The Val66Met polymorphism of the brain‐derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients
Abstract
Recent researches have suggested that brain‐derived neurotrophic factor (BDNF) may be implicated in the pathophysiology of mood disorder. This study examined the association between the BDNF Val66Met polymorphism and major depressive disorder (MDD) in a Japanese population. We genotyped the BDNF Val66Met polymorphism in 154 major depressive patients and 154 age‐ and sex‐matched control subjects. The genotypic distributions and allele frequencies were similar among the patients and control subjects. When the relationships of the polymorphism with several clinical variables (i.e., age, sex, age of onset, number of episode, presence of psychotic features, suicidal behavior, and family history) were examined, the dose of Met allele had significant effects on psychotic feature and suicidal behavior and family history. These results suggest that the BDNF Val66Met polymorphism is not related to the development of MDD but related to clinical features of MDD in a Japanese population. © 2007 Wiley‐Liss, Inc.
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The BDNF gene Met allele increases risk for suicidal behavior, particularly in depressed individuals and those exposed to early-life stress, where it may act by loss of ACC volume and altered decision-making or depression circuitry.
“The BDNF gene Met allele, a part of BDNF functional polymorphism (rs6265), increases the risk for suicidal behavior (183, 184), particularly in depressed individuals (185) and in those exposed to early-life stress (186, 187), where it may do so by loss of ACC volume (188) and altered decision-making or depression circuitry.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [183]
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- Authors
- Iga, J., Ueno, S., Yamauchi, K., Numata, S., Tayoshi‐Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., Sano, A., & Ohmori, T.
- Affiliations
- Tokushima University (JP)
- Ehime University (JP)
- Kagoshima University (JP)
- ORCID
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2007-05-17
- Volume
- 144B
- Issue
- 8
- Pages
- 1003-1006
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W1976807465
- Cited by
- 87
- References
- 26
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 1 · 2013: 8 · 2012: 10
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, major depressive disorder, psychotic features, suicidal behavior, family history (medicine), Japanese population, genetic association, mood disorders
- MeSH terms
- Adult, Major Depressive Disorder, Female, Humans, Male, Methionine, Middle Aged, Polymorphism, Genetic, Psychotic Disorders, Suicide, Valine, Case-Control Studies, Age of Onset, Age Distribution, Sex Distribution, Brain-Derived Neurotrophic Factor, Diagnostic and Statistical Manual of Mental Disorders
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