HIF-1: A Target For Cancer, Ischemia and Inflammation—Too Good to be True?
Open accessAbstract
The histone H2A variant, H2AX, is a core component of chromatin that is phosphorylated in chromatin flanking DNA double strand breaks (DSBs). Here, we summarize H2AX functions and outline a specific "anchoring" model, that can explain the translocation prone phenotype of H2AX-deficient and H2AX/p53-deficient mice. We also discuss how this model of H2AX function could account for some aspects of the genomic instability and cancer prone human phenotypes associated with Ataxia Telangiectasia (AT), Nijmegen Breakage Syndrome (NBS), Ataxia Telangiectasia Like Disorder (ATLD), and Bloom's Syndrome (BS).
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Research works printed but not linked: 18
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- Authors
- Melillo, G.
- Affiliations
- Leidos (United States) (US)
- Corresponding author
- Melillo, Giovanni
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2004-02
- Volume
- 3
- Issue
- 2
- Pages
- 149-150
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2016440796
- Cited by
- 247
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 18 · 2013: 11 · 2012: 7
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health (N01-CO-12400)
- U.S. Public Health Service (N01C012400)
- National Cancer Institute (CO-12400, N01CO12400)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- H2AX, histone H2A variant, DNA double-strand breaks, p53, genomic instability, cancer susceptibility, ataxia telangiectasia, NBS1, Nijmegen breakage syndrome, ataxia-telangiectasia-like disorder, Bloom syndrome, HIF-1
- MeSH terms
- Animals, Ataxia Telangiectasia, Cell Transformation, Neoplastic, Chromatin, DNA Damage, DNA-Binding Proteins, Histones, Humans, Models, Biological, Phosphorylation, Tumor Suppressor Protein p53, Protein Serine-Threonine Kinases, Mice, Knockout, Cell Cycle Proteins, Tumor Suppressor Proteins, Mice, Ataxia Telangiectasia Mutated Proteins
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