An evaluation of early cardiometabolic risk factors in children and adolescents with Turner syndrome

O'Gorman, Clodagh S.; Syme, Catriona; Lang, Jun; Bradley, Timothy J.; Wells, Greg D.; Hamilton, Jill K.

doi:10.1111/cen.12079

Cited by 67Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesDiabetes, Cardiovascular Risks, and LipoproteinsSexual Differentiation and Disorders

An evaluation of early cardiometabolic risk factors in children and adolescents with Turner syndrome

O'Gorman, Clodagh S., Syme, Catriona, Lang, Jun, Bradley, Timothy J., Wells, Greg D., Hamilton, Jill K.·2013·Clinical Endocrinology

DOI 10.1111/cen.12079

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Abstract

BACKGROUND AND OBJECTIVES: Turner syndrome (TS) confers increased lifetime risk of type 2 diabetes mellitus and cardiovascular disease. We compared cardiometabolic risk factors and measures of subcutaneous, visceral adipose tissue and intra-myocellular lipid between young TS girls and an age- and BMI-standard deviation scores (SDS)-matched healthy female cohort. PATIENTS AND METHODS: A cross-sectional cohort study was conducted at the Hospital for Sick Children, Toronto. Nineteen TS and 17 control girls (13.7 ± 2.5 vs 12.7 ± 3.4 years of age, respectively, P = 0.30). Multiple-sample oral glucose tolerance test with measurement of fasting insulin, LDL, HDL, triglycerides, adiponectin and highly sensitive C-reactive protein (hsCRP) was performed. Subcutaneous adipose tissue, visceral adipose tissue intramyocellular lipid levels evaluated by magnetic resonance techniques. Insulin secretion (IS), sensitivity (Si) and the insulin secretion-sensitivity index (ISSI-2) were calculated from oral glucose tolerance test data. RESULTS: Five TS and no controls had impaired fasting glucose or impaired glucose tolerance; none had type 2 diabetes mellitus. Insulin sensitivity and insulin secretion were similar between groups; ISSI-2 was lower in TS (923.5 ± 307.3 vs 659.1 ± 387.3; P = 0.03). TS girls had higher blood pressure (82.5 ± 13.6 vs 73.5 ± 5.5 mmHg; P = 0.0146), waist circumference (76.0 ± 11.8 vs 65.9 ± 9.7; P = 0.0087) and subcutaneous adipose tissue (135.6 ± 88.6 vs 69.3 ± 59.9; P = 0.01) than controls. Visceral adipose tissue, intramyocellular lipid levels and adiponectin were not different between groups. TS girls also had higher triglycerides (1.1 ± 0.6 vs 0.7 ± 0.3; P = 0.003), total cholesterol (4.4 ± 0.7 vs 3.9 ± 0.4; P = 0.02) and hsCRP (2.0 ± 1.9 vs 0.8 ± 0.3; P = 0.01). CONCLUSIONS: TS girls exhibit more cardiometabolic risk factors and reduced beta cell function compared with age- and BMI-SDS-matched girls. Increased awareness of early risk of type 2 diabetes mellitus and hypertension in TS girls is needed.

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The individuals in that study also had significantly higher waist circumference, impaired glucose tolerance, and higher blood pressures.
“However, the individuals in that study also had significantly higher waist circumference, impaired glucose tolerance, and higher blood pressures.477”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [477]
A small study showed marginally increased plasma lipids in children and adolescents with TS.
“A small study showed marginally increased plasma lipids in children and adolescents with TS.477”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [477]
Youth with TS have higher waist circumference and visceral adiposity.
“Youth with TS have higher waist circumference and visceral adiposity.477”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [477]

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Authors: O'Gorman, C. S., Syme, C., Lang, J., Bradley, T. J., Wells, G. D., & Hamilton, J. K.
Affiliations: Divisions of Endocrinology, The Hospital for Sick Children University of Toronto Toronto ON Canada
University of Toronto (CA)
ORCID: Syme, Catriona
Bradley, Timothy J.
Wells, Greg D.
Hamilton, Jill K.
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 2013-04-06
Volume: 78
Issue: 6
Pages: 907-913
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1111/cen.12079
OpenAlex: W2009993299
Cited by: 67
References: 31
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 5 · 2015: 8 · 2014: 6 · 2013: 3
FWCI: 3.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Sickkids Research Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: Turner syndrome, cardiometabolic risk factors, insulin resistance, insulin secretion, impaired glucose tolerance, subcutaneous adipose tissue, visceral adipose tissue, intramyocellular lipid, adiponectin, C-reactive protein, dyslipidemia, hypertension, children and adolescents, type 2 diabetes risk, cardiovascular risk
MeSH terms: Adolescent, Cardiovascular Diseases, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Obesity, Risk Factors, Triglycerides, Turner Syndrome, Cohort Studies, Glucose Intolerance, Metabolic Syndrome, Subcutaneous Fat, Intra-Abdominal Fat, Waist Circumference

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An evaluation of early cardiometabolic risk factors in children and adolescents with Turner syndrome

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