The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration
Open accessAbstract
Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration downstream of integrin engagement with the extracellular matrix. In this review, we focus on RhoA and Rac1--2 Rho GTPases that are required for efficient adhesion and migration--and describe how specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the extensive crosstalk that exists between them. In particular, we assess the role of GEFs and GAPs in light of recent, unexpected evidence concerning the spatiotemporal relationship between RhoA and Rac1 at the leading edge of migrating cells. Force is increasingly recognized as a key regulator of cell adhesion and we highlight the role of GEFs and GAPs in mechanotransduction, before debating the controversial role of tension in focal adhesion maturation.
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Cites
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The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
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Extracellular matrix and its therapeutic potential for cancer treatment
Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962
Mechanobiology of collective cell behaviours
Ladoux, B., & Mège, R.-M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.98 · Cited by 749
Rho GTPase signaling complexes in cell migration and invasion
Lawson, C. D., & Ridley, A. J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201612069 · Cited by 539
Self-citationGuo, S.-C., Tao, S.-C., Yin, W.-J., Qi, X., Yuan, T., & Zhang, C.-Q. (2017) · Theranostics · doi:10.7150/thno.16803 · Cited by 513
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
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Metadata
- Authors
- Lawson, C. D., & Burridge, K.
- Venue
- Small GTPases
- Publisher
- Informa UK Limited
- Published
- 2014-01
- Volume
- 5
- Issue
- 1
- Pages
- e27958
- ISSN
- 2154-1248 (ISSN-L)
- 2154-1256
- OpenAlex
- W1975829169
- Cited by
- 301
- References
- 132
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
