Malaria placentaria submicroscópica: Histopatología y expresión de mediadores de procesos fisiológicos
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OBJETIVES: To relate histopathological events of placental malaria (PM), immune cell behavior and gene expression associated with cytokines, hypoxia, inflammation and angiogenesis in placentas with or without plasmodial infection. MATERIALS AND METHODS: Transversal design, with three independent groups. Women were recruited, and their placentas were collected in 2009-2016, in the hospitals of Puerto Libertador and Tierralta, northwestern Colombia. The sample size was defined by convenience. The malaria diagnosis was based on real-time quantitative PCR. RESULTS: We studied 20 cases of PM by P. vivax (PM-V), 20 cases of PM by P. falciparum (PM-F) and 19 without PM; 95% of the cases of PM are submicroscopic placental plasmodial infection (SPPI). The three groups differ in frequency and number of histopathological events. Physiological process mediators showed significant difference between groups, except IL-2, VEGF, VEGFR-1 and C5a. CONCLUSIONS: Infected placentas are clearly different from uninfected ones. P. vivax behaves as pathogenic as P. falciparum. The approximation to the integral approach of the problem of PM is underlined. Submicroscopic placental plasmodial infection causes tissue and physiological mediator alterations as does microscopic infection, although probably to a lesser degree.
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The similar proportion of P. vivax and P. falciparum in PM would contradict several assumptions about P. vivax's lower capacity for clinical damage.
“the similar proportion of P. vivax and P. falciparum in PM would contradict several assumptions about P. vivax’s lower capacity for clinical damage [20,21,22,48]”
From Diagnostic Accuracy of a Thick Blood Smear Compared to qPCR for Malaria Associated with Pregnancy in Colombia (2023) · cites this paper as [21]
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- Authors
- López-Guzmán, C., & Carmona-Fonseca, J.
- Affiliations
- Universidad de Antioquia (CO)
- Venue
- Revista Peruana de Medicina Experimental y Salud Pública
- Publisher
- Instituto Nacional de Salud (Peru)
- Published
- 2020-06-17
- Volume
- 37
- Issue
- 2
- Pages
- 220-8
- ISSN
- 1726-4634 (ISSN-L)
- 1726-4642
- OpenAlex
- W3038926902
- Cited by
- 15
- References
- 21
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1 · 2022: 5 · 2021: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- es
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Revista Peruana de Medicina Experimental y Salud Pública (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- placental malaria, Plasmodium vivax, Plasmodium falciparum, placental pathology, cytokine gene expression, vascular endothelial growth factor, VEGFR1, C5a, interleukin-2, hypoxia, inflammation, angiogenesis, placental immunity
- MeSH terms
- Colombia, Female, Humans, Malaria, Physiological Phenomena, Placenta, Pregnancy, Malaria, Falciparum
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