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Cited by 13Schizophrenia research and treatmentMental Health and PsychiatryDementia and Cognitive Impairment Research

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Cognitive factors for predicting treatment response in schizophrenic patients: one-year follow-up study.

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Kim, Yong-Ku, Lee, Ae-Ra, Hur, Ji-Won, Yoon, Ho-Kyung, Lee, Bun-Hee, Ko, Young-Hoon·2008·Psychiatry Investigation
DOI 10.4306/pi.2008.5.2.106PMC PMC2796015
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Abstract

OBJECTIVE: This study was conducted to investigate the cognitive factors that can longitudinally predict the response to treatment in patients with schizophrenia. METHODS: The subjects were 49 patients with schizophrenia who were newly hospitalized in an acute psychiatry ward and had not been treated with medication for at least 8 weeks prior to the study. The symptoms and cognitive functions of the patients were evaluated at baseline before treatment (T0), at eight weeks after treatment (T1), and one year after treatment (T2). Clinical symptoms were assessed using the PANSS, and cognitive functions were estimated using the Vigilance Test, Cognitrone Test, Wisconsin Card Sorting Test (WCST), and the Korean version of the Memory Assessment Scales (K-MAS). RESULTS: The patient group showed marked impairments in cognitive function when compared to the normal group, but the patients' clinical symptoms and cognitive functions improved after drug treatment. The patients also showed consistent improvement in verbal and nonverbal memory function as time progressed. Furthermore, there was a significant correlation between clinical symptoms and cognitive functions in the patient group. The cognitive variables that best predicted treatment response and prognosis were total errors on the WCST and immediate list recall component of the K-MAS. It was also shown that the number of total errors on the WCST was a better cognitive predictor than the number of errors in immediate recall. CONCLUSION: The results of the present study show that the neurocognitive functions of patients with schizophrenia can be stabilized with treatment intervention, that treatment response is related to improvement in cognitive function, and that cognitive domains, especially executive function, can predict treatment response and prognosis in patients with schizophrenia.

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Metadata

Authors
Kim, Y.-K., Lee, A.-R., Hur, J.-W., Yoon, H.-K., Lee, B.-H., & Ko, Y.-H.
Affiliations
Korea University Ansan Hospital (KR)
Corresponding author
Kim, Yong-Ku
ORCID
Venue
Psychiatry Investigation
Publisher
Korean Neuropsychiatric Association
Published
2008
Volume
5
Issue
2
Pages
106
ISSN
1738-3684 (ISSN-L)
DOI
10.4306/pi.2008.5.2.106
PMC
PMC2796015
OpenAlex
W2108913387
Cited by
13
References
50
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychiatry Investigation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Korea Institute of Science and Technology
  • Korea Institute of Science and Technology Information
  • Ministry of Education and Human Resources Development
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
schizophrenia, cognitive function, treatment response prediction, prognosis, executive function, verbal memory, nonverbal memory, Wisconsin Card Sorting Test, antipsychotic drugs

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