The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
MicroRNAs as regulators of epithelial-mesenchymal transition
Open accessAbstract
Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells. This process allows the remodelling of tissues during embryonic development and is implicated in the promotion of tumor invasion and metastasis. Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. The miR-200 family participates in a signalling network with the E-cadherin transcriptional repressors ZEB1/deltaEF1 and ZEB2/SIP1, and TGFbeta2 that is postulated to facilitate maintenance of stable epithelial or mesenchymal states but also allow reversible switching between these states in response to EMT effectors (such as TGFbeta). This review summarises these recent findings and their implications in both developmental EMT and tumor progression.
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The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302
The Increasing Complexity of the Cancer Stem Cell Paradigm
Rosen, J. M., & Jordan, C. T. (2009) · Science · doi:10.1126/science.1171837 · Cited by 698
MicroRNA regulation by RNA-binding proteins and its implications for cancer
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Adherens Junction: Molecular Architecture and Regulation
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Metadata
- Authors
- Gregory, P. A., Bracken, C. P., Bert, A. G., & Goodall, G. J.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2008-10-15
- Volume
- 7
- Issue
- 20
- Pages
- 3112-3117
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2093464881
- Cited by
- 506
- References
- 13
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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