Cited by 189Diabetes Management and ResearchDiabetes Treatment and ManagementPancreatic function and diabetes

Models of subcutaneous insulin kinetics. A critical review

Nucci, Gianluca, Cobelli, Claudio·2000·Computer Methods and Programs in Biomedicine

Abstract

Subcutaneous insulin kinetics is a complex process whose quantitation is needed for a reliable glycemic control in the conventional therapy of insulin-dependent diabetes. The major difficulties in modeling include accounting for the distribution in the subcutaneous depot and transport to plasma. A single model describing in detail the various processes for all the commercially available insulin preparations is not available. Several models however have been proposed which vary in the degree of complexity. Virtually all of them handle the regular insulin preparation while a few handle the intermediate acting and the novel insulin analogues. In this paper we critically review these models.

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Registry

Crossref · 10.1016/s0169-2607(00)00071-7

Cites

28 of 28 references verified0 citation errors · 0 not checkable

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  • Model 1 follows the structure of the previously developed subcutaneous insulin delivery model.

    “Model 1, the simplest linear model representation with a pool compartment (compartment 2), follows the structure of the previously developed SC insulin delivery model.18,19”

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Authors
Nucci, G., & Cobelli, C.
Affiliations
University of Padua (IT)
Corresponding author
Cobelli, Claudio
Venue
Computer Methods and Programs in Biomedicine
Publisher
Elsevier BV
Published
2000-07
Volume
62
Issue
3
Pages
249-257
ISSN
0169-2607 (ISSN-L)
OpenAlex
W2083360466
Cited by
189
References
28
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 10
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Locations
  • Computer Methods and Programs in Biomedicine (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
insulin absorption, type 1 diabetes, glycemic control, intermediate-acting insulin, insulin analogues, regular insulin
MeSH terms
Absorption, Computer Simulation, Diabetes Mellitus, Type 1, Humans, Injections, Subcutaneous, Insulin, Kinetics, Models, Biological, Decision Support Systems, Clinical

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