How to Interpret LC3 Immunoblotting

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., & Yoshimori, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01131 · Cited by 1,394

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108

The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T., & Ohsumi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5971 · Cited by 1,060

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

Kanzawa, T., Germano, I. M., Komata, T., Ito, H., Kondo, Y., & Kondo, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401359 · Cited by 995

Methods for monitoring autophagy

Mizushima, N. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.005 · Cited by 899

The involvement of autophagy in the maintenance of endothelial homeostasis: The role of mitochondria

Dymkowska, D. (2021) · Mitochondrion · doi:10.1016/j.mito.2020.12.013 · Cited by 15

Autophagy Mediates Leptin-Induced Migration and ERK Activation in Breast Cancer Cells

García-Miranda, A., Alcalá, K. A. S., Montes-Alvarado, J. B., Rosas-Cruz, A., Reyes‐Leyva, J., Navarro‐Tito, N., Maycotte, P., & Castañeda-Saucedo, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.644851 · Cited by 18

Resveratrol and Angiogenin-2 Combined With PEGDA/TCS Hydrogel for the Targeted Therapy of Hypoxic Bone Defects via Activation of the Autophagy Pathway

Fan, D., Liu, H., Zhang, Z., Su, M., Yuan, Z., Lin, Y., Yang, S., Li, W., & Zhang, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.618724 · Cited by 16

CRISPR/Cas9 genome-wide screening identifies LUC7L2 that promotes radioresistance via autophagy in nasopharyngeal carcinoma cells

Shen, L., Li, C., Chen, F., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00783-8 · Cited by 16

Growth Factor Receptor-Bound Protein 2 Promotes Autophagic Removal of Amyloid-β Protein Precursor Intracellular Domain Overload in Neuronal Cells

Roy, K., Raychaudhuri, M., Chakrabarti, O., & Mukhopadhyay, D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130929 · Cited by 17

Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy

Chen, D., Tao, X., Wang, Y., et al. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2365 · Cited by 16

Autophagy is induced by adenoviral-mediated interferon α treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced

Xq, Z., Dunner, K., & Benedict, W. F. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.14 · Cited by 16

The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2

Hiebel, C., & Behl, C. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.03.020 · Cited by 16

A dihydroselenoquinazoline inhibits S6 ribosomal protein signalling, induces apoptosis and inhibits autophagy in MCF-7 cells

Moreno, E., Doughty-Shenton, D., Plano, D., Font, M., Encı́o, I., Palop, J. A., & Sanmartín, C. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.06.020 · Cited by 16

Prazosin induces p53-mediated autophagic cell death in H9C2 cells

Yang, Y., Wu, C., Chen, W., Chen, Y., & Su, M. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0657-3 · Cited by 16

Autophagy Modulation by Lanthionine Ketimine Ethyl Ester Improves Long-Term Outcome after Central Fluid Percussion Injury in the Mouse

Hensley, K., Poteshkina, A., Johnson, M. F., Eslami, P., Gabbita, S. P., Hristov, A. M., Venkova-Hristova, K., & Harris‐White, M. E. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.4196 · Cited by 16

Chapter 23 Kinetic Analysis of Autophagosome Formation and Turnover in Primary Mouse Macrophages

Swanson, M. S., Byrne, B. G., & Dubuisson, J. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)03623-9 · Cited by 16

Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model

Wang, Y., Ma, Q., Ma, X., Zhongxia, Z., Liu, N., & Wang, M. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4618 · Cited by 16

Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes

Burgeiro, A., Fonseca, A. C., Espinoza, D., Carvalho, L., Lourenço, N., Antunes, M., & Carvalho, E. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.025 · Cited by 16

Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome

Liu, Q., Sabirzhanova, I. B., Yanda, M. K., Bergbower, E. A. S., Boinot, C., Guggino, W. B., & Cebotaru, L. (2018) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2018.05.016 · Cited by 16

Cytoprotective effect of imatinib mesylate in non-BCR-ABL-expressing cells along with autophagosome formation

Ohtomo, T., Miyazawa, K., Naito, M., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.055 · Cited by 16

Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors

Bagamanshina, A. V., Troitskaya, O. S., Nushtaeva, A. A., Yunusova, A. Y., Starykovych, M. O., Kuligina, E. V., Kit, Y. Y., Richter, M., Wohlfromm, F., Kähne, T., et al. (2019) · BioMed Research International · doi:10.1155/2019/4087160 · Cited by 15

Identification of Dietary Phytochemicals Capable of Enhancing the Autophagy Flux in HeLa and Caco-2 Human Cell Lines

Ohnishi, K., Yano, S., Fujimoto, M., Sakai, M., Harumoto, E., Furuichi, A., Masuda, M., Ohminami, H., Yamanaka‐Okumura, H., Hara, T., et al. (2020) · Antioxidants · doi:10.3390/antiox9121193 · Cited by 17

Nutritional co-therapy with 1,3-butanediol and multi-ingredient antioxidants enhances autophagic clearance in Pompe disease

Nilsson, M. I., Crozier, M., Carlo, A. D., Xhuti, D., Manta, K., Roik, L. J., Bujak, A. L., Nederveen, J. P., Tarnopolsky, M. G., Hettinga, B. P., et al. (2022) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2022.06.001 · Cited by 15

Glycan degradation promotes macroautophagy

Baudot, A. D., Wang, V. M.-Y., Leach, J., O’Prey, J., Long, J. S., Paulus-Hock, V., Lilla, S., Thomson, D. M., Greenhorn, J., Ghaffar, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111506119 · Cited by 15

Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole

Feng, H., Chen, H., Qiang, J., Xu, B., Wu, X., Pan, E., Yang, H., Li, X., Zhang, J., & Dong, J. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105343 · Cited by 16

Autophagy regulation of virus infection in aquatic animals

Li, C., Zhang, Y., Zhao, X., Li, L., & Kong, X. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12785 · Cited by 15

Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling

Zhang, L., Xue, K., Fan, P., Chen, C., Hu, J., Huang, J., Lu, W., Xu, J., Xu, S., Ran, J., et al. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109416 · Cited by 15

Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration

Shome, I., Thathapudi, N. C., Aramati, B. M. R., Kowtharapu, B. S., & Jangamreddy, J. R. (2023) · International Ophthalmology · doi:10.1007/s10792-023-02767-2 · Cited by 17

ARL6IP5 Ameliorates α-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12

Siddique, I. A., Kamble, K., Gupta, S., Solanki, K., Bhola, S., Ahsan, N., & Gupta, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310499 · Cited by 16

Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles

Huang, S. ‐., Liu, Y., Wang, C., Xiang, W., Wang, N., Peng, L., Jiang, X., Zhang, X., & Fu, Z. (2023) · Orthopaedic Surgery · doi:10.1111/os.13848 · Cited by 15

The promoting effects of pyriproxyfen on autophagy and apoptosis in silk glands of non-target insect silkworm, Bombyx mori

Li, G., Li, Y., He, C., Wei, Y., Cai, K., Lu, Q., Liu, X., Zhu, Y., & Xu, K. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105586 · Cited by 16

Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer

Xie, L., Wang, L., Li, L., Liu, C., Guo, L., Liao, Y., Zhou, S., Wu, W., Duo, Y., Shi, L., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c17977 · Cited by 15

Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells

Shen, W., Zeng, X., Zeng, X., Hu, B., Ren, C., Lin, Z., Zhang, L., Rui, G., Yasen, M., & Chen, X. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.110904 · Cited by 16

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers

Miao, Y., Bai, Y., Miao, J., Murray, A. A., Lin, J., Dong, J., Qu, Z., Zhang, R., Nguyen, Q. D., Wang, S., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci177142 · Cited by 17

Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis

Rahim, M. A., Seo, H., Kim, S., Barman, I., Ghorbanian, F., Hossain, M. S., Shuvo, M. S. H., Lee, S., & Song, H. (2024) · Medical Microbiology and Immunology · doi:10.1007/s00430-024-00794-z · Cited by 18

Linoleic acid inhibits lipopolysaccharide-induced inflammation by promoting TLR4 regulated autophagy in murine RAW264.7 macrophages

Qin, Y., Li, K., Zhang, Q., Liu, J., Xie, Y., Zhang, T., Wang, X., Zhang, L., Yu, J., & Liu, G. (2024) · Journal of Applied Biomedicine · doi:10.32725/jab.2024.023 · Cited by 15

Radiotracers for Noninvasive Molecular Imaging of Tumor Cell Death

Kapty, J., Murray, D. L., & Mercer, J. R. (2010) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0793 · Cited by 15

Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B

Rommelaere, G., Michel, S., Mercy, L., Fattaccioli, A., Demazy, C., Ninane, N., Houbion, A., Renard, P., & Arnould, T. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00037.2010 · Cited by 15

Autophagy inhibition enhances radiosensitivity of Eca‑109 cells via the mitochondrial apoptosis pathway

Tao, H., Qian, P.-D., Lu, J., Guo, Y., Zhu, H., & Wang, F. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4349 · Cited by 15

Skeletal muscle autophagy remains responsive to hyperinsulinemia and hyperglycemia at higher plasma insulin concentrations in insulin-resistant mice

Ehrlicher, S. E., Stierwalt, H. D., Newsom, S. A., & Robinson, M. M. (2018) · Physiological Reports · doi:10.14814/phy2.13810 · Cited by 14

Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage

López-Pérez, Ó., Toivonen, J. M., Otero, A., Solanas, L., Zaragoza, P., Badiola, J. J., Osta, R., Bolea, R., & Martín‐Burriel, I. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0312-z · Cited by 15

Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibition

Kwon, M., Jang, M., Kim, G.-H., Oh, T., Ryoo, I., Ryu, H. W., Oh, S., Kim, B. Y., Jang, J., Ko, S., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113861 · Cited by 18

A hypothetical role for autophagy during the day/night rhythm‐regulated melatonin synthesis in the rat pineal gland

Ge, W., Yan, Z., Wang, L., Tan, S., Liu, J., Reiter, R. J., Luo, S., Sun, Q., & Shen, W. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12742 · Cited by 18

Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus

Sierra-Fonseca, J. A., Hamdan, J. N., Cohen, A. A., Cardenas, S. M., Saucedo, S., Lodoza, G. A., & Gosselink, K. L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.661993 · Cited by 15

Activation of Autophagy by Low-Dose Silica Nanoparticles Enhances Testosterone Secretion in Leydig Cells

Zhang, J., Ye, R., Grunberger, J. W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063104 · Cited by 15

The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

Ishikawa, M., Nakazawa, T., Kunikata, H., Sato, K., Yoshitomi, T., Krishnan, K., Covey, D. F., Zorumski, C. F., & Izumi, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.855779 · Cited by 16

Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy

Xie, T., Feng, M., Zhang, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1093289 · Cited by 15

Paeoniflorin protects HUVECs from AGE-BSA-induced injury via an autophagic pathway by acting on the RAGE.

Chen, Y., Du, X., Zhou, Y., Zhang, Y., Yang, Y., Liu, Z., Liu, C., & Xie, Y. (2015) · Europe PMC (PubMed Central) · Cited by 15

Axonal Accumulation of Lysosomal-Associated Membrane Protein 1 (LAMP1) Accompanying Alterations of Autophagy Dynamics in the Rat Hippocampus Upon Seizure-Induced Injury

Rami, A., Benz, A. P., Niquet, J., & Langhagen, A. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1704-0 · Cited by 15

ΔNp63α/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure

Ratovitski, E. A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.11.020 · Cited by 15

Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands

Korpis, K., Weber, F., Brune, S., Wünsch, B., & Bednarski, P. J. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.11.033 · Cited by 15

HIV-1 gp120 induces autophagy in cardiomyocytes via the NMDA receptor

Meng, L., Zhang, Z., Xu, K., & Qi, G. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.06.067 · Cited by 15

Sequential changes in autophagy in diabetic cardiac fibrosis

Gao, H., Yang, Q., Dong, R., Hou, F., & Wu, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4517 · Cited by 15

Induction of Cell Death by Betulinic Acid through Induction of Apoptosis and Inhibition of Autophagic Flux in Microglia BV-2 Cells

Seo, J., Jung, J., Jang, D. S., Kim, J., & Kim, J. H. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.255 · Cited by 15

Vitamin D, cell death pathways, and tuberculosis

Wahyunitisari, M. R., Mertaniasih, N. M., Amin, M., et al. (2017) · International Journal of Mycobacteriology · doi:10.4103/ijmy.ijmy_120_17 · Cited by 15

U1 small nuclear RNA overexpression implicates autophagic-lysosomal system associated with AD

Cheng, Z., Du, Z., Zhai, B., Yang, Z. R., & Zhang, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.01.006 · Cited by 15

Detection of Autophagy inCaenorhabditis elegansby Western Blotting Analysis of LGG-1Preprint

Palmisano, N. J., & Meléndez, A. (2016) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot086512 · Cited by 15

Assessment of the Nutraceutical Effects of Oleuropein and the Cytotoxic Effects of Adriamycin, When Administered Alone and in Combination, in MG-63 Human Osteosarcoma Cells

Gioti, K., Papachristodoulou, A., Benaki, D. C., Aligiannis, N., Skaltsounis, A., Mikros, E., & Τέντα, Ρ. (2021) · Nutrients · doi:10.3390/nu13020354 · Cited by 14

Porcine Epidemic Diarrhea Virus Infection Induces Autophagosome Formation but Inhibits Autolysosome Formation during Replication

Park, J., Ryu, J., Hong, E., & Shin, H. (2022) · Viruses · doi:10.3390/v14051050 · Cited by 14

Differences in the Autophagy Response to Hypoxia in the Hippocampus and Neocortex of Rats

Churilova, A. V., Зачепило, Т. Г., Baranova, K. A., & Rybnikova, E. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148002 · Cited by 13

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Roşianu, F., Mihaylov, S. R., Eder, N., Martiniuc, A., Claxton, S., Flynn, H. R., Jalal, S., Domart, M., Collinson, L., Skehel, M. J., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201712 · Cited by 14

The Autophagy Marker LC3 Is Processed during the Sperm Capacitation and the Acrosome Reaction and Translocates to the Acrosome Where It Colocalizes with the Acrosomal Membranes in Horse Spermatozoa

Aparicio, I. M., Rojo-Domínguez, P., Castillejo-Rufo, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020937 · Cited by 14

SQSTM1 is a therapeutic target for infection and sterile inflammation

Tang, D., & Kang, R. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156317 · Cited by 15

Panax quinquefolius saponins and panax notoginseng saponins attenuate myocardial hypoxia-reoxygenation injury by reducing excessive mitophagy

Xia, J., Chen, C., Sun, Y., Li, S., Li, Y., Cheng, B.-R., Pang, Y., Li, Y., Li, D., & Lin, Q. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01267-z · Cited by 14

Staphylococcus aureus persistence in osteocytes: weathering the storm of antibiotics and autophagy/xenophagy

Gunn, N. J., Zelmer, A. R., Kidd, S. P., Solomon, L. B., Yang, D., Roscioli, E., & Atkins, G. J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1403289 · Cited by 15

BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons

Jin, Y., Zhao, L., Zhang, Y., Chen, T., Shi, H., Sun, H., Ding, S., Chen, S., Cao, H., Zhang, G., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2393932 · Cited by 16

Treatment of polyethylene microplastics degraded by ultraviolet light irradiation causes lysosome-deregulated cell death

Manabe, S., Haga, Y., Tsujino, H., Ikuno, Y., Asahara, H., Higashisaka, K., & Tsutsumi, Y. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-74800-y · Cited by 16

9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation

Liu, W., Hu, J., Wang, Y., Gan, T., Ding, Y., Wang, X., Xu, Q., Xiong, J., Xiong, N., Lü, S., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156241 · Cited by 14

Measuring Autophagy in Macrophages

Harris, J., Hanrahan, O., & Haro, S. A. D. (2009) · Current Protocols in Immunology · doi:10.1002/0471142735.im1414s87 · Cited by 14

Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization

Kuger, S., Flentje, M. P., & Djuzenova, C. S. (2015) · Radiation Oncology · doi:10.1186/s13014-015-0514-5 · Cited by 16

Renilla Luciferase-LC3 Based Reporter Assay for Measuring Autophagic Flux

Farkas, T., & Jäättelä, M. (2016) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.09.072 · Cited by 14

A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death

Park, H., Choi, S.-W., Lee, G. J., Kim, Y.-D., Noh, H.-J., Oh, S.-J., Yoo, I., Ha, Y.-J., Koo, G.-B., Hong, S., et al. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.08.006 · Cited by 14

Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine

Santos-Llamas, A. I., Monte, M. J., Marı́n, J. J. G., & Perez, M. J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2200-5 · Cited by 15

Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse embryonic fibroblasts

Oldani, M., Manzoni, M., Villa, A., Stefanini, F. M., Melchioretto, P., Monti, E., Forcella, M. E., Urani, C., & Fusi, P. A. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129568 · Cited by 13

Simvastatin protects high glucose-induced H9c2 cells from injury by inducing autophagy

Lusha, E., & Jiang, H. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1839512 · Cited by 15

NQO1 Deficiency Aggravates Renal Injury by Dysregulating Vps34/ATG14L Complex during Autophagy Initiation in Diabetic Nephropathy

Hong, G.-L., Kim, K., Lee, C., Kim, T., & Jung, J. (2021) · Antioxidants · doi:10.3390/antiox10020333 · Cited by 14

Fluorescent Protein-Based Autophagy Biosensors

Kim, H., & Seong, J. (2021) · Materials · doi:10.3390/ma14113019 · Cited by 15

Dioscin-Mediated Autophagy Alleviates MPP+-Induced Neuronal Degeneration: An In Vitro Parkinson’s Disease Model

Azam, S., Haque, M. E., Cho, D.-Y., Kim, J.-S., Jakaria, M., Kim, I., & Choi, D. (2022) · Molecules · doi:10.3390/molecules27092827 · Cited by 15

Pre-ischaemic Treatment with Enriched Environment Alleviates Acute Neuronal Injury by Inhibiting Endoplasmic Reticulum Stress-dependent Autophagy and Apoptosis

Han, Y. K., Shen, X.-Y., Gao, Z.-K., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.12.014 · Cited by 14

Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy

Jang, I., Park, S., Cho, J. W., Yiğitkanlı, K., van Leyen, K., & Roth, J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.11.017 · Cited by 14

Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells

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Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury

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Effects of wortmannin on cardioprotection exerted by ischemic preconditioning in rat hearts subjected to ischemia-reperfusion

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Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis

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A comparative in-silico analysis of autophagy proteins in ciliates

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A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling

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Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D

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DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia

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in vivo cellular evidence of autophagic associated spermiophagy within the principal cells during sperm storage in epididymis of the turtle

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Changes in the cellular fatty acid profile drive the proteasomal degradation of α‐synuclein and enhance neuronal survival

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Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells

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Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Tyutyunyk‐Massey, L., Sun, Y., Dao, N., Ngo, H., Dammalapati, M., Vaidyanathan, A., Singh, M., Haqqani, S., Haueis, J. R. S., Finnegan, R., et al. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0743 · Cited by 14

Group IVA phospholipase A2 deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy

Ishihara, K., Kanai, S., Tanaka, K., Kawashita, E., & Akiba, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.186 · Cited by 14

Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action

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Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy

Kitajima, Y., Suzuki, N., Yoshioka, K., Izumi, R., Tateyama, M., Tashiro, Y., Takahashi, R., Aoki, M., & Ono, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00859 · Cited by 14

Small-molecule activators of NRF1 transcriptional activity prevent protein aggregation

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Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish

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BET inhibitors combined with chemotherapy synergistically inhibit the growth of NSCLC cells

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DNAJC24 is a potential therapeutic target in hepatocellular carcinoma through affecting ammonia metabolism

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The anti-apoptotic and anti-autophagic effects of EPO through PI3K/Akt/mTOR signaling pathway in MAC-T cells

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A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging

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Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma

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Long non-coding RNA PWRN1 affects ovarian follicular development by regulating the function of granulosa cells

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Autophagy in cancer biology and therapy

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Is Selective Autophagy Distinct from Starvation-Induced Autophagy?

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Bnip3 interacts with LC3 to induce selective removal of endoplasmic reticulum and mitochondria via autophagy

Hanna, R. A. (2011) · eScholarship (California Digital Library) · Cited by 2

Self-consumption: the interplay of autophagy and apoptosis

Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172

Posttranslational Modifications of Autophagy-related Proteins

Qian, H. (2013) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao