Low-Load Bench Press Training to Fatigue Results in Muscle Hypertrophy Similar to High-Load Bench Press Training
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The purpose of this study was to determine whether the training responses observed with low-load resistance exercise to volitional fatigue translates into significant muscle hypertrophy, and compare that response to high-load resistance training. Nine previously untrained men (aged 25 [SD 3] years at the beginning of the study, standing height 1.73 [SD 0.07] m, body mass 68.9 [SD 8.1] kg) completed 6-week of high load-resistance training (HL-RT) (75% of one repeti-tion maximal [1RM], 3-sets, 3x/wk) followed by 12 months of detraining. Following this, subjects completed 6 weeks of low load-resistance training (LL-RT) to volitional fatigue (30% 1 RM, 4 sets, 3x/wk). Increases (p 0.05) in magnetic resonance imaging-measured triceps brachii and pectorals major muscle cross-sectional areas were similar for both HL-RT (11.9% and 17.6%, respectively) and LL-RT (9.8% and 21.1%, respectively). In addition, both groups increased (p 0.05) 1RM and maximal elbow extension strength following training; however, the percent increases in 1RM (8.6% vs. 21.0%) and elbow extension strength (6.5% vs. 13.9%) were significantly (p 0.05) lower with LL-RT. Both protocols elicited similar increases in muscle cross-sectional area, however differences were observed in strength. An explanation of the smaller relative increases in strength may be due to the fact that detraining after HL-RT did not cause strength values to return to baseline levels thereby producing smaller changes in strength. In addition, the results may also suggest that the consistent practice of lifting a heavy load is necessary to maximize gains in muscular strength of the trained movement. These results demonstrate that significant muscle hypertrophy can occur without high-load resistance training and suggests that the focus on percentage of external load as the important deciding factor on muscle hypertrophy is too simplistic and inappropriate.
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Significant strength gains in 1RM are routinely observed with the use of low loads (≥20 repetitions per set).
“significant strength gains in this test are routinely observed with the use of low-loads (≥20 repetitions per set) [13,14,15].”
From Loading recommendations for muscle strength, hypertrophy, and local endurance: a re-examination of the repetition continuum. (2021) · cites this paper as [13]
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Progression Models in Resistance Training for Healthy Adults
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181915670 · Cited by 4,332 · cited 2× · see citing works
“Conventional thought is that at least 70% of one’s repetition maximum (1 RM) must be lifted repeatedly to observe a meaningful increase in muscular size [7].”
BackgroundResultSeynnes, O. R., de Boer, M., & Narici, M. V. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00789.2006 · Cited by 660 · cited 1× · see citing works
“[26] observed a 7% increase in quadriceps femoris CSA following 35 days of lower body bilateral knee extensions.”
BackgroundResistance exercise load does not determine training-mediated hypertrophic gains in young men
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2012 · Cited by 627 · see citing works
Burd, N. A., West, D. W. D., Staples, A. W., Atherton, P. J., Baker, J. M., Moore, D. R., Holwerda, A. M., Parise, G., Rennie, M. J., Baker, S. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012033 · Cited by 531 · see citing works
Control of the size of the human muscle mass
Rennie, M. J., Wackerhage, H., Spangenburg, E. E., & Booth, F. W. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.052102.134444 · Cited by 399 · see citing works
Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining
Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., & Gundersen, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913935107 · Cited by 327 · see citing works
West, D. W. D., Burd, N. A., Tang, J. E., Moore, D. R., Staples, A. W., Holwerda, A. M., Baker, S. K., & Phillips, S. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01147.2009 · Cited by 290 · cited 1× · see citing works
“This theory states that, assuming an adequate exercise volume is achieved, the recruitment of FT fibers appears to be the large driving force of skeletal muscle hypertrophy whereas the external load lifted and systemic endogenous hormone elevations may not be as important as previously thought [12,13].”
BackgroundTerzis, G., Georgiadis, G., Stratakos, G., Vogiatzis, I., Kavouras, S., Manta, P., Mascher, H., & Blomstrand, E. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0564-y · Cited by 242 · cited 1× · see citing works
“Furthermore, phosphorylation of this signaling protein has shown to be predictive of skeletal muscle hypertrophy [23].”
BackgroundExercise dosing to retain resistance training adaptations in young and older adults
BICKEL, C. S., CROSS, J. M., & BAMMAN, M. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318207c15d · Cited by 203 · see citing works
Comparison of muscle hypertrophy following 6-month of continuous and periodic strength training
Ogasawara, R., Yasuda, T., Ishii, N., & Abe, T. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2511-9 · Cited by 96 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 22
- M. J. Drummond, C. S. Fry, E. L. Glynn, K. L. Timmer- man, J. M. Dickinson, D. K. Walker, D. M. Gundermann, E. Volpi and B. B. Rasmussen, "Skeletal Muscle Amino Acid Transporter Expression Is Increased in Young and Older Adults Following Resistance Exercise," Journal of Applied Physiology, Vol. 111, No. 1, 2011, pp. 135-142. doi:10.1152/japplphysiol.01408.2010 · DOI · Paper page
- N. A. Burd, R. J. Andrews, D. W. West, J. P. Little, A. J. Cochran, A. J. Hector, J. G. Cashaback, M. J. Gibala, J. R. Potvin, S. K. Baker and S. M. Phillips, "Muscle Time un- der Tension during Resistance Exercise Stimulates Dif- ferential Muscle Protein Sub-Fractional Synthetic Re- sponses in Men," Journal of Physiology, Vol. 590, No. 2, 2012, pp. 351-362.
- G. Adams, "The Molecular Response of Skeletal Muscle to Resistance Training," Deutsche Zeitschrift Sportme- dizin, Vol. 61, No. 3, 2010, pp. 61-67.
- D. Wagner, "Skeletal Muscle Growth: Hypertrophy and Hyperplasia," Strength and Conditioning Journal, Vol. 18, No. 5, 1996, pp. 38-39. doi:10.1519/1073-6840(1996)018<0038:SMGHAH>2.3. CO;2 · DOI
- J. P. Loenneke, C. A. Fahs, J. M. Wilson and M. G. Bem- ben, "Blood Flow Restriction: The Metabolite/Volume Threshold Theory," Medical Hypotheses, Vol. 77, No. 5, 2011, pp. 748-752. doi:10.1016/j.mehy.2011.07.029 · DOI
- S. M. Phillips, "Physiologic and Molecular Bases of Mus- cle Hypertrophy and Atrophy: Impact of Resistance Exer- cise on Human Skeletal Muscle (Protein and Exercise Dose Effects)," Applied Physiology, Nutrition, and Me- tabolism, Vol. 34, No. 3, 2009, pp. 403-410. doi:10.1139/H09-042 · DOI
- J. M. Willardson, "The Application of Training to Failure in Periodized Multiple-Set Resistance Exercise Programs," Journal of Strength and Conditioning Research, Vol. 21, No. 2, 2007, pp. 628-631.
- G. E. Campos, T. J. Luecke, H. K. Wendeln, K. Toma, F. C. Hagerman, T. F. Murray, K. E. Ragg, N. A. Ratamess, W. J. Kraemer and R. S. Staron, "Muscular Adaptations in Response to Three Different Resistance-Training Re- gimens: Specificity of Repetition Maximum Training Zones," European Journal of Applied Physiology, Vol. 88, No. 1-2, 2002, pp. 50-60. doi:10.1007/s00421-002-0681-6 · DOI · Paper page
- B. Leger, R. Cartoni, M. Praz, S. Lamon, O. Deriaz, A. Crettenand, C. Gobelet, P. Rohmer, M. Konzelmann, F. Luthi and A. P. Russell, "Akt Signalling through GSK- 3Beta, mTOR and Foxo1 Is Involved in Human Skeletal Muscle Hypertrophy and Atrophy," Journal of Physiol- ogy, Vol. 576, No. 3, 2006, pp. 923-933. doi:10.1113/jphysiol.2006.116715 · DOI
- D. W. West and S. M. Phillips, "Associations of Exer- cise-Induced Hormone Profiles and Gains in Strength and Hypertrophy in a Large Cohort after Weight Training," European Journal of Applied Physiology, Vol. 112, No. 7, 2012, pp. 2693-2702. doi:10.1007/s00421-011-2246-z · DOI
- V. G. Coffey, Z. Zhong, A. Shield, B. J. Canny, A. V. Chibalin, J. R. Zierath and J. A. Hawley, "Early Signaling Responses to Divergent Exercise Stimuli in Skeletal Mus- cle from Well-Trained Humans," FASEB Journal, Vol. 20, No. 1, 2006, pp. 190-192.
- S. B. Wilkinson, M. A. Tarnopolsky, E. J. Grant, C. E. Correia and S. M. Phillips, "Hypertrophy with Unilateral Resistance Exercise Occurs without Increases in Endo- genous Anabolic Hormone Concentration," European Journal of Applied Physiology, Vol. 98, No. 6, 2006, pp. 546-555. doi:10.1007/s00421-006-0300-z · DOI
- R. Ogasawara, R. S. Thiebaud, J. P. Loenneke and T. Abe, "Time Course for Arm and Chest Muscle Thickness Changes Following Bench Press Training," Interventional Medicine and Applied Science, Vol. 4, No. 4, 2012, pp. 217-220. doi:10.1556/IMAS.4.2012.4.7 · DOI
- P. Kannus, D. Alosa, L. Cook, R. J. Johnson, P. Renstrom, M. Pope, B. Beynnon, K. Yasuda, C. Nichols and M. Kaplan, "Effect of One-Legged Exercise on the Strength, Power and Endurance of the Contralateral Leg. A Ran- domized, Controlled Study Using Isometric and Concen- tric Isokinetic Training," European Journal of Applied Physiology and Occupational Physiology, Vol. 64, No. 2, 1992, pp. 117-126. doi:10.1007/BF00717948 · DOI
- T. Abe, D. V. DeHoyos, M. L. Pollock and L. Garzarella, "Time Course for Strength and Muscle Thickness Changes Following Upper and Lower Body Resistance Training in Men and Women," European Journal of Applied Physi- ology, Vol. 81, No. 3, 2000, pp. 174-180. doi:10.1007/s004210050027 · DOI · Paper page
- T. Yasuda, R. Ogasawara, M. Sakamaki, H. Ozaki, Y. Sato and T. Abe, "Combined Effects of Low-Intensity Blood Flow Restriction Training and High-Intensity Re- sistance Training on Muscle Strength and Size," Euro- pean Journal of Applied Physiology, Vol. 111, No. 10, 2011, pp. 2525-2533. doi:10.1007/s00421-011-1873-8 · DOI
- J. Tannerstedt, W. Apro and E. Blomstrand, "Maximal Lengthening Contractions Induce Different Signaling Re- sponses in the Type I and Type II Fibers of Human Ske- letal Muscle," Journal of Applied Physiology, Vol. 106, No. 4, 2009, pp. 1412-1418. doi:10.1152/japplphysiol.91243.2008 · DOI
- R. Ogasawara, T. Yasuda, M. Sakamaki, H. Ozaki and T. Abe, "Effects of Periodic and Continued Resistance Training on Muscle CSA and Strength in Previously Un- trained Men," Clinical Physiology and Functional Imag- ing, Vol. 31, No. 5, 2011, pp. 399-404. doi:10.1111/j.1475-097X.2011.01031.x · DOI
- T. Yasuda, R. Ogasawara, M. Sakamaki, M. G. Bemben and T. Abe, "Relationship between Limb and Trunk Mus- cle Hypertrophy Following High-Intensity Resistance Training and Blood Flow-Restricted Low-Intensity Resis- tance Training," Clinical Physiology and Functional Im- aging, Vol. 31, No. 5, 2011, pp. 347-351. doi:10.1111/j.1475-097X.2011.01022.x · DOI
- R. S. Staron, M. J. Leonardi, D. L. Karapondo, E. S. Ma- licky, J. E. Falkel, F. C. Hagerman and R. S. Hikida, "Strength and Skeletal Muscle Adaptations in Heavy- Resistance-Trained Women after Detraining and Retrain- ing," Journal of Applied Physiology, Vol. 70, No. 2, 1991, pp. 631-640.
- K. Smith, K. Winegard, A. L. Hicks and N. McCartney, "Two Years of Resistance Training in Older Men and Women: The Effects of Three Years of Detraining on the Retention of Dynamic Strength," Canadian Journal of Applied Physiology, Vol. 28, No. 3, 2003, pp. 462-474. doi:10.1139/h03-034 · DOI
- C. Del Balso and E. Cafarelli, "Adaptations in the Activa- tion of Human Skeletal Muscle Induced by Short-Term Isometric Resistance Training," Journal of Applied Physi- ology, Vol. 103, No. 1, 2007, pp. 402-411. doi:10.1152/japplphysiol.00477.2006 · DOI · Paper page
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- Authors
- Ogasawara, R., Loenneke, J. P., Thiebaud, R. S., & Abe, T.
- Affiliations
- Ritsumeikan University (JP)
- University of Oklahoma (US)
- University of Mississippi (US)
- Corresponding author
- Abe, Takashi
- Venue
- International Journal of Clinical Medicine
- Publisher
- Scientific Research Publishing, Inc.
- Published
- 2013
- Volume
- 04
- Issue
- 02
- Pages
- 114-121
- ISSN
- 2158-284X (ISSN-L)
- 2158-2882
- OpenAlex
- W2015920222
- Cited by
- 139
- References
- 10
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 12 · 2019: 18 · 2018: 10 · 2017: 19 · 2016: 15 · 2015: 11 · 2014: 8 · 2013: 6
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- International Journal of Clinical Medicine (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- low-load resistance training, high-load resistance training, muscle hypertrophy, bench press, volitional fatigue, detraining, one-repetition maximum, muscle strength, muscle cross-sectional area, triceps brachii, pectoralis major
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