Microfluidic Organ-Chips and Infectious Diseases: Insights from the Development and Applications Perspective
Open accessAbstract
Artificial human organs or organ-on-chip technologies have rapidly evolved as a powerful tool for clinical diagnostics and drug discovery.Organ-on-chips, engineered microfluidic cell culture devices, reconstitute the microarchitecture and functions of living human organs by essentially mimicking the three-dimensional (3D) cross-sections of their major smallest functional units.The development of biomimetic microfluidic systems provided a bridge between the gap of in vitro and in vivo models by accommodating human cells in physiologically relevant microenvironments to accurately design and mimic the in vivo niche.Organ-on-chip technology is currently considered the most advanced model to recapitulate human physiology and pathophysiology with the possibility of using patient-specific cells.The implementation of new features such as the mechanical forces, blood flow, incorporation of immune cells with constant flow and the microbiome component represent a major step toward providing a window to the innerworkings of human cells and tissues.Currently, the most advanced organ-chip models include lung, intestine, kidney, liver, skin and blood-brain barrier.There are several applications of organ-chips including clinical diagnostics, drug discovery, drug delivery, biomarker discovery and disease modeling.Infectious disease research is an emerging field of organon-chip platforms.Investigations of bacterial, viral and parasitic pathogens and their interactions with host tissue in human-relevant systems hold the potential to drive novel advances in the biomedical field.
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Liver transplantation faces a shortage of organ donors, immune rejection, and high costs.
“While liver transplantation and pharmacological treatments are the primary therapeutic options, liver transplantation faces several obstacles, including a shortage of organ donors, immune rejection, and the high costs associated with the procedure [16–19].”
From Constructing biomimetic microenvironments for liver regeneration (2025) · cites this paper as [16]
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Cited by
Sorted by citations
- Authors
- Baddal, B.
- Affiliations
- Near East University (CY)
- Corresponding author
- Baddal, Buket
- ORCID
- Baddal, Buket
- Venue
- Cyprus Journal of Medical Sciences
- Publisher
- Galenos Yayinevi
- Published
- 2022-03-17
- Volume
- 7
- Issue
- 7
- Pages
- 1-8
- ISSN
- 2149-7893 (ISSN-L)
- 2536-507X
- OpenAlex
- W4220895020
- Cited by
- 6
- References
- 48
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Cyprus Journal of Medical Sciences (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, infectious diseases, microfluidic cell culture, biomimetic systems, disease modeling, drug discovery, clinical diagnostics, blood-brain barrier, microbiome, host-pathogen interaction
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