Cited by 82Estrogen and related hormone effectsHair Growth and DisordersSkin Protection and Aging

Oestrogen functions in skin and skin appendages

Thornton, M J·2005·Expert Opinion on Therapeutic Targets

Abstract

Oestrogens have significant effects on different cell types important in skin physiology, including the epidermal keratinocytes, dermal fibroblasts and melanocytes. In addition, they can also modulate skin appendages such as the hair follicle, the sebaceous gland and the apocrine glands. Oestrogens may also have important modulatory roles in events such as skin ageing, pigmentation, hair growth, sebum production and skin cancer. It is now recognised that oestrogens can modulate their actions via two distinct intracellular receptors (ERalpha and ERbeta) or via cell surface receptors, which activate specific second messenger signalling pathways. This paper highlights the effects of oestrogens on different components of the skin and reviews some of the more recent developments in terms of receptor expression and cell signalling pathways.

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Crossref · 10.1517/14728222.9.3.617

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Authors
Thornton, M. J.
Affiliations
University of Bradford (GB)
Corresponding author
Thornton, M J
Venue
Expert Opinion on Therapeutic Targets
Published
2005-06
Volume
9
Issue
3
Pages
617-629
ISSN
  • 1472-8222 (ISSN-L)
  • 1744-7631
OpenAlex
W2043858708
Cited by
82
References
115
Citations by year
2026: 2 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 1
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Therapeutic Targets (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
estrogen, skin, skin appendages, keratinocytes, dermal fibroblasts, melanocytes, hair follicle, sebaceous glands, apocrine glands, skin aging, skin pigmentation, hair growth, sebum production, skin cancer, estrogen receptor alpha, estrogen receptor beta, second messenger signaling
MeSH terms
Estrogens, Humans, Skin, Skin Neoplasms, Hair Follicle

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