The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health
Open accessAbstract
The INK4b-ARF-INK4a locus encodes for two cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a) and a regulator of the p53 pathway, ARF. In addition ANRIL, a non-coding RNA, is also transcribed from the locus. ARF, p15(INK4b) and p16(INK4a) are well-established tumor suppressors which function is frequently disabled in human cancers. Recent studies showed that single nucleotide polymorphisms mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. The INK4b-ARF-INK4a locus is regulated by Polycomb repressive complexes (PRCs), and its expression can be invoked by activating signals. Other epigenetic modifiers such as the histone demethylases JMJD3 and JHDM1B, the SWI/SNF chromatin remodeling complex and DNA methyltransferases regulate the locus interplaying with PRCs. In view of the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit.
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“Moreover, p16 is under the control of epigenetic regulation, which plays an important role in mediating the stress-induced activation of p16 transcription [18].”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [18]
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Flagged first, then by citations
1 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Nielsen GP, 1999, Lab Invest, 79, 1137
- Herman JG, 1997, Cancer Res, 57, 837
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Items 201–202 of 202
Modulation de la sénescence induite par les oncogènes par les glucocorticoïdes et rôle de EGR1
Carvalho, C. (2018) · theses.fr (ABES) · doi:10.70675/7cafc6a4za30dz467dz81a1z7033a7846a52
Metadata
- Authors
- Popov, N., & Gil, J.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Gil, Jesús
- ORCID
- Gil, Jesús
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2010-11
- Volume
- 5
- Issue
- 8
- Pages
- 685-690
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- PMC
- PMC3052884
- OpenAlex
- W1969204301
- Cited by
- 202
- References
- 72
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 13 · 2015: 24 · 2014: 21 · 2013: 26 · 2012: 18
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epigenetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- LifeArc
- Cancer Research UK
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- p16INK4a, CDKN2B, ARF, ANRIL, non-coding RNA, polycomb repressive complex, histone demethylase, JMJD3, SWI/SNF chromatin remodeling, DNA methyltransferases, tumor suppressor, single nucleotide polymorphisms, epigenetic regulation, cancer
- MeSH terms
- Alzheimer Disease, Animals, Cardiovascular Diseases, Chromatin, Diabetes Mellitus, Type 2, Humans, Repressor Proteins, Transcription, Genetic, DNA Modification Methylases, Signal Transduction, Tumor Suppressor Protein p53, G1 Phase, Cyclin-Dependent Kinase Inhibitor p16, ADP-Ribosylation Factors, RNA, Untranslated, Epigenesis, Genetic, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Proto-Oncogene Proteins c-mdm2, Genetic Loci, Histone Demethylases, Polycomb-Group Proteins
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