Activation of PPARα enhances astroglial uptake and degradation of β-amyloid

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 2× · see citing works

How to Interpret LC3 Immunoblotting

Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595 · see citing works

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · see citing works

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works

LC3 and Autophagy

Tanida, I., Ueno, T., & Kominami, E. (2008) · Methods in Molecular Biology™ · doi:10.1007/978-1-59745-157-4_4 · Cited by 1,785 · see citing works

LC3 conjugation system in mammalian autophagy

Tanida, I., Ueno, T., & Kominami, E. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.009 · Cited by 1,469 · see citing works

Characterization of ameboid microglia isolated from developing mammalian brain

Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300 · see citing works

ROS, mitochondria and the regulation of autophagy

Scherz-Shouval, R., & Elazar, Z. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.009 · Cited by 954 · see citing works

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749 · see citing works

LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization

Kuma, A., Matsui, M., & Mizushima, N. (2007) · Autophagy · doi:10.4161/auto.4012 · Cited by 555 · see citing works

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

Mueller-Steiner, S., Zhou, Y.-G., Arai, H., Roberson, E., Sun, B.-G., Chen, J., Wang, X., Yu, G.-Q., Esposito, L., Mucke, L., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.027 · Cited by 466 · see citing works

Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates

Barrett, A. J. (1980) · Biochemical Journal · doi:10.1042/bj1870909 · Cited by 404 · see citing works

Induction of Glial Fibrillary Acidic Protein Expression in Astrocytes by Nitric Oxide

Brahmachari, S., Fung, Y. K., & Pahan, K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5480-05.2006 · Cited by 390 · see citing works

Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory

Mansuy, I. M., Mayford, M. R., Jacob, B., Kandel, E. R., & Bach, M. E. (1998) · Cell · doi:10.1016/s0092-8674(00)80897-1 · Cited by 361 · see citing works

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

Chen, Y., Liang, Z., Blanchard, J., Dai, C., Sun, S., Lee, M. H., Grundke, I., Iqbal, K., Liu, F., & Gong, C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8375-5 · Cited by 286 · see citing works

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.013 · Cited by 274 · see citing works

Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis

Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E., Burchett, J. M., Schuler, D. R., Cirrito, J. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3788-13.2014 · Cited by 266 · see citing works

Generation of amyloid β protein from its precursor is sequence specific

Citron, M., Teplow, D. B., & Selkoe, D. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90323-2 · Cited by 263 · see citing works

Up-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine

Saha, R. N., Liu, X., & Pahan, K. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9020-8 · Cited by 258 · see citing works

Maturation and Pro-peptide Cleavage of β-Secretase

Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., & Haass, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003202200 · Cited by 247 · see citing works

Human Light Chain 3/MAP1LC3B Is Cleaved at Its Carboxyl-terminal Met121 to Expose Gly120 for Lipidation and Targeting to Autophagosomal Membranes

Tanida, I., Ueno, T., & Kominami, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407016200 · Cited by 244 · see citing works

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E. R., Tripoli, D. L., Czerniewski, L. R., Ballabio, A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0705-15.2015 · Cited by 230 · see citing works

Heparan sulphate proteoglycans in Alzheimer's disease and amyloid‐related disorders

van Horssen, J., Wesseling, P., van den Heuvel, L. P. J. W., de Waal, R. M. W., & Verbeek, M. M. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00484-8 · Cited by 226 · see citing works

Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments

Vetrivel, K. S., & Thinakaran, G. (2006) · Neurology · doi:10.1212/01.wnl.0000192107.17175.39 · Cited by 217 · see citing works

Lysosomal Membrane Damage in Soluble Aβ-Mediated Cell Death in Alzheimer's Disease

Ditaranto, K., Tekirian, T. L., & Yang, A. J. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0364 · Cited by 192 · see citing works

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

Basak, J. M., Verghese, P. B., Yoon, H., Kim, J., & Holtzman, D. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.288746 · Cited by 192 · see citing works

Autophagy and Neuronal Cell Death in Neurological DisordersPreprint

Nixon, R. A., & Yang, D.-S. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008839 · Cited by 179 · see citing works

Regulation of Cyclic AMP Response Element Binding and Hippocampal Plasticity-Related Genes by Peroxisome Proliferator-Activated Receptor α

Roy, A., Jana, M., Corbett, G. T., Ramaswamy, S., Kordower, J. H., Gonzalez, F. J., & Pahan, K. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.028 · Cited by 166 · see citing works

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

Roy, A., Jana, M., Kundu, M., Corbett, G. T., Rangaswamy, S. B., Mishra, R. K., Luan, C., Gonzalez, F. J., & Pahan, K. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.022 · Cited by 160 · see citing works

Pathological and physiological functions of presenilins

Vetrivel, K. S., Zhang, Y., Xu, H., & Thinakaran, G. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-4 · Cited by 158 · see citing works

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

Castellano, J. M., Deane, R., Gottesdiener, A. J., Verghese, P. B., Stewart, F. R., West, T., Paoletti, A. C., Kasper, T. R., DeMattos, R. B., Zlokovic, B. V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206446109 · Cited by 154 · see citing works

The lysosome and neurodegenerative diseases

Zhang, L., Sheng, R., & Qin, Z. (2009) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmp031 · Cited by 152 · see citing works

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

Corbett, G. T., Gonzalez, F. J., & Pahan, K. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504890112 · Cited by 151 · see citing works

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

Takahashi, R. H., Capetillo-Zarate, E., Lin, M. T., Milner, T. A., & Gouras, G. K. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.021 · Cited by 150 · see citing works

Activation of Peroxisome Proliferator-activated Receptor α Induces Lysosomal Biogenesis in Brain Cells

Ghosh, A., Jana, M., Modi, K. K., Gonzalez, F. J., Sims, K. B., Berry‐Kravis, E., & Pahan, K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.610659 · Cited by 129 · see citing works

The role of intracellular amyloid β in Alzheimer's disease

Li, M. C., Chen, L., Lee, D. H. S., Yu, L., & Zhang, Y. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.08.002 · Cited by 116 · see citing works

Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

Khasnavis, S., & Pahan, K. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9552-2 · Cited by 112 · see citing works

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease

Modi, K. K., Roy, A., Brahmachari, S., Rangasamy, S. B., & Pahan, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130398 · Cited by 100 · see citing works

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

Patel, D. R., Roy, A., Kundu, M., Jana, M., Luan, C.-H., Gonzalez, F. J., & Pahan, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802021115 · Cited by 93 · see citing works

Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B

Bond, J. S., & Barrett, A. J. (1980) · Biochemical Journal · doi:10.1042/bj1890017 · Cited by 93 · see citing works

Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Modifies T Cells at Multiple Steps and Inhibits Adoptive Transfer of Experimental Allergic Encephalomyelitis

Brahmachari, S., & Pahan, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.275 · Cited by 91 · see citing works

Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease

Galeano, P., Adami, P. V. M., Carmo, S. D., Blanco, E., Rotondaro, C., Capani, F., Castaño, E. M., Cuello, A. C., & Morelli, L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00321 · Cited by 88 · see citing works

Gemfibrozil Ameliorates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Independent of Peroxisome Proliferator-Activated Receptor-α

Dasgupta, S., Roy, A., Jana, M., Hartley, D. M., & Pahan, K. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033787 · Cited by 86 · see citing works

Gemfibrozil, stretching arms beyond lipid lowering

Roy, A., & Pahan, K. (2009) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970902785253 · Cited by 84 · see citing works

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

Tanida, I., Yamaji, T., Ueno, T., Ishiura, S., Kominami, E., & Hanada, K. (2008) · Autophagy · doi:10.4161/auto.5233 · Cited by 83 · see citing works

Identification and characterization of PPARα ligands in the hippocampus

Roy, A., Kundu, M., Jana, M., Mishra, R. K., Yung, Y. P., Luan, C.-H., Gonzalez, F. J., & Pahan, K. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2204 · Cited by 83 · see citing works

A Simplified Method for Isolating Highly Purified Neurons, Oligodendrocytes, Astrocytes, and Microglia from the Same Human Fetal Brain Tissue

Jana, M., Jana, A., Pal, U., & Pahan, K. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9340-y · Cited by 75 · see citing works

Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model

Katsouri, L., & Georgopoulos, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021880 · Cited by 72 · see citing works

Induction of β-Amyloid-Containing Polypeptides in Hippocampus: Evidence for a Concomitant Loss of Synaptic Proteins and Interactions with an Excitotoxin

Bahr, B. A., Abai, B., Gall, C. M., Vanderklish, P. W., Hoffman, K. B., & LYNCH, G. S. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1149 · Cited by 72 · see citing works

Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer’s Disease via Peroxisome Proliferator-Activated Receptor α

Chandra, S., & Pahan, K. (2019) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-190104 · Cited by 68 · see citing works

Sodium Phenylbutyrate Enhances Astrocytic Neurotrophin Synthesis via Protein Kinase C (PKC)-mediated Activation of cAMP-response Element-binding Protein (CREB)

Corbett, G. T., Roy, A., & Pahan, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426536 · Cited by 62 · see citing works

Gemfibrozil, a Lipid-Lowering Drug, Upregulates IL-1 Receptor Antagonist in Mouse Cortical Neurons: Implications for Neuronal Self-Defense

Corbett, G. T., Roy, A., & Pahan, K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102624 · Cited by 60 · see citing works

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

Carey, K. L., Paulus, G. L. C., Wang, L., Balce, D. R., Luo, J. W., Bergman, P., Ferder, I. C., Kong, L., Renaud, N., Singh, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108371 · Cited by 55 · see citing works

Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer’s Disease

Rangasamy, S. B., Corbett, G. T., Roy, A., Modi, K. K., Bennett, D. A., Mufson, E. J., Ghosh, S., & Pahan, K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150040 · Cited by 53 · see citing works

Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia

Saha, R. N., & Pahan, K. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.022 · Cited by 49 · see citing works

A Loss of Function Mutant of the Presenilin Homologue SEL-12 Undergoes Aberrant Endoproteolysis in Caenorhabditis elegans and Increases Aβ42 Generation in Human Cells

Okochi, M., Eimer, S., Böttcher, A., Baumeister, R., Romig, H., Walter, J., Capell, A., Steiner, H., & Haass, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005254200 · Cited by 37 · see citing works

Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders

Kim, K., Kleinman, H. K., Lee, H.-J., & Pahan, K. (2017) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-017-0663-8 · Cited by 31 · see citing works

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Basak, J. M., Kim, J., Pyatkivskyy, Y., Wildsmith, K. R., Jiang, H., Parsadanian, M., Patterson, B. W., Bateman, R. J., & Holtzman, D. M. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-14 · Cited by 27 · see citing works

PPARα: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases

Lin, Y., Wang, Y., & Li, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1074911 · Cited by 146 · see citing works

Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments

Rodríguez-Giraldo, M., González-Reyes, R. E., Ramírez-Guerrero, S., Bonilla-Trilleras, C. E., Guardo-Maya, S., & Nava-Mesa, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113630 · Cited by 118 · see citing works

Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms

Zhang, X.-W., 澳门大学中华医药研究院中药质量研究国家重点实验室, 澳. 凼. 9., State Key Laboratory of Quality Research in Chinese Medicine, I. O. C. M. S., Zhu, X.-X., Tang, D.-S., Lu, J.-H., 佛山大学广东省动物分子设计与精准育种重点实验室, 广., & Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, G. E. T. C. O. G. P. (2023) · Zoological Research · doi:10.24272/j.issn.2095-8137.2023.294 · Cited by 77 · see citing works

Transcriptional regulation of autophagy and its implications in human disease

Lei, Y., & Klionsky, D. J. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01162-9 · Cited by 70 · see citing works

TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implications

Gu, Z., Cao, H., Zuo, C., Huang, Y., Miao, J., Song, Y., Yang, Y., Zhu, L., & Wang, F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105855 · Cited by 63 · see citing works

Vitamin A metabolites inhibit ferroptosis

Jakaria, M., Belaidi, A. A., Bush, A. I., & Ayton, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114930 · Cited by 61 · see citing works

Treadmill exercise reduces α-synuclein spreading via PPARα

Dutta, D., Paidi, R. K., Raha, S., Roy, A., Chandra, S., & Pahan, K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111058 · Cited by 57 · see citing works

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

Garcia, G., Pinto, S., Ferreira, S., Lopes, D., Serrador, M. J., Fernandes, A., Vaz, A. R., Mendonça, A. D., Edenhofer, F., Malm, T., et al. (2022) · Cells · doi:10.3390/cells11213377 · Cited by 55 · see citing works

The role of glial autophagy in Alzheimer’s disease

Litwiniuk, A., Juszczak, G. R., Stankiewicz, A. M., & Urbańska, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02242-5 · Cited by 54 · see citing works

Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00648-x · Cited by 31 · see citing works

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis

Ye, J., Zhong, S., Wan, H., Guo, X., Yao, X., Liu, Q., Chen, L., Wang, J., & Xiao, S. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00796-2 · Cited by 30 · see citing works

A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis

Needham, H., Torpey, G., Flores, C. C., Davis, C. J., Vanderheyden, W. M., & Gerstner, J. R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.798994 · Cited by 28 · see citing works

Glial cell nutrient sensing: mechanisms of nutrients regulating Alzheimer’s pathogenesis and precision intervention

Yan, Q., Qin, Q., Zhang, S., Chen, F., Ru, Y., Zhong, Y., & Wu, G. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2568606 · Cited by 27 · see citing works

PPARα Signaling: A Candidate Target in Psychiatric Disorder Management

Scheggi, S., Pinna, G., Braccagni, G., Montis, M. G. D., & Gambarana, C. (2022) · Biomolecules · doi:10.3390/biom12050723 · Cited by 25 · see citing works

Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization

Li, Y., Zhang, Y., Wang, Q., Wu, C., Du, G., & Yang, L. (2023) · Pharmaceuticals · doi:10.3390/ph16040621 · Cited by 24 · see citing works

Unveiling the role of astrogliosis in Alzheimer’s disease Pathology: Insights into mechanisms and therapeutic approaches

Paidlewar, M., Kumari, S., Dhapola, R., Sharma, P., & HariKrishnaReddy, D. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112940 · Cited by 25 · see citing works

Bezafibrate confers neuroprotection in the 5xFAD mouse model of Alzheimer's disease

Lu, Y., Fujioka, H., Wang, W., & Zhu, X. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166841 · Cited by 24 · see citing works

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice

Paidi, R. K., Raha, S., Roy, A., & Pahan, K. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112717 · Cited by 20 · see citing works

Dissecting the multifaced function of transcription factor EB (TFEB) in human diseases: From molecular mechanism to pharmacological modulation

Zhang, L., Li, Z., Zhang, L., Qin, Y., & Yu, D. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115698 · Cited by 17 · see citing works

Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer’s disease

Rangasamy, S. B., Jana, M., Dasarathi, S., Kundu, M., & Pahan, K. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.01.009 · Cited by 17 · see citing works

PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer’s Disease Defects By Inducing Autophagy in Mice Models

Krishnamoorthi, S., Iyaswamy, A., Sreenivasmurthy, S. G., Thakur, A., Vasudevan, K., Kumar, G., Guan, X.-J., Lu, K., Gaurav, I., Su, C.-F., et al. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10083-w · Cited by 17 · see citing works

Knockdown of astrocytic Grin2a exacerbated sleep deprivation-induced cognitive impairments and elevation of amyloid-beta

Zhang, W., Chen, X., Du, Z., Mao, X., Gao, R., Chen, Z., Wang, H., Zhang, G., Zhang, N., Li, H., et al. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.08.021 · Cited by 16 · see citing works

The Potential of Edible and Medicinal Resource Polysaccharides for Prevention and Treatment of Neurodegenerative Diseases

Gan, Q., Ding, Y., Peng, M., Chen, L., Dong, J., Hu, J., & Ma, Y. (2023) · Biomolecules · doi:10.3390/biom13050873 · Cited by 16 · see citing works

Activation of PPARα Exhibits Therapeutic Efficacy in a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis

Jana, M., Dutta, D., Poddar, J., & Pahan, K. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2447-21.2023 · Cited by 16 · see citing works

Isoform- and cell-state-specific APOE homeostasis and function

Lindner, K., & Gavin, A.-C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01470 · Cited by 13 · see citing works

Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia in mice via augmenting lipoprotein assembly-induced clearance of low-density lipoprotein and intermediate-density lipoprotein

Wei, G., Huang, N., Li, M., Guan, F., Chen, L., Liao, Y.-Y., Xie, X., Li, Y., Su, Z., Chen, J., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176433 · Cited by 13 · see citing works

Targeting phagocytosis for amyloid-β clearance: implications of morphology remodeling and microglia activation probed by bifunctional chimaeras

Wang, Y., Wang, Z., Liu, Z., Li, J., Yang, S., Zhao, Y., Huang, Y., Liao, C., Zhang, Y., Zhao, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63458-3 · Cited by 9 · see citing works

Prenol, but Not Vitamin C, of Fruit Binds to SARS-CoV-2 Spike S1 to Inhibit Viral Entry: Implications for COVID-19

Paidi, R. K., Jana, M., Raha, S., Mishra, R. K., Jeong, B. M., Sheinin, M., & Pahan, K. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200279 · Cited by 9 · see citing works

Mechanisms of increased Alzheimer’s disease pathology with R47H and R62H TREM2 variants

Fancy, N. N., Willumsen, N., Chau, V. M. N., Boulger, S. L., Whitwell, H. J., Wang, W., Avot, B., Thomas, M., Talbot-Martin, J., Tsartsalis, S., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03036-z · Cited by 8 · see citing works

Lipid-Lowering Drug Gemfibrozil Protects Mice from Tay-Sachs Disease via Peroxisome Proliferator-Activated Receptor α

Raha, S., Dutta, D., Paidi, R. K., & Pahan, K. (2023) · Cells · doi:10.3390/cells12242791 · Cited by 8 · see citing works

Cinnamic acid, a natural plant compound, exhibits neuroprotection in a mouse model of Sandhoff disease via PPARα

Raha, S., Paidi, R. K., Dutta, D., & Pahan, K. (2024) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0027 · Cited by 8 · see citing works

Astrocytes and Memory: Implications for the Treatment of Memory-related Disorders

Wang, J., Cheng, P., Qu, Y., & Zhu, G. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240128102039 · Cited by 7 · see citing works

Astrocyte–Neuron Interactions in Alzheimer’s Disease

Muñoz‐Castro, C., & Serrano‐Pozo, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_14 · Cited by 7 · see citing works

Protection of dopaminergic neurons in hemiparkinsonian monkeys by flavouring ingredient glyceryl tribenzoate

Rangasamy, S. B., Dutta, D., Mondal, S., Majumder, M., Dasarathi, S., Chandra, G., & Pahan, K. (2022) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2022-0005 · Cited by 7 · see citing works

Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of Aβ1−42-induced Alzheimer’s disease rat model

Wang, P., Zhang, S., Hu, C., Ren, L., & Bi, J. (2023) · Molecular Biology Reports · doi:10.1007/s11033-022-08213-3 · Cited by 7 · see citing works

Astrocytic mGluR5-dependent calcium hyperactivity promotes amyloid-β pathology and cognitive impairment

Yang, T., Zhang, D., Huang, H., Liu, F., Wu, J., Ma, X., Liu, S., Huang, M., Zhou, Y., & Shen, Y. (2025) · Brain · doi:10.1093/brain/awaf186 · Cited by 6 · see citing works

Unraveling the Function of PPARα in Neurodegenerative Disorders: A Potential Pathway to Novel Therapies

Galanou, O.-N., & Konstandi, M. (2025) · Biomedicines · doi:10.3390/biomedicines13112813 · Cited by 4 · see citing works

Identification of Cinnamein, a Component of Balsam of Tolu/Peru, as a New Ligand of PPARα for Plaque Reduction and Memory Protection in a Mouse Model of Alzheimer’s Disease

McKay, M. A., Gorai, S., Paidi, R. K., Mondal, S., & Pahan, K. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230179 · Cited by 5 · see citing works

Gemfibrozil-Induced Intracellular Triglyceride Increase in SH-SY5Y, HEK and Calu-3 Cells

Bachmann, C. M., Janitschke, D., Lauer, A. A., Erhardt, T., Hartmann, T., Grimm, M. O. W., & Grimm, H. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032972 · Cited by 5 · see citing works

Activation of PPARα by gemfibrozil lowers tau-associated neuropathology in the MAPT mouse model of Alzheimer’s disease

Majumder, M., Dutta, D., Paidi, R. K., & Pahan, K. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150089 · Cited by 3 · see citing works

Distinguishing Curable from Progressive Dementias for Defining Cancer Care Options

Schein, C. H. (2023) · Cancers · doi:10.3390/cancers15041055 · Cited by 3 · see citing works

PPARs (Peroxisome Proliferator-activated Receptors) and Their Agonists in Alzheimer's Disease

Kumar, M., Sharma, A. A., Datusalia, A. K., & Khatik, G. L. (2024) · Medicinal Chemistry · doi:10.2174/0115734064295063240422100615 · Cited by 3 · see citing works

Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects

Wu, Z., Zhao, Y., Hao, S., An, M., Song, C., & Li, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01371 · Cited by 4 · see citing works

Astrocyte Autophagy in Neurodegenerative Diseases: Current Progress in Mechanisms and Therapeutics

Qian, J., Ren, S., Ren, T., Shi, R., Qiao, L., & Kang, J. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04532-6 · Cited by 3 · see citing works

Predifferentiation Neurotoxicity of GenX Exposure on hiPSC-Derived Cortical Neurons

Wu, S., Xie, J., Zhao, X., Zhao, H., Sánchez, O. F., Yu, S., Rochet, J.-C., Freeman, J. L., & Yuan, C. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c13193 · Cited by 2 · see citing works

L‐Leucine Upregulates Lysosomal Biogenesis and Autophagy to Lower Plaques in 5XFAD Mouse Model of Alzheimer's Disease

Paidi, R. K., Gorai, S., Mondal, S., & Pahan, K. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70432 · Cited by 2 · see citing works

Amyloid-β clearance: an astrocytic perspective

Li, J., Lv, Z., Chen, X. P., Fu, F., Yang, K., Lai, G., Wu, H., & Xie, G. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1812081 · Cited by 3 · see citing works

Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype

Sung, J. H., Ou, Y., & Barger, S. W. (2023) · eNeuro · doi:10.1523/eneuro.0376-22.2023 · Cited by 2 · see citing works

Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, attenuates molecular pathological alterations in learning memory in AD mice

Li, Y., Zhang, Y., Wang, Q., Wu, C. K., Du, G., Zeng, Y., Song, Z., Jiang, X., Jiang, X., Zhuo, R., et al. (2024) · Neurological Research · doi:10.1080/01616412.2024.2325313 · Cited by 2 · see citing works

Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer’s diseasePreprint

Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2484513/v1 · Cited by 4 · see citing works

Astrocytic Activation Completely Corrects Memory Performance in an Alzheimer’s Disease ModelPreprint

Kreisel, T., Weinstein, Y., Groysman, M., Doron, A., Refaeli, R., London, M., & Goshen, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.29.679133 · Cited by 2 · see citing works

Autophagic and Lysosomal Disorders

Chandra, S., & Pahan, K. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_11 · Cited by 1 · see citing works

Low-density lipoprotein receptor interacts with clusterin to regulate A1/A2 astrocyte polarization and ameliorate hemorrhagic brain injury

Yin, H., Li, X., Yang, J., Lü, J., Xu, Z., Bai, L., Liu, J., Sun, C., & Li, H. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115539 · Cited by 1 · see citing works

Human iPSC‐NSC‐Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease‐Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis

Madhu, L. N., Attaluri, S., Kotian, S., Upadhya, R., Somayaji, Y., Rao, S., Tarale, P., Ganesh, S. V., Huard, C., Kodali, M., et al. (2026) · Aging Cell · doi:10.1111/acel.70590 · Cited by 1 · see citing works

High-throughput screening reveals paeoniflorin’s efficacy against Apoc2-deficient hypertriglyceridemia via HNF4A/PPARA/LDLR

Li, Q., Qi, K., Wu, S., Shen, A., & Zhao, L. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117351 · Cited by 1 · see citing works

Amyloid β-peptide impacts on glucose regulation are dependent on apolipoprotein E genotypePreprint

Sung, J. H., Ou, Y., & Barger, S. W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.22.497222

Neuroprotective and detrimental effects of astrocytes on amyloid plaque formation

Gan, H.-R. (2023) · Journal of Student Research · doi:10.47611/jsrhs.v12i1.4295

Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway

Zhang, X., Fu, Y., Li, X., Zhang, Y., Li, L., Yi, T., Jiang, H., & Lu, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199303

Additional file 1 of Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. (2023) · Figshare · doi:10.6084/m9.figshare.23949585

PPAR-α agonist pirinixic acid alleviates periodontitis-induced AD-like pathology via suppression of the IRF7-IFN-β-IFITM3 axis in glial cellsPreprint

Li, J. N., Liu, L., Chang, X., Jiang, Y. N., Li, M., Zhang, J., Yang, Y., Zhang, A., & Wang, F. (2026) · Research Square · doi:10.21203/rs.3.rs-9421608/v1

Glycolysis: The Bridge Between Cellular Interaction and Alzheimer’s Disease

Lei, Q., He, Y., & Fang, B. (2026) · Biomolecules · doi:10.3390/biom16060796

Selective inhibition of TLR2 stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes

Chakrabarti, S., Jana, M., Gorai, S., & Pahan, K. (2026) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2026-0021

Glyceryl tribenzoate, a flavoring agent, stimulates hippocampal plasticity and protects memory via PPARα

Patel, D. R., Rangasamy, S. B., Gorai, S., Paidi, R. K., & Pahan, K. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106270

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

Luo, R., Su, L.-Y., Li, G., Yang, J., Liu, Q., Yang, L.-X., Zhang, D.-F., Zhou, H., Xu, M., Fan, Y., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1596488 · Cited by 364 · see citing works

Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα

Chandra, S., Jana, M., & Pahan, K. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0054-18.2018 · Cited by 134 · see citing works

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

Mandrekar-Colucci, S., Karlo, J. C., & Landreth, G. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5268-11.2012 · Cited by 355 · see citing works

PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-12.2012 · Cited by 326 · see citing works

Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis

Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E., Burchett, J. M., Schuler, D. R., Cirrito, J. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3788-13.2014 · Cited by 266 · see citing works