Oxidatively generated complex DNA damage: Tandem and clustered lesions

Oxidative stress, inflammation, and cancer: How are they linked?

Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works

Advances in metal-induced oxidative stress and human disease

Jomová, K., & Valko, M. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.001 · Cited by 3,226 · see citing works

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882 · see citing works

The comet assay: a method to measure DNA damage in individual cells

Olive, P. L., & Banáth, J. P. (2006) · Nature Protocols · doi:10.1038/nprot.2006.5 · Cited by 1,845 · see citing works

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

Rothkamm, K., & Löbrich, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830918100 · Cited by 1,645 · see citing works

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

Ward, J. F. (1988) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60611-x · Cited by 1,499 · see citing works

Base-excision repair of oxidative DNA damage

David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238 · see citing works

Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA

Goodhead, D. T. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550021 · Cited by 1,204 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

Ultraviolet radiation-mediated damage to cellular DNA

Cadet, J., Sage, E., & Douki, T. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.012 · Cited by 932 · see citing works

Role of oxidative stress and DNA damage in human carcinogenesis

Kryston, T. B., Georgiev, A. B., Pissis, P., & Georgakilas, A. G. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.016 · Cited by 927 · see citing works

Free-Radical-Induced DNA Damage and Its Repair

von Sonntag, C. (2006) · Springer eBooks · doi:10.1007/3-540-30592-0 · Cited by 811 · see citing works

Mechanisms of free radical-induced damage to DNA

Dizdaroğlu, M., & Jaruga, P. (2012) · Free Radical Research · doi:10.3109/10715762.2011.653969 · Cited by 748 · see citing works

Base excision repair of oxidative DNA damage and association with cancer and aging

Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works

The Complexity of DNA Damage: Relevance to Biological Consequences

Ward, J. F. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414551401 · Cited by 633 · see citing works

Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage

O'Donovan, P., Perrett, C. M., Zhang, X., Montaner, B., Xu, Y., Harwood, C. A., McGregor, J., Walker, S. L., Hanaoka, F., & Karran, P. (2005) · Science · doi:10.1126/science.1114233 · Cited by 631 · see citing works

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

Ziech, D., Franco, R., Pappa, A., & Panayiotidis, M. I. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.015 · Cited by 568 · see citing works

Oxidatively Generated Damage to the Guanine Moiety of DNA: Mechanistic Aspects and Formation in Cells

Cadet, J., Douki, T., & Ravanat, J.-L. (2008) · Accounts of Chemical Research · doi:10.1021/ar700245e · Cited by 555 · see citing works

Oxidatively generated base damage to cellular DNA

Cadet, J., Douki, T., & Ravanat, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.025 · Cited by 543 · see citing works

Encyclopedia of radicals in chemistry, biology and materials

(2012) · Choice Reviews Online · doi:10.5860/choice.49-6017 · Cited by 532 · see citing works

Computational Approach for Determining the Spectrum of DNA Damage Induced by Ionizing Radiation

Nikjoo, H., O'Neill, P., Wilson, W. E., & GOODHEAD, D. T. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0577:cafdts]2.0.co;2 · Cited by 495 · see citing works

Oxidative stress and oxidative damage in chemical carcinogenesis

Klaunig, J. E., Wang, Z., Pu, X., & Zhou, S. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.11.028 · Cited by 475 · see citing works

Molecular targets of oxidative stress

Avery, S. V. (2011) · Biochemical Journal · doi:10.1042/bj20101695 · Cited by 474 · see citing works

The redox stress hypothesis of aging

Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473 · see citing works

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

Sutherland, B. M., Bennett, P. V., Sidorkina, O. M., & Laval, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.103 · Cited by 473 · see citing works

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

Ivashkevich, A., Redon, C. E., Nakamura, A. J., Martin, R. F., & Martin, O. A. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.025 · Cited by 462 · see citing works

Formation of Clustered DNA Damage after High-LET Irradiation: A Review

Hada, M., & Georgakilas, A. G. (2008) · Journal of Radiation Research · doi:10.1269/jrr.07123 · Cited by 450 · see citing works

Exercise-induced oxidative stress in humans: cause and consequences

Powers, S. K., Nelson, W. B., & Hudson, M. B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.009 · Cited by 441 · see citing works

DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

Povirk, L. F. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(96)00023-1 · Cited by 432 · see citing works

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

Mladenov, E., & Iliakis, G. E. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.005 · Cited by 381 · see citing works

Oxidative Stress as a Mediator of Cardiovascular Disease

Elahi, M. M., Kong, Y. X. G., & Matata, B. M. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9441 · Cited by 362 · see citing works

Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells

Kuraoka, I., Bender, C., Romieu, A., Cadet, J., Wood, R. D., & Lindahl, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070471597 · Cited by 346 · see citing works

Role of oxidatively induced DNA lesions in human pathogenesis

Sedelnikova, O. A., Redon, C. E., Dickey, J. S., Nakamura, A., Georgakilas, A. G., & Bonner, W. M. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.12.005 · Cited by 339 · see citing works

Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective

von Sonntag, C. (2005) · CERN Document Server (European Organization for Nuclear Research) · Cited by 333 · see citing works

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

Lliakis, G. (1991) · BioEssays · doi:10.1002/bies.950131204 · Cited by 329 · see citing works

Singlet Oxygen Induces Oxidation of Cellular DNA

Ravanat, J., Mascio, P. D., Martinez, G. R., de Medeiros, M. H. G., & Cadet, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006681200 · Cited by 327 · see citing works

Mechanism of neocarzinostatin action: role of DNA microstructure in determination of chemistry of bistranded oxidative damage

GOLDBERG, I. H. (1991) · Accounts of Chemical Research · doi:10.1021/ar00007a001 · Cited by 320 · see citing works

DNA?protein crosslinks: their induction, repair, and biological consequences

BARKER, S., Weinfeld, M., & MURRAY, D. (2005) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.11.003 · Cited by 315 · see citing works

Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli

Janion, C. (2008) · International Journal of Biological Sciences · doi:10.7150/ijbs.4.338 · Cited by 303 · see citing works

Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction

Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300 · see citing works

The Oxidative DNA Lesion 8,5′-(S)-Cyclo-2′-deoxyadenosine Is Repaired by the Nucleotide Excision Repair Pathway and Blocks Gene Expression in Mammalian Cells

Brooks, P. J., Wise, D. S., Berry, D. A., Kosmoski, J. V., Smerdon, M. J., Somers, R. L., Mackie, H., Spoonde, A. Y., Ackerman, E. J., Coleman, K. G., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002259200 · Cited by 298 · see citing works

Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

Lonkar, P. S., & Dedon, P. C. (2010) · International Journal of Cancer · doi:10.1002/ijc.25815 · Cited by 286 · see citing works

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

Asaithamby, A., Hu, B., & Chen, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016045108 · Cited by 283 · see citing works

New functions of XPC in the protection of human skin cells from oxidative damage

D'Errico, M., Parlanti, E., Teson, M., de Jesus, B. M. B., Degan, P., Calcagnile, A., Jaruga, P., Bjørås, M., Crescenzi, M., Pedrini, A. M., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601277 · Cited by 271 · see citing works

New insights on oxidative stress in cancer.

Visconti, R., & Grieco, D. (2009) · PubMed · Cited by 265 · see citing works

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

Svilar, D., Goellner, E. M., Almeida, K. H., & Sobol, R. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3466 · Cited by 254 · see citing works

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

Eccles, L. J., O’Neill, P., & Lomax, M. E. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.11.003 · Cited by 234 · see citing works

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

Sage, É., & Harrison, L. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.010 · Cited by 233 · see citing works

Formation of Modified DNA Bases in Cells Exposed either to Gamma Radiation or to High-LET Particles1

Pouget, J., Frelon, S., Ravanat, J., Testard, I., Odin, F., & Cadet, J. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)157[0589:fomdbi]2.0.co;2 · Cited by 219 · see citing works

Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death

Stewart, R. D., Yu, V. K., Georgakilas, A. G., Koumenis, C., Park, J. H., & Carlson, D. J. (2011) · Radiation Research · doi:10.1667/rr2663.1 · Cited by 214 · see citing works

The Chemical Toxicology of 2-Deoxyribose Oxidation in DNA

Dedon, P. C. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700283c · Cited by 213 · see citing works

The carbonate radical and related oxidants derived from bicarbonate buffer

Medinas, D. B., Cerchiaro, G., Trindade, D. F., & Augusto, O. (2007) · IUBMB Life · doi:10.1080/15216540701230511 · Cited by 198 · see citing works

Rapid DNA–protein cross-linking and strand scission by an abasic site in a nucleosome core particle

Sczepanski, J. T., Wong, R. S., McKnight, J. N., Bowman, G. D., & Greenberg, M. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012860108 · Cited by 194 · see citing works

A Fast Monte Carlo Algorithm to Simulate the Spectrum of DNA Damages Formed by Ionizing Radiation

Semenenko, V. A., & Stewart, R. D. (2004) · Radiation Research · doi:10.1667/rr3140 · Cited by 190 · see citing works

The Carbonate Radical Is a Site-selective Oxidizing Agent of Guanine in Double-stranded Oligonucleotides

Shafirovich, V., Dourandin, A., Huang, W., & Geacintov, N. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101131200 · Cited by 186 · see citing works

The role of homologous recombination in radiation-induced double-strand break repair

Jeggo, P. A., Geuting, V., & Löbrich, M. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.06.019 · Cited by 184 · see citing works

Radiation chemistry comes before radiation biology

O’Neill, P., & Wardman, P. (2009) · International Journal of Radiation Biology · doi:10.1080/09553000802640401 · Cited by 179 · see citing works

Oxidation Reactions of Cytosine DNA Components by Hydroxyl Radical and One-Electron Oxidants in Aerated Aqueous Solutions

Wagner, J. R., & Cadet, J. (2010) · Accounts of Chemical Research · doi:10.1021/ar9002637 · Cited by 167 · see citing works

Guanine Oxidation: One‐ and Two‐Electron Reactions

Pratviel, G., & Meunier, B. (2006) · Chemistry - A European Journal · doi:10.1002/chem.200600539 · Cited by 159 · see citing works

Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion

Regulus, P., Duroux, B., Bayle, A., Favier, A. E., Cadet, J., & Ravanat, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706044104 · Cited by 157 · see citing works

Chronic inflammation and mutagenesis

Ferguson, L. R. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.03.007 · Cited by 156 · see citing works

Parkinson's disease and cancer: two wars, one front

Devine, M. J., Plun‐Favreau, H., & Wood, N. W. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3150 · Cited by 153 · see citing works

DNA−Protein Cross-links between Guanine and Lysine Depend on the Mechanism of Oxidation for Formation of C5 Vs C8 Guanosine Adducts

Xu, X., Muller, J. G., Ye, Y., & Burrows, C. J. (2007) · Journal of the American Chemical Society · doi:10.1021/ja077102a · Cited by 152 · see citing works

Bulky DNA Lesions Induced by Reactive Oxygen Species

Wang, Y. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700411g · Cited by 152 · see citing works

Molecular mechanisms of oxidative stress‐induced carcinogenesis: From epidemiology to oxygenomics

Toyokuni, S. (2008) · IUBMB Life · doi:10.1002/iub.61 · Cited by 151 · see citing works

More forks on the road to replication stress recovery

Allen, C., Ashley, A. K., Hromas, R., & Nickoloff, J. A. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq049 · Cited by 147 · see citing works

Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

Cadet, J., Loft, S. H., Oliński, R., Evans, M. D., Białkowski, K., Wagner, J. R., Dedon, P. C., Möller, P., Greenberg, M. M., & Cooke, M. S. (2012) · Free Radical Research · doi:10.3109/10715762.2012.659248 · Cited by 143 · see citing works

Characterization of Lysine−Guanine Cross-Links upon One-Electron Oxidation of a Guanine-Containing Oligonucleotide in the Presence of a Trilysine Peptide

Perrier, S., Hau, J., Gasparutto, D., Cadet, J., Favier, A., & Ravanat, J.-L. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057656i · Cited by 141 · see citing works

Processing of bistranded abasic DNA clusters in -irradiated human hematopoietic cells

Georgakilas, A. G. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh871 · Cited by 138 · see citing works

Purine 5′,8-cyclonucleoside lesions: chemistry and biology

Chatgilialoglu, C., Ferreri, C., & Terzidis, M. A. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00061b · Cited by 137 · see citing works

HO • radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases

Bergeron, F., Auvré, F., Radicella, J. P., & Ravanat, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000193107 · Cited by 137 · see citing works

The role of CSA in the response to oxidative DNA damage in human cells

D'Errico, M., Parlanti, E., Teson, M., Degan, P., Lemma, T., Calcagnile, A., Iavarone, I., Jaruga, P., Ropolo, M., Pedrini, A. M., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210232 · Cited by 137 · see citing works

Measurement of oxidatively generated base damage in cellular DNA

Cadet, J., Douki, T., & Ravanat, J.-L. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.02.004 · Cited by 136 · see citing works

DNA damage spectra induced by photosensitization

Epe, B. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05190c · Cited by 133 · see citing works

Functional relevance of the histone γH2Ax in the response to DNA damaging agents

Revet, I. M., Feeney, L., Bruguera, S., Wilson, W., Dong, T. K., Oh, D. H., Dankort, D. L., & Cleaver, J. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105866108 · Cited by 133 · see citing works

Covalent Trapping of Human DNA Polymerase β by the Oxidative DNA Lesion 2-Deoxyribonolactone

DeMott, M. S., Beyret, E., Wong, D., Bales, B. C., Hwang, J.-T., Greenberg, M. M., & Demple, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100577200 · Cited by 127 · see citing works

Free radical-induced double lesions in DNA

Box, H. C., Dawidzik, J. B., & Budzinski, E. E. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00653-0 · Cited by 126 · see citing works

The 8,5′-cyclopurine-2′-deoxynucleosides: Candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair

Brooks, P. J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.016 · Cited by 125 · see citing works

The Loss of γH2AX Signal is a Marker of DNA Double Strand Breaks Repair Only at Low Levels of DNA Damage

Bouquet, F., Muller, C., & Salles, B. (2006) · Cell Cycle · doi:10.4161/cc.5.10.2799 · Cited by 124 · see citing works

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

Lovell, M. A., Soman, S., & Bradley, M. A. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.08.003 · Cited by 124 · see citing works

Processing of DNA damage clusters in human cells: current status of knowledge

Georgakilas, A. G. (2007) · Molecular BioSystems · doi:10.1039/b713178j · Cited by 122 · see citing works

The case for 8,5′-cyclopurine-2′-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum

Brooks, P. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.025 · Cited by 121 · see citing works

Repair and biochemical effects of DNA–protein crosslinks

Ide, H., Shoulkamy, M. I., Nakano, T., Miyamoto‐Matsubara, M., & Salem, A. M. H. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.007 · Cited by 119 · see citing works

Oxygen Free Radical Damage to DNA

Kuraoka, I., Robins, P., Masutani, C., Hanaoka, F., Gasparutto, D., Cadet, J., Wood, R. D., & Lindahl, T. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107779200 · Cited by 116 · see citing works

Oxidatively generated damage to DNA by UVA radiation in cells and human skin

Cadet, J., & Douki, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.51 · Cited by 116 · see citing works

Identification of Mammalian Proteins Cross-linked to DNA by Ionizing Radiation

Barker, S., Weinfeld, M., Zheng, J., Li, L., & Murray, D. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502477200 · Cited by 115 · see citing works

γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”

Cleaver, J. E. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00995.x · Cited by 112 · see citing works

Cross-Linked Thymine-Purine Base Tandem Lesions: Synthesis, Characterization, and Measurement in γ-Irradiated Isolated DNA

Bellon, S., Ravanat, J., Gasparutto, D., & Cadet, J. (2002) · Chemical Research in Toxicology · doi:10.1021/tx015594d · Cited by 110 · see citing works

Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light

Zhang, X., Jeffs, G., Ren, X., O’Donovan, P., Montaner, B., Perrett, C. M., Karran, P., & Xu, Y.-Z. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.003 · Cited by 110 · see citing works

Quantification of Oxidative DNA Lesions in Tissues of Long-Evans Cinnamon Rats by Capillary High-Performance Liquid Chromatography−Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method

Wang, J., Yuan, B., Guerrero, C. R., Bahde, R., Gupta, S. K., & Wang, Y. (2011) · Analytical Chemistry · doi:10.1021/ac103099s · Cited by 110 · see citing works

Tandem Base Lesions Are Generated by Hydroxyl Radical within Isolated DNA in Aerated Aqueous Solution

Bourdat, A.-G., Douki, T., Frelon, S., Gasparutto, D., & Cadet, J. (2000) · Journal of the American Chemical Society · doi:10.1021/ja994282i · Cited by 109 · see citing works

Minor contribution of direct ionization to DNA base damage inducedby heavy ions

Douki, T., Ravanat, J.-L., Pouget, J.-P., Testard, I., & Cadet, J. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000600573788 · Cited by 106 · see citing works

DNA-PROTEIN CROSS-LINKS PRODUCED BY VARIOUS CHEMICALS IN CULTURED HUMAN LYMPHOMA CELLS

Costa, M., Zhitkovich, A., Harris, M., Paustenbach, D. J., & Gargas, M. L. (1997) · Journal of Toxicology and Environmental Health · doi:10.1080/00984109708984000 · Cited by 100 · see citing works

Formation and genotoxicity of a guanine–cytosine intrastrand cross-link lesion in vivo

Hong, H., Cao, H., & Wang, Y. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm851 · Cited by 100 · see citing works

Radiation-induced formation of purine 5′,8-cyclonucleosides in isolated and cellular DNA: high stereospecificity and modulating effect of oxygen

Belmadoui, N., Boussicault, F., Guerra, M., Ravanat, J., Chatgilialoglu, C., & Cadet, J. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c004531d · Cited by 97 · see citing works

UVA photosensitization of thiopurines and skin cancer in organ transplant recipients

Attard, N. R., & Karran, P. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05194f · Cited by 94 · see citing works

Involvement of Nucleotide Excision and Mismatch Repair Mechanisms in Double Strand Break Repair

Zhang, Y., Rohde, L. H., & Wu, H. (2009) · Current Genomics · doi:10.2174/138920209788488544 · Cited by 93 · see citing works

DNA Tandem Lesions Containing 8-Oxo-7,8-dihydroguanine and Formamido Residues Arise from Intramolecular Addition of Thymine Peroxyl Radical to Guanine

Douki, T., Rivière, J., & Cadet, J. (2002) · Chemical Research in Toxicology · doi:10.1021/tx0155909 · Cited by 90 · see citing works

Synthesis and Characterization of Oligonucleotides Containing 5‘,8-Cyclopurine 2‘-Deoxyribonucleosides: (5‘R)-5‘,8-Cyclo-2‘-deoxyadenosine, (5‘S)-5‘,8-Cyclo-2‘-deoxyguanosine, and (5‘R)-5‘,8-Cyclo-2‘-deoxyguanosine

Romieu, A., Gasparutto, D., & Cadet, J. (1999) · Chemical Research in Toxicology · doi:10.1021/tx9802668 · Cited by 90 · see citing works

The 2-Deoxyribonolactone Lesion Produced in DNA by Neocarzinostatin and Other Damaging Agents Forms Cross-links with the Base-Excision Repair Enzyme Endonuclease III

HASHIMOTO, M. W., Greenberg, M. M., Kow, Y. W., Hwang, J.-T., & Cunningham, R. P. (2001) · Journal of the American Chemical Society · doi:10.1021/ja003354z · Cited by 87 · see citing works

Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5‐Hydroxymethylcytosine, 5‐Formylcytosine and 5‐Carboxylcytosine

Münzel, M., Lischke, U., Stathis, D., Pfaffeneder, T., Gnerlich, F. A., Deiml, C. A., Koch, S. C., Karaghiosoff, K., & Carell, T. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201102782 · Cited by 87 · see citing works

Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines

Crean, C. W., Uvaydov, Y., Geacintov, N. E., & Shafirovich, V. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1092 · Cited by 86 · see citing works

DNA-Protein Cross-link Formation Mediated by Oxanine

Nakano, T., Terato, H., Asagoshi, K., Masaoka, A., Mukuta, M., Ohyama, Y., Suzuki, T., Makino, K., & Ide, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212847200 · Cited by 86 · see citing works

Characterization and Mechanism of Formation of Tandem Lesions in DNA by a Nucleobase Peroxyl Radical

Hong, I. S., Carter, K. N., Sato, K., & Greenberg, M. M. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0692276 · Cited by 81 · see citing works

Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells

Marietta, C. A., & Brooks, P. J. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400932 · Cited by 81 · see citing works

Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into Oligodeoxyribonucleotides

Romieu, A., Gasparutto, D., Molko, D., & Cadet, J. (1998) · The Journal of Organic Chemistry · doi:10.1021/jo980083q · Cited by 80 · see citing works

Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins

Éot-Houllier, G. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki165 · Cited by 79 · see citing works

Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus

Takayanagi, R., Inoguchi, T., & Ohnaka, K. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-014fr · Cited by 78 · see citing works

Radiation induced DNA DSBs: Contribution from stalled replication forks?

Harper, J. V., Anderson, J. A., & O’Neill, P. (2010) · DNA Repair · doi:10.1016/j.dnarep.2010.06.002 · Cited by 78 · see citing works

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage

Eccles, L. J., Lomax, M. E., & O’Neill, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1070 · Cited by 78 · see citing works

Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine

Brem, R., & Karran, P. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.01043.x · Cited by 76 · see citing works

Self-Promoted DNA Interstrand Cross-Link Formation by an Abasic Site

Sczepanski, J. T., Jacobs, A. C., & Greenberg, M. M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8030642 · Cited by 76 · see citing works

All That Glitters Is Not Gold

González-Parra, C., & Simon, J. W. (2008) · American Behavioral Scientist · doi:10.1177/0002764208318930 · Cited by 75 · see citing works

A model of the cell nucleus for DNA damage calculations

Nikjoo, H., & Girard, P. M. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2011.640860 · Cited by 74 · see citing works

A single 8,5′-cyclo-2′-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo

Marietta, C. A., Gulam, H., & Brooks, P. J. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00148-9 · Cited by 74 · see citing works

New Insights into the Reaction Paths of Hydroxyl Radicals with 2′-Deoxyguanosine

Chatgilialoglu, C., D’Angelantonio, M., Kciuk, G., & Bobrowski, K. (2011) · Chemical Research in Toxicology · doi:10.1021/tx2003245 · Cited by 74 · see citing works

Assays for Determining Lesion Bypass Efficiency and Mutagenicity of Site‐Specific DNA Lesions In Vivo

Delaney, J. C., & Essigmann, J. M. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)08001-3 · Cited by 73 · see citing works

Structure and mechanism of hydroxyl radical-induced formation of a DNA-protein cross-link involving thymine and lysine in nucleohistone.

Dizdaroglu, M., & Gajewski, E. (1989) · PubMed · Cited by 73 · see citing works

Induction and Processing of Oxidative Clustered DNA Lesions in56Fe-Ion-Irradiated Human Monocytes

Tsao, D., Kalogerinis, P. T., Tabrizi, I., Dingfelder, M., Stewart, R. D., & Georgakilas, A. G. (2007) · Radiation Research · doi:10.1667/rr0865.1 · Cited by 72 · see citing works

PIG3: A novel link between oxidative stress and DNA damage response in cancer

Kotsinas, A., Aggarwal, V. S., Tan, E., Levy, B., & Gorgoulis, V. G. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.009 · Cited by 71 · see citing works

Scope and Mechanism of Interstrand Cross-Link Formation by the C4′-Oxidized Abasic Site

Sczepanski, J. T., Jacobs, A. C., Majumdar, A. K., & Greenberg, M. M. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903404v · Cited by 69 · see citing works

Free Radical-Induced Double Base Lesions

Box, H. C., Freund, H. G., Budzinski, E. E., Wallace, J. C., & Maccubbin, A. E. (1995) · Radiation Research · doi:10.2307/3579095 · Cited by 67 · see citing works

In Vivo Formation and in Vitro Replication of a Guanine−Thymine Intrastrand Cross-Link Lesion

Jiang, Y., Hong, H., Cao, H., & Wang, Y. (2007) · Biochemistry · doi:10.1021/bi7012195 · Cited by 66 · see citing works

Synthesis and enzymatic processing of oligodeoxynucleotides containing tandem base damage

Bourdat, A.-G. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.4.1015 · Cited by 65 · see citing works

The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells

Kozmin, S. G., Sedletska, Y., Reynaud-Angelin, A., Gasparutto, D., & Sage, É. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp010 · Cited by 64 · see citing works

Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic

Bellon, S., Shikazono, N., Cunniffe, S. M. T., Lomax, M. E., & O’Neill, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp422 · Cited by 63 · see citing works

Type II topoisomerases--inhibitors, repair mechanisms and mutations

Heisig, P. (2009) · Mutagenesis · doi:10.1093/mutage/gep035 · Cited by 63 · see citing works

Selective one-electron oxidation of duplex DNA oligomers: reaction at thymines

Ghosh, A., Joy, A., Schuster, G. B., Douki, T., & Cadet, J. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b717437c · Cited by 62 · see citing works

Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks

Cleaver, J. E., Feeney, L., & Revet, I. (2011) · Cell Cycle · doi:10.4161/cc.10.19.17448 · Cited by 62 · see citing works

High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing

Yuan, B., Wang, J., Cao, H., Sun, R., & Wang, Y. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr159 · Cited by 61 · see citing works

Induction of linear tracks of DNA double-strand breaks by α-particle irradiation of cells

Stap, J., Krawczyk, P. M., van Oven, C. H., Barendsen, G. W., Essers, J., Kanaar, R., & Aten, J. A. (2008) · Nature Methods · doi:10.1038/nmeth.f.206 · Cited by 59 · see citing works

DNA−Protein Cross-Linking from Oxidation of Guanine via the Flash−Quench Technique

Nguyen, K. L., Steryo, M., Kurbanyan, K., Nowitzki, K. M., Butterfield, S. M., Ward, S. R., & Stemp, E. D. A. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993502p · Cited by 59 · see citing works

The Fate of C5′ Radicals of Purine Nucleosides under Oxidative Conditions

Boussicault, F., Kaloudis, P., Caminal, C., Mulazzani, Q. G., & Chatgilialoglu, C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja800763j · Cited by 58 · see citing works

Effects of Duplex Stability on Charge-Transfer Efficiency within DNA

Douki, T., Ravanat, J., Angelov, D., Wagner, J. R., & Cadet, J. (2012) · Topics in current chemistry · doi:10.1007/b94409 · Cited by 57 · see citing works

DNA interstrand cross-links induced by ionizing radiation: An unsung lesion

Dextraze, M.-E., Gantchev, T. G., Girouard, S., & Hunting, D. J. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.12.007 · Cited by 56 · see citing works

Repair of DNA–Protein Cross-links in Mammalian Cells

Reardon, J. T., Cheng, Y., & Sancar, A. (2006) · Cell Cycle · doi:10.4161/cc.5.13.2892 · Cited by 56 · see citing works

Radiation-Induced Formation of a Crosslink between Base Moieties of Deoxyguanosine and Thymidine in Deoxygenated Solutions of d(CpGpTpA)

Box, H. C., Budzinski, E. E., Dawidzik, J. D., Wallace, J. C., Evans, M. S., & Gobey, J. S. (1996) · Radiation Research · doi:10.2307/3579285 · Cited by 56 · see citing works

Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines

Jaruga, P., Xiao, Y., Vartanian, V. L., Lloyd, R. S., & Dizdaroğlu, M. (2010) · Biochemistry · doi:10.1021/bi902161f · Cited by 56 · see citing works

DNA-protein cross-linking between thymine and tyrosine in chromatin of γ-irradiated or H2O2-treated cultured human cells

Oliński, R., Nackerdien, Z. E., & Dizdaroğlu, M. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90651-c · Cited by 55 · see citing works

Mutational Specificity of γ-Radiation-Induced Guanine−Thymine and Thymine−Guanine Intrastrand Cross-Links in Mammalian Cells and Translesion Synthesis Past the Guanine−Thymine Lesion by Human DNA Polymerase η

Colis, L. C., Raychaudhury, P., & Basu, A. (2008) · Biochemistry · doi:10.1021/bi800529f · Cited by 55 · see citing works

Use of near infrared femtosecond lasers as sub-micron radiation microbeam for cell DNA damage and repair studies

Botchway, S. W., Reynolds, P., Parker, A. W., & O'Neill, P. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.003 · Cited by 54 · see citing works

DNA−Protein Cross-Linking via Guanine Oxidation:  Dependence upon Protein and Photosensitizer

Kurbanyan, K., Nguyen, K. L., To, P., Rivas, E. V., Lueras, A. M. K., Kosinski, C., Steryo, M., González, A., Mah, D. A., & Stemp, E. D. A. (2003) · Biochemistry · doi:10.1021/bi020713p · Cited by 53 · see citing works

(5′ S )-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli

Jasti, V. P., Das, R. S., Hilton, B., Weerasooriya, S., Zou, Y., & Basu, A. K. (2011) · Biochemistry · doi:10.1021/bi2004944 · Cited by 52 · see citing works

Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences

Éot-Houllier, G., Gonera, M., Gasparutto, D., Giustranti, C., & Sage, É. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm190 · Cited by 51 · see citing works

Are endogenous clustered dna damages induced in human cells?

Bennett, P. V., Cintron, N. S., Gros, L., Laval, J., & Sutherland, B. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.004 · Cited by 51 · see citing works

LC-MS/MS Identification and Yeast Polymerase η Bypass of a Novel γ-Irradiation-Induced Intrastrand Cross-Link Lesion G[8−5]C

Gu, C., & Wang, Y. (2004) · Biochemistry · doi:10.1021/bi0497749 · Cited by 51 · see citing works

Studies on the Replication of the Ring Opened Formamidopyrimidine, Fapy·dG in Escherichia coli

Patro, J. N., Wiederholt, C. J., Jiang, Y. L., Delaney, J. C., Essigmann, J. M., & Greenberg, M. M. (2007) · Biochemistry · doi:10.1021/bi700628c · Cited by 50 · see citing works

No formation of DNA double-strand breaks and no activation of recombination repair with UVA

Rizzo, J. L., Dunn, J., Rees, A., & Rünger, T. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.365 · Cited by 50 · see citing works

Oxidative Stress and Inducible Nitric Oxide Synthase Induction in Carcinogenesis

Farinati, F., Piciocchi, M., Lavezzo, E., Bortolami, M., & Cardin, R. (2010) · Digestive Diseases · doi:10.1159/000320052 · Cited by 49 · see citing works

Base Damage Immediately Upstream from Double-Strand Break Ends is a More Severe Impediment to Nonhomologous End Joining than Blocked 3′-Termini

Datta, K., Purkayastha, S., Neumann, R. D., Pastwa, E., & Winters, T. A. (2010) · Radiation Research · doi:10.1667/rr2332.1 · Cited by 49 · see citing works

Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation

Brem, R., Daehn, I., & Karran, P. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.05.010 · Cited by 48 · see citing works

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA

Gueranger, Q., Kia, A., Frith, D., & Karran, P. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr112 · Cited by 47 · see citing works

Recognition and Incision of γ-Radiation-Induced Cross-Linked Guanine−Thymine Tandem Lesion G[8,5-Me]T by UvrABC Nuclease

Yang, Z., Colis, L. C., Basu, A. K., & Zou, Y. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050147+ · Cited by 45 · see citing works

Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells

Bennett, P. V., Cuomo, N. L., Paul, S., Tafrov, S. T., & Sutherland, B. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.05.008 · Cited by 45 · see citing works

Repair and replication of oxidized DNA bases using modified oligodeoxyribonucleotides

Gasparutto, D., Bourdat, A.-G., d’Ham, C., Duarte, V., Romieu, A., & Cadet, J. (2000) · Biochimie · doi:10.1016/s0300-9084(00)00347-3 · Cited by 45 · see citing works

Structure of (5′S)-8,5′-Cyclo-2′-deoxyguanosine in DNA

Huang, H., Das, R. S., Basu, A. K., & Stone, M. P. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207407n · Cited by 45 · see citing works

Efficient Formation of the Tandem Thymine Glycol/8-Oxo-7,8-dihydroguanine Lesion in Isolated DNA and the Mutagenic and Cytotoxic Properties of the Tandem Lesions in Escherichia coli Cells

Yuan, B., Jiang, Y., Wang, Y., & Wang, Y. (2009) · Chemical Research in Toxicology · doi:10.1021/tx9004264 · Cited by 44 · see citing works

DNA Interstrand Cross-Link Formation by the 1,4-Dioxobutane Abasic Lesion

Guan, L., & Greenberg, M. M. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9061695 · Cited by 44 · see citing works

Generation of Guanine–Thymidine Cross-Links in DNA by Peroxynitrite/Carbon Dioxide

Yun, B. H., Geacintov, N. E., & Shafirovich, V. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200139c · Cited by 44 · see citing works

Guanine–thymine intrastrand cross-linked lesion containing oligonucleotides: from chemical synthesis to in vitro enzymatic replication

Bellon, S., Gasparutto, D., Saint‐Pierre, C., & Cadet, J. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b609460k · Cited by 43 · see citing works

Recognition and Incision of Oxidative Intrastrand Cross-Link Lesions by UvrABC Nuclease

Gu, C., Zhang, Q., Yang, Z., Wang, Y., Zou, Y., & Wang, Y. (2006) · Biochemistry · doi:10.1021/bi060423z · Cited by 42 · see citing works

Repair of Tandem Base Lesions in DNA by Human Cell Extracts Generates Persisting Single-strand Breaks

Budworth, H., Matthewman, G. E., O’Neill, P., & Dianov, G. L. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.06.069 · Cited by 42 · see citing works

Detection of new radiation‐induced DNA lesions by liquid chromatography coupled to tandem mass spectrometry

Regulus, P., Spessotto, S., Gateau, M., Cadet, J., Favier, A. E., & Ravanat, J. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1612 · Cited by 42 · see citing works

Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by Human and Yeast DNA Polymerase η

Raychaudhury, P., & Basu, A. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/101495 · Cited by 37 · see citing works

Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells

Gentil, A., Page, F. L., Cadet, J., & Sarasin, A. R. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00034-8 · Cited by 33 · see citing works

A method for the isolation of covalent DNA–protein crosslinks suitable for proteomics analysis

Barker, S., Murray, D. L., Zheng, J., Li, L., & Weinfeld, M. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.06.039 · Cited by 33 · see citing works

Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases

Kamiya, H. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.06.003 · Cited by 32 · see citing works

Bistranded Oxidized Purine Damage Clusters: Induced in DNA by Long-Wavelength Ultraviolet (290−400 nm) Radiation?

Song, J. M., Milligan, J. R., & Sutherland, B. M. (2002) · Biochemistry · doi:10.1021/bi020137x · Cited by 30 · see citing works

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks

Mah, L.-J., Orlowski, C., Ververis, K., Vasireddy, R. S., El‐Osta, A., & Karagiannis, T. C. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-3 · Cited by 29 · see citing works

Structural, energetic and dynamic properties of guanine(C8)–thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair

Ding, S., Kropachev, K. Y., Cai, Y., Kolbanovskiy, M., Durandina, S. A., Liu, Z., Shafirovich, V., Broyde, S. B., & Geacintov, N. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1087 · Cited by 28 · see citing works

XPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromate

Zecevic, A., Hagan, E., Reynolds, M., Poage, G. M., Johnston, T., & Zhitkovich, A. (2010) · Mutagenesis · doi:10.1093/mutage/geq017 · Cited by 28 · see citing works

The Radiation Chemistry of d(CpGpTpA) in the Presence of Oxygen

Budzinski, E. E., Dawidzik, J. D., Wallace, J. C., Freund, H. G., & Box, H. C. (1995) · Radiation Research · doi:10.2307/3578973 · Cited by 28 · see citing works

In Vitro Replication and Repair Studies of Tandem Lesions Containing Neighboring Thymidine Glycol and 8-Oxo-7,8-dihydro-2′-deoxyguanosine

Jiang, Y., Wang, Y., & Wang, Y. (2009) · Chemical Research in Toxicology · doi:10.1021/tx8003449 · Cited by 26 · see citing works

Thermodynamic and in Vitro Replication Studies of an Intrastrand G[8-5]C Cross-Link Lesion

Gu, C., & Wang, Y. (2005) · Biochemistry · doi:10.1021/bi050036+ · Cited by 25 · see citing works

Endogenous DNA breaks: γH2AX and the role of telomeres

Olive, P. L. (2009) · Aging · doi:10.18632/aging.100025 · Cited by 22 · see citing works

Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells

Bennett, P. V., Ishchenko, A. A., Laval, J., Paap, B. K., & Sutherland, B. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.007 · Cited by 21 · see citing works

Guanine radical chemistry reveals the effect of thermal fluctuations in gene promoter regions

Cuesta‐López, S., Menoni, H., Angelov, D., & Peyrard, M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr096 · Cited by 21 · see citing works

Probing DNA interstrand cross-link formation by an oxidized abasic site using nonnative nucleotides

Sczepanski, J. T., Hiemstra, C. N., & Greenberg, M. M. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.08.024 · Cited by 20 · see citing works

Vascular-derived reactive oxygen species for homeostasis and diseases

Satoh, K., Berk, B. C., & Shimokawa, H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.04.005 · Cited by 19 · see citing works

The Mutagenicity of Thymidine Glycol in Escherichia coli Is Increased When It Is Part of a Tandem Lesion

Huang, H., Imoto, S., & Greenberg, M. M. (2009) · Biochemistry · doi:10.1021/bi900927d · Cited by 19 · see citing works

Genetic Requirement for Mutagenesis of the G[8,5-Me]T Cross-Link in Escherichia coli : DNA Polymerases IV and V Compete for Error-Prone Bypass

Raychaudhury, P., & Basu, A. K. (2011) · Biochemistry · doi:10.1021/bi102064z · Cited by 19 · see citing works

DNA lesion complexity and induction of apoptosis by ionizing radiation

Radford, I. R. (2002) · International Journal of Radiation Biology · doi:10.1080/09553000110120337 · Cited by 19 · see citing works

The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions

Noguchi, M., Urushibara, A., Yokoya, A., O’Neill, P., & Shikazono, N. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.12.009 · Cited by 18 · see citing works

Solution Study of the NF-κB p50-DNA Complex by UV Laser Protein-DNA Cross-linking¶

Angelov, D., Charra, M., Müller, C. W., Cadet, J., & Dimitrov, S. (2007) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0770592ssotnp2.0.co2 · Cited by 18 · see citing works

Theoretical study of the tandem cross-linkage lesion in DNA

Zhang, R. B., & Eriksson, L. A. (2005) · Chemical Physics Letters · doi:10.1016/j.cplett.2005.10.020 · Cited by 18 · see citing works

Dependence of DNA–Protein Cross-Linking via Guanine Oxidation upon Local DNA Sequence As Studied by Restriction Endonuclease Inhibition

Madison, A. L., Perez, Z. A., To, P., Maisonet, T., Rios, E. V., Trejo, Y., Ochoa-Paniagua, C., Reno, A., & Stemp, E. D. A. (2012) · Biochemistry · doi:10.1021/bi201087q · Cited by 18 · see citing works

Analysis of Base Excision DNA Repair of the Oxidative Lesion 2‐Deoxyribonolactone and the Formation of DNA–Protein Cross‐Links

Sung, J., & Demple, B. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)08004-9 · Cited by 17 · see citing works

Divergent effects of oxidatively induced modification to the C8 of 2′‐deoxyadenosine on transcription factor binding: 8,5′(S)‐cyclo‐2′‐deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8‐oxo‐2′‐deoxyadenosine increases binding of CREB and NF‐kappa B to DNA

Abraham, J., & Brooks, P. J. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20619 · Cited by 12 · see citing works

Oxidatively Generated Nucleobase Modifications in Isolated and Cellular DNA

Cadet, J., Douki, T., Gasparutto, D., Ravanat, J., & Wagner, J. R. (2012) · Wiley eBooks · doi:10.1002/9781119953678.rad038 · Cited by 7 · see citing works

An ancient intron in eubacteria: New light on intron origins

Liu, X. (1991) · BioEssays · doi:10.1002/bies.950130407 · Cited by 2 · see citing works

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039 · see citing works

Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases

Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971 · see citing works

DNA damage and the balance between survival and death in cancer biology

Roos, W. P., Thomas, A. D., & Kaina, B. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.2 · Cited by 1,189 · see citing works

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903 · see citing works

The role of oxidative stress during inflammatory processes

Lugrin, J., Rosenblatt‐Velin, N., Parapanov, R., & Liaudet, L. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0241 · Cited by 742 · see citing works

Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer

Thanan, R., Oikawa, S., Hiraku, Y., Ohnishi, S., Ma, N., Pinlaor, S., Yongvanit, P., Kawanishi, S., & Murata, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010193 · Cited by 459 · see citing works

Formation of UV-induced DNA damage contributing to skin cancer development

Cadet, J., & Douki, T. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00395a · Cited by 435 · see citing works

Sunlight damage to cellular DNA: focus on oxidatively generated lesions

Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works

Photodynamic Therapy: Current Status and Future Directions

Benov, L. (2014) · Medical Principles and Practice · doi:10.1159/000362416 · Cited by 428 · see citing works

Oxidatively Generated Damage to Cellular <scp>DNA</scp> by <scp>UVB</scp> and <scp>UVA</scp>  Radiation ^,

Cadet, J., Douki, T., & Ravanat, J. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12368 · Cited by 355 · see citing works

Formation and repair of oxidatively generated damage in cellular DNA

Cadet, J., Davies, K. J. A., de Medeiros, M. H. G., Mascio, P. D., & Wagner, J. R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.049 · Cited by 356 · see citing works

Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions^†

Cadet, J., Mouret, S., Ravanat, J., & Douki, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01200.x · Cited by 300 · see citing works

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

Georgakilas, A. G., O'Neill, P., & Stewart, R. D. (2013) · Radiation Research · doi:10.1667/rr3041.1 · Cited by 278 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

Introduction to Radiobiology of Targeted Radionuclide Therapy

Pouget, J., Lozza, C., Deshayes, E., Boudousq, V., & Navarro‐Teulon, I. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00012 · Cited by 233 · see citing works

Autophagy and genomic integrity

Vessoni, A. T., Filippi‐Chiela, E. C., Menck, C. F. M., & Lenz, G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.103 · Cited by 210 · see citing works

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Baptista, M. S., Cadet, J., Greer, A., & Thomas, A. H. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13470 · Cited by 205 · see citing works

Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

Nickoloff, J. A., Sharma, N., & Taylor, L. E. (2020) · Genes · doi:10.3390/genes11010099 · Cited by 198 · see citing works

Stress-induced DNA damage biomarkers: applications and limitations

Nikitaki, Z., Hellweg, C. E., Georgakilas, A. G., & Ravanat, J. (2015) · Frontiers in Chemistry · doi:10.3389/fchem.2015.00035 · Cited by 182 · see citing works

Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis

Mavragani, I. V., Nikitaki, Z., Souli, M., Aziz, A., Nowsheen, S., Aziz, K., Rogakou, E. P., & Georgakilas, A. G. (2017) · Cancers · doi:10.3390/cancers9070091 · Cited by 177 · see citing works

Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies

Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Kamal, F. Z., Lefter, R. M., Ali, A., Ech‐Chahad, A., Truş, C., Ciobica, A. S., & Timofte, D. V. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9965916 · Cited by 170 · see citing works

Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: similarities and differences

Cadet, J., & Wagner, J. R. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.001 · Cited by 169 · see citing works

Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid

Poulsen, H. E., Llovera, L., Broedbaek, K., Nielsen, P. E., & Weimann, A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.009 · Cited by 162 · see citing works

Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis

Pouget, J., Georgakilas, A. G., & Ravanat, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7267 · Cited by 160 · see citing works

One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA

Cadet, J., Wagner, J. R., Shafirovich, V., & Geacintov, N. E. (2013) · International Journal of Radiation Biology · doi:10.3109/09553002.2013.877176 · Cited by 152 · see citing works

Oxidative Stress Under Ambient and Physiological Oxygen Tension in Tissue Culture

Jagannathan, L., Cuddapah, S., & Costa, M. (2016) · Current Pharmacology Reports · doi:10.1007/s40495-016-0050-5 · Cited by 150 · see citing works

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

Tornovsky-Babeay, S., Dadon, D., Ziv, O., Tzipilevich, E., Kadosh, T., Schyr, R. B., Hija, A., Stolovich-Rain, M., Furth‐Lavi, J., Granot, Z., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.007 · Cited by 150 · see citing works

Photochemical and Photodynamical Properties of Sulfur‐Substituted Nucleic Acid Bases,

Ashwood, B., Pollum, M., & Crespo‐Hernández, C. E. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12975 · Cited by 149 · see citing works

Association between Oxidative DNA Damage and Risk of Colorectal Cancer: Sensitive Determination of Urinary 8-Hydroxy-2′-deoxyguanosine by UPLC-MS/MS Analysis

Guo, C., Li, X., Wang, R., Yu, J., Ye, M., Mao, L., Zhang, S., & Zheng, S. S. (2016) · Scientific Reports · doi:10.1038/srep32581 · Cited by 145 · see citing works

Metal interaction with redox regulation: an integrating concept in metal carcinogenesis?

Hartwig, A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.009 · Cited by 143 · see citing works

Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Kciuk, M., Alam, M., Ali, N., Rashid, S., Głowacka, P., Rajamanikandan, S., Çeli̇k, İ., Yahya, E. B., Dubey, A., Zerroug, E., et al. (2023) · Molecules · doi:10.3390/molecules28135246 · Cited by 148 · see citing works

Chemistry and biochemistry of cold physical plasma derived reactive species in liquids

Wende, K., von Woedtke, T., Weltmann, K., & Bekeschus, S. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0242 · Cited by 139 · see citing works

Non-homologous end joining: Emerging themes and unanswered questions

Radhakrishnan, S. K., Jette, N., & Lees‐Miller, S. P. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.01.009 · Cited by 131 · see citing works

Targeting DNA repair pathway in cancer: Mechanisms and clinical application

Wang, M., Chen, S., & Ao, D. (2021) · MedComm · doi:10.1002/mco2.103 · Cited by 134 · see citing works

Solar UV Radiation-Induced DNA Bipyrimidine Photoproducts: Formation and Mechanistic Insights

Cadet, J., Grand, A., & Douki, T. (2014) · Topics in current chemistry · doi:10.1007/128_2014_553 · Cited by 130 · see citing works

The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System

Boguszewska, K., Szewczuk, M., Kaźmierczak-Barańska, J., & Karwowski, B. T. (2020) · Molecules · doi:10.3390/molecules25122857 · Cited by 144 · see citing works

DNA Oxidation and Excision Repair Pathways

Lee, T.-H., & Kang, T.-H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236092 · Cited by 116 · see citing works

Model studies of the role of oxygen in the FLASH effect

Favaudon, V., Labarbe, R., & Limoli, C. L. (2021) · Medical Physics · doi:10.1002/mp.15129 · Cited by 101 · see citing works

Contribution of reactive oxygen species to thymineless death in Escherichia coli

Hong, Y., Li, L., Luan, G., Drlica, K., & Zhao, X. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0037-y · Cited by 99 · see citing works

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancerPreprint

Jager, M., Blokzijl, F., Kuijk, E., Bertl, J., Vougioukalaki, M., Janssen, R., Besselink, N. J. M., Boymans, S., de Ligt, J., Pedersen, J. S., et al. (2019) · Genome Research · doi:10.1101/gr.246223.118 · Cited by 94 · see citing works

Spectrum of Radiation-Induced Clustered Non-DSB Damage – A Monte Carlo Track Structure Modeling and Calculations

Watanabe, R., Rahmanian, S., & Nikjoo, H. (2015) · Radiation Research · doi:10.1667/rr13902.1 · Cited by 95 · see citing works

UV and ionizing radiations induced DNA damage, differences and similarities

Ravanat, J.-L., & Douki, T. (2016) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2016.07.007 · Cited by 94 · see citing works

DNA damage as a biological sensor for environmental sunlight

Schuch, A. P., Machado Garcia, C. C., Makita, K., & Menck, C. F. M. (2013) · Photochemical &amp; Photobiological Sciences · doi:10.1039/c3pp00004d · Cited by 90 · see citing works

Research Development on Anti-Microbial and Antioxidant Properties of Camel Milk and Its Role as an Anti-Cancer and Anti-Hepatitis Agent

Khan, M. Z., Xiao, J., Ma, Y., Ma, J., Liu, S., Khan, A. A., Khan, J. M., & Cao, Z. (2021) · Antioxidants · doi:10.3390/antiox10050788 · Cited by 93 · see citing works

Radiation-induced DNA–protein cross-links: Mechanisms and biological significance

Nakano, T., Xu, X., Salem, A. M. H., Shoulkamy, M. I., & Ide, H. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.041 · Cited by 85 · see citing works

NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR

Zhao, Y., He, J., Li, Y., Lv, S., & Cui, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0137-7 · Cited by 84 · see citing works

The shape of the radiation dose response for DNA double-strand break induction and repair

Barnard, S. G. R., Bouffler, S. D., & Rothkamm, K. (2013) · Genome Integrity · doi:10.1186/2041-9414-4-1 · Cited by 83 · see citing works

Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem Cells

Richardson, C., Yan, S., & Vestal, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16022366 · Cited by 81 · see citing works

Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells

Povirk, L. F. (2012) · ISRN Molecular Biology · doi:10.5402/2012/345805 · Cited by 74 · see citing works

Future development of biologically relevant dosimetry

Palmans, H., Rabus, H., Belchior, A., Bug, M. U., Galer, S., Giesen, U., Gonon, G., Gruel, G., Hilgers, G., Moro, D., et al. (2014) · British Journal of Radiology · doi:10.1259/bjr.20140392 · Cited by 69 · see citing works

Nucleosomes Suppress the Formation of Double-strand DNA Breaks during Attempted Base Excision Repair of Clustered Oxidative Damages

Cannan, W. J., Tsang, B. P., Wallace, S. S., & Pederson, D. S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571588 · Cited by 68 · see citing works

Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells in vitro

Liu, X., Wu, R.-Y., Sun, X., Cheng, S., Zhang, R.-Q., Zhang, T., Zhang, X., Zhao, Y. M., Shen, W., & Li, L. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.23898 · Cited by 68 · see citing works

End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

Menon, V., & Povirk, L. F. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.011 · Cited by 67 · see citing works

Targeting DNA Damage Response in the Radio(Chemo)therapy of Non-Small Cell Lung Cancer

Li, L., Zhu, T., Gao, Y., Zheng, W., Wang, C., Xiao, L., Huang, M., Yin, J., Zhou, H., & Liu, Z. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060839 · Cited by 65 · see citing works

Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy

Nakano, T., Akamatsu, K., Tsuda, M., Tujimoto, A., Hirayama, R., Hiromoto, T., Tamada, T., Ide, H., & Shikazono, N. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119132119 · Cited by 63 · see citing works

Oxidized extracellular DNA as a stress signal that may modify response to anticancer therapy

Glebova, K. V., Вейко, Н. Н., Kostyuk, S. V., Izhevskaya, V. L., & Baranova, A. V. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.005 · Cited by 61 · see citing works

Important cellular targets for antimicrobial photodynamic therapy

Awad, M. M., Tovmasyan, A. G., Craik, J. D., Batinic̈‐Haberle, I., & Benov, L. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7632-3 · Cited by 61 · see citing works

The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity

Yu, J., Shi, J., Zhang, Y., Zhang, Y., Huang, Y., Chen, Z., & Yang, J. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.24635 · Cited by 59 · see citing works

Health Risks of Space Exploration: Targeted and Nontargeted Oxidative Injury by High-Charge and High-Energy Particles

Li, M., Gonon, G., Buonanno, M., Autsavapromporn, N., de Toledo, S. M., Pain, D., & Azzam, E. I. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5649 · Cited by 56 · see citing works

Radiation-mediated formation of complex damage to DNA: a chemical aspect overview

Ravanat, J., Breton, J., Douki, T., Gasparutto, D., Grand, A., Rachidi, W., & Sauvaigo, S. (2014) · British Journal of Radiology · doi:10.1259/bjr.20130715 · Cited by 55 · see citing works

Removal of oxidatively generated DNA damage by overlapping repair pathways

Shafirovich, V., & Geacintov, N. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.507 · Cited by 56 · see citing works

Ferulic acid (FA) abrogates γ-radiation induced oxidative stress and DNA damage by up-regulating nuclear translocation of Nrf2 and activation of NHEJ pathway

Das, U. B., Manna, K., Khan, A., Sinha, M., Biswas, S., Sengupta, A., Chakraborty, A., & Dey, S. (2017) · Free Radical Research · doi:10.1080/10715762.2016.1267345 · Cited by 55 · see citing works

Chromatin and the Cellular Response to Particle Radiation-Induced Oxidative and Clustered DNA Damage

Danforth, J. M., Provencher, L., & Goodarzi, A. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.910440 · Cited by 52 · see citing works

Radiation-induced bystander and systemic effects serve as a unifying model system for genotoxic stress responses

Burdak‐Rothkamm, S., & Rothkamm, K. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.08.001 · Cited by 54 · see citing works

TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine

Cadet, J., & Wagner, J. R. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.09.001 · Cited by 50 · see citing works

X-ray Activated Nanoplatforms for Deep Tissue Photodynamic Therapy

Souris, J. S., Leoni, L., Zhang, H. J., Pan, A., Tanios, E., Tsai, H., Balyasnikova, I. V., Bissonnette, M., & Chen, C. (2023) · Nanomaterials · doi:10.3390/nano13040673 · Cited by 45 · see citing works

Very low doses of heavy oxygen ion radiation induce premature ovarian failure

Mishra, B., Ripperdan, R., Ortiz, L., & Luderer, U. (2017) · Reproduction · doi:10.1530/rep-17-0101 · Cited by 44 · see citing works

Radioimmunotherapy for delivery of cytotoxic radioisotopes: current status and challenges

Martins, C. D., Krämer-Marek, G., & Oyen, W. J. G. (2017) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1378180 · Cited by 44 · see citing works

The basic chemistry of exercise-induced DNA oxidation: oxidative damage, redox signaling, and their interplay

Cobley, J. N., Margaritelis, N. V., Morton, J. P., Close, G. L., Nikolaidis, M. G., & Malone, J. K. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00182 · Cited by 43 · see citing works

Glutathione Depletion and Carbon Ion Radiation Potentiate Clustered DNA Lesions, Cell Death and Prevent Chromosomal Changes in Cancer Cells Progeny

Hanot, M., Boivin, A., Malésys, C., Beuve, M., Colliaux, A., Foray, N., Douki, T., Ardail, D., & Rodriguez‐Lafrasse, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044367 · Cited by 43 · see citing works

Charged iron particles, components of space radiation, destroy ovarian follicles

Mishra, B., Ortiz, L., & Luderer, U. (2016) · Human Reproduction · doi:10.1093/humrep/dew126 · Cited by 43 · see citing works

Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases

Talhaoui, I., Matkarimov, B. T., Tchénio, T., Zharkov, D. O., & Saparbaev, M. K. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.040 · Cited by 44 · see citing works

Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: past, present, and future

Hu, M.-L., Pan, Y.-R., Yong, Y.-Y., Liu, Y., Yu, L., Qin, D.-L., Qiao, G., Law, B. Y.-K., Wu, J.-M., Zhou, X.-G., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102078 · Cited by 44 · see citing works

The Triplet State of 6‐thio‐2′‐deoxyguanosine: Intrinsic Properties and Reactivity Toward Molecular Oxygen

Pollum, M., Ortiz‐Rodríguez, L. A., Jockusch, S., & Crespo‐Hernández, C. E. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12563 · Cited by 43 · see citing works

OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect

Hirayama, R., Ito, A., Noguchi, M., Matsumoto, Y., Uzawa, A., Kobashi, G., Okayasu, R., & Furusawa, Y. (2013) · Radiation Research · doi:10.1667/rr13368.1 · Cited by 41 · see citing works

Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue

Berra, C. M., de Oliveira, C. S., Garcia, C. C. M., Rocha, C. R. R., Lerner, L. K., Lima, L. C. D. A., Baptista, M. D. S., & Menck, C. F. M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.026 · Cited by 40 · see citing works

Cardiac Oxidative Stress and the Therapeutic Approaches to the Intake of Antioxidant Supplements and Physical Activity

Valaei, K., Taherkhani, S., Arazi, H., & Suzuki, K. (2021) · Nutrients · doi:10.3390/nu13103483 · Cited by 40 · see citing works

Exercise and Oxidative Damage in Nucleoid DNA Quantified Using Single Cell Gel Electrophoresis: Present and Future Application

Davison, G. W. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00249 · Cited by 38 · see citing works

Urinary Markers of Oxidative Stress in Children with Autism Spectrum Disorder (ASD)

Osredkar, J., Gosar, D., Maček, J., Kumer, K., Fabjan, T., Finderle, P., Šterpin, S., Zupan, M., & Vrhovšek, M. J. (2019) · Antioxidants · doi:10.3390/antiox8060187 · Cited by 39 · see citing works

OECD Series on Adverse Outcome Pathways

OECD (2016) · OECD series on adverse outcome pathways · doi:10.1787/2415170x · Cited by 36 · see citing works

Gastroprotective effect of kefir on ulcer induced in irradiated rats

Fahmy, H. A., & Ismail, A. F. M. (2015) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2015.02.009 · Cited by 35 · see citing works

Early Events in Radiobiology: Isolated and Cluster DNA Damage Induced by Initial Cations and Nonionizing Secondary Electrons

Dong, Y., Liao, H. H., Gao, Y., Cloutier, P., Zheng, Y., & Sanche, L. (2021) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.0c03341 · Cited by 34 · see citing works

XLF/Cernunnos: An important but puzzling participant in the nonhomologous end joining DNA repair pathway

Menon, V., & Povirk, L. F. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.08.003 · Cited by 33 · see citing works

Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells

Wozny, A., Alphonse, G., Cassard, A., Malésys, C., Louati, S., Beuve, M., Lalle, P., Ardail, D., Nakajima, T., & Rodriguez‐Lafrasse, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78354-7 · Cited by 32 · see citing works

Either Non-Homologous Ends Joining or Homologous Recombination Is Required to Repair Double-Strand Breaks in the Genome of Macrophage-Internalized Mycobacterium tuberculosis

Brzostek, A. M., Szulc-Kiełbik, I., Klink, M., Brzezinska, M., Sułowska, Z., & Dziadek, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092799 · Cited by 31 · see citing works

Developmental toxicity and apoptosis in zebrafish embryos induced by low-dose γ-ray irradiation

Zhao, W., Hu, N., Ding, D., Long, D., Li, S., Li, G., & Zhang, H. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3893-y · Cited by 31 · see citing works

Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs

Baiken, Y., Kanayeva, D. A., Taipakova, S., Groisman, R., Ishchenko, A. A., Бегимбетова, Д., Matkarimov, B. T., & Saparbaev, M. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.617884 · Cited by 31 · see citing works

Non-DSB clustered DNA lesions. Does theory colocalize with the experiment?

Nikitaki, Z., Nikolov, V., Mavragani, I. V., Plante, I., Emfietzoglou, D., Iliakis, G. E., & Georgakilas, A. G. (2016) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2016.06.020 · Cited by 31 · see citing works

Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells

de Toledo, S. M., Buonanno, M., Harris, A. L., & Azzam, E. I. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1334980 · Cited by 31 · see citing works

Chromatin associated mechanisms in base excision repair - nucleosome remodeling and DNA transcription, two key players

Menoni, H., Mascio, P. D., Cadet, J., Dimitrov, S. I., & Angelov, D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.026 · Cited by 29 · see citing works

Evolutionary diversity and novelty of DNA repair genes in asexual Bdelloid rotifers

Hecox-Lea, B. J., & Welch, D. B. M. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1288-9 · Cited by 29 · see citing works

Biphotonic Ionization of DNA : From Model Studies to Cell

Cadet, J., Wagner, J. R., & Angelov, D. (2018) · Photochemistry and Photobiology · doi:10.1111/php.13042 · Cited by 29 · see citing works

Oxidized DNA induces an adaptive response in human fibroblasts

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