The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Nanoparticles and their interactions with the dermal barrier
Open accessAbstract
The dermal application of drugs is promising due to the ease of application. In this context nano-scale carrier systems were already evaluated in several studies with respect to the skin interaction and the impact on drug penetration. At the same time the upcoming production of engineered nano-scale materials requires a thorough safety evaluation. Drug delivery as well as risk assessment depends crucially on the ability of such carriers to overcome the skin barrier and reach deeper tissue layers. Therefore, the interaction of nanoparticles with skin and especially skin models is an intriguing field. However, the data obtained do not show a clear image on the effect of nano-carriers. Especially the penetration of such particles is an open and controversially discussed topic. The literature reports different results mainly on pig or murine skin showing strong penetration (pig and mouse) or the opposite. Looking only at the sizes of the particles also no conclusive picture can be obtained. Nevertheless, size is regarded to play an important role for skin penetration. Furthermore, the state of the skin influences penetration (hydration) and the mechanical stress is of outmost importance.
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Cites
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
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Lam, C.-W., James, J. T., McCluskey, R., Arepalli, S., & Hunter, R. L. (2006) · Critical Reviews in Toxicology · doi:10.1080/10408440600570233 · Cited by 1,237
Carbon nanotubes as nanomedicines: From toxicology to pharmacology☆
LACERDA, L., BIANCO, A., PRATO, M., & KOSTARELOS, K. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.015 · Cited by 839
Multi-walled carbon nanotube interactions with human epidermal keratinocytes
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Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety
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Nanoparticles – An efficient carrier for drug delivery into the hair follicles
Lademann, J., Richter, H., Teichmann, A., Otberg, N., Blume-Peytavi, U., Luengo, J., Weiß, B., Schaefer, U. F., Lehr, C.-M., & Wepf, R. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.10.019 · Cited by 573
Self-citationPenetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties
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Prow, T. W., Grice, J. E., Lin, L. L., Faye, R., Butler, M., Becker, W., Wurm, E. M. T., Yoong, C., Robertson, T. A., Soyer, H. P., et al. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.012 · Cited by 873
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Metadata
- Authors
- Schneider, M., Stracke, F., Hansen, S., & Schaefer, U. F.
- Venue
- Dermato-Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2009-07
- Volume
- 1
- Issue
- 4
- Pages
- 197-206
- ISSN
- 1938-1972 (ISSN-L)
- 1938-1980
- OpenAlex
- W2028349699
- Cited by
- 489
- References
- 66
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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