Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression
Abstract
OBJECTIVES: Current evidence supports participation of neurotrophic and inflammatory factors in the pathogenesis of major depressive disorder (MDD). Some studies reported an association between the Val66Met polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF levels. However, no previous studies have examined the association of this polymorphism with inflammation. The present study assessed the association of the Val66Met polymorphism with serum levels of BDNF and inflammatory markers among depressed outpatients. METHODS: All participants (n = 73) met DSM-IV criteria for a unipolar depressive episode. The serum levels of BDNF and inflammatory biomarkers (IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ) were compared between individuals presenting with at least one Met allele (Met-carriers) and those homozygous for the Val allele. RESULTS: In our sample (84.9% female, mean age 52.4 ± 10.3 years), 24.7% (n = 18) were Met-carriers. After Bonferroni correction, the Met allele was significantly associated with higher BDNF and lower TNF-α. These associations persisted after adjusting for potential confounders. CONCLUSIONS: The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism. The association of a polymorphism in the BDNF gene with inflammatory markers in addition to BDNF levels suggests an interaction between these systems.
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The BDNF Val66Met polymorphism is associated with cognitive processes and cognitive impairment in neurodegenerative disease such as Parkinson's disease and Alzheimer's disease, and with several brain disorders including MDD, bipolar disorder, epilepsy, schizophrenia, aging and dementia, and stroke.
“More specifically, BDNF Val66Met polymorphism is associated with cognitive processes [112,123,124,125,126,127], and cognitive impairment in neurodegenerative disease, such as Parkinson’s disease (PD) [128,129] and AD [130,131], and even more with several brain disorders, including MDD and bipolar disorder [132,133,134,135,136,137], epilepsy [138,139,140], schizophrenia [125,141,142,143,144], aging”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [135]
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Association between comorbid asthma and depression and depression-related gene SNPs
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- Authors
- Caldieraro, M. A., McKee, M., Leistner-Segal, S., Vares, E. A., Kubaski, F., Spanemberg, L., Brusius-Facchin, A. C., Fleck, M. P., & Mischoulon, D.
- Affiliations
- Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA;
- Massachusetts General Hospital (US)
- Medical Genetics Service, Molecular Genetics Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil;
- Universidade Federal do Rio Grande do Sul (BR)
- Alfred I. duPont Hospital for Children (US)
- Harvard University (US)
- Venue
- The World Journal of Biological Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2017-07-12
- Volume
- 19
- Issue
- 5
- Pages
- 402-409
- ISSN
- 1562-2975 (ISSN-L)
- 1814-1412
- OpenAlex
- W2727301451
- Cited by
- 39
- References
- 65
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The World Journal of Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundo de Incentivo à Pesquisa e Eventos do Hospital de Clínicas de Porto Alegre (09-176)
- Pesquisa e Eventos do Hospital de Clínicas de Porto Alegre
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (473459/2010-8)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- BDNF Val66Met polymorphism, BDNF gene, major depressive disorder, serum BDNF, inflammatory markers, TNF-α, cytokines, neuroinflammation, genetic polymorphism, depression pathogenesis
- MeSH terms
- Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Inflammation, Male, Middle Aged, Tumor Necrosis Factor-alpha, Biomarkers, Brain-Derived Neurotrophic Factor, Polymorphism, Single Nucleotide
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