Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: A theoretical review
Open accessAbstract
Normal aging involves a gradual breakdown of physiological processes that leads to a decline in cognitive functions and brain integrity, yet the onset and progression of decline are variable among older individuals. While many biological changes may contribute to this degree of variability, oxidative stress is a key mechanism of the aging process that can cause direct damage to cellular architecture within the brain. Oligodendrocytes are at a high risk for oxidative damage due to their role in myelin maintenance and production and limited repair mechanisms, suggesting that white matter may be particularly vulnerable to oxidative activity. Antioxidant defense enzymes within the brain, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST), are crucial for breaking down the harmful end products of oxidative phosphorylation. Previous studies have revealed that allele variations of polymorphisms that encode these antioxidants are associated with abnormalities in SOD, CAT, GPx, and GST activity in the central nervous system. This review will focus on the role of oxidative stress in the aging brain and the impact of decreased antioxidant defense on brain integrity and cognitive function. Directions for future research investigations of antioxidant defense genes will also be discussed.
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Oxidative stress has a role, especially during ageing, in the development of cognitive problems in working memory, reasoning, or problem solving.
“Oxidative stress has a role, especially during ageing, in the development of cognitive problems in working memory, reasoning, or problem solving [149].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [149]
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- Authors
- Salminen, L. E., & Paul, R. H.
- Affiliations
- University of Missouri–St. Louis (US)
- Corresponding author
- Salminen, Lauren E.
- Venue
- Reviews in the Neurosciences
- Publisher
- Walter de Gruyter GmbH
- Published
- 2014-01-01
- Volume
- 25
- Issue
- 6
- Pages
- 805-19
- ISSN
- 0334-1763 (ISSN-L)
- 2191-0200
- PMC
- PMC6378111
- OpenAlex
- W2094909334
- Cited by
- 113
- References
- 194
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 21 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 11 · 2015: 11
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Reviews in the Neurosciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (F31AG050450)
- National Institute of Mental Health (R21MH090494)
- National Institute of Neurological Disorders and Stroke (R01NS039538, R01NS052470)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, brain aging, antioxidant defense, genetic polymorphism, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, oligodendrocytes, white matter, cognitive decline, brain integrity, gene-environment interaction
- MeSH terms
- Aging, Animals, Antioxidants, Brain, Brain Diseases, Cognition Disorders, Genetic Markers, Humans, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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