The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Host innate immune responses to sepsis
Open accessAbstract
The immune response to sepsis can be seen as a pattern recognition receptor-mediated dysregulation of the immune system following pathogen invasion in which a careful balance between inflammatory and anti-inflammatory responses is vital. Invasive infection triggers both pro-inflammatory and anti-inflammatory host responses, the magnitude of which depends on multiple factors, including pathogen virulence, site of infection, host genetics, and comorbidities. Toll-like receptors, the inflammasomes, and other pattern recognition receptors initiate the immune response after recognition of danger signals derived from microorganisms, so-called pathogen-associated molecular patterns or derived from the host, so-called danger-associated molecular patterns. Further dissection of the role of host-pathogen interactions, the cytokine response, the coagulation cascade, and their multidirectional interactions in sepsis should lead toward the development of new therapeutic strategies in sepsis.
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Cites
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“shock proteins, fibrinogen, S100 proteins, hyaluronic acid, and high-mobility group box-1 protein (HMGB-1).(22,23) PPRs can be categorized on the basis of their cellular localization.”
BackgroundLevy, M. M., Dellinger, R. P., Townsend, S. R., Linde-Zwirble, W. T., Marshall, J. C., Bion, J., Schorr, C., Artigas, A., Ramsay, G., Beale, R., et al. (2010) · Intensive Care Medicine · doi:10.1007/s00134-009-1738-3 · Cited by 868
Cited by
The third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250
The immunopathology of sepsis and potential therapeutic targets
van der Poll, T., van de Veerdonk, F. L., Scicluna, B. P., & Netea, M. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.36 · Cited by 1,957
van der Poll, T., Shankar-Hari, M., & Wiersinga, W. J. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.012 · Cited by 1,010
Self-citationThe role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594
Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review
Barichello, T., Generoso, J. S., Singer, M., & Dal-Pizzol, F. (2022) · Critical Care · doi:10.1186/s13054-021-03862-5 · Cited by 462
Metadata
- Authors
- Wiersinga, W. J., Leopold, S. J., Cranendonk, D. R., & van der Poll, T.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-06-17
- Volume
- 5
- Issue
- 1
- Pages
- 36-44
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W1969437137
- Cited by
- 460
- References
- 15
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wiersinga, W. J., Leopold, S. J., Cranendonk, D. R., & van der Poll, T. (2014). Host innate immune responses to sepsis. Virulence. https://doi.org/10.4161/viru.25436
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
