The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Estrogens and aging skin
Open accessAbstract
Estrogen deficiency following menopause results in atrophic skin changes and acceleration of skin aging. Estrogens significantly modulate skin physiology, targeting keratinocytes, fibroblasts, melanocytes, hair follicles and sebaceous glands, and improve angiogenesis, wound healing and immune responses. Estrogen insufficiency decreases defense against oxidative stress; skin becomes thinner with less collagen, decreased elasticity, increased wrinkling, increased dryness and reduced vascularity. Its protective function becomes compromised and aging is associated with impaired wound healing, hair loss, pigmentary changes and skin cancer. Skin aging can be significantly delayed by the administration of estrogen. This paper reviews estrogen effects on human skin and the mechanisms by which estrogens can alleviate the changes due to aging. The relevance of estrogen replacement, selective estrogen receptor modulators (SERMs) and phytoestrogens as therapies for diminishing skin aging is highlighted. Understanding estrogen signaling in skin will provide a basis for interventions in aging pathologies.
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Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Role of antioxidants in the skin: Anti-aging effects
Masaki, H. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.03.003 · Cited by 788
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
Ashcroft, G. S., Dodsworth, J., Boxtel, E. V., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S., & Ferguson, M. W. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1209 · Cited by 573
Regulation of melanogenesis – controversies and new concepts
Schallreuter, K. U., Kothari, S., Chavan, B., & Spencer, J. D. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00675.x · Cited by 352
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
Ashcroft, G. S., Mills, S. J., Lei, K., Gibbons, L., Jeong, M.-J., Taniguchi, M., Burow, M., Horan, M. A., Wahl, S. M., & Nakayama, T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16288 · Cited by 335
Oestrogen functions in skin and skin appendages
Thornton, M. J. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.3.617 · Cited by 82
Self-citationThe role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis
Inoue, T., Miki, Y., Abe, K., Hatori, M., Hosaka, M., Kariya, Y., Kakuo, S., Fujimura, T., Hachiya, A., Aiba, S., et al. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.015 · Cited by 34
Cited by
The 2022 hormone therapy position statement of The North American Menopause Society
(2022) · Menopause · doi:10.1097/gme.0000000000002028 · Cited by 977
Tobin, D. J. (2017) · Journal of Tissue Viability · doi:10.1016/j.jtv.2016.03.002 · Cited by 701
Phytoestrogens and their effects
Sirotkin, A. V., & Harrath, A. H. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.057 · Cited by 397
Skin collagen through the lifestages: importance for skin health and beauty
Reilly, D. M., & Lozano, J. (2021) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2020.153 · Cited by 241
Waldera Lupa, D. M., Kalfalah, F., Safferling, K., Boukamp, P., Poschmann, G., Volpi, E., Götz-Rösch, C., Bernerd, F., Haag, L., Huebenthal, U., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.120 · Cited by 224
Metadata
- Authors
- Thornton, M. J.
- Venue
- Dermato-Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2013-04
- Volume
- 5
- Issue
- 2
- Pages
- 264-270
- ISSN
- 1938-1972 (ISSN-L)
- 1938-1980
- OpenAlex
- W2107230853
- Cited by
- 270
- References
- 7
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
