The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Biofilm delays wound healing: A review of the evidence
Open accessAbstract
Biofilm is the predominant mode of life for bacteria and today it is implicated in numerous human diseases. A growing body of scientific and clinical evidence now exists regarding the presence of biofilm in wounds. This review summarizes the clinical experiences and in vivo evidence that implicate biofilm in delayed wound healing. The various mechanisms by which biofilm may impede healing are highlighted, including impaired epithelialization and granulation tissue formation, and reduced susceptibilities to antimicrobial agents and host defenses. Strategies to manage biofilm and encourage progression to wound healing are discussed; these include debridement and appropriate antimicrobial therapies which may be improved upon in the future with the emergence of anti-biofilm technologies.
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Cites
Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo
Davis, S. C., Ricotti, C., Cazzaniga, A., Welsh, E., Eaglstein, W. H., & Mertz, P. M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00303.x · Cited by 393
Pastar, I., Nusbaum, A. G., Gil, J., Patel, S. B., Chen, J., Valdes, J., Stojadinovic, O., Plano, L. R., Tomic-Canic, M., & Davis, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056846 · Cited by 391
An in vivo polymicrobial biofilm wound infection model to study interspecies interactions
Dalton, T., Dowd, S. E., Wolcott, R. D., Sun, Y., Watters, C., Griswold, J. A., & Rumbaugh, K. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027317 · Cited by 372
Schierle, C. F., De la Garza, M., Mustoe, T. A., & Galiano, R. D. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00489.x · Cited by 311 · cited 2×
“Visible biofilm was observed to significantly delay closure of the epithelial gap in a murine splinted wound model [Table 3],([44]) before an established,”
BackgroundTime course study of delayed wound healing in a biofilm-challenged diabetic mouse model
Zhao, G., Usui, M. L., Underwood, R. A., Singh, P. K., James, G. A., Stewart, P. S., Fleckman, P., & Olerud, J. E. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00793.x · Cited by 127
Cited by
Falanga, V., Isseroff, R. R., Soulika, A. M., Romanelli, M., Margolis, D., Kapp, S., Granick, M., & Harding, K. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00377-3 · Cited by 1,020
Biofilms in Chronic Wounds: Pathogenesis and Diagnosis
Wu, Y.-K., Cheng, N.-C., & Cheng, C.-M. (2019) · Trends in Biotechnology · doi:10.1016/j.tibtech.2018.10.011 · Cited by 473
Collagen‐based biomaterials for biomedical applications
Rezvani Ghomi, E., Nourbakhsh, N., Akbari Kenari, M., Zare, M., & Ramakrishna, S. (2021) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.34881 · Cited by 406
Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation
Versey, Z., da Cruz Nizer, W. S., Russell, E., Zigic, S., DeZeeuw, K. G., Marek, J. E., Overhage, J., & Cassol, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648554 · Cited by 253
Strategies for combating antibiotic resistance in bacterial biofilms
Grooters, K. E., Ku, J. C., Richter, D. M., Krinock, M. J., Minor, A., Li, P., Kim, A., Sawyer, R., & Li, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1352273 · Cited by 156
Metadata
- Authors
- Metcalf, D., & Bowler, P.
- Venue
- Burns & Trauma
- Publisher
- Medknow
- Published
- 2013
- Volume
- 1
- Issue
- 1
- Pages
- 5
- ISSN
- 2321-3868 (ISSN-L)
- OpenAlex
- W2285654014
- Cited by
- 306
- References
- 5
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
