The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Does vitamin C act as a pro‐oxidant under physiological conditions?
Abstract
Vitamin C readily scavenges reactive oxygen and nitrogen species and may thereby prevent oxidative damage to important biological macromolecules such as DNA, lipids, and proteins. Vitamin C also reduces redox active transition metal ions in the active sites of specific biosynthetic enzymes. The interaction of vitamin C with ‘free’, catalytically active metal ions could contribute to oxidative damage through the production of hydroxyl and alkoxyl radicals; whether these mechanisms occur in vivo , however, is uncertain. To examine this issue, we reviewed studies that investigated the role of vitamin C, both in the presence and absence of metal ions, in oxidative DNA, lipid, and protein damage. We found compelling evidence for antioxidant protection of lipids by vitamin C in biological fluids, animals, and humans, both with and without iron cosupplementation. Although the data on protein oxidation in humans are sparse and inconclusive, the available data in animals consistently show an antioxidant role of vitamin C. The data on vitamin C and DNA oxidation in vivo are inconsistent and conflicting, but some of the discrepancies can be explained by flaws in experimental design and methodology. These and other important issues discussed here need to be addressed in future studies of the role of vitamin C in oxidative damage.—Carr, A., Frei, B. Does vitamin C act as a pro‐oxidant under physiological conditions? FASEB J. 13, 1007–1024 (1999)
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Cites
Instability and decay of the primary structure of DNA
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The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
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“1), have low reduction potentials (21) and can react with most other biologically relevant radicals and oxidants (some of which are listed in Table 1).”
BackgroundAscorbate is an outstanding antioxidant in human blood plasma
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Self-citationFormation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
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Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
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Vitamin C exhibits pro-oxidant properties
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Cited by
Free radicals and antioxidants in normal physiological functions and human disease
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Oxidative Stress: Harms and Benefits for Human Health
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8416763 · Cited by 4,837
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178
Metadata
- Authors
- Carr, A., & Frei, B.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 13
- Issue
- 9
- Pages
- 1007-1024
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1887679324
- Cited by
- 884
- References
- 9
- FWCI
- 17.68
- Type
- journal article
- Language
- en
- Open access
- closed
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