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Cited by 121Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesPI3K/AKT/mTOR signaling in cancer

Leptin and mTOR: Partners in metabolism and inflammation

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Maya-Monteiro, Clarissa, Bozza, Patricia·2008·Cell Cycle
DOI 10.4161/cc.7.12.6157
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Abstract

Leptin is both a hormone/cytokine that plays a major role in the regulation of feeding and energy expenditure. Beyond its central role in the hypothalamus, leptin modulates peripheral tissues' responses to growth and storage based on nutrient availability, and it regulates the innate and adaptive immune responses. mTOR (mammalian Target of Rapamycin) is a core component of intracellular signaling for cellular growth, mRNA translation, and metabolism. Here, we review recent findings on the cross talk between mTOR and leptin signaling. Important roles for mTOR on leptin signaling have been established both in hypothalamic centers to control food intake and in peripheral cells to regulate lipid metabolism and inflammation. Leptin directly activates resident macrophages to form ADRP-enriched lipid droplets and enhances eicosanoid production via a mechanism that is dependent on activation of the PI3K/mTOR pathway. Leptin-induced mTOR activation may have implications for obesity-related pathophysiological conditions such as diabetes, cardiovascular disease and cancer.

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Authors
Maya-Monteiro, C., & Bozza, P.
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2008-06-15
Volume
7
Issue
12
Pages
1713-1717
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
DOI
10.4161/cc.7.12.6157
OpenAlex
W2046052197
Cited by
121
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 12
FWCI
0.87
Type
journal article
Language
en
Open access
Locations
  • Cell Cycle (publishedVersion)
  • PubMed (publishedVersion)
  • Arca - Repositório Institucional da Fiocruz (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • Oklahoma Medical Research Foundation
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
  • Fundação Oswaldo Cruz
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
leptin, mTOR, PI3K/mTOR signaling, energy homeostasis, lipid metabolism, inflammation, macrophages, adipose tissue, lipid droplets, eicosanoid biosynthesis, obesity, diabetes mellitus, cardiovascular disease, cancer
MeSH terms
Humans, Hypothalamus, Immunity, Inflammation, Macrophage Activation, Macrophages, Protein Kinases, Signal Transduction, Leptin, Lipid Metabolism, TOR Serine-Threonine Kinases

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