Altered Postnatal Cell Proliferation in Brains of Mouse Pups Prenatally Exposed to IgG from Mothers of Children with Autistic Disorder
Open accessAbstract
Auto antibodies found in the mothers of children with autistic disorder (MCAD) when passively transferred to pregnant mice cause behavioral alterations in juvenile and adult offspring. The goal of this study was to identify whether intraperitoneal injection of MCAD-IgG during gestation affected postnatal cell proliferation and survival in P7 offspring. Pooled MCAD-IgG or IgG from mothers of unaffected children (MUC) or phosphate-buffered saline was injected daily into C57BL/J6 pregnant dams (gestational days E13–E18). MCAD-IgG exposure significantly increased cell proliferation in the subventricular and subgranular zones. In contrast, BrdU-labeled cells on P1 and surviving until P7 (P1-generated cells) showed reduced cell densities in layers 2–4 of frontal and parietal cortices of MCAD mice compared to those in MUC and PBS-injected mice. In conclusion, significant increases in cell proliferation at P7 and reduced densities of P1-generated cells distinguish in utero exposure to MCAD compared to MUC and PBS.
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Experimental mice exposed to maternal autoantibodies in utero show increased cell proliferation during cortical neurogenesis and increased neuronal and brain size in adulthood.
“Experimental mice exposed to maternal autoantibodies in utero show increased cell proliferation during cortical neurogenesis [184, 229] and increased neuronal and brain size in adulthood [229].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [184]
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Research works printed but not linked: 4
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Autism spectrum disorder: neuropathology and animal models
Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works
- Authors
- Kadam, S. D., French, B. M., Kim, S.-T., Morris-Berry, C. M., Zimmerman, A. W., Blue, M. E., & Singer, H. S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Kadam, Shilpa D.
- Venue
- Journal of Experimental Neuroscience
- Publisher
- SAGE Publications
- Published
- 2013-01
- Volume
- 7
- Pages
- 93-9
- ISSN
- 1179-0695 (ISSN-L)
- PMC
- PMC4089726
- OpenAlex
- W2042367006
- Cited by
- 10
- References
- 28
- Citations by year
- 2024: 1 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Experimental Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Center for Research Resources (S10RR027445)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, maternal autoantibodies, prenatal exposure, IgG transfer, neuronal survival, subventricular zone, subgranular zone, cortical layers, prenatal immune activation, mouse model
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