The Efficacy of Hypnotherapy in the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis
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BACKGROUND/AIMS: Hypnotherapy is considered as a promising intervention for irritable bowel syndrome (IBS), but the evidence is still limited. The aims of this study were to conduct a systematic review and meta-analysis to estimate the efficacy of hypnotherapy for the treatment of IBS. METHODS: A literature search was performed using MEDLINE (PubMed), Embase, PsycINFO and the Cochrane Central Register of Controlled Trials (CENTRAL database). Only randomized controlled trials that compared hypnotherapy with any other conven-tional treatment or no treatment in patients with IBS were included. Studies had to report outcomes as IBS symptom score or quality of life. The mean change in outcome score was used to pool these outcomes for the meta-analysis. Data were syn-thesized using the standardized mean difference for continuous data. RESULTS: Seven randomized controlled trials (6 papers) involving 374 patients with IBS were identified. Performance bias was high in all trials because it was impossible to blind participants and therapists in this type of intervention. The outcomes in this meta-anal-ysis were evaluated at 3 months for short-term effects and at 1 year for long-term effects. The change in abdominal pain score at 3 months was significant in the hypnotherapy group (standardized mean difference, -0.83; 95% CI, -1.65 to -0.01). Three of the 4 trials showed greater improvement in overall gastrointestinal symptoms in the hypnotherapy group. CONCLUSIONS: This study provides clearer evidence that hypnotherapy has beneficial short-term effects in improving gastrointestinal symptoms of patients with IBS.
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Hypnosis has been demonstrated to be effective in other chronic conditions such as IBS and those with lower back pain.
“Hypnosis has been demonstrated to be effective in other chronic conditions such asIBS and those with lower back pain.58,59”
From Psychological interventions for women with persistent pelvic pain: A survey of mental health clinicians (2021) · cites this paper as [58]
The Discussion reports that hypnotherapy improved abdominal pain and overall gastrointestinal symptoms in patients with IBS, supporting the IBS example. It limits that finding to short-term treatment of refractory IBS and explicitly says the benefits cannot be generalized to all IBS patients. The lower-back-pain example has a separate citation and is not assessed against this source. (LLM, conf=0.82)
Experimental — accuracy not yet measuredImprovements in pain-related outcomes appears to be dependent on suggestibility and the use of analgesic suggestions.
“Improvements in pain-related outcomes appears to be dependent on suggestibility and the use of analgesic suggestions.58,59”
From Psychological interventions for women with persistent pelvic pain: A survey of mental health clinicians (2021) · cites this paper as [58]
The Results > Effects section reports improved abdominal pain after gut-directed hypnotherapy in patients with IBS. The Discussion says the mechanism is not well understood; neither section establishes that pain improvement depends on suggestibility or the use of analgesic suggestions (searched both terms). Page numbers were not available in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredOnly one effect size was large in IBS (abdominal pain; Lee et al., 2014).
“Only one effect size was large (abdominal pain; Lee et al., 2014).”
From Meta-analytic evidence on the efficacy of hypnosis for mental and somatic health issues: a 20-year perspective (2024) · cites this paper as Lee et al., 2014
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Hypnotherapy and IBS : Time to take control of the Asian gut
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Colorectal Diseases and Gut Microbiome
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Ericksonian Hypnotherapy: A Systematic Review and Meta-Analysis of RCTs
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Hypnotherapy in Treatment of Mastocytosis: A Prospective Study
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- Authors
- Lee, H. H., Choi, Y. Y., & Choi, M.-G.
- Affiliations
- Catholic University of Korea (KR)
- Yonsei University (KR)
- Corresponding author
- Choi, Myung-Gyu
- Venue
- Journal of Neurogastroenterology and Motility
- Published
- 2014-04-30
- Volume
- 20
- Issue
- 2
- Pages
- 152-162
- ISSN
- 2093-0879 (ISSN-L)
- 2093-0887
- PMC
- PMC4015203
- OpenAlex
- W2122854831
- Cited by
- 81
- References
- 38
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Neurogastroenterology and Motility (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- hypnotherapy, irritable bowel syndrome, abdominal pain, gastrointestinal symptoms, quality of life, symptom scores, treatment efficacy, performance bias
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