The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
Open accessAbstract
One general principle of gene regulation is that DNA-binding transcription factors modulate transcription by recruiting cofactors that modify histones and chromatin structure. A second implicit principle is that a particular cofactor is necessary at all the target genes where the cofactor is recruited. Increasingly, these principles do not appear to be absolute, as experimentally defined relationships between transcription, cofactors and chromatin modification grow in complexity. The KAT3 histone acetyltransferases CREB binding protein (CBP) and p300 have at least 400 interacting protein partners, thereby acting as hubs in gene regulatory networks. Studies using mutant primary cells indicate that the occurrence of CBP and p300 at any given target gene sometimes correlates with, rather than dictates transcription. This suggests that there are unexpected levels of redundancy between CBP/p300 and other unrelated coactivators, or that CBP/p300 recruitment may sometimes be coincidental. A transcription factor may therefore recruit the same group of coactivators as part of its "toolbox", but it is the characteristics of the individual target gene that determine which coactivation "tools" are required for its transcription.
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Citations
Cites
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CBP/p300 in cell growth, transformation, and development
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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
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Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
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Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929
Jin, Q., Yu, L., Wang, L., Zhang, Z., Kasper, L. H., Lee, J., Wang, C., Brindle, P. K., Dent, S. Y. R., & Ge, K. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.318 · Cited by 877
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RNA Binding to CBP Stimulates Histone Acetylation and Transcription
Bose, D. A., Donahue, G., Reinberg, D., Shiekhattar, R., Bonasio, R., & Berger, S. L. (2017) · Cell · doi:10.1016/j.cell.2016.12.020 · Cited by 426
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Metadata
- Authors
- Bedford, D. C., Kasper, L. H., Fukuyama, T., & Brindle, P. K.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2010-01
- Volume
- 5
- Issue
- 1
- Pages
- 9-15
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2008837855
- Cited by
- 292
- References
- 9
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bedford, D. C., Kasper, L. H., Fukuyama, T., & Brindle, P. K. (2010). Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics. https://doi.org/10.4161/epi.5.1.10449
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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