the hospital setting

Tran, N. K., LaValley, C., Bagley, B., & Rodrigo, J. (2023) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2023.2170316 · Cited by 16 · see citing works

What are the drugs having potential against COVID-19?

Küçükoğlu, K., Faydalı, N., & Bul, D. (2020) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02625-1 · Cited by 13 · see citing works

High-dose vitamin C ameliorates cardiac injury in COVID-19 pandemic: a retrospective cohort study

Xia, G., Qin, B., Ma, C., Zhu, Y., & Zheng, Q. (2021) · Aging · doi:10.18632/aging.203503 · Cited by 14 · see citing works

Vitamin C: From Bench to Bedside

Carr, A. C., & Lykkesfeldt, J. (2021) · Nutrients · doi:10.3390/nu13041102 · Cited by 13 · see citing works

Mycotoxicosis and oxidative stress in poultry: pathogenesis and therapeutic insights

Alam, M. S., Maowa, Z., Subarna, S. D., & Hoque, M. N. (2024) · World s Poultry Science Journal · doi:10.1080/00439339.2024.2347307 · Cited by 16 · see citing works

GLP-1 as a regulator of sepsis outcomes: Insights into cellular metabolism, inflammation, and therapeutic potential

Fan, W., Zhang, Q., Wang, C., Sun, J., Zhang, J., & Yin, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114390 · Cited by 12 · see citing works

Anti-inflammatory and antioxidant properties of betaine protect against sepsis-induced acute lung injury: CT and histological evidence

Sorgun, O., Çakır, A., Bora, E. S., Erdoğan, M. A., Uyanıkgil, Y., & Erbaş, O. (2023) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2023e12906 · Cited by 11 · see citing works

High-dose Vitamin C injection ameliorates against sepsis induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats

Cui, Y., Tian, N., Luo, Y.-H., Zhao, J., Bi, C.-F., Gou, Y., Liu, J., Feng, K., & Zhang, J. (2024) · Aging · doi:10.18632/aging.205735 · Cited by 12 · see citing works

Oxygen therapy for sepsis and prevention of complications

Minasyan, H. A. (2022) · Acute and Critical Care · doi:10.4266/acc.2021.01200 · Cited by 11 · see citing works

Is it time to reconsider the administration of thiamine alone or in combination with vitamin C in critically ill patients? A meta-analysis of clinical trial studies

Mashhadi, N. S., Aliyari, A., Hajhashemy, Z., Saadat, S., & Rouhani, M. H. (2022) · Journal of Intensive Care · doi:10.1186/s40560-022-00594-8 · Cited by 11 · see citing works

Pemberian Terapi Vitamin C pada COVID-19

Hasan, M. N., Levani, Y., Laitupa, A. A., & Triastuti, N. (2021) · JURNAL PANDU HUSADA · doi:10.30596/jph.v2i2.5754 · Cited by 10 · see citing works

High-Dose Vitamin C Supplementation as a Legitimate Anti-SARS-CoV-2 Prophylaxis in Healthy Subjects—Yes or No?

Gruber, B. (2022) · Nutrients · doi:10.3390/nu14050979 · Cited by 10 · see citing works

An Enzyme-Free Photoelectrochemical Sensor Platform for Ascorbic Acid Detection in Human Urine

Zhao, Z., Han, D., Xiao, R., Wang, T., Liang, Z., Wu, Z., Han, F., Han, D., Ma, Y., & Niu, L. (2022) · Chemosensors · doi:10.3390/chemosensors10070268 · Cited by 10 · see citing works

The effect of intravenous vitamin C on clinical outcomes in patients with sepsis or septic shock: A meta-analysis of randomized controlled trials

Zhu, H., Xu, X., Zhang, K., & Ye, Q. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.964484 · Cited by 10 · see citing works

High-dose ascorbic acid potentiates immune modulation through STAT1 phosphorylation inhibition and negative regulation of PD-L1 in experimental sepsis

Zhang, X., Ji, W., Deng, X., & Bo, L. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01319-5 · Cited by 10 · see citing works

The effect of vitamin C in adults with sepsis: a meta-analysis of randomized controlled trials

Luo, X., Zhu, Y., Zhang, R., Zhu, J., Kuang, H., Shao, Y., Guo, X., & Ning, B. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1244484 · Cited by 9 · see citing works

COVID-19: Novel Opinion on Strategic Prophylaxis and Cure Using Vitamin C (Ascorbic Acid)

Ohanube, G. A. K. (2020) · Acta Scientifci Nutritional Health · doi:10.31080/asnh.2020.04.0697 · Cited by 9 · see citing works

Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Lu, D., & Mao, W. (2023) · Clinical and investigative medicine · doi:10.25011/cim.v46i1.40275 · Cited by 9 · see citing works

COVID-19: A brief overview on the role of Vitamins specifically Vitamin C as immune modulators and in prevention and treatment of SARS-Cov-2 infections

Jan, H. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.28.004648 · Cited by 9 · see citing works

High-dose ascorbate exerts anti-tumor activities and improves inhibitory effect of carboplatin through the pro-oxidant function pathway in uterine serous carcinoma cell lines

Shen, X., Wang, J., Deng, B., Chen, S., John, C., Zhao, Z., Sinha, N., Haag, J. G., Sun, W., Kong, W., et al. (2024) · Gynecologic Oncology · doi:10.1016/j.ygyno.2024.03.021 · Cited by 8 · see citing works

The effects of vitamin C supplementation in the critically ill patients outcomes: A systematic review and meta-analysis of randomized controlled trials

Yong, S., Suping, L., Peng, Z., Dong, L., & Qing, W. (2024) · Medicine · doi:10.1097/md.0000000000037420 · Cited by 8 · see citing works

Dietary Factors Influencing the Intensity of Low-Grade Inflammation in Obesity

Fic, W., & Polak-Szczybyło, E. (2025) · Obesities · doi:10.3390/obesities5010012 · Cited by 8 · see citing works

Ascorbate protects human kidney organoids from damage induced by cell-free hemoglobin

Bejoy, J., Farry, J. M., Qian, E. S., Dearing, C. H., Ware, L. B., Bastarache, J. A., & Woodard, L. E. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050342 · Cited by 8 · see citing works

The Role of Immunomodulatory Nutrients in Alleviating Complications Related to SARS-CoV-2: A Scoping Review

Jandaghi, P., Hosseini, Z., Chilibeck, P. D., Hanley, A. J., DeGuire, J. R., Bandy, B., Pahwa, P., & Vatanparast, H. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab128 · Cited by 8 · see citing works

Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling’s Vitamin C Therapy

Yamasaki, H., Imai, H., Tanaka, A., & Otaki, J. M. (2023) · Microorganisms · doi:10.3390/microorganisms11020397 · Cited by 8 · see citing works

The Critical Exploration into Current Evidence behind the Role of the Nutritional Support in Adult Patients Who Undergo Haematogenic Stem Cell Transplantation

Pawłowski, P., Pawłowska, P., Ziętara, K. J., & Samardakiewicz, M. (2023) · Nutrients · doi:10.3390/nu15163558 · Cited by 7 · see citing works

Therapeutic options for the treatment of post-acute sequelae of COVID-19: a scoping review

Seo, Y. B., Choi, Y. J., Seo, J.-W., Kim, E. J., Lee, J., & Song, J. Y. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-11131-x · Cited by 7 · see citing works

Failed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically effective therapeutics

Battaglini, D., Cruz, F. F., Robba, C., Pelosi, P. P., & Rocco, P. R. M. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2120801 · Cited by 7 · see citing works

Integrative Cancer Therapies: Learning From COVID-19

Block, K. I. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420932652 · Cited by 7 · see citing works

Safety of High-Dose Vitamin C in Critically Ill Patients: A Systematic Review and Meta-analysisPreprint

Shrestha, D. B., Budhathoki, P., Sedhai, Y. R., Mandal, S. K., Shikhrakar, S., Karki, S., Baniya, R. K., Kashiouris, M. G., Qiao, X., & Fowler, A. A. (2021) · Research Square · doi:10.21203/rs.3.rs-766215/v1 · Cited by 7 · see citing works

Wide-Range SPRi Sensors Based on Aptamer/sPD-L1/anti–PD-L1 Sandwich and AuNPs Enhancement for Ultrasensitive Detection of sPD-L1

Peng, Y., Jiang, L., Li, Y., & Yu, X. (2023) · Coatings · doi:10.3390/coatings13081400 · Cited by 6 · see citing works

Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency

Santiworakul, C., Saisorn, W., Siripen, N., Leelahavanichkul, A., & Rianthavorn, P. (2023) · Pediatric Nephrology · doi:10.1007/s00467-023-06189-1 · Cited by 6 · see citing works

Effects of Vitamin C Supplementation on Total Antioxidant Status, Inflammation, and Histopathological Changes in Aged Rats

Başeğmez, M., Eryavuz, A., & Demirel, H. H. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70324 · Cited by 6 · see citing works

Patterns of inflammatory immune responses in patients with septic shock receiving vitamin C, hydrocortisone, and thiamine: clustering analysis in Korea

You, S., Kweon, O. J., Jung, S., Baek, M. S., & Kim, W. (2023) · Acute and Critical Care · doi:10.4266/acc.2023.00507 · Cited by 6 · see citing works

Biomarker Analysis for Combination Therapy of Vitamin C and Thiamine in Septic Shock: A Post-Hoc Study of the ATESS Trial

Park, J. E., Jo, Y. H., Hwang, S. Y., Kim, W. Y., Ryoo, S. M., Jang, D.-H., Kim, T., Kim, Y.-J., Kim, S., Cho, H., et al. (2021) · Shock · doi:10.1097/shk.0000000000001850 · Cited by 6 · see citing works

Review of Pharmacotherapy Trialed for Management of the Coronavirus Disease-19

Hall, K., MFONE, F., Shallcross, M., & Pathak, V. (2021) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2021.20384 · Cited by 6 · see citing works

Vitamin C: The next Step in Sepsis Management?

Teng, J., Pourmand, A., & Mazer-Amirshahi, M. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.09.031 · Cited by 82 · see citing works

The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis

Muhammad, M., Jahangir, A., Kassem, A., Sattar, S. B. A., Jahangir, A., Sahra, S., Niazi, M. R. K., Mustafa, A., Zia, Z., Siddiqui, F. S., et al. (2022) · Advances in respiratory medicine · doi:10.3390/arm90040038 · Cited by 17 · see citing works

Vitamin C in sepsis treatment: Not necessarily beneficial

Shao, Q., & Liu, F. (2025) · Journal of Translational Critical Care Medicine · doi:10.1097/jtccm-d-24-00020 · Cited by 2 · see citing works

Current role of high dose vitamin C in sepsis management: A concise review

Juneja, D., Nasa, P., & Jain, R. (2022) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v11.i6.349 · Cited by 19 · see citing works

Intravenous Vitamin C as an Add-on Therapy for the Treatment of Sepsis in an Intensive Care Unit: A Prospective Cohort Study

González-Vázquez, S. A., Gómez-Ramírez, E. E., González-López, L., Gámez-Nava, J. I., Peraza-Zaldívar, J. A., Santiago-Garcia, A. P., Ramírez-Villafaña, M., González-Ponce, F., Gomez-Camarena, J. J., Saldaña-Cruz, A. M., et al. (2024) · Medicina · doi:10.3390/medicina60030464 · Cited by 3 · see citing works