The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Oxidative Stress as a Mediator of Cardiovascular Disease
Open accessAbstract
During physiological processes molecules undergo chemical changes involving reducing and oxidizing reactions. A molecule with an unpaired electron can combine with a molecule capable of donating an electron. The donation of an electron is termed as oxidation whereas the gaining of an electron is called reduction. Reduction and oxidation can render the reduced molecule unstable and make it free to react with other molecules to cause damage to cellular and sub‐cellular components such as membranes, proteins and DNA. In this paper, we have discussed the formation of reactive oxidant species originating from a variety of sources such as nitric oxide (NO) synthase (NOS), xanthine oxidases (XO), the cyclooxygenases, nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase isoforms and metal‐catalyzed reactions. In addition, we present a treatise on the physiological defences such as specialized enzymes and antioxidants that maintain reduction‐oxidation (redox) balance. We have also given an account of how enzymes and antioxidants can be exhausted by the excessive production of reactive oxidant species (ROS) resulting in oxidative stress/nitrosative stress, a process that is an important mediator of cell damage. Important aspects of redox imbalance that triggers the activity of a number of signaling pathways including transcription factors activity, a process that is ubiquitous in cardiovascular disease related to ischemia/reperfusion injury have also been presented.
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Cites
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Cited by
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971
“In myocardial ischemia, hypoxia and reoxygenation trigger an increase in free radical production in cardiac tissue (Elahi et al., 2009).”
BackgroundInfluentialBouayed, J., & Bohn, T. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.4.12858 · Cited by 1,095
Markers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans
Pandey, K. B., & Rizvi, S. I. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.10476 · Cited by 444
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233
Saremi, A., Howell, S., Schwenke, D. C., Bahn, G., Beisswenger, P. J., Reaven, P. D., & for the VADT Investigators (2017) · Diabetes Care · doi:10.2337/dc16-1875 · Cited by 90
Metadata
- Authors
- Elahi, M. M., Kong, Y. X., & Matata, B. M.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 2
- Issue
- 5
- Pages
- 259-269
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W1966114904
- Cited by
- 360
- References
- 147
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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