Metabolic consequences of recombinant human growth hormone therapy in patients with Turner syndrome
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Skróty: TS -zespół Turnera, rGH -rekombinowany hormon wzrostu, OGTT -doustny test toleracji glukozy, HbA 1c -hemoglobina glikowana, HOMA-IR -wskaźnik insulinooporności, HOMA-β -model homeostazy dotyczący czynności komórek β trzustki, QUICKI -wskaźnik insulinowrażliwości, BM -wskaźnik masy ciała, WHR -wskaźnik talia-biodra, T-C -cholesterol całkowity, HDL-C -cholesterol HDL, LDL-C -cholesterol LDL; TG -trójglicerydy Abbreviations: TS -Turner syndrome, rGH -recombined growth hormone, OGTT -oral glucose tolerance test, HbA 1c -glycated haemoglobin, HOMA-IR -homeostasis model assessment of insulin resistance, HOMA-β -homeostasis model assessment of β-cell function, QUICKI -quantitative insulin sensitivity check index, BMI -Body mass index, WHR -waist-to-hip ratio, T-C -total cholesterol, HDL-C -cholesterol HDL, LDL-C -cholesterol LDL, TG -triglycerides Abstract Introduction: Turner syndrome (TS) predisposes to metabolic complications.Currently, TS patients are treated with recombinant human growth hormone (rGH) as standard therapy.The long-term effect of this therapy on carbohydrate metabolism remains unclear.Aim of the study: To assess possible metabolic alterations following rGH therapy.Material and methods: We enrolled 53 TS participants, comprising 37 patients who finished rGH therapy (group 1) and 16 patients who did not receive growth promoting therapy (group 2).Several anthropometric measurements were made.Carbohydrate and lipid metabolism, adipokines, and hs-CRP were assessed basing on laboratory test.The following indices were calculated: HOMA-IR, HOMA-β, QUICKI, and Matsuda.Results: There were no statistically significant differences between the 2 groups in terms of BMI or WHR.There was a statistically significant lower mean percentage of fat tissue in group 1 compared to group 2 (27.46% vs. 31.75%).Insulin resistance and sensitivity indices were not statistically different between groups.Using the Matsuda index, more patients who met criteria of insulin resistance were found in group 2 than in group 1 (56.25% vs. 37.84%); however, this difference was not statistically significant (p = 0.2).No statistically significant differences were found in lipid profile, adipokines, and hsCRP between groups.Conclusions: rGH therapy leads to a beneficial change in body composition of TS patients despite unchanged BMI.A decrease in body fat persists for several years after finishing rGH treatment; rGH treatment is connected with a trend toward increased insulin sensitivity.
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No permanent negative effects of GH treatment on insulin sensitivity or beta-cell secretory capacity have been observed.
“no permanent negative effects of GH treatment on insulin sensitivity or beta-cell secretory capacity have been observed.229,230”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [230]
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Research works printed but not linked: 1
- [1]Davenport M. Turner syndrome. In: Pescovitz OH, Erica A (ed.). Pediatric Endocrinology: Mechanisms, Manifestations, and Management. Lippincott Williams & Wilkins, Philadelphia 2004; 203- 223.
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
- Authors
- Gnacińska, M., Magnuszewska, H., & Sworczak, K.
- Affiliations
- Gdańsk Medical University (PL)
- Corresponding author
- Gnacińska, Maria
- ORCID
- Sworczak, Krzysztof
- Venue
- Pediatric Endocrinology Diabetes and Metabolism
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2023
- Volume
- 29
- Issue
- 1
- Pages
- 16-21
- ISSN
- 1234-625X (ISSN-L)
- 2081-237X
- PMC
- PMC10226455
- OpenAlex
- W4313433476
- Cited by
- 12
- References
- 33
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Pediatric Endocrinology Diabetes and Metabolism (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Turner syndrome, recombinant human growth hormone, growth hormone therapy, insulin resistance, insulin sensitivity, carbohydrate metabolism, lipid metabolism, adipokines, adipose tissue, metabolic complications, anthropometry, C-reactive protein, Matsuda index, QUICKI, HOMA-IR, HOMA-β, body fat percentage, dyslipidemia, dyslipoproteinemia
- MeSH terms
- Humans, Insulin, Insulin Resistance, Turner Syndrome, Human Growth Hormone, Metabolic Syndrome, Adipokines
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