Oestrogen functions in skin and skin appendages
Abstract
Oestrogens have significant effects on different cell types important in skin physiology, including the epidermal keratinocytes, dermal fibroblasts and melanocytes. In addition, they can also modulate skin appendages such as the hair follicle, the sebaceous gland and the apocrine glands. Oestrogens may also have important modulatory roles in events such as skin ageing, pigmentation, hair growth, sebum production and skin cancer. It is now recognised that oestrogens can modulate their actions via two distinct intracellular receptors (ERalpha and ERbeta) or via cell surface receptors, which activate specific second messenger signalling pathways. This paper highlights the effects of oestrogens on different components of the skin and reviews some of the more recent developments in terms of receptor expression and cell signalling pathways.
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Estrogens protect from photoageing.
“protect from photoageing [213]”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [213]
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- Authors
- Thornton, M. J.
- Affiliations
- University of Bradford (GB)
- Corresponding author
- Thornton, M J
- ORCID
- Thornton, M J
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa Healthcare
- Published
- 2005-06
- Volume
- 9
- Issue
- 3
- Pages
- 617-629
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W2043858708
- Cited by
- 82
- References
- 115
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- estrogen, skin, skin appendages, keratinocytes, dermal fibroblasts, melanocytes, hair follicle, sebaceous glands, apocrine glands, skin aging, skin pigmentation, hair growth, sebum production, skin cancer, estrogen receptor alpha, estrogen receptor beta, second messenger signaling
- MeSH terms
- Estrogens, Humans, Skin, Skin Neoplasms, Hair Follicle
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