A combined treatment with myo-inositol and monacolin K improve the androgen and lipid profiles of insulin-resistant PCOS patients
Open accessAbstract
Objective: We sought to assess and compare the effects of myo-inositol combined with monacolin k (Group A) versus inositol only (Group B) and metformin (Group C), on the clinical, hormonal, metabolic and lipid profiles of insulin-resistant PCOS patients. Study design: 60 insulin resistant PCOS patients were randomly assigned into three groups. All groups were treated for 6 months with either myo-inositol and monacolin k, inositol only or metformin. Patients clinical, hormonal and metabolic profiles were compared between all groups, and within each group, prior and following the aforementioned treatment. Results: All treatment arms improved patients' clinical, hormonal and metabolic profiles, with a tendency toward better results in patients using the combination of myo-inositol and monacolin k. Conclusion: The combined treatment with the natural products: monacolin K and myo-inositol represents a valid and well tolerated alternative to the common medical therapy, improving the PCOS related symptoms, with minimal side effects.
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One included trial had 3 arms comparing MI + monacolin K to MI alone and also to metformin alone.
“One had 3 arms comparing MI + monacolin K to MI alone and also to metformin alone (39).”
From Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines (2024) · cites this paper as [39]
Twelve included studies used metformin at doses of 1000 mg to 2000 mg daily alone or in combination with FA as a comparator.
“Twelve used metformin at doses of 1000 mg to 2000 mg daily alone or in combination with FA as a comparator (26, 28, 30, 33, 39, 41, 42, 49-54, 56).”
From Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines (2024) · cites this paper as [39]
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- Authors
- Maria Concetta Musacchio, V. D. L.
- Venue
- Journal of Metabolic Syndrome
- Publisher
- OMICS Publishing Group
- Published
- 2013
- Volume
- 02
- Issue
- 02
- ISSN
- 2167-0943 (ISSN-L)
- OpenAlex
- W2131839288
- Cited by
- 19
- References
- 34
- Citations by year
- 2024: 2 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Metabolic Syndrome (publishedVersion, cc-by)
- Use Siena air (University of Siena) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, insulin resistance, myo-inositol, lovastatin, metformin, androgen levels, lipid profile, insulin sensitizers, combination therapy, natural products
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