The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Assembly and disassembly of the nucleolus during the cell cycle
Open accessAbstract
The nucleolus is a large nuclear domain in which transcription, maturation and assembly of ribosomes take place. In higher eukaryotes, nucleolar organization in three sub-domains reflects the compartmentation of the machineries related to active or inactive transcription of the ribosomal DNA, ribosomal RNA processing and assembly with ribosomal proteins of the two (40S and 60S) ribosomal subunits. The assembly of the nucleoli during telophase/early G(1) depends on pre-existing machineries inactivated during prophase (the transcription machinery and RNP processing complexes) and on partially processed 45S rRNAs inherited throughout mitosis. In telophase, the 45S rRNAs nucleate the prenucleolar bodies and order the dynamics of nucleolar assembly. The assembly/disassembly processes of the nucleolus depend on the equilibrium between phosphorylation/dephosphorylation of the transcription machinery and on the RNP processing complexes under the control of the CDK1-cyclin B kinase and PP1 phosphatases. The dynamics of assembly/disassembly of the nucleolus is time and space regulated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Boisvert, F.-M., van Koningsbruggen, S., Navascués, J., & Lamond, A. I. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2184 · Cited by 1,619
A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells
Patterson, G. H., & Lippincott-Schwartz, J. (2002) · Science · doi:10.1126/science.1074952 · Cited by 1,612
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes
Brangwynne, C. P., Mitchison, T. J., & Hyman, A. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017150108 · Cited by 1,263
Andersen, J. S., Lam, Y. W., Leung, A. K. L., Ong, S.-E., Lyon, C. E., Lamond, A. I., & Mann, M. (2005) · Nature · doi:10.1038/nature03207 · Cited by 1,149
Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis
Gavet, O., & Pines, J. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.013 · Cited by 844
The Nucleolus and Ribosome Biogenesis
Hadjiolov, A. A. (1985) · Cell Biology Monographs · doi:10.1007/978-3-7091-8742-5 · Cited by 524
Synthesis of RNA and protein during mitosis in mammalian tissue culture cells
Prescott, D. M., & Bender, M. A. (1962) · Experimental Cell Research · doi:10.1016/0014-4827(62)90176-3 · Cited by 500
Orchestrating nuclear envelope disassembly and reassembly during mitosis
Güttinger, S., Laurell, E., & Kutay, U. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2641 · Cited by 474
The nucleolus: an old factory with unexpected capabilities
Olson, M. O. J., Dundr, M., & Szebeni, A. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01738-4 · Cited by 397
Initial Genomics of the Human Nucleolus
Németh, A., Conesa, A., Santoyo-Lopez, J., Medina, I., Montaner, D., Péterfia, B., Solovei, I., Cremer, T., Dopazo, J., & Längst, G. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000889 · Cited by 382
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase
Peter, M., Nakagawa, J., Dorée, M., Labbé, J. C., & Nigg, E. A. (1990) · Cell · doi:10.1016/0092-8674(90)90093-t · Cited by 345
van Koningsbruggen, S., Gierliński, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T., & Lamond, A. I. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0508 · Cited by 327
The nucleolus: an organelle formed by the act of building a ribosome
Mélèse, T., & Xue, Z. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80085-9 · Cited by 287
Roussel, P., André, C., Comai, L., & Hernandez-Verdun, D. (1996) · The Journal of cell biology · doi:10.1083/jcb.133.2.235 · Cited by 266
Self-citationThe Dynamics of Postmitotic Reassembly of the Nucleolus
Dundr, M., Misteli, T., & Olson, M. O. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.433 · Cited by 261
The nucleolus: structure/function relationship in RNA metabolism
Hernandez‐Verdun, D., Roussel, P., Thiry, M., Sirri, V., & Lafontaine, D. L. J. (2010) · WIREs RNA · doi:10.1002/wrna.39 · Cited by 261
Self-citationRNA viruses: hijacking the dynamic nucleolus
Hiscox, J. A. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1597 · Cited by 260
Ribosomal Protein Genes RPS10 and RPS26 Are Commonly Mutated in Diamond-Blackfan Anemia
Doherty, L., Sheen, M. R., Vlachos, A., Choesmel, V., O'Donohue, M.-F., Clinton, C., Schneider, H. E., Sieff, C. A., Newburger, P. E., Ball, S. E., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.12.015 · Cited by 259
Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins
Chen, D., Dundr, M., Wang, C., Leung, A., Lamond, A., Misteli, T., & Huang, S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407182 · Cited by 200
Signal recognition particle components in the nucleolus
Politz, J. C., Yarovoi, S., Kilroy, S. M., Gowda, K., Zwieb, C., & Pederson, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.55 · Cited by 189
New Insights into Nucleolar Architecture and Activity
Raška, I., Shaw, P. J., & Cmarko, D. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55004-1 · Cited by 182
Okuwaki, M., Tsujimoto, M., & Nagata, K. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-03-0036 · Cited by 179
Nucleolar Assembly of the Rrna Processing Machinery in Living Cells
Savino, T. M., Gébrane-Younès, J., De Mey, J., Sibarita, J.-B., & Hernandez-Verdun, D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.1097 · Cited by 170
Self-citationLeung, A. K. L., Gerlich, D., Miller, G., Lyon, C., Lam, Y. W., Lleres, D., Daigle, N., Zomerdijk, J., Ellenberg, J., & Lamond, A. I. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405013 · Cited by 168
Nucleolar Factors Direct the 2′-O-Ribose Methylation and Pseudouridylation of U6 Spliceosomal RNA
Ganot, P., Jády, B. E., Bortolin, M.-L., Darzacq, X., & Kiss, T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6906 · Cited by 162
Potapova, T., Sivakumar, S., Flynn, J. N., Li, R., & Gorbsky, G. J. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0599 · Cited by 161
Heix, J., Vente, A., Voit, R., Budde, A., Michaelidis, T. M., & Grummt, I. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7373 · Cited by 154
The nucleolus: a model for the organization of nuclear functions
Hernandez‐Verdun, D. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0212-3 · Cited by 153
Self-citationCyclin-dependent kinases govern formation and maintenance of the nucleolus
Sirri, V., Hernandez‐Verdun, D., & Roussel, P. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201024 · Cited by 152
Self-citationIn search of nonribosomal nucleolar protein function and regulation
Pederson, T., & Tsai, R. Y. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812014 · Cited by 145
Nucleologenesis: Composition and fate of prenucleolar bodies
Ochs, R. L., Lischwe, M. A., Shen, E., et al. (1985) · Chromosoma · doi:10.1007/bf00327463 · Cited by 136
Initiation of Nucleolar Assembly Is Independent of RNA Polymerase I Transcription
Dousset, T., Wang, C., Verheggen, C., Chen, D., Hernandez‐Verdun, D., & Huang, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.8.2705 · Cited by 136
Self-citationEmerging concepts of nucleolar assembly
Hernandez‐Verdun, D., Roussel, P., & Gébrane‐Younès, J. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.11.2265 · Cited by 131
Self-citationReorganization of the nuclear envelope during open mitosis
Kutay, U., & Hetzer, M. W. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.09.010 · Cited by 125
Rajapakse, I., & Groudine, M. T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010129 · Cited by 123
Mitotic phosphatases: no longer silent partners
Trinkle‐Mulcahy, L., & Lamond, A. I. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.09.001 · Cited by 119
The AgNOR proteins: qualitative and quantitative changes during the cell cycle
Sirri, V., Roussel, P., & Hernandez-Verdun, D. (2000) · Micron · doi:10.1016/s0968-4328(99)00068-2 · Cited by 111
Self-citationDutca, L. M., Gallagher, J. E. G., & Baserga, S. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr044 · Cited by 106
Gautier, T., Robert‐Nicoud, M., Guilly, M., & Hernandez‐Verdun, D. (1992) · Journal of Cell Science · doi:10.1242/jcs.102.4.729 · Cited by 106
Self-citationWhen rDNA transcription is arrested during mitosis, UBF is still associated with non-condensed rDNA
Gébrane‐Younès, J., Fomproix, N., & Hernandez‐Verdun, D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.19.2429 · Cited by 103
Self-citationHooser, A. A. V., Yuh, P., & Heald, R. (2005) · Chromosoma · doi:10.1007/s00412-005-0021-9 · Cited by 102
Piñol-Roma, S. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.1.77 · Cited by 98
Lamin B1 maintains the functional plasticity of nucleoli
Martin, C., Chen, S., Maya‐Mendoza, A., Lovrić, J., Sims, P. F. G., & Jackson, D. A. (2009) · Journal of Cell Science · doi:10.1242/jcs.046284 · Cited by 89
Sirri, V., Roussel, P., & Hernandez‐Verdun, D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.2.259 · Cited by 88
Self-citationDundr, M., Meier, U. T., Lewis, N., Rekosh, D. M., Hammarskjöld, M., & Olson, M. O. J. (1997) · Chromosoma · doi:10.1007/bf02510477 · Cited by 86
Dundr, M., & Olson, M. O. J. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2407 · Cited by 85
Effects of anti-fibrillarin antibodies on building of functional nucleoli at the end of mitosis
Fomproix, N., Gébrane‐Younès, J., & Hernandez‐Verdun, D. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.3.359 · Cited by 80
Self-citationTracking the Interactions of rRNA Processing Proteins during Nucleolar Assembly in Living Cells
Angelier, N., Tramier, M., Louvet, É., Coppey‐Moisan, M., Savino, T. M., Mey, J. D., & Hernandez‐Verdun, D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0041 · Cited by 75
Self-citationCell and Molecular Biology of Nucleolar Assembly and Disassembly
DiMario, P. J. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)39003-0 · Cited by 66
Verheggen, C., Panse, S. L., Almouzni, G., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.5.1167 · Cited by 66
Internal Modification of U2 Small Nuclear (Snrna) Occurs in Nucleoli of Xenopus Oocytes
Yu, Y., Shu, M.-D., Narayanan, A., Terns, R. M., Terns, M. P., & STEITZ, J. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.6.1279 · Cited by 60
Verheggen, C., Almouzni, G., & Hernandez‐Verdun, D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.2.293 · Cited by 55
Self-citationRRP1B Targets PP1 to Mammalian Cell Nucleoli and Is Associated with Pre-60S Ribosomal Subunits
Chamousset, D., Wever, V. D., Moorhead, G. B. G., Chen, Y., Boisvert, F., Lamond, A. I., & Trinkle‐Mulcahy, L. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-04-0287 · Cited by 50
Zirwes, R. F., Kouzmenko, A., Peters, J., Franke, W. W., & Schmidt-Zachmann, M. S. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.2.231 · Cited by 44
Muro, E., Gébrane‐Younès, J., Jobart‐Malfait, A., Louvet, É., Roussel, P., & Hernandez‐Verdun, D. (2010) · Nucleus · doi:10.4161/nucl.11334 · Cited by 42
Self-citationBiogenesis of the signal recognition particle
Leung, E., & Brown, J. D. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381093 · Cited by 22
Martin, C., Chen, S., & Jackson, D. A. (2010) · Chromosome Research · doi:10.1007/s10577-010-9137-8 · Cited by 18
Jellbauer, S., & Jansen, R. (2008) · RNA Biology · doi:10.4161/rna.7163 · Cited by 16
Cited by
The nucleolus as a multiphase liquid condensate
Lafontaine, D. L. J., Riback, J. A., Bascetin, R., & Brangwynne, C. P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0272-6 · Cited by 1,051
Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization
Wang, C., Lu, T., Emanuel, G., Babcock, H. P., & Zhuang, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903808116 · Cited by 111
“RNAs can be localized to cellular compartments formed by phase separation via two mechanisms (20): (i) RNAs can act as a scaffold, which could facilitate the nucleation of phase separation, such as mRNAs in P body and stress granules (49) and preribosome RNAs in nucleoli (50), and (ii) RNAs can be recruited to the pha…”
BackgroundMapping the invisible chromatin transactions of prophase chromosome remodeling
Samejima, I., Spanos, C., Samejima, K., Rappsilber, J., Kustatscher, G., & Earnshaw, W. C. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.12.039 · Cited by 21
Conserved nucleolar stress at the onset of cell death
Golstein, P. (2017) · The FEBS Journal · doi:10.1111/febs.14095 · Cited by 7
Metadata
- Authors
- Hernandez-Verdun, D.
- Venue
- Nucleus
- Publisher
- Informa UK Limited
- Published
- 2011-05
- Volume
- 2
- Issue
- 3
- Pages
- 189-194
- ISSN
- 1949-1034 (ISSN-L)
- 1949-1042
- OpenAlex
- W2024368545
- Cited by
- 310
- References
- 58
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
