Role of antioxidants in the skin: Anti-aging effects

Masaki, Hitoshi

doi:10.1016/j.jdermsci.2010.03.003

Cited by 800Skin Protection and AgingAntioxidant Activity and Oxidative Stressmelanin and skin pigmentation

Role of antioxidants in the skin: Anti-aging effects

Masaki, Hitoshi·2010·Journal of Dermatological Science

DOI 10.1016/j.jdermsci.2010.03.003

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Abstract

Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS generation and ROS elimination in the body are summarized. The effects of ROS generated in the skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of representative antioxidants on the skin are summarized with a focus on skin aging.

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Most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells; clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on polyphenol cytotoxicity.
“This article lists some experimental cases of food-derived polyphenol extracts to alleviate skin aging (Table 2), but most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells. Nonetheless, the clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on the cytotoxicity of poly”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [114]

Diversity of structures and properties among catalases
Chelikani, P., Fita, I., & Loewen, P. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3206-5 · Cited by 1,701 · see citing works
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523 · see citing works
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,460 · see citing works
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
Zhang, D. D. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600971974 · Cited by 1,091 · see citing works
Mechanism of Human SIRT1 Activation by Resveratrol
Borra, M. T., Smith, B. C., & Denu, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501250200 · Cited by 1,065 · see citing works
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works
Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation
Denu, J. M., & Tanner, K. G. (1998) · Biochemistry · doi:10.1021/bi973035t · Cited by 945 · see citing works
The Neutrophil NADPH Oxidase
BABIOR, B. M., Lambeth, J. D., & Nauseef, W. M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2642 · Cited by 911 · see citing works
Oxygen free radicals and metallothionein
Sato, M., & Bremner, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90029-t · Cited by 855 · see citing works
Thioredoxin reductase
Mustacich, D. J., & Powis, G. (2000) · Biochemical Journal · doi:10.1042/bj3460001 · Cited by 828 · see citing works
Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury
Granger, D. N. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.6.h1269 · Cited by 825 · see citing works
In Vivo and In Vitro Evidence for Hydrogen Peroxide (H2O2) Accumulation in the Epidermis of Patients with Vitiligo and its Successful Removal by a UVB-Activated Pseudocatalase
Schallreuter, K. U., Moore, J., Wood, J. M., Beazley, W. D., Gaze, D. C., Tobin, D. J., Marshall, H. S., Panske, A., Panzig, E., & Hibberts, N. A. (1999) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsp.5640189 · Cited by 440 · see citing works
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin
Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner‐Felmayer, G., & Werner, E. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004392200 · Cited by 421 · see citing works
Superoxide dismutase: The first twenty years (1968–1988)
McCord, J. M., & Fridovich, I. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90109-8 · Cited by 381 · see citing works
The GI-GPx Gene Is a Target for Nrf2
Banning, A., Deubel, S., Kluth�, D., Zhou, Z., & Brigelius‐Flohé, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4914-4923.2005 · Cited by 344 · see citing works
Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol
Cooney, R. V., Franke, A. A., Harwood, P. J., Hatch-Pigott, V, Custer, L. J., & Mordan, L. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1771 · Cited by 343 · see citing works
Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B
Chakraborty, A. K., Funasaka, Y., Slominski, A., Ermak, G., Hwang, J., Pawelek, J. M., & Ichihashi, M. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(96)00063-8 · Cited by 333 · see citing works
Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial
Dougados, M., Nguyen, M., Berdah, L., Mazi�res, B., Vignon, E. P., Lequesne, M. G., & for the ECHODIAH Investigators Study Group (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200111)44:11 · Cited by 320 · see citing works
An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β
Chung, K. Y., Agarwal, A., Uitto, J., & Mauviel, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.3272 · Cited by 314 · see citing works
Hemin-induced Activation of the Thioredoxin Gene by Nrf2
Kim, Y. C., Masutani, H., Yamaguchi, Y., Itoh, K., Yamamoto, M. P., & Yodoi, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100103200 · Cited by 313 · see citing works
Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis.
Roméro-Graillet, C., Aberdam, É., Durand‐Clément, M., Ortonne, J. ‐., & Ballotti, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119206 · Cited by 287 · see citing works
UVA‐INDUCED AUTOCRINE STIMULATION OF FIBROBLAST‐DERIVED COLLAGENASE/MMP‐1 BY INTERRELATED LOOPS OFINTERLEUKIN–1 andINTERLEUKIN–6
Wlaschek, M., Heinen, G., Poswig, A., Schwarz, A., Krieg, T., & Scharffetter‐Kochanek, K. (1994) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1994.tb02982.x · Cited by 280 · see citing works
INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER
Maher, J. M., Cheng, X., Slitt, A. L., Dieter, M. Z., & Klaassen, C. D. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.003798 · Cited by 255 · see citing works
Up-Regulation of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene Involves Binding of Nrf-2 to an Electrophile Responsive Element
Moinova, H., & Mulcahy, R. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1109 · Cited by 245 · see citing works
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase.
Myllylä, R., Majamaa, K., Günzler, V., Hanauske-Abel, H. M., & Kivirikko, K. I. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91023-9 · Cited by 243 · see citing works
Inhibitory effect of magnesium l-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo
Kameyama, K., Sakai, C., Kondoh, S., Yonemoto, K., Nishiyama, S., Tagawa, M., Murata, T., Ohnuma, T., Quigley, J., Dorsky, A., et al. (1996) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(96)90830-0 · Cited by 242 · see citing works
Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene
Vollrath, V., Wielandt, A. M., Iruretagoyena, M., & José Chianale, B. (2006) · Biochemical Journal · doi:10.1042/bj20051518 · Cited by 225 · see citing works
Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters
Wei, H., & Frenkel, K. (1993) · Carcinogenesis · doi:10.1093/carcin/14.6.1195 · Cited by 216 · see citing works
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF‐E2‐related factor‐2
Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., & Hara, S. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20246 · Cited by 207 · see citing works
Nox1-Based NADPH Oxidase Is the Major Source of UVA-Induced Reactive Oxygen Species in Human Keratinocytes
Valencia, A., & Kochevar, I. E. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700960 · Cited by 194 · see citing works
Detection of Hydrogen Peroxide and Hydroxyl Radicals in Murine Skin Fibroblasts under UVB Irradiation
Masaki, H., Atsumi, T., & Sakurai, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1067 · Cited by 184 · see citing works
Self-citation
Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition
Ricciarelli, R., Maroni, P., Özer, N. K., Zingg, J.-M., & Azzi, A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00007-6 · Cited by 180 · see citing works
Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes
Boyce, S. T., Supp, A. P., Swope, V. B., & Warden, G. D. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01717.x · Cited by 172 · see citing works
SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
Cao, C., Lü, S., Kivlin, R., Wallin, B., Card, E., Bagdasarian, A., Tamakloe, T., Wang, W., Song, X., Chu, W., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00453.x · Cited by 171 · see citing works
Astaxanthin, canthaxanthin and β‐carotene differently affect UVA‐induced oxidative damage and expression of oxidative stress‐responsive enzymes
Camera, E., Mastrofrancesco, A., Fabbri, C., Daubrawa, F., Picardo, M., Sies, H., & Stahl, W. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00790.x · Cited by 170 · see citing works
(−)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: Involvement of mitogen-activated protein kinase
Bae, J., Choi, J.-S., Choi, Y. J., Shin, S.-Y., Kang, S., Han, S. J., & Kang, Y. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.112 · Cited by 163 · see citing works
Nrf2-Keap1 Signaling Pathway Regulates Human UGT1A1 Expression in Vitro and in Transgenic UGT1 Mice
Yueh, M., & Tukey, R. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610790200 · Cited by 157 · see citing works
Singlet oxygen induces collagenase expression in human skin fibroblasts
Scharffetter‐Kochanek, K., Wlaschek, M., Briviba, K., & Sies, H. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80357-z · Cited by 155 · see citing works
Protein oxidative damage in the stratum corneum: evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan.
Niwa, Y., Sumi, H., Kawahira, K., Terashima, T., Nakamura, T., & Akamatsu, H. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05417.x · Cited by 152 · see citing works
Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin
Grange, P., Chéreau, C., Raingeaud, J., Nicco, C., Weill, B. J., Dupin, N., & Batteux, F. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000527 · Cited by 140 · see citing works
Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light
Warren, J. B. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.2.7509761 · Cited by 136 · see citing works
EPR Detection of Free Radicals in UV‐lrradiated Skin: Mouse Versus Human
Jurkiewicz, B. A., & Buettner, G. R. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb01856.x · Cited by 134 · see citing works
Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin
Rao, G. R., Rao, A. D., Moorthy, B., Rao, T., Sravani, P., Babu, N. K., & Gopal, K. V. T. (2009) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.48427 · Cited by 131 · see citing works
Cutaneous concentration of lycopene correlates significantly with the roughness of the skin
Darvin, M. E., Patzelt, A., Gehse, S., Schanzer, S., Benderoth, C., Sterry, W., & Lademann, J. M. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.01.034 · Cited by 119 · see citing works
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases
Rhodes, L. E., Gledhill, K., Masoodi, M., Haylett, A. K., Brownrigg, M., Thody, A. J., Tobin, D. J., & Nicolaou, A. (2009) · The FASEB Journal · doi:10.1096/fj.09-136077 · Cited by 118 · see citing works
Post-Transcriptional Regulation of Melanin Biosynthetic Enzymes by cAMP and Resveratrol in Human Melanocytes
Newton, R. A., Cook, A. L., Roberts, D. W., Leonard, J. H., & Sturm, R. A. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700840 · Cited by 114 · see citing works
Lipid Peroxidation and Biogenic Aldehydes: From the Identification of 4-Hydroxynonenal to Further Achievements in Biopathology
Comportl, M. (1998) · Free Radical Research · doi:10.3109/10715769809065818 · Cited by 109 · see citing works
The effect of reactive oxygen species on the biosynthesis of collagen and glycosaminoglycans in cultured human dermal fibroblasts
Tanaka, H., Okada, T., Konishi, H., & Tsuji, T. (1993) · Archives of Dermatological Research · doi:10.1007/bf00371836 · Cited by 106 · see citing works
Keratinocytes act as a source of reactive oxygen species by transferring hydrogen peroxide to melanocytes.
Pelle, E., Mammone, T., Maes, D., & Frenkel, K. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23661.x · Cited by 105 · see citing works
H2O2 Accumulation by Catalase Reduction Changes MAP Kinase Signaling in Aged Human Skin In Vivo
Shin, M. H., Rhie, G., Kim, Y. K., Park, C., Cho, K. H., Kim, K. H., Eun, H. C., & Chung, J. H. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23823.x · Cited by 103 · see citing works
Changes of MMP-1 and collagen type Iα1 by UVA, UVB and IRA are differentially regulated by Trx-1
Buechner, N., Schröeder, P., Jakob, S., Kunze, K., Maresch, T., Calles, C., Krutmann, J., & Haendeler, J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.009 · Cited by 99 · see citing works
Mechanisms of inhibitory effects of CoQ10 on UVB‐induced wrinkle formation in vitro and in vivo
Inui, M., Ooe, M., Fujii, K., Matsunaka, H., Yoshida, M., & Ichihashi, M. (2008) · BioFactors · doi:10.1002/biof.5520320128 · Cited by 94 · see citing works
Up‐regulation of Tyrosinase Gene by Nitric Oxide in Human Melanocytes
SASAKI, M., Horikoshi, T., Uchiwa, H., & Miyachi, Y. (2000) · Pigment Cell Research · doi:10.1034/j.1600-0749.2000.130406.x · Cited by 88 · see citing works
Generation of active oxygen species from advanced glycation end-products (AGEs) during ultraviolet light A (UVA) irradiation and a possible mechanism for cell damaging
Masaki, H., Okano, Y., & Sakurai, H. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00056-2 · Cited by 84 · see citing works
Self-citation
A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties
Ochiai, Y., Kaburagi, S., Obayashi, K., Ujiie, N., Hashimoto, S., Okano, Y., Masaki, H., Ichihashi, M., & Sakurai, H. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.07.001 · Cited by 83 · see citing works
Self-citation
Effects of Oral Epigallocatechin Gallate Supplementation on the Minimal Erythema Dose and UV-Induced Skin Damage
Jeon, H. Y., Kim, J. K., Kim, W. G., & Lee, S. J. (2009) · Skin Pharmacology and Physiology · doi:10.1159/000201562 · Cited by 79 · see citing works
L‐Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF‐α and MMP‐1 expression in UV‐irradiated human dermal fibroblasts
Obayashi, K., Kurihara, K., Okano, Y., Masaki, H., & Yarosh, D. B. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.0142-5463.2005.00265_2.x · Cited by 75 · see citing works
Self-citation
Coenzyme Q10 protects against oxidative stress‐induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells
Muta, K., Terada, T., Yamanishi, H., Ashida, Y., Inomata, S., Nishiyama, T., & Amano, S. (2009) · BioFactors · doi:10.1002/biof.56 · Cited by 66 · see citing works
Characteristics of Skin Wrinkling and Dermal Changes Induced by Repeated Application of Squalene Monohydroperoxide to Hairless Mouse Skin
Chiba, K., Kawakami, K., Sone, T., & Onoue, M. (2003) · Skin Pharmacology and Physiology · doi:10.1159/000070847 · Cited by 65 · see citing works
A simple and non‐invasive visualization for assessment of carbonylated protein in the stratum corneum
Fujita, H., Hirao, T., & Takahashi, M. (2007) · Skin research and technology · doi:10.1111/j.1600-0846.2007.00195.x · Cited by 61 · see citing works
Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway
Park, K., & Lee, J. (2008) · Oncology Reports · doi:10.3892/or.19.2.413 · Cited by 61 · see citing works
Effects of UV irradiation on the sebaceous gland and sebum secretion in hamsters
Akitomo, Y., Akamatsu, H., Okano, Y., Masaki, H., & Horio, T. (2003) · Journal of Dermatological Science · doi:10.1016/s0923-1811(03)00003-3 · Cited by 58 · see citing works
Self-citation
Stress-Induced Peroxiredoxins
Ishii, T., & Yanagawa, T. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-6051-9_18 · Cited by 57 · see citing works
Topically applied vitamin E prevents massive cutaneous inflammatory and oxidative stress responses induced by double application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in mice
Rahman, S., Bhatia, K., Khan, A. Q., Kaur, M., Ahmad, F., Rashid, H., Athar, M., Islam, F., & Raisuddin, S. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2007.11.017 · Cited by 57 · see citing works
Human phenylalanine hydroxylase is activated by H2O2: a novel mechanism for increasing the l-tyrosine supply for melanogenesis in melanocytes
Schallreuter, K. U., Wazir, U., Kothari, S., Gibbons, N. C. J., Moore, J., & Wood, J. M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.082 · Cited by 57 · see citing works
Topical Application of a Novel, Hydrophilic γ-Tocopherol Derivative Reduces Photo-Inflammation in Mice Skin
Yoshida, E., Watanabe, T., Takata, J., Yamazaki, A., Karube, Y., & Kobayashi, S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700236 · Cited by 54 · see citing works
Squalene as a Target Molecule in Skin Hyperpigmentation Caused by Singlet Oxygen
Ryu, A., Arakane, K., Koide, C., Arai, H., & Nagano, T. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1504 · Cited by 52 · see citing works
IL-8 production and AP-1 transactivation induced by UVA in human keratinocytes: Roles of d-α-tocopherol
Wu, S., Gao, J., Dinh, Q. T., Chen, C. I.-U., & Fimmel, S. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.11.019 · Cited by 48 · see citing works
Exogenous nitric oxide enhances the synthesis of type I collagen and heat shock protein 47 by normal human dermal fibroblasts
Obayashi, K., Akamatsu, H., Okano, Y., Matsunaga, K., & Masaki, H. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.08.004 · Cited by 48 · see citing works
Self-citation
Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram
Ohshima, H., Mizukoshi, K., Oyobikawa, M., Matsumoto, K., Takiwaki, H., Kanto, H., & Itoh, M. (2009) · Skin Research and Technology · doi:10.1111/j.1600-0846.2009.00356.x · Cited by 47 · see citing works
α-Tocopherol Increases the Intracellular Glutathione Level in HaCaT Keratinocytes
Masaki, H., Okano, Y., Ochiai, Y., Obayashi, K., Akamatsu, H., & Sakurai, H. (2002) · Free Radical Research · doi:10.1080/10715760210873 · Cited by 45 · see citing works
Self-citation
Increased carbonyl protein levels in the stratum corneum of the face during winter
Kobayashi, Y., Iwai, I., Akutsu, N., & Hirao, T. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2008.00422.x · Cited by 38 · see citing works
Iontophoresis promotes percutaneous absorption of l-ascorbic acid in rat skin
Ebihara, M., Akiyama, M., Ohnishi, Y., Tajima, S., Komata, K.-I., & Mitsui, Y. (2003) · Journal of Dermatological Science · doi:10.1016/s0923-1811(03)00105-1 · Cited by 38 · see citing works
Fructose‐1,6‐diphosphate attenuates prostaglandin E2 production and cyclo‐oxygenase‐2 expression in UVB‐irradiated HaCaT keratinocytes
Ahn, S. M., Yoon, H., Lee, B. G., Park, K. C., Chung, J. H., Moon, C., & Lee, S. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704896 · Cited by 38 · see citing works
Studies of mitochondria in oxidative embryotoxicity
Fantel, A. G., Person, R., Tumbic, R. W., Nguyen, T., & Mackler, B. F. (1995) · Teratology · doi:10.1002/tera.1420520404 · Cited by 36 · see citing works
Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells
Kamei, Y., Otsuka, Y., & Abe, K. (2009) · Cytotechnology · doi:10.1007/s10616-009-9207-y · Cited by 32 · see citing works
Suppression of melanogenesis by induction of endogenous intracellular metallothionein in human melanocytes
Sasaki, M., Kizawa, K., Igarashi, S., Horikoshi, T., Uchiwa, H., & Miyachi, Y. (2004) · Experimental Dermatology · doi:10.1111/j.0906-6705.2004.00204.x · Cited by 32 · see citing works
Ascorbic Acid 2-O-.ALPHA.-Glucoside, a Stable Form of Ascorbic Acid, Rescues Human Keratinocyte Cell Line, SCC, from Cytotoxicity of Ultraviolet Light B.
Miyai, E., Yanagida, M., AKIYAMA, J.-I., & Yamamoto, I. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.984 · Cited by 25 · see citing works
Enhancement of Neurite Outgrowth in PC12 Cells Stimulated with Cyclic AMP and NGF by 6-Acylated Ascorbic Acid 2-O-.ALPHA.-Glucosides (6-Acyl-AA-2G), Novel Lipophilic Ascorbate Derivatives.
Zhou, X., Tai, A., & Yamamoto, I. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.341 · Cited by 22 · see citing works
A New Wrinkle on Topical Vitamin E and Photo-inflammation: Mechanistic Studies of a Hydrophilic γ-Tocopherol Derivative Compared with α-Tocopherol
Konger, R. L. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700308 · Cited by 19 · see citing works
A Zn(II)–glycine complex suppresses UVB‐induced melanin production by stimulating metallothionein expression
Ochiai, Y., Kaburagi, S., Okano, Y., Masaki, H., Ichihashi, M., Funasaka, Y., & Sakurai, H. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2007.00423.x · Cited by 19 · see citing works
Self-citation
Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human skin fibroblasts.
Ohuchida, M., Sasaguri, Y., Morimatsu, M., Nagase, H., & Yagi, K. (1991) · PubMed · Cited by 12 · see citing works
Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human skin fibroblasts
大内田, 昌. (1992) · Medical Entomology and Zoology · doi:10.11501/3059125 · Cited by 8 · see citing works

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Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
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Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092126 · Cited by 875 · see citing works
Fighting against Skin Aging: The Way from Bench to Bedside
Zhang, S., & Duan, E. (2018) · Cell Transplantation · doi:10.1177/0963689717725755 · Cited by 739 · see citing works
Medicinal prospects of antioxidants: A review
Neha, K., Haider, M. R., Pathak, A., & Yar, M. S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.010 · Cited by 724 · see citing works
Exploring the potential of using algae in cosmetics
Wang, H., Chen, C.-C., Huynh, P., & Chang, J. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.12.001 · Cited by 485 · see citing works
A Review of the Biological Activities of Microalgal Carotenoids and Their Potential Use in Healthcare and Cosmetic Industries
Sathasivam, R., & Ki, J. (2018) · Marine Drugs · doi:10.3390/md16010026 · Cited by 481 · see citing works
Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process
Michalak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020585 · Cited by 460 · see citing works
Astaxanthin as feed supplement in aquatic animals
Lim, K. C., Yusoff, F. M., Shariff, M., & Kamarudin, M. S. (2017) · Reviews in Aquaculture · doi:10.1111/raq.12200 · Cited by 449 · see citing works
Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources
Solano, F. (2020) · Molecules · doi:10.3390/molecules25071537 · Cited by 376 · see citing works
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Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345 · see citing works
An overview of nanoemulsion: concepts of development and cosmeceutical applications
Marzuki, N. H. C., Wahab, R. A., & Hamid, M. A. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2019.1620124 · Cited by 332 · see citing works
The emerging role of nanotechnology in skincare
Salvioni, L., Morelli, L., Ochoa, E., Labra, M., Fiandra, L., Palugan, L., Prosperi, D., & Colombo, M. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102437 · Cited by 331 · see citing works
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
Velarde, M. C., Flynn, J. M., Day, N. U., Melov, S., & Campisi, J. (2012) · Aging · doi:10.18632/aging.100423 · Cited by 299 · see citing works
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Kozlov, A. V., Javadov, S. A., & Sommer, N. (2024) · Antioxidants · doi:10.3390/antiox13050602 · Cited by 284 · see citing works
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Dunaway, S., Odin, R., Zhou, L., Ji, L., Zhang, Y., & Kadekaro, A. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00392 · Cited by 280 · see citing works
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Thornton, M. J. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23872 · Cited by 279 · see citing works
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Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
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Shen, L., Zhang, Y., Wang, Q., Xu, L., & Feng, N. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.017 · Cited by 221 · see citing works
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Sen, S., & Chakraborty, R. (2011) · ACS symposium series · doi:10.1021/bk-2011-1083.ch001 · Cited by 216 · see citing works
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Costa, R., & Santos, L. (2017) · Powder Technology · doi:10.1016/j.powtec.2017.07.086 · Cited by 215 · see citing works
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Yang, D., Moh, S. H., Son, D., You, S., Kinyua, A. W., Ko, C. M., Song, M., Yeo, J.-H., Choi, Y., & Kim, K. W. (2016) · Molecules · doi:10.3390/molecules21070899 · Cited by 212 · see citing works
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Taofiq, O., Gonzaléz‐Paramás, A. M., Martins, A., Barreiro, M. F., & Ferreira, I. C. F. R. (2016) · Industrial Crops and Products · doi:10.1016/j.indcrop.2016.06.012 · Cited by 193 · see citing works
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Zhu, Y., Wang, K., Jia, X., Fu, C., Yu, H., & Wang, Y. (2023) · Medicinal Research Reviews · doi:10.1002/med.21986 · Cited by 192 · see citing works
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Zouboulis, C. C., Picardo, M., Ju, Q., Kurokawa, I., Törőcsik, D., Bíró, T., & Schneider, M. R. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9389-5 · Cited by 174 · see citing works
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Wijesinghe, W. A. J. P., & Jeon, Y. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9214-4 · Cited by 155 · see citing works
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Shaal, L. A., Shegokar, R., & Müller, R. H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.018 · Cited by 140 · see citing works
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Ni, Z., Zhang, Y., Chen, S., Thakur, K., Wang, S., Zhang, J., Shang, Y., & Wei, Z. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1881439 · Cited by 105 · see citing works
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Xu, P., Yu, X., Zhang, Z., Zou, X., Xue, K., Zhang, H., Zhang, W., & Liu, K. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01777-6 · Cited by 104 · see citing works
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Vitale, G. A., Coppola, D., Esposito, F. P., Buonocore, C., Ausuri, J., Tortorella, E., & de Pascale, D. (2020) · Antioxidants · doi:10.3390/antiox9121183 · Cited by 87 · see citing works
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Sugata, M., Lin, C., & Shih, Y.-C. (2015) · BioMed Research International · doi:10.1155/2015/768093 · Cited by 83 · see citing works
Antioxidants for the Prevention and Treatment of Non-communicable Diseases
Ayoka, T. O., Ezema, B. O., Eze, C. N., & Nnadi, C. O. (2022) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2022.00028 · Cited by 82 · see citing works
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Białczyk, A., Wełniak, A., Kamińska, B., & Czajkowski, R. (2023) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-023-00672-z · Cited by 82 · see citing works
Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-κB and AP-1 activation in macrophages
Tsai, H.-H., Lee, W.-R., Wang, P.-H., Cheng, K.-T., Chen, Y., & Shen, S. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.10.009 · Cited by 82 · see citing works
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Matsui, M., Tanaka, K., Higashiguchi, N., Okawa, H., Yamada, Y. M. A., Tanaka, K., Taira, S., Aoyama, T., Takanishi, M., Natsume, C., et al. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.08.004 · Cited by 82 · see citing works
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Tamayo, M. Z., Gueguen, V., Pavon‐Djavid, G., & Letourneur, D. (2017) · Bioimpacts · doi:10.15171/bi.2017.01 · Cited by 81 · see citing works
Impact of Eye Cosmetics on the Eye, Adnexa, and Ocular Surface
Ng, A., Evans, K., North, R. V., Jones, L., & Purslow, C. (2015) · Eye & Contact Lens Science & Clinical Practice · doi:10.1097/icl.0000000000000181 · Cited by 80 · see citing works
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Cao, C., Xiao, Z., Tong, H., Liu, Y., Wu, Y., & Ge, C. (2022) · Nutrients · doi:10.3390/nu14081622 · Cited by 78 · see citing works
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Kim, M., Jang, H. Y., Kim, W., Kim, D., & Park, J. H. (2023) · Antioxidants · doi:10.3390/antiox12061286 · Cited by 74 · see citing works
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Authors: Masaki, H.
Affiliations: Cosmos Technical Center Co., Ltd. (Japan) (JP)
Corresponding author: Masaki, Hitoshi
ORCID: Masaki, Hitoshi
Venue: Journal of Dermatological Science
Publisher: Elsevier BV
Published: 2010-05
Volume: 58
Issue: 2
Pages: 85-90
ISSN: 0923-1811 (ISSN-L)
DOI: 10.1016/j.jdermsci.2010.03.003
OpenAlex: W2078923345
Cited by: 788
References: 83
Citations by year: 2026: 48 · 2025: 71 · 2024: 77 · 2023: 61 · 2022: 87 · 2021: 73 · 2020: 56 · 2019: 58 · 2018: 53 · 2017: 36 · 2016: 37 · 2015: 36 · 2014: 37 · 2013: 17 · 2012: 18
FWCI: 3.25
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Dermatological Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: antioxidants, skin aging, oxidative stress, reactive oxygen species, photoaging, ultraviolet radiation, wrinkles, hyperpigmentation, reactive oxygen species scavenging
MeSH terms: Aging, Antioxidants, Ascorbic Acid, Carotenoids, Flavonoids, Humans, Inflammation, Models, Biological, Phenols, Sebaceous Glands, Skin, Ultraviolet Rays, Vitamin E, Skin Aging, Reactive Oxygen Species, Oxidative Stress, Polyphenols

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Role of antioxidants in the skin: Anti-aging effects

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