The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Oral microbiome: Unveiling the fundamentals
Open accessAbstract
The oral cavity has the second largest and diverse microbiota after the gut harboring over 700 species of bacteria. It nurtures numerous microorganisms which include bacteria, fungi, viruses and protozoa. The mouth with its various niches is an exceptionally complex habitat where microbes colonize the hard surfaces of the teeth and the soft tissues of the oral mucosa. In addition to being the initiation point of digestion, the oral microbiome is crucial in maintaining oral as well as systemic health. Because of the ease of sample collection, it has become the most well-studied microbiome till date. Previously, studying the microbiome was limited to the conventional culture-dependent techniques, but the abundant microflora present in the oral cavity could not be cultured. Hence, studying the microbiome was difficult. The emergence of new genomic technologies including next-generation sequencing and bioinformatics has revealed the complexities of the oral microbiome. It has provided a powerful means of studying the microbiome. Understanding the oral microbiome in health and disease will give further directions to explore the functional and metabolic alterations associated with the diseased states and to identify molecular signatures for drug development and targeted therapies which will ultimately help in rendering personalized and precision medicine. This review article is an attempt to explain the different aspects of the oral microbiome in health.
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“After the colon, the oral microbiome represents the second most diverse microbiota in the human host, with over 700 bacterial species presently identified.35”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [35]
In the citing paper
“due to improved understanding of the crucial role played by the oral microbiome in initiating food digestion and maintaining oral and systemic health.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [35]
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Cites
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Cited by
Sorted by citations
Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171
“Oral microbiota is considered the second largest microbial community in human.(9) The oral cavity can be further divided into multiple habitats of microbiota, including saliva, tongue, tooth surfaces, gums, buccal mucosa, palate, and subgingival/supragingival plaque, which may exhibit substantial and rapid changes in…”
BackgroundOral squamous cell carcinomas: state of the field and emerging directions
Tan, Y., Wang, Z., Xu, M., Li, B., Huang, Z., Qin, S., Nice, E. C., Tang, J., & Huang, C. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00249-w · Cited by 965
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
The oralome and its dysbiosis: New insights into oral microbiome-host interactions
Radaic, A., & Kapila, Y. L. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.02.010 · Cited by 510
“Approximately 700 bacterial species have been identified in the oral cavity [7,41,42], making the oral cavity the second largest bacterial community in the human body, after the gut [1].”
BackgroundCaselli, E., Fabbri, C., D’Accolti, M., Soffritti, I., Bassi, C., Mazzacane, S., & Franchi, M. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01801-y · Cited by 410
“Among protozoa, Entamoeba gingivalis and Trichomonas tenax are the most commonly found protozoa and are mainly saprophytic [34].”
Background
Metadata
- Authors
- Deo, P., & Deshmukh, R.
- Affiliations
- Bharati Vidyapeeth (Deemed to be University) (IN)
- Venue
- Journal of Oral and Maxillofacial Pathology
- Published
- 2019
- Volume
- 23
- Issue
- 1
- Pages
- 122
- ISSN
- 0973-029X (ISSN-L)
- PMC
- PMC6503789
- OpenAlex
- W2952216579
- Semantic Scholar
- 011d7d246666d3378bdbf330e6a83816e349f558
- Cited by
- 1,121
- References
- 48
- Citations by year
- 2026: 162 · 2025: 214 · 2024: 238 · 2023: 191 · 2022: 140 · 2021: 129 · 2020: 38 · 2019: 7
- FWCI
- 87.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Oral and Maxillofacial Pathology (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Keywords
- oral microbiota, oral health, oral diseases, microbial colonization, oral mucosa, dental plaque, next-generation sequencing, precision medicine
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