CoChat
Sign Up
Cited by 9Pancreatic function and diabetesDiabetes Management and ResearchGrowth Hormone and Insulin-like Growth Factors

A mathematical model on the effect of growth hormone on glucose homeostasis

Open access
Ali, Hannah Al, Wiam, Boutayeb, Abdesslam, Boutayeb, Nora, Merabet·2019·Revue Africaine de Recherche en Informatique et Mathématiques Appliquées
DOI 10.46298/arima.4945
Open this paper in CoChat — free accountOpen PDF

Abstract

Extending an existing model devoted to the interaction between β-Cell Mass, Insulin, Glucose, Receptor Dynamics and Free Fatty Acids in glucose regulatory system simulation, this paper proposes a mathematical model introducing the effect of growth hormone on the glucose homeostasis alongside the other variables. Stability analysis is carried out and pragmatic explanation of the equilibrium points is emphasized. Finally, simulation illustrated how β-Cell Mass, Insulin, Glucose, Receptor Dynamics, Free Fatty Acids and Growth Hormone may vary with different values of some parameters in the model. Prolongeant un précédent model publié dédié à l'interaction entre les cellules beta, l'insuline, le glucose, les recpteurs d'insuline et les acides gras libres, cet article propose un modele mathématique introduisant l'effet de l'hrmone de croissance sur la homéostasie du glucose. L'analyse de stabilité a été suivie d'explication pratique des points d'équilibre. Enfin, la simulation a illustré comment les cellules beta, l'insuline, le glucose, les recpteurs d'insuline, les acides gras libres et l'hormone de croissance peuvent varier en fonction des différentes valeurs de certains paramètres.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.46298/arima.4945

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • There has been one model established so far incorporating the influence of growth hormones to the long-term glucose regulation.

    “There has been one model established so far incorporating the influence of growth hormones to the long-term glucose regulation (52).”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [52]

    The Abstract describes a model incorporating growth hormone into glucose homeostasis. The Conclusion calls it, to the authors’ knowledge, the first model combining glucose, insulin, free fatty acids and growth hormone, but says only that very few models address growth hormone’s effect on glucose homeostasis. It does not establish that this was the sole such model or explicitly characterize it as a model of long-term regulation. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • This work provides the first mathematical model that incorporates GH into the glucose regulatory system.

    “This work provides the first mathematical model that incorporates GH into the glucose regulatory system.”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [52]

    The Mathematical Model section adds GH dynamics to a glucose-regulation model. The Conclusion claims priority only for modeling the combined interaction of glucose, insulin, free fatty acids, and GH; it also says a few earlier models addressed GH and glucose homeostasis. It therefore does not support the broader claim that this is the first model to incorporate GH into a glucose regulatory system. (LLM, conf=0.89)

    Experimental — accuracy not yet measured

  • Alali et al. developed a model studying the effect of growth hormone on glucose homeostasis.

    “Alali et al. developed a model studying the effect of growth hormone on glucose homeostasis (52).”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [52]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. DIAS CIFHA C., KAMATH S., VIDYASAGAR S., « Mathematical modelling and simulation of β-cell mass, insulin and glucose dynamics: Effect of genetic predisposition to diabetes », International Journal of Bioinformatics Research and Applications, Inderscience Publishers (IEL), vol. 4, n o 1-2, 90-103, 2018.

Cited by

Sorted by citations

Related

Authors
Ali, H. A., Wiam, B., Abdesslam, B., & Nora, M.
Affiliations
  • School of Mathematics, Statistics & Computing
  • Department of Mathematics
ORCID
Ali, Hannah Al
Venue
Revue Africaine de Recherche en Informatique et Mathématiques Appliquées
Publisher
Centre pour la Communication Scientifique Directe (CCSD)
Published
2019-06-08
Volume
Volume 30 - 2019 - MADEV...
ISSN
1638-5713 (ISSN-L)
DOI
10.46298/arima.4945
OpenAlex
W2903611035
Cited by
9
References
15
Citations by year
2025: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2
FWCI
1.67
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Revue Africaine de la Recherche en Informatique et Mathématiques Appliquées (publishedVersion, cc-by)
  • HAL (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
growth hormone, glucose homeostasis, beta-cell mass, insulin, insulin receptor, free fatty acids, glucose regulation, stability analysis, equilibrium points

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review