Cited by 18Vitamin D Research StudiesNeurological Disease Mechanisms and TreatmentsNerve injury and regeneration

Vitamin D (Calcifediol) Supplementation Modulates NGF and BDNF and Improves Memory Function in Postmenopausal Women: a Pilot Study

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Pozzi, Flavio, Aloe, Luigi, Frajese, Giovanni, Frajese, Gaetano·2013·Research in Endocrinology

Abstract

1,25-dihydroxy vitamin D (vitamin D), a steroid hormone essential for calcium metabolism and various extra skeletal functions, is an in vitro inducer of Nerve Growth Factor (NGF) and modulates Brain-Derived Neurotrophic Factor (BDNF) in neurons, while its receptor is expressed in central nervous system.Due to restricted sunlight exposure and/or dietary intake many people are vitamin D-deficient and need supplementation.Vitamin D status has been associated with impairment in cognitive functions, but up to now no clinical studies have been conducted to verify its effect on neurotrophins and memory in humans.20 postmenopausal women with low vitamin D levels were treated by calcifediol (25-OH D3) and followed in open for three months.At baseline and after three months NGF and BDNF together with Wechsler Memory Scale (WMS) were assessed.Mean plasma vitamin D levels were 14.52 (+/-5.65 SD) ng/ml at baseline and 47.58 (+/-15.05SD) ng/ml after three months of supplementation.At the end of the study a statistical significant decrease in both neurotrophins was observed.NGF plasma levels were respectively: 451.13 (+/-243.20 SD) pg/ml and 323.68 (+/-195.60SD) pg/ml (p=0.05);BDNF levels were 431.10 (+/-182.21SD) pg/ml and 366.25 (+/-142.75SD) pg/ml (p=0.02).WMS scored meanly 97.00 (+/-13.54SD) at baseline and 107.82 (+/-16.19SD) after three months (p=0.003).Considering the role of vitamin D in calcium metabolism and neurotrophic factors regulation, it seems indispensable in brain function and its deficiency must be considered in cognitive diseases.

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  • Vitamin D analogues decrease BDNF and concomitantly improve memory in postmenopausal women.

    “Vitamin D analogues have been shown to upregulate NGF in cultured glial cell and embryonic hippocampal cells [177,178], to decrease the percentage of cultured hippocampal cells undergoing mitosis [178], and to decrease BDNF and concommitantly to improve memory in postmenopausal women [179].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [179]

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  1. Flavio Pozzi, Luigi Aloe, Giovanni Vanni Frajese and Gaetano Frajese (2013), Research in Endocrinology, DOI: 10.5171/2013. 552758 levels, lower extremity function, blood pressure, and markers of innate immunity". Journal of Bone and Mineral Research, 27 (1) 160-169. · DOI
  2. Gascon Barre, and M. Huet, P.M. (1983) "Apparent (3H) 1,25 hydroxyvitamin D3 uptake by canin and rodent brain". American Journal of Physiology Endocrinology and Metabolism, 244 E266-E271.
  3. Flavio Pozzi, Luigi Aloe, Giovanni Vanni Frajese and Gaetano Frajese (2013), Research in Endocrinology, DOI: 10.5171/2013. 552758 for Osteoporosis". Osteoporosis International, 10 4 259-264. · DOI
  4. Flavio Pozzi, Luigi Aloe, Giovanni Vanni Frajese and Gaetano Frajese (2013), Research in Endocrinology, DOI: 10.5171/2013. 552758 · DOI
  5. McCann, J.C. and Ames, B.N. (2008). "Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction?" Journal of the Federation of American Societies for Experimental Biology. 22 982-1001.
  6. Flavio Pozzi, Luigi Aloe, Giovanni Vanni Frajese and Gaetano Frajese (2013), Research in Endocrinology, DOI: 10.5171/2013. 552758 · DOI

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Authors
Pozzi, F., Aloe, L., Frajese, G., & Frajese, G.
Affiliations
  • University of Rome Tor Vergata (IT)
  • National Research Council (IT)
Corresponding author
Pozzi, Flavio
Venue
Research in Endocrinology
Published
2013-12-30
Pages
1-11
ISSN
2331-7485 (ISSN-L)
OpenAlex
W2145938850
Cited by
18
References
54
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2017: 4 · 2016: 1 · 2014: 1 · 2013: 1
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
Research in Endocrinology (publishedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
vitamin D supplementation, 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D, nerve growth factor, brain-derived neurotrophic factor, neurotrophins, memory function, postmenopausal women, vitamin D deficiency, cognitive function, Wechsler Memory Scale

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