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Cited by 275

The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.

Human Copper Transporters: Mechanism, Role in Human Diseases and Therapeutic Potential

Open access
Gupta, Arnab, Lutsenko, Svetlana·2009·Future Medicinal Chemistry
DOI 10.4155/fmc.09.84
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Abstract

Normal copper homeostasis is essential for human growth and development. Copper deficiency, caused by genetic mutations, inadequate diet or surgical interventions, may lead to cardiac hypertrophy, poor neuronal myelination, blood vessel abnormalities and impaired immune response. Copper overload is associated with morphological and metabolic changes in tissues and, if untreated, eventual death. Recent reports also indicate that changes in the expression of copper transporters alter the sensitivity of cancer cells to major chemotherapeutic drugs, such as cisplatin, although the mechanism behind this important phenomenon remains unclear. This review summarizes current information on the molecular characteristics of copper transporters CTR1, CTR2, ATP7A and ATP7B, their roles in mammalian copper homeostasis and the physiological consequences of their inactivation. The mechanisms through which copper transporters may influence cell sensitivity to cisplatin are discussed. Regulation of human copper homeostasis has significant therapeutic potential and requires the detailed understanding of copper transport mechanisms.

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Metadata

Authors
Gupta, A., & Lutsenko, S.
Venue
Future Medicinal Chemistry
Publisher
Informa UK Limited
Published
2009-09
Volume
1
Issue
6
Pages
1125-1142
ISSN
  • 1756-8919 (ISSN-L)
  • 1756-8927
DOI
10.4155/fmc.09.84
OpenAlex
W1967868572
Cited by
275
References
96
FWCI
8.47
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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