Cited by 202Epigenetics and DNA MethylationChromatin Remodeling and CancerGenomics and Chromatin Dynamics

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Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health

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Popov, Nikolay, Gil, Jesús·2010·Epigenetics

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Abstract

The INK4b-ARF-INK4a locus encodes for two cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a) and a regulator of the p53 pathway, ARF. In addition ANRIL, a non-coding RNA, is also transcribed from the locus. ARF, p15(INK4b) and p16(INK4a) are well-established tumor suppressors which function is frequently disabled in human cancers. Recent studies showed that single nucleotide polymorphisms mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease. The INK4b-ARF-INK4a locus is regulated by Polycomb repressive complexes (PRCs), and its expression can be invoked by activating signals. Other epigenetic modifiers such as the histone demethylases JMJD3 and JHDM1B, the SWI/SNF chromatin remodeling complex and DNA methyltransferases regulate the locus interplaying with PRCs. In view of the intimate involvement of the INK4b-ARF-INK4a locus on disease, to understand its regulation is the first step for manipulate it to therapeutic benefit.

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753
A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751
The Polycomb group protein EZH2 directly controls DNA methylation
Viré, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.-M., et al. (2006) · Nature · doi:10.1038/nature04431 · Cited by 2,204
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194
Role of histone H2A ubiquitination in Polycomb silencing
Wang, H., Wang, L., Erdjument‐Bromage, H., Vidal, M., Tempst, P., Jones, R. S., & Zhang, Y. (2004) · Nature · doi:10.1038/nature02985 · Cited by 1,856
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., & Carson, D. A. (1994) · Nature · doi:10.1038/368753a0 · Cited by 1,742
A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Baker, A., Palsson, A., et al. (2007) · Science · doi:10.1126/science.1142842 · Cited by 1,594
A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science · doi:10.1126/science.1142447 · Cited by 1,587
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex
Müller, J., Hart, C. M., Francis, N. J., Vargas, M. L., Sengupta, A. K., Wild, B., Miller, E., O’Connor, M. B., Kingston, R. E., & Simon, J. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00976-5 · Cited by 1,553
Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites
Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,536
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485
Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a
Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391
Self-citation
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226
Epigenetic stem cell signature in cancer
Widschwendter, M., Fiegl, H., Egle, D., Mueller-Holzner, E., Spizzo, G., Marth, C., Weisenberger, D. J., Campan, M., Young, J., Jacobs, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1941 · Cited by 1,143
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Ohm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., et al. (2007) · Nature Genetics · doi:10.1038/ng1972 · Cited by 1,130
The Regulation of INK4/ARF in Cancer and Aging
Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009
Nucleolar Arf sequesters Mdm2 and activates p53
Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., & Bar-Sagi, D. (1999) · Nature Cell Biology · doi:10.1038/8991 · Cited by 940
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843
Self-citation
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Yu, W., Gius, D. R., Onyango, P. O., Muldoon‐Jacobs, K., Karp, J. E., Feinberg, A. P., & Cui, H. (2008) · Nature · doi:10.1038/nature06468 · Cited by 801
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.Preprint
van der Lugt, N. M. T., Domen, J., Linders, K., van ROON, M. A., Robanus-Maandag, E. C., Riele, H. T., van der Valk, M., Deschamps, J., Sofroniew, M. V., & van Lohuizen, M. (1994) · Genes & Development · doi:10.1101/gad.8.7.757 · Cited by 781
Signatures of mutation and selection in the cancer genome
Bignell, G. R., Greenman, C. D., Davies, H., Butler, A. P., Edkins, S., Andrews, J. M., Buck, G., Chen, L., Beare, D., Latimer, C., et al. (2010) · Nature · doi:10.1038/nature08768 · Cited by 707
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654
Characterization of a Germ-Line Deletion, Including the Entire INK4/ARF Locus, in a Melanoma-Neural System Tumor Family: Identification of ANRIL , an Antisense Noncoding RNA Whose Expression Coclusters with ARF
Pasmant, É., Laurendeau, I., Héron, D., Vidaud, M., Vidaud, D., & Bièche, I. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2004 · Cited by 618
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
Zindy, F., Quelle, D. E., Roussel, M. F., & Sherr, C. J. (1997) · Oncogene · doi:10.1038/sj.onc.1201178 · Cited by 574
Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin
Bernstein, E., Duncan, E. M., Masui, O., Gil, J., Heard, É., & Allis, C. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2560-2569.2006 · Cited by 531
Self-citation
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Bracken, A. P., & Helin, K. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2736 · Cited by 523
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
Visel, A., Zhu, Y., May, D., Afzal, V., Gong, E., Attanasio, C., Blow, M. J., Cohen, J. C., Rubin, E. M., & Pennacchio, L. A. (2010) · Nature · doi:10.1038/nature08801 · Cited by 472
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activitiesPreprint
Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M. S., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.377406 · Cited by 430
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence
Agger, K., Cloos, P. A. C., Rudkjær, L., Williams, K., Andersen, G., Christensen, J., & Helin, K. (2009) · Genes & Development · doi:10.1101/gad.510809 · Cited by 427
The Drosophila Polycomb Group Gene pleiohomeotic Encodes a DNA Binding Protein with Homology to the Transcription Factor YY1
Brown, J. L., Mucci, D., Whiteley, M., Dirksen, M., & Kassis, J. A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80106-9 · Cited by 415
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.
Herman, J. G., Civin, C. I., Issa, J. J., Collector, M. I., Sharkis, S. J., & Baylin, S. B. (1997) · PubMed · Cited by 405
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
Kanhere, A., Viiri, K. M., Araújo, C. C., Rasaiyaah, J., Bouwman, R. D., Whyte, W. A., Pereira, C., Brookes, E., Walker, K., Bell, G. W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.019 · Cited by 386
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
Cunnington, M. S., Santibanez‐Koref, M., Mayosi, B. M., Burn, J., & Keavney, B. D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000899 · Cited by 385
Rnf2 ( Ring1b ) deficiency causes gastrulation arrest and cell cycle inhibition
Voncken, J. W., Roelen, B. A. J., Roefs, M., de Vries, S., Verhoeven, E., Marino, S., Deschamps, J., & van Lohuizen, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0434312100 · Cited by 363
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
Barradas, M., Anderton, E., Acosta, J. C., Li, S., Banito, A., Rodriguez-Niedenführ, M., Maertens, G., Banck, M., Zhou, M.-M., Walsh, M. J., et al. (2009) · Genes & Development · doi:10.1101/gad.511109 · Cited by 352
Self-citation
Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets
Gearhart, M. D., Corcoran, C. M., Wamstad, J. A., & Bardwell, V. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00630-06 · Cited by 352
Polycomb CBX7 has a unifying role in cellular lifespan.
Gil, J., Bernard, D., Martínez, D., & Beach, D. (2004) · Nature Cell Biology · doi:10.1038/ncb1077 · Cited by 341
Self-citation
A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness
Woo, C. J., Kharchenko, P. V., Daheron, L. M., Park, P. J., & Kingston, R. E. (2010) · Cell · doi:10.1016/j.cell.2009.12.022 · Cited by 333
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
Bruggeman, S. W. M., Valk-Lingbeek, M. E., van der Stoop, P. P. M., Jacobs, J. J. L., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., et al. (2005) · Genes & Development · doi:10.1101/gad.1299305 · Cited by 315
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
He, J., Kallin, E. M., Tsukada, Y.-I., & Zhang, Y. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1499 · Cited by 302
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
Frescas, D., Guardavaccaro, D., Bassermann, F., Koyama-Nasu, R., & Pagano, M. (2007) · Nature · doi:10.1038/nature06255 · Cited by 284
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
Krimpenfort, P., IJpenberg, A., Song, J.-Y., van der Valk, M., Nawijn, M., Zevenhoven, J., & Berns, A. (2007) · Nature · doi:10.1038/nature06084 · Cited by 269
SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus
Kia, S. K., Gorski, M. M., Giannakopoulos, S., & Verrijzer, C. P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02019-07 · Cited by 269
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis
Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Mohlke, K. L., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005027 · Cited by 248
Transcription factor YY1 functions as a PcG protein in vivo
Atchison, L., Ghias, A., Wilkinson, F. H., Bonini, N. M., & Atchison, M. L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg124 · Cited by 217
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus
Dietrich, N., Bracken, A. P., Trinh, E., Schjerling, C. K., Koseki, H., Rappsilber, J., Helin, K., & Hansen, K. H. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601632 · Cited by 187
Cancer and ageing: convergent and divergent mechanisms
Serrano, M., & Blasco, M. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2242 · Cited by 182
MAPKAP Kinase 3pK Phosphorylates and Regulates Chromatin Association of the Polycomb Group Protein Bmi1
Voncken, J. W., Niessen, H. E. C., Neufeld, B., Rennefahrt, U. E. E., Dahlmans, V. E. H., Kubben, N., Holzer, B., Ludwig, S., & Rapp, U. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407155200 · Cited by 173
Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues.
Nielsen, G. P., Stemmer-Rachamimov, A. O., Shaw, J., Roy, J. E., Koh, J., & Louis, D. N. (1999) · PubMed · Cited by 169
p16 Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells
Oruetxebarria, I., Venturini, F., Kekarainen, T., Houweling, A., Zuijderduijn, L. M. P., Mohd-Sarip, A., Vries, R. G. J., Hoeben, R. C., & Verrijzer, C. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309333200 · Cited by 164
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm‐deficient mice
Suzuki, T., Minehata, K., Akagi, K., Jenkins, N. A., & Copeland, N. G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601215 · Cited by 148
Gene silencing by DNA methylation in haematological malignancies
Boultwood, J., & Wainscoat, J. S. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06604.x · Cited by 146
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a / Arf locus
Tzatsos, A., Pfau, R., Kampranis, S. C., & Tsichlis, P. N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813139106 · Cited by 131
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
Pfau, R., Tzatsos, A., Kampranis, S. C., Serebrennikova, O. B., Bear, S. E., & Tsichlis, P. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711865105 · Cited by 119
Frequent p16-Independent Inactivation of p14ARF in Human Melanoma
Freedberg, D. E., Rigas, S. H., Russak, J. E., Gai, W., Kaplow, M., Osman, I., Turner, F., Randerson‐Moor, J. A., Houghton, A. N., BUSAM, K. J., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn157 · Cited by 110
Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation
Mohammad, H. P., Cai, Y., McGarvey, K. M., Easwaran, H., Neste, L. V., Ohm, J. E., O’Hagan, H. M., & Baylin, S. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0065 · Cited by 86
A common variant of the p16INK4a genetic region is associated with physical function in older people
Melzer, D., Frayling, T. M., Murray, A., Hurst, A. J., Harries, L. W., Song, H., Khaw, K., Luben, R., Surtees, P. G., Bandinelli, S. S., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.03.005 · Cited by 84
Tissue-specific p19 Arf regulation dictates the response to oncogenic K-ras
Young, N. P., & Jacks, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004796107 · Cited by 59
Linkage and Association Study of Late‐Onset Alzheimer Disease Families Linked to 9p21.3
Zuchner, S. L., Gilbert, J. R., Martin, E. R., Guerrero, C. R. L., Xu, P. ‐., Browning, C., Bronson, P. G., Whitehead, P. G., Schmechel, D. E., Haines, J. L., et al. (2008) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2008.00474.x · Cited by 57
Pc-G/trx-G and the SWI/SNF connection: Developmental gene regulation through chromatin remodeling
Gebuhr, T. C., Bultman, S. J., & Magnuson, T. (2000) · genesis · doi:10.1002/(sici)1526-968x(200003)26:3 · Cited by 37
An INKlination for epigenetic control of senescence
Peters, G. G. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1108-1133 · Cited by 9

Research works printed but not linked: 2

Nielsen GP, 1999, Lab Invest, 79, 1137
Herman JG, 1997, Cancer Res, 57, 837

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Authors: Popov, N., & Gil, J.
Affiliations: Imperial College London (GB)
Corresponding author: Gil, Jesús
ORCID: Gil, Jesús
Venue: Epigenetics
Publisher: Informa UK Limited
Published: 2010-11
Volume: 5
Issue: 8
Pages: 685-690
ISSN: 1559-2294 (ISSN-L)
1559-2308
DOI: 10.4161/epi.5.8.12996
PMC: PMC3052884
OpenAlex: W1969204301
Cited by: 202
References: 72
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 13 · 2015: 24 · 2014: 21 · 2013: 26 · 2012: 18
FWCI: 1.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Epigenetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: LifeArc
Cancer Research UK
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: p16INK4a, CDKN2B, ARF, ANRIL, non-coding RNA, polycomb repressive complex, histone demethylase, JMJD3, SWI/SNF chromatin remodeling, DNA methyltransferases, tumor suppressor, single nucleotide polymorphisms, epigenetic regulation, cancer
MeSH terms: Alzheimer Disease, Animals, Cardiovascular Diseases, Chromatin, Diabetes Mellitus, Type 2, Humans, Repressor Proteins, Transcription, Genetic, DNA Modification Methylases, Signal Transduction, Tumor Suppressor Protein p53, G1 Phase, Cyclin-Dependent Kinase Inhibitor p16, ADP-Ribosylation Factors, RNA, Untranslated, Epigenesis, Genetic, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Proto-Oncogene Proteins c-mdm2, Genetic Loci, Histone Demethylases, Polycomb-Group Proteins

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Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health

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