Cited by 135Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

DNA methylation and epigenetic control of cellular differentiation

Open access
Khavari, David A., Sen, George L., Rinn, John L.·2010·Cell Cycle

Abstract

In mammals the genome is shaped by epigenetic regulation to manifest numerous cellular identities. The term epigenetics has been used to refer to changes in gene expression, which are heritable through multiple cell division cycles that are not due to variations in primary DNA sequence. Stable suppression of differentiation genes is required to sustain the undifferentiated state in cells ranging from embryonic stem cells to somatic stem cell progenitors that constantly replenish self-renewing tissues. However, the epigenetic mechanisms behind the maintenance of cellular dedifferentiation are not yet fully understood. Major effectors of epigenetic control include regulators of DNA methylation and histone modification as well as ATP-dependent chromatin remodeling enzymes. These interact with other regulators, such as DNA sequence-specific transcription factors and noncoding RNAs to landscape the genome during development, differentiation and cancer. DNA methylation is a classic and powerful example of the epigenetic inheritance of cellular identity that is widely used in eukaryotes. DNA methylation confers distinct epigenetic states via several mechanisms. Here we discuss fundamental mechanisms of DNA methylation and their interplay with several regulatory pathways that define cellular physiology and differentiation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4161/cc.9.19.13385

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 5

  1. Feinberg AP. Phenotypic plasticity and the epi- genetics of human disease. Nature 2007; 447:7-9.
  2. Pandey RR, Mondal T, Mohammad F, Enroth S, Redrup L, Komorowski J, et al. Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcrip- tional silencing through chromatin-level regulation. Mol Cell 2008; 32:232-46.
  3. Sleutels F, Zwart R, Barlow DP. The noncoding Air RNA is required for silencing autosomal imprinted genes. Nature 2002; 415:810-3.
  4. Lazarov M, Green CL, Zhang JY, Kubo Y, Dajee M, Khavari PA. Escaping G 1 restraints on neoplasia- Cdk4 regulation by Ras and NFkappaB. Cell Cycle 2003; 2:79-80.
  5. Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, et al. Genome-scale DNA meth- ylation maps of pluripotent and differentiated cells. Nature 2008; 454:766-70.

Cited by

Sorted by citations

Authors
Khavari, D. A., Sen, G. L., & Rinn, J. L.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Rinn, John L.
Venue
Cell Cycle
Published
2010-10
Volume
9
Issue
19
Pages
3880-3883
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
OpenAlex
W2015347426
Cited by
135
References
29
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 2 · 2021: 7 · 2020: 12 · 2019: 19 · 2018: 10 · 2017: 11 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 7 · 2012: 11
FWCI
2.86
Type
journal article
Language
en
Open access
Locations
  • Cell Cycle (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
DNA methylation, epigenetic regulation, cell differentiation, cell identity, stem cell self-renewal, histone modifications, chromatin remodeling, transcription factors, non-coding RNA, cancer epigenetics, embryonic stem cells, adult stem cells
MeSH terms
Animals, Cell Differentiation, Gene Expression Regulation, Humans, DNA Methylation, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review