Flat and microstructured polymeric membranes in organs-on-chips

Matrix elasticity directs stem cell lineage specification

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Reconstituting organ-level lung functions on a chip

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From 3D cell culture to organs-on-chips

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Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

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Mediation of biomaterial-cell interactions by adsorbed proteins: a review

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PDMS absorption of small molecules and consequences in microfluidic applications

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A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

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Interplay of matrix stiffness and protein tethering in stem cell differentiation

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Emergent patterns of growth controlled by multicellular form and mechanics

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Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

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Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

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Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds

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Microfabrication meets microbiology

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Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

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Microfabrication of human organs-on-chips

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Microengineered physiological biomimicry: Organs-on-Chips

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Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening

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The effect of geometry on three-dimensional tissue growth

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Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients

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Small molecule absorption by PDMS in the context of drug response bioassays

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Interaction of Different Types of Cells on Polymer Surfaces with Wettability Gradient

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A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

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Effect of Surface Wettability and Topography on the Adhesion of Osteosarcoma Cells on Plasma-modified Polystyrene

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Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition

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Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

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One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

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Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

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Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

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A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

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Controlling the porosity of fibrous scaffolds by modulating the fiber diameter and packing density

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Increasing the Pore Size of Electrospun Scaffolds

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Placenta-on-a-chip: a novel platform to study the biology of the human placenta

Lee, J. S., Romero, R. J., Han, Y. M., Kim, H. C., Kim, C. J., Hong, J., & Huh, D. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1038518 · Cited by 272 · see citing works

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

Maoz, B. M., Herland, A., Henry, O. Y. F., Leineweber, W. D., Yadid, M., Doyle, J., Mannix, R., Kujala, V. J., FitzGerald, E. A., Parker, K. K., et al. (2017) · Lab on a Chip · doi:10.1039/c7lc00412e · Cited by 266 · see citing works

Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers

Shin, S. R., Zhang, Y. S., Kim, D. J., Manbohi, A., Avcı, H., Silvestri, A., Aleman, J., Hu, N., Kiliç, T., Keung, W., et al. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02028 · Cited by 234 · see citing works

Microfluidic gut-on-a-chip with three-dimensional villi structure

Shim, K.-Y., Lee, D., Han, J., Nguyen, N.-T., Park, S., & Sung, J. H. (2017) · Biomedical Microdevices · doi:10.1007/s10544-017-0179-y · Cited by 229 · see citing works

Micro-well arrays for 3D shape control and high resolution analysis of single cells

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Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

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The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

Marzorati, M., Vanhoecke, B. W. A., Ryck, T. D., Sadabad, M. S., Pinheiro, I., Possemiers, S., den Abbeele, P. V., Derycke, L., Bracke, M., Pieters, J., et al. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-133 · Cited by 208 · see citing works

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

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Interfacial geometry dictates cancer cell tumorigenicity

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Copolymers of trimethylene carbonate and ε-caprolactone for porous nerve guides: Synthesis and properties

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Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

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Cell-extracellular matrix interaction and physico-chemical characteristics of titanium surfaces depend on the roughness of the material

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Liver sinusoid on a chip: Long‐term layered co‐culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

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One-step fabrication of porous micropatterned scaffolds to control cell behavior

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Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

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Fabrication of a transparent superamphiphobic coating with improved stability

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Direct quantification of transendothelial electrical resistance in organs-on-chips

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Phase Separation Micromolding: A New Generic Approach for Microstructuring Various Materials

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Construction of 3D multicellular microfluidic chip for an in vitro skin model

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Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device

Gao, D., Liu, H., Lin, J.-M., Wang, Y., & Jiang, Y. (2013) · Lab on a Chip · doi:10.1039/c2lc41215b · Cited by 135 · see citing works

Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications

Sticker, D., Rothbauer, M., Lechner, S., Hehenberger, M.-T., & Ertl, P. (2015) · Lab on a Chip · doi:10.1039/c5lc01028d · Cited by 130 · see citing works

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

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A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model

Lee, H., Kim, D. S., Ha, S. K., Choi, I., Lee, J. M., & Sung, J. H. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26087 · Cited by 126 · see citing works

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

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3D tissue culture substrates produced by microthermoforming of pre-processed polymer films

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Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function

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WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

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Interaction of fibroblasts on polycarbonate membrane surfaces with different micropore sizes and hydrophilicity

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Surface modification of poly(lactic acid) by UV/Ozone irradiation

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Polymeric microsieves produced by phase separation micromolding

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Flexible fluidic microchips based on thermoformed and locally modified thin polymer films

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Microimpedance tomography system to monitor cell activity and membrane movements in a breathing lung-on-chip

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Enzyme-Catalyzed Synthesis of Hyperbranched Aliphatic Polyesters

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A microfluidic circulatory system integrated with capillary-assisted pressure sensors

Chen, Y., Chan, H. N., Michael, S. A., Shen, Y., Chen, Y., Tian, Q., Huang, L., & Wu, H. (2017) · Lab on a Chip · doi:10.1039/c6lc01427e · Cited by 82 · see citing works

Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters

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Analysis of high-throughput screening reveals the effect of surface topographies on cellular morphology

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Characterization of In Vitro Endothelial Linings Grown Within Microfluidic Channels

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Nanobionics: the impact of nanotechnology on implantable medical bionic devices

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Membrane Pore Spacing Can Modulate Endothelial Cell–Substrate and Cell–Cell Interactions

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Microwell Scaffolds for the Extrahepatic Transplantation of Islets of Langerhans

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Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells

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A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation

Punde, T. H., Wu, W., Lien, P.-C., Chang, Y., Kuo, P.-H., Chang, M. D., Lee, K., Huang, C., Kuo, H., Chan, Y.-F., et al. (2014) · Integrative Biology · doi:10.1039/c4ib00239c · Cited by 63 · see citing works

3D-templated, fully automated microfluidic input/output multiplexer for endocrine tissue culture and secretion sampling

Li, X., Brooks, J. C., Hu, J., Ford, K. I., & Easley, C. J. (2016) · Lab on a Chip · doi:10.1039/c6lc01201a · Cited by 63 · see citing works

Integrated microfluidic system for cell co-culture and simulation of drug metabolism

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Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip

Li, Z., Guo, Y., Yu, Y., Xu, C., Xu, H. M., & Qin, J. (2016) · Integrative Biology · doi:10.1039/c6ib00162a · Cited by 53 · see citing works

Cell sheet mechanics: How geometrical constraints induce the detachment of cell sheets from concave surfaces

Yamashita, T., Kollmannsberger, P., Mawatari, K., Kitamori, T., & Viola Vogel, B. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.08.044 · Cited by 52 · see citing works

Microdroplet chain array for cell migration assays

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Engineering the Microstructure of Electrospun Fibrous Scaffolds by Microtopography

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Water Contact Angles on Poly(ethylene terephthalate) Film Exposed to Atmospheric Pressure Plasma

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A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces

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Single-cell measurement of red blood cell oxygen affinity

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Microfabricated porous SU-8 membranes as innervation interfaces for hiPSC-neurons in microfluidic devices

Salpavaara, T., Joki, T., Skogberg, A., Calejo, M. T., Lekkala, J. O., Narkilahti, S., & Kallio, P. J. (2021) · Journal of Physics Communications · doi:10.1088/2399-6528/ac314d · Cited by 6 · see citing works

Reducing Inert Materials for Optimal Cell–Cell and Cell–Matrix Interactions within Microphysiological Systems

Olaizola‐Rodrigo, C., Castro-Abril, H. A., Perisé-Badía, I., Pancorbo, L., Ochoa, I., Monge, R., & Oliván, S. (2024) · Biomimetics · doi:10.3390/biomimetics9050262 · Cited by 5 · see citing works

Simple-Flow: A 3D-Printed Multiwell Flow Plate to Coculture Primary Human Lung Cells at the Air–Liquid Interface

Iriondo, C., Koornneef, S., Skarp, K., Kempen, M. B., Munck, A. B., & Rottier, R. J. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01322 · Cited by 5 · see citing works

Track‐Etched Membranes for Drug Pharmaceutical Research

Cuanalo-Contreras, K., Hogrebe, A. M. R., Teichmann, K., & Benkmann, D. (2023) · Chemie Ingenieur Technik · doi:10.1002/cite.202300089 · Cited by 5 · see citing works

A flexible strategy to fabricate trumpet-shaped porous PDMS membranes for organ-on-chip application

Xie, Y., Guo, Y., Xie, F., Dong, Y., Zhang, X., Li, X., & Zhang, X. (2024) · Biomicrofluidics · doi:10.1063/5.0227148 · Cited by 4 · see citing works

Skin-on-Chip

Chaturvedi, D., Mukherjee, S., Sawant, P., Jain, P. D., & Majumder, A. (2022) · Springer eBooks · doi:10.1007/978-981-19-1379-2_22 · Cited by 4 · see citing works

Fabrication of Ultra-Thin Micro-Porous PDMS Membrane for Cell Co-Culture in Blood Brain Barrier Model on Chip

Zheng, F., Li, Q., Yang, P., Qiu, S., Mao, H., & Zhao, J. (2021) · International Conference on Solid-State Sensors, Actuators and Microsystems · doi:10.1109/transducers50396.2021.9495546 · Cited by 4 · see citing works

Two-dimensional cell culturing on glass and plastic: the past, the present, and the future

Malakpour‐Permlid, A., & Oredsson, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90871-9.00008-5 · Cited by 3 · see citing works

Lung-on-a-Chip

Poojary, B. (2022) · Springer eBooks · doi:10.1007/978-981-19-1379-2_20 · Cited by 2 · see citing works

Development of Human-on-a-Chip

Jacob, E. M., Borah, A., & Kumar, D. S. (2022) · Springer eBooks · doi:10.1007/978-981-19-1379-2_12 · Cited by 2 · see citing works

Collagen-Based Gut-on-Chip for in vitro modeling of intestinal barrier function and host-pathogen interactionsPreprint

García, F. L., Leng, J., Oliveira, H., Nassoy, P., & Dementhon, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.24.655930 · Cited by 2 · see citing works

PVA‐co‐PAMPS Membranes with Selective Anticancer Activity and Metabolic Stimulation of Healthy Cells

Varguez‐Catzim, P., González‐Díaz, M. O., Claudio‐Rizo, J. A., León‐Campos, M. I., Huhn‐Ibarra, M., & Aguilar-Vega, M. J. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500178 · Cited by 1 · see citing works

Skin-on-chip: Quo vadis?

Răileanu, M., Tihăuan, B.-M., Lixandru-Petre, I.-O., Gheorghiu, G.-L., Pîrcălăbioru, G. G., Cioca, G., Iliescu, F. S., & Iliescu, C. (2025) · APL Bioengineering · doi:10.1063/5.0268706 · Cited by 1 · see citing works

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

Sathe, T., & Bodas, D. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500078 · Cited by 1 · see citing works

Applications of Nanofiber Membranes in Microphysiological Systems

Kanabekova, P., Martin, A., Kemelbekova, A., & Kulsharova, G. (2022) · Bulletin of the Karaganda University Chemistry series · doi:10.31489/2022ch3/3-22-12 · Cited by 1 · see citing works

Honeycomb pattern formation on poly(vinyl chloride) films: electrically-driven microparticle trapping and the effect of drying temperature

Budlayan, M. L. M., Patricio, J. N., Yap, G., Gayosa, J. J. A., Arco, S. D., Diaz, J. M. A., & Guerrero, R. A. (2023) · Materials Research Express · doi:10.1088/2053-1591/acefb1 · Cited by 1 · see citing works

Fabrication and characterization of CMOS-compatible perforated micromembranes for biomedical applications

Brechmann, N., Michel, M. D., Bola, A., Renz, F., Pickhinke, A., & Seidl, K. (2023) · Current Directions in Biomedical Engineering · doi:10.1515/cdbme-2023-1110 · Cited by 1 · see citing works

A Human Cornea-on-A-Chip for the Study of Epithelial Wound Healing by Extracellular VesiclesPreprint

Yu, Z., Hao, R., Du, J., Wu, X., Chen, X., Zhang, P. Y., Li, W. S., Gu, Z., & Yang, H. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3899430 · Cited by 1 · see citing works

Organ on Chip Development for The Improvement of New Smart Cancer Therapeutic Carriers Study

Alem, H. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.23.003841

Micro-structured membrane as a 3D biodegradable scaffold: development, characterization and cell-matrix interaction

Das, P. (2018) · doi:10.3990/1.159058878

Poly(trimethylene carbonate)-based membranes for biomimetic lung epithelial-endothelial models

Pasman, T. (2021) · doi:10.3990/1.9789036552288

Breathing life into in vitro models

Baptista, D. (2023) · doi:10.26481/dis.20231003db

Technology for organ-on-chip applications

Ramón‐Azcón, J., Grochala, D., Paleczek, A., & Rydosz, A. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15384-6.00006-9

Tissue-based models for ocular permeability studies

Agarwal, P., & Rupenthal, I. D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15510-9.00006-2

Organ-on-chip models for other mucosal permeability studies

Pereira, C. L., & Sarmento, B. F. C. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15510-9.00010-4

A bovine oviduct microfluidic platform to evaluate the effects of cisplatin and hormones on cilia beating frequencies

Bustillo-Perez, B. M., Escobedo, C., & Wells, L. A. (2024) · Materials Today Communications · doi:10.1016/j.mtcomm.2024.109985

A breast Duct-on-Chip model for emulating invasive ductal carcinoma and testing therapiesPreprint

Jouybar, M., & den Toonder, J. M. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.24.655087

Micro-structured membrane as a 3D biodegradable scaffold : development, characterization and cell-matrix interaction

Das, P. (2018) · doi:10.70675/6e3a943ezc9e3z4439zb4adzf8bdaa9ba833

Scalable microfluidic blood oxygenator with compliant membrane for improved performance

Calzuola, S. T. (2024) · doi:10.70675/ba5166b4ze915z4b43zb98fz2b278bb6ee65

Multi-step femtosecond laser-fabricated membranes for regulated migration of biomolecules and cellsPreprint

Gopalakrishnan, A., Denduluri, A. J., Gallegos, S., Ramirez, I., Schneider, S. E., Çetınkaya, Z., Kabutz, H., Hedrick, A., Jayaram, K., Neu, C. P., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.22.726371

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

García, F. L., Leng, J., Oliveira, H., Nassoy, P., & Dementhon, K. (2026) · Advanced Materials Technologies · doi:10.1002/admt.71187

Membrane-Integrated Organ-on-a-Chip Systems

Kali, M., Rakhymzhanov, A., & Kulsharova, G. (2026) · Biosensors · doi:10.3390/bios16100534

Polymeric and biological membranes for organ-on-a-chip devices

Corral-Nájera, K., Chauhan, G., Serna-Saldivar, S. O., Martinez-Chapa, S. O., & Aeinehvand, M. M. (2023) · Microsystems & Nanoengineering · doi:10.1038/s41378-023-00579-z · Cited by 90 · see citing works

Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance

Das, P., van der Meer, A. D., Vivas, A., Arık, Y. B., Remigy, J., Lahitte, J., Lammertink, R. G. H., & Bacchin, P. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0021 · Cited by 12 · see citing works

Basement membrane properties and their recapitulation in organ-on-chip applications

Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100301 · Cited by 57 · see citing works

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

Sathe, T., & Bodas, D. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500078 · Cited by 1 · see citing works

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arık, Y. B., Silvestri, C., van Engeland, N. C. A., van der Meer, A. D., Passier, R. C., Sahlgren, C., Bouten, C. V. C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31912-6 · Cited by 104 · see citing works