Glutaminolysis as a target for cancer therapy
Open accessAbstract
Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in these metabolic processes could provide novel approaches to improve cancer treatment. This review summarizes current findings on the role of glutaminolytic enzymes in human cancers and provides an update on the development of small molecule inhibitors to target glutaminolysis for cancer therapy.
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None of the agents targeting glutaminolysis have yet been used clinically.
“Throughout the discovery of agents targeting glutaminolysis, none have yet been used clinically197.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [197]
GLS inhibition suppresses proliferation.
“GLS inhibition suppresses proliferation, and GLS inhibitors are being evaluated in clinical studies for a number of cancers.31,38,39”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [39]
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The multifaceted contributions of mitochondria to cellular metabolism
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“In this context, it has been observed that glucose starvation increased activity of glutamate dehydrogenase (Jin et al., 2016).”
BackgroundEpigenome modifiers and metabolic rewiring: New frontiers in therapeutics
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- Authors
- Jin, L., Alesi, G. N., & Kang, S.
- Affiliations
- Emory University (US)
- Corresponding author
- Jin, L
- Kang, S
- Venue
- Oncogene
- Published
- 2015-11-23
- Volume
- 35
- Issue
- 28
- Pages
- 3619-3625
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC5225500
- OpenAlex
- W2176297535
- Cited by
- 459
- References
- 92
- Citations by year
- 2026: 17 · 2025: 43 · 2024: 46 · 2023: 40 · 2022: 73 · 2021: 62 · 2020: 57 · 2019: 36 · 2018: 44 · 2017: 27 · 2016: 13 · 2015: 1
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society
- Georgia Cancer Coalition
- National Institutes of Health
- National Cancer Institute (R01CA175316, F31CA183365)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- glutaminolysis, glutamine metabolism, cancer metabolism, small molecule inhibitors, cancer therapy, redox homeostasis, macromolecular synthesis, signaling pathways, tumor suppressor, oncogenic mutations
- MeSH terms
- Antineoplastic Agents, Cell Survival, Glutamine, Humans, Neoplasms, Molecular Structure, Cell Proliferation, Metabolic Networks and Pathways, Small Molecule Libraries, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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