Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
Open accessAbstract
OBJECTIVE: Both clinical and biological factors influence the course of depressive disorders. This study tested for associations between the brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the course of major depressive disorder (MDD). METHODS: Three hundred ten Korean subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 (G/A), which produces an amino acid substitution at codon 66 (Val66Met) of the gene for BDNF. Course of illness was evaluated both by chronicity of current episode (episode duration >24 months) and by the lifetime history of recurrences. RESULTS: Patients with the Met/Met BDNF genotype had a significantly higher rate of chronic depression than all others. There was a significant dose effect of the Met allele on chronicity. Compared with the Val/Val genotype, the relative risk of chronicity was 1.67 for the Val/Met genotype, and 2.58 for the Met/Met genotype. Lifetime history of recurrent episodes was not related to BDNF genotypes but was significantly associated with younger age of onset and with a history of depression in first degree relatives. CONCLUSION: BDNF genotyping may be informative for anticipating chronicity in major depression.
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People, particularly males, with the BDNF Val66Met single nucleotide polymorphism are more likely to experience chronic depression.
“people (particularly males) with the brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism—a condition that reduces activity-dependent BDNF release (20)—are more likely to experience chronic depression (21, 22)”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [21]
The Results (Chronicity and recurrent tendencies) report higher rates of chronic depression among patients with major depressive disorder carrying the Met allele, with the highest rate in the Met/Met group. The paper does not establish that the association is particularly strong in males; its Results (Subject characteristics) report no significant sex difference between patients with and without chronicity. The finding also concerns chronicity among patients already diagnosed with depression, not the general likelihood of developing depression. (LLM, conf=0.88)
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- Authors
- Lee, Y., Lim, S. W., Kim, S. Y., Chung, J. W., Kim, J., Myung, W., Song, J., Kim, S., Carroll, B. J., & Kim, D. K.
- Affiliations
- Samsung Medical Center (KR)
- Sungkyunkwan University (KR)
- Samsung Biomedical Research Institute (KR)
- Pacific Behavioral Research Foundation, Carmel, CA, USA.
- Corresponding author
- Kim, Doh Kwan
- Venue
- Psychiatry Investigation
- Publisher
- Korean Neuropsychiatric Association
- Published
- 2013
- Volume
- 10
- Issue
- 1
- Pages
- 56
- ISSN
- 1738-3684 (ISSN-L)
- 1976-3026
- PMC
- PMC3590431
- OpenAlex
- W2120473358
- Cited by
- 41
- References
- 23
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 3 · 2014: 4 · 2013: 1
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychiatry Investigation (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Korea Science and Engineering Foundation
- H. Lundbeck A/S
- Samsung
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, major depressive disorder, chronic depression, clinical course, depression recurrence, age of onset, family history of depression, genetic susceptibility, dosage effect
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