Models of subcutaneous insulin kinetics. A critical review
Abstract
Subcutaneous insulin kinetics is a complex process whose quantitation is needed for a reliable glycemic control in the conventional therapy of insulin-dependent diabetes. The major difficulties in modeling include accounting for the distribution in the subcutaneous depot and transport to plasma. A single model describing in detail the various processes for all the commercially available insulin preparations is not available. Several models however have been proposed which vary in the degree of complexity. Virtually all of them handle the regular insulin preparation while a few handle the intermediate acting and the novel insulin analogues. In this paper we critically review these models.
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Model 1 follows the structure of the previously developed subcutaneous insulin delivery model.
“Model 1, the simplest linear model representation with a pool compartment (compartment 2), follows the structure of the previously developed SC insulin delivery model.18,19”
From Pharmacokinetics Modeling of Exogenous Glucagon in Type 1 Diabetes Mellitus Patients (2013) · cites this paper as [18]
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- Authors
- Nucci, G., & Cobelli, C.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Cobelli, Claudio
- Venue
- Computer Methods and Programs in Biomedicine
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 62
- Issue
- 3
- Pages
- 249-257
- ISSN
- 0169-2607 (ISSN-L)
- OpenAlex
- W2083360466
- Cited by
- 189
- References
- 28
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 10
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Computer Methods and Programs in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- insulin absorption, type 1 diabetes, glycemic control, intermediate-acting insulin, insulin analogues, regular insulin
- MeSH terms
- Absorption, Computer Simulation, Diabetes Mellitus, Type 1, Humans, Injections, Subcutaneous, Insulin, Kinetics, Models, Biological, Decision Support Systems, Clinical
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