Effect of Methylphenidate on Sleep Parameters in Children with ADHD
Open accessAbstract
OBJECTIVE: The primary aim of this study was to investigate the acute impact of methylphenidate (MPH) on sleep parameters in attention-deficit/hyperactivity disorder (ADHD) children. The second aim was to investigate the different effects of intermediate- and longacting MPH on sleep parameters. The third aim was to test the different effects of dose and age on sleep parameters. METHODS: Ninety-three ADHD children were enrolled and randomized to two different MPH preparations. Baseline and daily sleep diaries were evaluated for four weeks after taking medication. Weekday and weekend bedtimes, wake-up times, sleep latencies and total sleep times were compared by weeks. RESULTS: After taking MPH, there was a significant delay in bedtimes and a significant reduction of total sleep time (TST) both on weekdays and at weekends. There was also a significant delay in wake-up time on weekdays. However, the difference was applied to younger age group children only. There was no difference in changes of TST between metadate-CD and OROS-MPH. There also was no difference in changes of TST with different doses of MPH. CONCLUSION: MPH had negative impacts on sleep among young ADHD children, but different preparations and doses did not affect the result.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a randomized study in children with ADHD, both OROS-MPH and another extended-release methylphenidate formulation led to statistically significant reductions in total sleep time 1-4 weeks after initiation of treatment, based on parental sleep diaries.
“Based on parental sleep diaries, both OROS-MPH and another extended-release methylphenidate formulation led to statistically significant reductions in total sleep time 1–4 weeks after initiation of treatment in a randomized study in children with ADHD (Lee et al. 2012).”
From Associations of sleep disturbance with ADHD: implications for treatment (2015) · cites this paper as Lee et al. 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148 · see citing works
Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,683 · see citing works
Dulcan, M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199710001-00007 · Cited by 628 · see citing works
Pelham, W. E., Gnagy, E. M., Burrows-Maclean, L., Williams, A., Fabiano, G. A., Morrisey, S. M., Chronis, A. M., Forehand, G. L., Nguyen, C. A., Hoffman, M. T., et al. (2001) · Pediatrics · doi:10.1542/peds.107.6.e105 · Cited by 378 · see citing works
Kim, Y. S., Cheon, K.-A. A., Kim, B., Chang, S. A., Yoo, H. J., Kim, J., Cho, S. C., Seo, D. H., Bae, M. O., So, Y. K., et al. (2004) · Yonsei Medical Journal · doi:10.3349/ymj.2004.45.1.81 · Cited by 354 · see citing works
Fallone, G., Acebo, C., Arnedt, J. T., Seifer, R., & Carskadon, M. A. (2001) · Perceptual and Motor Skills · doi:10.2466/pms.2001.93.1.213 · Cited by 305 · see citing works
Effects of Atomoxetine and Methylphenidate on Sleep in Children With ADHD
Sangal, R. B., Owens, J., Allen, A. J., Sutton, V., Schuh, K., & Kelsey, D. (2006) · Sleep · doi:10.1093/sleep/29.12.1573 · Cited by 214 · see citing works
Unravelling Sleep Problems in Treated and Untreated Children with ADHD
Stein, M. A. (1999) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.1999.9.157 · Cited by 163 · see citing works
Prevalence of Sleep Problems in Hong Kong Primary School Children
Ng, D. K., Kwok, K., Cheung, J. M. Y., Leung, S.-Y., Chow, P.-Y., Wong, W. H. S., Chan, C., & Ho, J. C. (2005) · CHEST Journal · doi:10.1378/chest.128.3.1315 · Cited by 129 · see citing works
Modi, N. B., Lindemulder, B., & Gupta, S. (2000) · The Journal of Clinical Pharmacology · doi:10.1177/00912700022009080 · Cited by 100 · see citing works
Corkum, P. V., Panton, R., Ironside, S., Macpherson, M. J., & Williams, T. (2007) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsm106 · Cited by 98 · see citing works
GALLAND, B. C., TRIPP, E. G., & TAYLOR, B. J. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00795.x · Cited by 85 · see citing works
Sleep-related Disorders in ADHD: A Review
van der Heijden, K. B., Smits, M. G., & Gunning, W. B. (2005) · Clinical Pediatrics · doi:10.1177/000992280504400303 · Cited by 75 · see citing works
Weekend Holidays During Methylphenidate Use in ADHD Children: A Randomized Clinical Trial
Martins, S., Tramontina, S., Polanczyk, G. V., Eizirik, M., Swanson, J. M., & Rohde, L. A. (2004) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/1044546041649066 · Cited by 74 · see citing works
Actigraphic Monitoring During Sleep of Children With ADHD on Methylphenidate and Placebo
SCHWARTZ, G., AMOR, L. B., GRIZENKO, N., LAGEIX, P., BARON, C., BOIVIN, D. B., & JOOBER, R. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000135802.94090.93 · Cited by 70 · see citing works
Management of attention deficit hyperactivity disorder: A parental perspective
Concannon, P., & Tang, Y. (2005) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2005.00771.x · Cited by 59 · see citing works
Effects of sleep restriction on cognition in women
Stenuit, P., & Kerkhofs, M. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.011 · Cited by 56 · see citing works
Kim, H.-W., Yoon, I.-Y., Cho, S.-C., Kim, B.-N., Chung, S., Lee, H., Kim, C.-W., Park, S.-K., & Yoo, H. J. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e3283364411 · Cited by 56 · see citing works
Effects of Once-Daily Oral and Transdermal Methylphenidate on Sleep Behavior of Children With ADHD
Faraone, S. V., Glatt, S. J., Bukstein, O. G., Lopez, F. A., Arnold, L. E., & Findling, R. L. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708314844 · Cited by 56 · see citing works
Sleep patterns and their age-related changes in elementary-school children
Seo, W. S., Sung, H.-M., Lee, J. H., Koo, B., Kim, M. J., Kim, S. Y., Choi, S.-J., & Shin, I. H. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.03.011 · Cited by 52 · see citing works
Self-citationPharmacological Management of Treatment-Induced Insomnia in ADHD
Kratochvil, C. J., Lake, M., Pliszka, S. R., & Walkup, J. T. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000155322.32500.3a · Cited by 47 · see citing works
Methylphenidate HCl: therapy for attention deficit hyperactivity disorder
Capp, P. K., Pearl, P. L., & Conlon, C. J. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.3.325 · Cited by 41 · see citing works
Pediatric sleep disorders: new developments and evolving understanding
Anstead, M. (2000) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200011000-00007 · Cited by 37 · see citing works
Dose-proportional pharmacokinetics of a methylphenidate extended-release capsule
Rochdi, M., Ángel-González, M., & Dirksen, S. J. H. (2004) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp42285 · Cited by 17 · see citing works
Ashkenasi, A. (2011) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2011.09.003 · Cited by 17 · see citing works
Rapport, M. D., Randall, R., & Moffitt, C. E. (2002) · Journal of Attention Disorders · doi:10.1177/108705470200600103 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Associations of sleep disturbance with ADHD: implications for treatment
Hvolby, A. (2015) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0151-0 · Cited by 339 · see citing works
Storebø, O. J., Pedersen, N., Ramstad, E., Kielsholm, M. L., Nielsen, S. S., Krogh, H. B., Moreira-Maia, C. R., Magnusson, F. L., Holmskov, M., Gerner, T., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012069.pub2 · Cited by 321 · see citing works
Stimulant medications and sleep for youth with ADHD: a meta-analysis
Kidwell, K. M., Van Dyk, T. R., Lundahl, A., & Nelson, T. D. (2015) · Pediatrics · doi:10.1542/peds.2015-1708 · Cited by 133 · see citing works
Hyperactivity and male‐specific sleep deficits in the 16p11.2 deletion mouse model of autism
Angelakos, C. C., Watson, A. J., O'Brien, W. T., Krainock, K. S., Nickl‐Jockschat, T., & Abel, T. (2017) · Autism Research · doi:10.1002/aur.1707 · Cited by 83 · see citing works
Bondopadhyay, U., Díaz-Orueta, U., & Coogan, A. N. (2021) · Journal of Attention Disorders · doi:10.1177/1087054720978556 · Cited by 83 · see citing works
The circadian rhythm in adult attention-deficit/hyperactivity disorder: current state of affairs
Kooij, J. J. S., & Bijlenga, D. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.836301 · Cited by 78 · see citing works
The Effect of Home-based Daily Journal Writing in Korean Adolescents with Smartphone Addiction
Lee, H., Seo, M. J., & Choi, T. Y. (2016) · Journal of Korean Medical Science · doi:10.3346/jkms.2016.31.5.764 · Cited by 51 · see citing works
Self-citationJones, Z., & Dafny, N. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1101-2 · Cited by 37 · see citing works
Anand, S., Tong, H. H. Y., Besag, F., Chan, E. W., Cortese, S., & Wong, I. C. K. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0224-6 · Cited by 37 · see citing works
Ricketts, E. J., Sturm, A., McMakin, D. L., Mcguire, J. F., Tan, P. Z., Smalberg, F. B., McCracken, J. T., Colwell, C. S., & Piacentini, J. C. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0038 · Cited by 18 · see citing works
Examining daily stimulant medication use and sleep in adolescents with ADHD
Wiggs, K. K., Breaux, R., Langberg, J. M., Peugh, J., & Becker, S. P. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02204-w · Cited by 9 · see citing works
Broussard, E., Reyes-Vázquez, C., & Dafny, N. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14402 · Cited by 9 · see citing works
Jones, Z., Vazquez, C. R., & Dafny, N. (2014) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2014.44020 · Cited by 9 · see citing works
Lee, Y., Kong, N., Koo, S., Bai, D.-S., Kim, H. J., Jeong, H., & Seo, W. S. (2022) · Psychiatry Investigation · doi:10.30773/pi.2021.0309 · Cited by 8 · see citing works
Self-citationMedina, A. C., Vasquez, C. R., Kharas, N., & Dafny, N. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.013 · Cited by 7 · see citing works
Sadprasid, B., Tabor, A., Scheme, E., & Bateman, S. (2022) · Annual Symposium on Computer-Human Interaction in Play · doi:10.1145/3505270.3558381 · Cited by 7 · see citing works
The Role of the Circadian System in Attention Deficit Hyperactivity Disorder
Bondopadhyay, U., Díaz-Orueta, U., & Coogan, A. N. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-81147-1_7 · Cited by 7 · see citing works
The Effect of Methylphenidate on Neurological Soft Signs in ADHD
Hrtánek, I., Ondrejka, I., Tonhajzerová, I., Šnircová, E., Kulhan, T., Farský, I., & Nosalova, G. (2015) · Psychiatry Investigation · doi:10.4306/pi.2015.12.4.545 · Cited by 6 · see citing works
Medina, A. C., Kabani, A. A., Reyes-Vasquez, C., & Dafny, N. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-022-02526-0 · Cited by 5 · see citing works
Chen, M. L., Wardlaw, M., & Stein, M. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814180-9.00006-5 · Cited by 5 · see citing works
Ritalin Dose Response Effect on Medial Prefrontal Cortex and on Animal Behavior
Reyes-Vasquez, C., Cannon, C. J., & Dafny, N. (2016) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2016.63015 · Cited by 4 · see citing works
Restless Sleep in a Hyperactive Girl
Pozzi, M., Bertella, S., Molteni, M., Antoniazzi, S., Carnovale, C., Gentili, M., Pellegrino, P., Perrone, V., Clementi, E., & Radice, S. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000396 · Cited by 3 · see citing works
Sleep and Attention-Deficit/Hyperactivity Disorder
Dimakos, J., Giorgio, L.-M., & Gruber, R. (2022) · Springer eBooks · doi:10.1007/978-981-16-0123-1_25 · Cited by 3 · see citing works
Silk, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814180-9.00013-2 · Cited by 4 · see citing works
Dafny, N., Claussen, C. M., Frazier, E., & Liu, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115938 · Cited by 1 · see citing works
Jones, Z. (2013) · Digital Commons-TMC (Texas Medical Center)
The Impact of Methylphenidate on Circadian Rhythms and Clock Gene Expression
Coogan, A. N., Thome, J., & Baird, A. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00066-4
史枝, 堀., 憲太郎, 河., & 靖哲, 岡. (2017) · 児童青年精神医学とその近接領域 · doi:10.20615/jscap.58.5_618
Effect of methylphenidate on sleep status of children with attention deficit hyperactivity disorder
Soltanifar, A., Soleimani, M., Moharari, F., & Jalali, M. (2021) · کومش · doi:10.29252/koomesh.23.1.49
ЗНАЧЕННЯ СНУ В РОЗВИТКУ ДІТЕЙ З РОЗЛАДАМИ ДЕФІЦИТУ УВАГИ ТА ГІПЕРАКТИВНІСТЮ : ТЕОРЕТИЧНИЙ АСПЕКТ
Чобанян, А. (2021) · Наукові перспективи (Naukovì perspektivi) · doi:10.52058/2708-7530-2021-12(18)-514-522
- Authors
- Lee, S. H., Seo, W. S., Sung, H. M., Choi, T. Y., Kim, S. Y., Choi, S.-J., Koo, B. H., & Lee, J. H.
- Affiliations
- Yeungnam University College (KR)
- CHA University (KR)
- Daegu Catholic University (KR)
- Department of Neuropsychiatry, Yeungnam University College of Medicine, Daegu, Republic of Korea.
- Corresponding author
- Seo, Wan Seok
- Venue
- Psychiatry Investigation
- Publisher
- Korean Neuropsychiatric Association
- Published
- 2012
- Volume
- 9
- Issue
- 4
- Pages
- 384
- ISSN
- 1738-3684 (ISSN-L)
- 1976-3026
- PMC
- PMC3521116
- OpenAlex
- W2075241411
- Cited by
- 30
- References
- 26
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 5 · 2021: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 3
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychiatry Investigation (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Yeungnam University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, children, sleep parameters, bedtime, wake-up time, sleep latency, total sleep time, extended-release methylphenidate, immediate-release methylphenidate, dosage effect, age effects, sleep diary
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
