Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
Abstract
MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed miRNAs occurs at a distance of 50 kb, implying that miRNAs separated by <50 kb typically derive from a common transcript. Some microRNAs are within the introns of host genes. Intronic miRNAs are usually coordinately expressed with their host gene mRNA, implying that they also generally derive from a common transcript, and that in situ analyses of host gene expression can be used to probe the spatial and temporal localization of intronic miRNAs.
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A subset of miR-15/107 miRNA genes has been detected in mammalian tissues including heart, skeletal muscle, brain, lung, liver, kidney, spleen and placenta.
“A subset of these miRNA genes has been detected in mammalian tissues including heart, skeletal muscle, brain, lung, liver, kidney, spleen and placenta [25–31].”
From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [27]
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- Authors
- BASKERVILLE, S., & BARTEL, D. P.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-02-08
- Volume
- 11
- Issue
- 3
- Pages
- 241-247
- ISSN
- 1355-8382
- 1469-9001
- Cited by
- 1,241
- References
- 2
- Language
- en
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