The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Human Copper Transporters: Mechanism, Role in Human Diseases and Therapeutic Potential
Open accessAbstract
Normal copper homeostasis is essential for human growth and development. Copper deficiency, caused by genetic mutations, inadequate diet or surgical interventions, may lead to cardiac hypertrophy, poor neuronal myelination, blood vessel abnormalities and impaired immune response. Copper overload is associated with morphological and metabolic changes in tissues and, if untreated, eventual death. Recent reports also indicate that changes in the expression of copper transporters alter the sensitivity of cancer cells to major chemotherapeutic drugs, such as cisplatin, although the mechanism behind this important phenomenon remains unclear. This review summarizes current information on the molecular characteristics of copper transporters CTR1, CTR2, ATP7A and ATP7B, their roles in mammalian copper homeostasis and the physiological consequences of their inactivation. The mechanisms through which copper transporters may influence cell sensitivity to cisplatin are discussed. Regulation of human copper homeostasis has significant therapeutic potential and requires the detailed understanding of copper transport mechanisms.
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Cites
Mechanisms for copper acquisition, distribution and regulation
Kim, B.-E., Nevitt, T., & Thiele, D. J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.72 · Cited by 1,588
Molecular mechanisms of resistance and toxicity associated with platinating agents
Rabik, C. A., & Dolan, M. E. (2007) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2006.09.006 · Cited by 1,564
Matsushima, G. K., & Morell, P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00385.x · Cited by 984
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
Ishida, S., Lee, J., Thiele, D. J., & Herskowitz, I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162491399 · Cited by 927
Why Does Cisplatin Reach Guanine-N7 with Competing S-Donor Ligands Available in the Cell?
Reedijk, J. (1999) · Chemical Reviews · doi:10.1021/cr980422f · Cited by 771
Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659
Biology, structure and mechanism of P-type ATPases
Kühlbrandt, W. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1354 · Cited by 619
Biochemical Characterization of the Human Copper Transporter Ctr1
Lee, J., Peña, M. M. O., Nose, Y., & Thiele, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104728200 · Cited by 608
h CTR1: A human gene for copper uptake identified by complementation in yeast
Zhou, B., & Gitschier, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7481 · Cited by 567
Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development
Lee, J., Prohaska, J. R., & Thiele, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111058698 · Cited by 472
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Copper Homeostasis at the Host-Pathogen Interface
Hodgkinson, V., & Petris, M. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.316406 · Cited by 316
Cu Homeostasis in Bacteria: The Ins and Outs
Andrei, A., Öztürk, Y., Khalfaoui-Hassani, B., Rauch, J., Marckmann, D., Trasnea, P.-I., Daldal, F., & Koch, H.-G. (2020) · Membranes · doi:10.3390/membranes10090242 · Cited by 153
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The Mechanism of Cu+ Transport ATPases
Padilla-Benavides, T., McCann, C. J., & Argüello, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420810 · Cited by 81
Curnock, R., & Cullen, P. J. (2020) · Journal of Cell Science · doi:10.1242/jcs.249201 · Cited by 60
Computational studies on the functional and structural impact of pathogenic mutations in enzymes
Dissanayake, U. C., Roy, A., Maghsoud, Y., Polara, S., Debnath, T., & Cisneros, G. A. (2025) · Protein Science · doi:10.1002/pro.70081 · Cited by 8
Metadata
- Authors
- Gupta, A., & Lutsenko, S.
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2009-09
- Volume
- 1
- Issue
- 6
- Pages
- 1125-1142
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W1967868572
- Cited by
- 275
- References
- 96
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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