Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
Open accessAbstract
A cancer cell comprising largely of carbon, hydrogen, oxygen, phosphorus, nitrogen and sulfur requires not only glucose, which is avidly transported and converted to lactate by aerobic glycolysis or the Warburg effect, but also glutamine as a major substrate. Glutamine and essential amino acids, such as methionine, provide energy through the TCA cycle as well as nitrogen, sulfur and carbon skeletons for growing and proliferating cancer cells. The interplay between utilization of glutamine and glucose is likely to depend on the genetic make-up of a cancer cell. While the MYC oncogene induces both aerobic glycolysis and glutaminolysis, activated β-catenin induces glutamine synthesis in hepatocellular carcinoma. Cancer cells that have elevated glutamine synthetase can use glutamate and ammonia to synthesize glutamine and are hence not addicted to glutamine. As such, cancer cells have many degrees of freedom for re-programming cell metabolism, which with better understanding will result in novel therapeutic approaches.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glutamine serves as an anaplerosis substrate to fuel the TCA cycle for energy generation and provides nitrogen for protein synthesis.
“Glutamine serves as an anaplerosis substrate to fuel the TCA cycle for energy generation and also provides nitrogen for protein synthesis (Dang, 2010; Wise and Thompson, 2010; DeBerardinis and Cheng, 2010; Daye and Wellen, 2012; Gaglio et al., 2009; Johnson et al., 2003; Rajagopalan and DeBerardinis, 2011; Shanware et al., 2011; Weinberg et al., 2010).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Dang, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The publisher hasn’t deposited this paper’s reference list.
Research works printed but not linked: 5
- Baggetto LG. Deviant energetic metabolism of glyco- lytic cancer cells. Biochimie 1992; 74:959-74.
- Dang CV. Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 2010; 70:859-62.
- Weinhouse S. Glycolysis, respiration and anoma- lous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture. Cancer Res 1972; 32:2007-16.
- Linder-Horowitz M, Knox WE, Morris HP. Glutaminase activities and growth rates of rat hepa- tomas. Cancer Res 1969; 29:1195-9.
- Kovacevic Z, Morris HP. The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res 1972; 32:326-33.
Cited by
Sorted by citations
Targeting cancer metabolism: a therapeutic window opens
Heiden, M. G. V. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3504 · Cited by 1,409 · see citing works
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395 · see citing works
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927 · see citing works
Phan, L. M., Yeung, S. J., & Lee, M. H. (2014) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2014.01.001 · Cited by 500 · see citing works
The Right Ventricle in Pulmonary Arterial Hypertension
Ryan, J. J., & Archer, S. L. (2014) · Circulation Research · doi:10.1161/circresaha.113.301129 · Cited by 474 · see citing works
Cancer as a metabolic disease: implications for novel therapeutics
Seyfried, T. N., Flores, R. E., Poff, A. M., & D’Agostino, D. P. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt480 · Cited by 472 · see citing works
Glutaminolysis as a target for cancer therapy
Jin, L., Alesi, G. N., & Kang, S. (2016) · Oncogene · doi:10.1038/onc.2015.447 · Cited by 459 · see citing works
Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works
Molecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402 · see citing works
Daemen, A., Peterson, D., Sahu, N., McCord, R., Du, X., Liu, B., Kowanetz, K., Hong, R., Moffat, J., Gao, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501605112 · Cited by 398 · see citing works
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
Sun, L., Suo, C., Li, S., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 366 · see citing works
Yang, L., Moss, T., Mangala, L. S., Marini, J., Zhao, H., Wahlig, S., Armaiz‐Pena, G., Jiang, D., Achreja, A., Win, J., et al. (2014) · Molecular Systems Biology · doi:10.1002/msb.20134892 · Cited by 326 · see citing works
Glutathione in Cancer Cell Death
Ortega, Á., Mena, S., & Estrela, J. M. (2011) · Cancers · doi:10.3390/cancers3011285 · Cited by 315 · see citing works
McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Franklin, R. A., Montalto, G., Cervello, M., Libra, M., Candido, S., Malaponte, G., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.659 · Cited by 313 · see citing works
Sun, L., Song, L., Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., et al. (2015) · Cell Research · doi:10.1038/cr.2015.33 · Cited by 311 · see citing works
A Review of Applications of Metabolomics in Cancer
Beger, R. D. (2013) · Metabolites · doi:10.3390/metabo3030552 · Cited by 289 · see citing works
Cassago, A., Ferreira, A. P. S., Ferreira, I. M., Fornezari, C., Gomes, E. R. M., Greene, K. S., Pereira, H. M., Garratt, R. C., Dias, S. M. G., & Ambrosio, A. L. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112495109 · Cited by 287 · see citing works
Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
Wong, C. C., Qian, Y., & Yu, J. Q. (2017) · Oncogene · doi:10.1038/onc.2016.485 · Cited by 260 · see citing works
The Warburg effect: Insights from the past decade
Upadhyay, M., Samal, J., Kandpal, M., Singh, O. V., & Vivekanandan, P. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.11.003 · Cited by 245 · see citing works
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
Mathew, R., & White, E. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.008 · Cited by 235 · see citing works
Cancer Metabolism: Current Understanding and Therapies
Counihan, J. L., Grossman, E. A., & Nomura, D. K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00775 · Cited by 229 · see citing works
Keller, K. E., Tan, I. S., & Lee, Y.-S. (2012) · Science · doi:10.1126/science.1224409 · Cited by 228 · see citing works
Stable isotope-resolved metabolomics and applications for drug development
Fan, T. W. ‐., Lorkiewicz, P. K., Sellers, K., Moseley, H., Higashi, R. M., & Lane, A. N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.007 · Cited by 209 · see citing works
Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension
Ryan, J. J., & Archer, S. L. (2015) · Circulation · doi:10.1161/circulationaha.114.006979 · Cited by 206 · see citing works
Right Ventricular Adaptation and Failure in Pulmonary Arterial Hypertension
Ryan, J. J., Huston, J., Kutty, S., Hatton, N. D., Bowman, L., Tian, L., Herr, J. E., Johri, A. M., & Archer, S. L. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.01.023 · Cited by 195 · see citing works
Moreno‐Sánchez, R., Marín‐Hernández, Á., Saavedra, E., Pardo, J. P., Ralph, S. J., & Rodríguez‐Enríquez, S. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.01.025 · Cited by 185 · see citing works
Piao, L. H., Fang, Y., Parikh, K. S., Ryan, J. J., Tóth, P. T., & Archer, S. L. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1064-7 · Cited by 179 · see citing works
Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK
Moldogazieva, N. T., Mokhosoev, I. M., & Terentiev, A. A. (2020) · Cancers · doi:10.3390/cancers12040862 · Cited by 176 · see citing works
Sotgia, F., Martinez‐Outschoorn, U., Pavlides, S., Howell, A., Pestell, R. G., & Lisanti, M. P. (2011) · Breast Cancer Research · doi:10.1186/bcr2892 · Cited by 177 · see citing works
PET Imaging of Glutaminolysis in Tumors by 18 F-( 2S,4R )4-Fluoroglutamine
Lieberman, B. P., Plöessl, K., Wang, L., Qü, W., Zha, Z., Wise, D. R., Chodosh, L. A., Belka, G. K., Thompson, C. B., & Kung, H. F. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.093815 · Cited by 176 · see citing works
Pouysségur, J., Marchiq, I., Parks, S. K., Durivault, J., Ždralević, M., & Vučetić, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.07.004 · Cited by 172 · see citing works
Liu, W., Hancock, C. N., Fischer, J. W., Harman, M., & Phang, J. M. (2015) · Scientific Reports · doi:10.1038/srep17206 · Cited by 171 · see citing works
Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
Singh, D. P., Arora, R., Kaur, P., Singh, B., Mannan, R., & Arora, S. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0190-2 · Cited by 166 · see citing works
Targeting cancer metabolism – aiming at a tumour's sweet-spot
Jones, N. P., & Schulze, A. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.12.017 · Cited by 162 · see citing works
PET Radiomics in NSCLC: state of the art and a proposal for harmonization of methodology
Sollini, M., Cozzi, L., Antunovic, L., Chiti, A., & Kirienko, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00426-y · Cited by 158 · see citing works
Therapeutic Strategies Impacting Cancer Cell Glutamine Metabolism
Lukey, M. J., Wilson, K. F., & Cerione, R. A. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.130 · Cited by 151 · see citing works
The regulation of cellular metabolism by tumor suppressor p53
Liang, Y., Liu, J., & Feng, Z. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-9 · Cited by 147 · see citing works
Huang, S., Chong, N. Y. Y., Lewis, N. E., Jia, W. P., Xie, G., & Garmire, L. X. (2016) · Genome Medicine · doi:10.1186/s13073-016-0289-9 · Cited by 144 · see citing works
Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer
Kim, S., Kim, D. H., Jung, W.-H., & Koo, J. S. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0398 · Cited by 138 · see citing works
Nair, V. S., Gevaert, O., Davidzon, G., Napel, S. A., Graves, E. E., Hoang, C. D., Shrager, J. B., Quon, A. S. W., Rubin, D. L., & Plevritis, S. K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3943 · Cited by 135 · see citing works
On the Origin of ATP Synthesis in Cancer
Seyfried, T., Arismendi-Morillo, G., Mukherjee, P., & Chinopoulos, C. (2020) · iScience · doi:10.1016/j.isci.2020.101761 · Cited by 117 · see citing works
Preparation and Characterization of l-[5-11C]-Glutamine for Metabolic Imaging of Tumors
Qü, W., Oya, S., Lieberman, B. P., Plöessl, K., Wang, L., Wise, D. R., Divgi, C. R., Chodosh, L. A., Thompson, C. B., & Kung, H. F. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.093831 · Cited by 123 · see citing works
Gameiro, P. A., Laviolette, L. A., Kelleher, J. K., Iliopoulos, O., & Stephanopoulos, G. N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.396796 · Cited by 123 · see citing works
Long, Y., Tsai, W.-B., Wangpaichitr, M., Tsukamoto, T., Savaraj, N., Feun, L. G., & Kuo, M. T. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0302 · Cited by 121 · see citing works
O-GlcNAcylation and Metabolic Reprograming in Cancer
Åowiak, P. J., Forma, E., Bryś, M., & Krześlak, A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00145 · Cited by 119 · see citing works
Signaling, metabolism, and cancer: An important relationship for therapeutic intervention
Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 117 · see citing works
Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway
Yuan, L., Sheng, X., Willson, A. K., Roque, D. R., Stine, J. E., Guo, H., Jones, H. M., Zhou, C., & Bae-Jump, V. L. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0192 · Cited by 116 · see citing works
Damiani, C., Colombo, R., Gaglio, D., Mastroianni, F., Pescini, D., Westerhoff, H. V., Mauri, G., Vanoni, M., & Alberghina, L. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005758 · Cited by 112 · see citing works
T Cells and Cancer: How Metabolism Shapes Immunity
Molon, B., Calì, B., & Viola, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00020 · Cited by 100 · see citing works
Stress-induced cleavage of Myc promotes cancer cell survivalPreprint
Conacci‐Sorrell, M., Ngouenet, C., Anderson, S., Brabletz, T., & Eisenman, R. N. (2014) · Genes & Development · doi:10.1101/gad.231894.113 · Cited by 100 · see citing works
Alterations in cancer cell metabolism: The Warburg effect and metabolic adaptation
Asgari, Y., Zabihinpour, Z., Salehzadeh‐Yazdi, A., Schreiber, F., & Masoudi‐Nejad, A. (2015) · Genomics · doi:10.1016/j.ygeno.2015.03.001 · Cited by 98 · see citing works
Pi, M., Kuang, H., Yue, C., Yang, Q., Wu, A., Li, Y., Assaraf, Y. G., Yang, D., & Wu, S. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100822 · Cited by 98 · see citing works
Comparative Evaluation of 18 F-Labeled Glutamic Acid and Glutamine as Tumor Metabolic Imaging Agents
Plöessl, K., Wang, L., Lieberman, B. P., Qü, W., & Kung, H. F. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.101279 · Cited by 95 · see citing works
Tripathi, P., Kamarajan, P., Somashekar, B. S., MacKinnon, N., Chinnaiyan, A. M., Kapila, Y. L., Rajendiran, T. M., & Ramamoorthy, A. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.06.025 · Cited by 93 · see citing works
MicroRNAs in Tumor Cell Metabolism: Roles and Therapeutic Opportunities
Pedroza‐Torres, A., Romero-Cordoba, S. L., Justo-Garrido, M., Salido-Guadarrama, I., Rodríguez‐Bautista, R., Montaño, S., Muñiz-Mendoza, R., Arriaga-Canon, C., Fragoso‐Ontiveros, V., Álvarez-Gómez, R. M., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01404 · Cited by 89 · see citing works
Caveolin-1–LRP6 Signaling Module Stimulates Aerobic Glycolysis in Prostate Cancer
Tahir, S. A., Yang, G., Goltsov, A. A., Song, K., Ren, C., Wang, J., Chang, W., & Thompson, T. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3040 · Cited by 89 · see citing works
Cala, M. P., Agulló-Ortuño, M. T., Prieto‐García, E., González-Riaño, C., Parrilla‐Rubio, L., Barbas, C., Díaz‐García, C. V., Garcı́a, A., Pernaut, C., Adeva, J., et al. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12270 · Cited by 87 · see citing works
dos Reis, L. M., Adamóski, D., Souza, R. O. O., Ascenção, C. F. R., de Oliveira, K. R. S., Corrêa‐da‐Silva, F., Patroni, F. M. D. S., Dias, M. M., Consonni, S. R., Moraes‐Vieira, P. M., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008180 · Cited by 88 · see citing works
Qie, S., Chu, C., Li, W., Wang, C., & Sang, N. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24684 · Cited by 87 · see citing works
Press-pulse: a novel therapeutic strategy for the metabolic management of cancer
Seyfried, T. N., Yu, G. W., Maroon, J. C., & D’Agostino, D. P. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0178-2 · Cited by 86 · see citing works
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming
Phan, L. M., Chou, P., Velázquez-Torres, G., Samudio, I. J., Parreno, K., Huang, Y., Tseng, C., Vu, T., Gully, C., Su, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms8530 · Cited by 87 · see citing works
miRNAs link metabolic reprogramming to oncogenesis
Hatziapostolou, M., Polytarchou, C., & Iliopoulos, D. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.03.002 · Cited by 80 · see citing works
Kotze, H. L., Armitage, E. G., Sharkey, K. J., Allwood, J. W., Dunn, W. B., Williams, K. J., & Goodacre, R. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-107 · Cited by 78 · see citing works
Hens, J. R., Sinha, I., Perodin, F., Cooper, T. K., Sinha, R., Plummer, J. D., Perrone, C. E., & Orentreich, D. S. (2016) · BMC Cancer · doi:10.1186/s12885-016-2367-1 · Cited by 75 · see citing works
Biomarkers in bladder cancer: A metabolomic approach using in vitro and ex vivo model systems
Rodrigues, D., Jerónimo, C., Henrique, R., Belo, L., Bastos, M. D. L., de Pinho, P. G., & Carvalho, M. C. (2016) · International Journal of Cancer · doi:10.1002/ijc.30016 · Cited by 72 · see citing works
Seyfried, T. N., Marsh, J., Shelton, L. M., Huysentruyt, L. C., & Mukherjee, P. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.06.017 · Cited by 70 · see citing works
Impériale, A., Moussallieh, F., Roche, P., Battini, S., Çiçek, A. E., Sebag, F. A., Brunaud, L., Barlier, A., Elbayed, K., Loundou, A., et al. (2015) · Neoplasia · doi:10.1016/j.neo.2014.10.010 · Cited by 69 · see citing works
Low- and High-Grade Bladder Cancer Determination via Human Serum-Based Metabolomics Approach
Bansal, N., Gupta, A. K., Mitash, N., Shakya, P. S., Mandhani, A., Mahdi, A. A., Sankhwar, S. N., & Mandal, S. K. (2013) · Journal of Proteome Research · doi:10.1021/pr400859w · Cited by 69 · see citing works
Carbon Source Metabolism and Its Regulation in Cancer Cells
Yin, C., Qie, S., & Sang, N. (2012) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v22.i1.20 · Cited by 66 · see citing works
Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells
Sazeides, C., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_11 · Cited by 72 · see citing works
Dysregulated metabolic enzymes and metabolic�reprogramming in cancer cells (Review)
Sreedhar, A., & Zhao, Y. (2017) · Biomedical Reports · doi:10.3892/br.2017.1022 · Cited by 66 · see citing works
Mitochondrial mutations and metabolic adaptation in pancreatic cancer
Initiative, A. P. C. G., Hardie, R., van Dam, E., Cowley, M. J., Han, T.-L., Balaban, S., Pajic, M., Pinese, M., Iconomou, M., Shearer, R. F., et al. (2017) · Cancer & Metabolism · doi:10.1186/s40170-017-0164-1 · Cited by 64 · see citing works
Tripathi, P., Somashekar, B. S., Ponnusamy, M. P., Gursky, A. M., Dailey, S. M., Kunju, P., Lee, C. T., Chinnaiyan, A. M., Rajendiran, T. M., & Ramamoorthy, A. (2013) · Journal of Proteome Research · doi:10.1021/pr4004135 · Cited by 64 · see citing works
Lu, H., Li, X.-Q., Lu, Y., Qiu, S., & Fan, Z. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.07.020 · Cited by 58 · see citing works
A key role for transketolase-like 1 in tumor metabolic reprogramming
Díaz‐Moralli, S., Aguilar, E., Marín, S., Coy, J. F., Dewerchin, M. A., Antoniewicz, M. R., Meca‐Cortés, Ó., Notebaert, L., Ghesquière, B., Eelen, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10429 · Cited by 62 · see citing works
The role of GSK3 in metabolic pathway perturbations in cancer
Papadopoli, D. J., Pollak, M., & Topisirović, I. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119059 · Cited by 63 · see citing works
Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy
Shao, W., Gu, J., Huang, C., Liu, D., Huang, H., Huang, Z., Lin, Z., Yang, W., Liu, K., Lin, D., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-197 · Cited by 61 · see citing works
Natural Polyphenols in Cancer Chemoresistance
Hussain, S. A., Sulaiman, A. A., Balch, C., Chauhan, H., Alhadidi, Q., & Tiwari, A. K. (2016) · Nutrition and Cancer · doi:10.1080/01635581.2016.1192201 · Cited by 61 · see citing works
Matschke, J., Riffkin, H., Klein, D., Handrick, R., Lüdemann, L., Metzen, E., Shlomi, T., Stuschke, M., & Jendrossek, V. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6589 · Cited by 60 · see citing works
Effects of glutamine deprivation on oxidative stress and cell survival in breast cell lines
Gwangwa, M. V., Joubert, A. M., & Visagie, M. H. (2019) · Biological Research · doi:10.1186/s40659-019-0224-9 · Cited by 58 · see citing works
Lopes‐Coelho, F., Gouveia-Fernandes, S., Gonçalves, L. G., Nunes, C., Faustino, I., SILVA, F. A. B. N. D., Félix, A., Pereira, S. A., & Serpa, J. (2015) · Tumor Biology · doi:10.1007/s13277-015-4290-5 · Cited by 57 · see citing works
Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function
Bettonville, M., d'Aria, S., Weatherly, K., Porporato, P. E., Zhang, J., Bousbata, S., Sonveaux, P., & Braun, M. Y. (2018) · eLife · doi:10.7554/elife.30938 · Cited by 56 · see citing works
Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness
Vasseur, S., Tomasini, R., Tournaire, R., & Iovanna, J. (2010) · Cancers · doi:10.3390/cancers2042138 · Cited by 55 · see citing works
Understanding tumor anabolism and patient catabolism in cancer-associated cachexia.
Schcolnik‐Cabrera, A., Chávez-Blanco, A. D., Domínguez-Gómez, G., & Dueñas‐González, A. (2017) · Europe PMC (PubMed Central) · Cited by 54 · see citing works
Kinetic properties of Streptomyces canarius L- Glutaminase and its anticancer efficiency
Reda, F. M. (2015) · Brazilian Journal of Microbiology · doi:10.1590/s1517-838246420130847 · Cited by 55 · see citing works
Qie, S., Liang, D., Yin, C., Gu, W., Meng, M., Wang, C., & Sang, N. (2012) · Cell Cycle · doi:10.4161/cc.21944 · Cited by 52 · see citing works
Mitochondrial Metabolism Inhibitors for Cancer Therapy
Ramsay, E. E., Hogg, P. J., & Dilda, P. J. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0584-5 · Cited by 51 · see citing works
Luby, A., & Alves‐Guerra, M. (2021) · Cancers · doi:10.3390/cancers13235912 · Cited by 47 · see citing works
Oxidative stress and metabolic reprogramming in Cr(VI) carcinogenesis
Clementino, M., Shi, X., & Zhang, Z. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.11.015 · Cited by 48 · see citing works
Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism
Beltrán‐Anaya, F. O., Cedro‐Tanda, A., Hidalgo‐Miranda, A., & Romero-Cordoba, S. L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00342 · Cited by 44 · see citing works
Metabolic PET Imaging in Oncology
Sai, K. K. S., Zachar, Z., Bingham, P. M., & Mintz, A. (2017) · American Journal of Roentgenology · doi:10.2214/ajr.17.18112 · Cited by 43 · see citing works
Botman, D., Tigchelaar, W., & Noorden, C. J. F. V. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414551177 · Cited by 41 · see citing works
Sasakawa, A., Hosomi, K., Sumitomo, Y., Takizawa, T., Tomura-Suruki, S., Imaizumi, M., Kasai, N., Poh, T. W., Yamano, K., Yong, W. P., et al. (2018) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells
Sazeides, C., & Le, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65768-0_14 · Cited by 41 · see citing works
Glutaminolysis and carcinogenesis of oral squamous cell carcinoma
Cetindis, M., Biegner, T., Munz, A., Teriete, P., Reinert, S., & Grimm, M. R. (2015) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-015-3543-7 · Cited by 39 · see citing works
New Biochemical Insights into the Mechanisms of Pulmonary Arterial Hypertension in Humans
Wawrzyniak, R., Mateo, J., Blanco, I., Izquierdo-García, J. L., Dudzik, D., Markuszewski, M. J., Peinado, V. I., Laclaustra, M., Barberà, J. A., Barbas, C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160505 · Cited by 39 · see citing works
14-3-3 σ: A potential biomolecule for cancer therapy
Huang, Y., Yang, M., & Huang, W. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.09.009 · Cited by 39 · see citing works
Sun, H., Zhang, C., Yang, Z., Liu, C., Wang, X., & Cong, X. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03523-3 · Cited by 38 · see citing works
Normoxic accumulation of HIF1α is associated with glutaminolysis
Kappler, M., Pabst, U., Rot, S., Taubert, H. W., Wichmann, H., Schubert, J., Bache, M., Weinholdt, C., Immel, U., Große, I., et al. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1780-9 · Cited by 37 · see citing works
Lee, Y.-Y., Li, C., Lin, C., Lee, S., Sheu, M.-J., Lin, L.-C., Chen, T.-J., Wu, T.-F., & Hsing, C. (2014) · Tumor Biology · doi:10.1007/s13277-014-2425-8 · Cited by 38 · see citing works
- Authors
- Dang, C. V.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Dang, Chi V.
- ORCID
- Dang, Chi V.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2010-10
- Volume
- 9
- Issue
- 19
- Pages
- 3884-3886
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1986517285
- Cited by
- 245
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 21 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 13 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 25 · 2013: 21 · 2012: 17
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- glutaminolysis, glutamine metabolism, cancer metabolism, aerobic glycolysis, Warburg effect, TCA cycle, MYC oncogene, β-catenin, glutamine synthetase, glutamine addiction, hepatocellular carcinoma, methionine, metabolic reprogramming, cancer therapy
- MeSH terms
- Amino Acids, Carbon, Citric Acid Cycle, Energy Metabolism, Glucose, Glutamine, Glycolysis, Humans, Neoplasms, Nitrogen, Proto-Oncogene Proteins c-myc, Glutamic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
