VDR gene variants associate with cognitive function and depressive symptoms in old age

Kuningas, Maris; Mooijaart, Simon P.; Jolles, Jelle; Slagboom, P. Eline; Westendorp, Rudi G.J.; van Heemst, Diana

doi:10.1016/j.neurobiolaging.2007.07.001

Cited by 149Vitamin D Research StudiesDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

VDR gene variants associate with cognitive function and depressive symptoms in old age

Kuningas, Maris, Mooijaart, Simon P., Jolles, Jelle, Slagboom, P. Eline, Westendorp, Rudi G.J., van Heemst, Diana·2009·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2007.07.001

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Abstract

Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2, FokI, BsmI, ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI (p=0.013) and TaqI (p=0.004) polymorphisms, and of haplotype 2 (BAt) (p=0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.

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SNPs of VDR and ZnT3 genes are associated with MDD.
“findings by Kuningas et al. (2009) [32] and Lye et al. [33] that single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and zinc transporter-3 (SLC30A3) genes were respectively associated with MDD”
From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [32]
Kuningas et al. found that Dutch patients with the baT haplotype of the Vitamin D receptor (VDR) gene were less prone to depression compared with carriers of BAt.
“Kuningas et al. (32) found that Dutch patients with the baT haplotype of the Vitamin D receptor (VDR) gene were less prone to depression compared with carriers of BAt.”
From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [32]

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701 · see citing works
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
Seasonal Affective Disorder: A Description of the Syndrome and Preliminary Findings With Light Therapy
Rosenthal, N. E. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790120076010 · Cited by 2,385 · see citing works
Multiple Imputation for Nonresponse in Surveys.
Lynn, P. J., & Rubin, D. B. (1988) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348774 · Cited by 2,330 · see citing works
Insights into the ageing mind: a view from cognitive neuroscience
Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223 · see citing works
Genetics and biology of vitamin D receptor polymorphisms
Uitterlinden, A. G., Fang, Y., van Meurs, J. B. J., Pols, H. A. P., & van Leeuwen, J. P. T. M. (2004) · Gene · doi:10.1016/j.gene.2004.05.014 · Cited by 1,542 · see citing works
Vitamin D intake and incidence of multiple sclerosis
Munger, K. L., Zhang, S. M., O’Reilly, É. J., Hernán, M. Á., Olek, M. J., Willett, W. C., & Ascherio, A. (2004) · Neurology · doi:10.1212/01.wnl.0000101723.79681.38 · Cited by 1,090 · see citing works
New clues about vitamin D functions in the nervous system
Garcion, E., Wion-Barbot, N., Montero-Menei, C. N., Berger, F., & Wion, D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00547-1 · Cited by 904 · see citing works
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.
Cantorna, M. T., Hayes, C. E., & DeLuca, H. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7861 · Cited by 720 · see citing works
Vitamin d3 and brain development
Eyles, D. W., Brown, J., Mackay‐Sim, A., McGrath, J. J., & Feron, F. P. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00040-x · Cited by 552 · see citing works
Molecular mechanisms of calcium-dependent excitotoxicity
Sattler, R., & Tymianski, M. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000077 · Cited by 477 · see citing works
Vitamin D Deficiency Is Associated With Low Mood and Worse Cognitive Performance in Older Adults
Wilkins, C. H., Sheline, Y. I., Roe, C. M., Birge, S. J., & Morris, J. C. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000240986.74642.7c · Cited by 464 · see citing works
Vitamin D Hormone Confers Neuroprotection in Parallel with Downregulation of L-Type Calcium Channel Expression in Hippocampal Neurons
Brewer, L. D., Thibault, V., Chen, K.-C., Langub, M. C., Landfield, P. W., & Porter, N. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00098.2001 · Cited by 458 · see citing works
The design of a prospective study of pravastatin in the elderly at risk (PROSPER)
Shepherd, J., Blauw, G. J., Murphy, M. B., Cobbe, S. M., Bollen, E. L. E. M., Buckley, B. M., Ford, I., Jukema, J. W., Hyland, M., Gaw, A., et al. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00533-0 · Cited by 449 · see citing works
Self-citation
Learning and Retrieval Rate of Words Presented Auditorily and Visually
Brand, N., & JOLLES, J. (1985) · The Journal of General Psychology · doi:10.1080/00221309.1985.9711004 · Cited by 426 · see citing works
Self-citation
1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
Brown, J., Bianco, J. I., McGrath, J. J., & Eyles, D. W. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00303-3 · Cited by 377 · see citing works
Accuracy of the 15‐item geriatric depression scale (GDS‐15) in a community sample of the oldest old
de Craen, A. J. M., Heeren, T. J., & Gussekloo, J. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.773 · Cited by 364 · see citing works
Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to Osteoporotic Fracture: The Rotterdam Study
Fang, Y., van Meurs, J. B. J., d’Alésio, A., Jhamai, M. M., Zhao, H., Rivadeneira, F., Albert Hofman, D., van Leeuwen, J. P. T. M., Jehan, F., Pols, H. A. P., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/497438 · Cited by 322 · see citing works
Elevated Postsynaptic [Ca2+]iand L-Type Calcium Channel Activity in Aged Hippocampal Neurons: Relationship to Impaired Synaptic Plasticity
Thibault, O., Hadley, R. W., & Landfield, P. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09744.2001 · Cited by 276 · see citing works
Vitamin D 3 enhances mood in healthy subjects during winter
Lansdowne, A. T. G., & Provost, S. (1998) · Psychopharmacology · doi:10.1007/s002130050517 · Cited by 265 · see citing works
1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells
Neveu, I., Naveilhan, P., Jehan, F., Baudet, C., Wion, D., De Luca, H. F., & Brachet, P. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90119-8 · Cited by 241 · see citing works
Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function
Przybelski, R. J., & Binkley, N. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.12.018 · Cited by 239 · see citing works
Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states
Uitterlinden, A. G., Fang, Y., van Meurs, J. B. J., van Leeuwen, J. P. T. M., & Pols, H. A. P. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.083 · Cited by 234 · see citing works
1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor
Naveilhan, P., Neveu, I., Wion, D., & Brachet, P. (1996) · Neuroreport · doi:10.1097/00001756-199609020-00023 · Cited by 213 · see citing works
Vitamin D3 attenuates cortical infarction induced by middle cerebral arterial ligation in rats
Wang, Y., Chiang, Y., Su, T., HAYASHI, T., Morales, M., Hoffer, B. J., & Lin, S. Z. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00255-5 · Cited by 212 · see citing works
A high response is not essential to prevent selection bias
Wiel, A. B. D., van Exel, E. R., de Craen, A. J. M., Gussekloo, J., Lagaay, A. M., Knook, D. L., & Westendorp, R. G. J. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00505-x · Cited by 203 · see citing works
Self-citation
1,25-Dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes
Neveu, I., Naveilhan, P., Baudet, C., Brachet, P., & METSIS, M. L. (1994) · Neuroreport · doi:10.1097/00001756-199412300-00032 · Cited by 196 · see citing works
Prevalence of hypercalcaemia in a health survey: a 14‐year follow‐up study of serum calcium values
PALMÉR, M., Jakobsson, S., Åkerström, G., & Ljunghall, S. (1988) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1988.tb01163.x · Cited by 185 · see citing works
Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats
Becker, A., Eyles, D. W., McGrath, J. J., & Grecksch, G. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.02.015 · Cited by 174 · see citing works
Evidence of functional vitamin D receptors in rat hippocampus
Langub, M. C., Herman, J. P., Malluche, H. H., & Koszewski, N. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00049-5 · Cited by 173 · see citing works
Testing cognitive function in elderly populations: the PROSPER study
Houx, P. J. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.4.385 · Cited by 153 · see citing works
Developmental Vitamin D Deficiency Alters MK 801-Induced Hyperlocomotion in the Adult Rat: An Animal Model of Schizophrenia
Kesby, J. P., Burne, T. H. J., McGrath, J. J., & Eyles, D. W. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.033 · Cited by 149 · see citing works
Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats
Burne, T. H. J., Becker, A., Brown, J., Eyles, D. W., Mackay‐Sim, A., & McGrath, J. J. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.03.023 · Cited by 130 · see citing works
Increased anxiety in mice lacking vitamin D receptor gene
Kalueff, A. V., Lou, Y., Laaksi, I., & Tuohimaa, P. (2004) · Neuroreport · doi:10.1097/01.wnr.0000129370.04248.92 · Cited by 129 · see citing works
Age-related working memory impairment is correlated with increases in the L-type calcium channel protein α1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment
Veng, L., Mesches, M. H., & Browning, M. D. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00643-5 · Cited by 128 · see citing works
Effect of test duration on age-related differences in stroop interference
Klein, M., Ponds, R., Houx, P. J., & JOLLES, J. (1997) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639708403838 · Cited by 122 · see citing works
Self-citation
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
Vinkers, D. J., Stek, M. L., van der Mast, R. C., de Craen, A. J. M., le Cessie, S., Jolles, J., Westendorp, R. G. J., & Gussekloo, J. (2005) · Neurology · doi:10.1212/01.wnl.0000167544.54228.95 · Cited by 105 · see citing works
Self-citation
Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis.
de Viragh, P. A., Haglid, K. G., & Celio, M. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3887 · Cited by 98 · see citing works
Behavioural anomalies in mice evoked by “Tokyo” disruption of the Vitamin D receptor gene
Kalueff, A. V., Keisala, T., Minasyan, A., Kuuslahti, M., Miettinen, S., & Tuohimaa, P. (2006) · Neuroscience Research · doi:10.1016/j.neures.2005.12.008 · Cited by 86 · see citing works
Seasonal Variations of Current Symptoms in a Healthy Population
Schlager, D. S., Schwartz, J. E., & Bromet, E. J. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.163.3.322 · Cited by 84 · see citing works
Chronic 1,25-dihydroxyvitamin D3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain
Saporito, M. S., Brown, E. R., Hartpence, K. C., Wilcox, H. M., Vaught, J. L., & Carswell, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91539-3 · Cited by 83 · see citing works
Cloning and sequencing of the gene encoding the mouse vitamin D receptor
Kamei, Y., Kawada, T., Fukuwatari, T., Ono, T., Kato, S., & Sugimoto, E. (1995) · Gene · doi:10.1016/0378-1119(94)00735-b · Cited by 83 · see citing works
Chronic 1α,25-(OH)2vitamin D3 treatment reduces Ca2+-mediated hippocampal biomarkers of aging
Brewer, L. D., Porter, N. M., Kerr, D. S., Landfield, P. W., & Thibault, O. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.04.001 · Cited by 82 · see citing works
Vitamin D Receptor 3′ Haplotypes Are Unequally Expressed in Primary Human Bone Cells and Associated With Increased Fracture Risk: The MrOS Study in Sweden and Hong Kong
Grundberg, E., Lau, E. M. C., Pastinen, T., Kindmark, A., Nilsson, O., Ljunggren, Ö., Mellström, D., ORWOLL, E. S., Redlund-Johnell, I., Holmberg, A. H., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070317 · Cited by 44 · see citing works
Dimensional measurement of seasonal variation in mood and behavior
Spoont, M. R., Depue, R. A., & Krauss, S. S. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90093-5 · Cited by 36 · see citing works

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Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
McCann, J. C., & Ames, B. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-9326rev · Cited by 409 · see citing works
Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?
Buell, J. S., & Dawson‐Hughes, B. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.001 · Cited by 342 · see citing works
Serum 25-Hydroxyvitamin D and Depressive Symptoms in Older Women and Men
Milaneschi, Y., Shardell, M. D., Corsi, A. M., Vazzana, R., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0347 · Cited by 221 · see citing works
Vitamin D cell signalling in health and disease
Berridge, M. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.008 · Cited by 214 · see citing works
Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia
Berridge, M. J. (2013) · Prion · doi:10.4161/pri.21767 · Cited by 209 · see citing works
Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact
Moretti, R., Morelli, M. E., & Caruso, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082245 · Cited by 190 · see citing works
Vitamin D, Cognition and Alzheimer’s Disease: The Therapeutic Benefit is in the D-Tails
Landel, V., Annweiler, C., Millet, P., Morello, M., & Feron, F. P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150943 · Cited by 185 · see citing works
Serum 25-hydroxyvitamin D levels and the risk of depression: A systematic review and meta-analysis
Ju, S.-Y., Lee, Y. J., & Jeong, S.-N. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0418-0 · Cited by 147 · see citing works
Potential Role of Vitamin D for the Management of Depression and Anxiety
Casseb, G. A. S., Kaster, M. P., & Rodrigues, A. L. S. (2019) · CNS Drugs · doi:10.1007/s40263-019-00640-4 · Cited by 153 · see citing works
Vitamin D and neurocognitive function
Holick, M. F., & Schlögl, M. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s51785 · Cited by 143 · see citing works
Premature aging in vitamin D receptor mutant mice
Keisala, T., Minasyan, A., Lou, Y., Zou, J., Kalueff, A. V., Pyykkö, I. V., & Tuohimaa, P. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.03.007 · Cited by 132 · see citing works
Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases
Bäcker‐Koduah, P., Paul, F., & Dörr, J.-M. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0120-8 · Cited by 129 · see citing works
The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical Neurons
Gezen‐Ak, D., Dursun, E., & Yılmazer, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017553 · Cited by 129 · see citing works
Vitamin D, reactive oxygen species and calcium signalling in ageing and disease
Berridge, M. J. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0434 · Cited by 127 · see citing works
The role of vitamin D in the prevention of late-life depression
Okereke, O. I., & Singh, A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.022 · Cited by 111 · see citing works
Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases
Pál, É., Ungvari, Z. I., Benyó, Z., & Várbı́ró, S. (2023) · Nutrients · doi:10.3390/nu15020334 · Cited by 108 · see citing works
Vitamin D, Cognitive Dysfunction and Dementia in Older Adults
Dickens, A., Lang, I., Langa, K. M., Kos, K., & Llewellyn, D. J. (2011) · CNS Drugs · doi:10.2165/11593080-000000000-00000 · Cited by 100 · see citing works
1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier
Ito, S., Ohtsuki, S., Nezu, Y., Koitabashi, Y., Murata, S., & Terasaki, T. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-20 · Cited by 97 · see citing works
Why Vitamin D in Alzheimer's Disease? The Hypothesis
Gezen‐Ak, D., Yılmazer, S., & Dursun, E. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131970 · Cited by 98 · see citing works
1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport
Guo, Y.-X., He, L., Zhang, M., Wang, F., Liu, F., & Peng, W. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.041 · Cited by 96 · see citing works
Low Vitamin D Status and Suicide: A Case-Control Study of Active Duty Military Service Members
Umhau, J. C., George, D. T., Heaney, R. P., Lewis, M. D., Ursano, R. J., Heilig, M. A., Hibbeln, J. R., & Schwandt, M. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051543 · Cited by 87 · see citing works
The vitamin D receptor gene is associated with Alzheimer's disease
Lehmann, D. J., Refsum, H., Warden, D. R., Medway, C., Wilcock, G. K., & Smith, A. D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.057 · Cited by 86 · see citing works
Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review
Aghajafari, F., Letourneau, N. L., Mahinpey, N., Cosic, N., & Giesbrecht, G. F. (2018) · Nutrients · doi:10.3390/nu10040478 · Cited by 86 · see citing works
Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease
Gezen‐Ak, D., Dursun, E., Bılgıç, B., Hanagasi, H. A., Ertan, T., Gurvit, H. I., Emre, M., Eker, E., Ulutin, T., Uysal, Ö., et al. (2012) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.228.189 · Cited by 86 · see citing works
Effect of ageing on tactile transduction processes
Decorps, J., Saumet, J. L., Sommer, P., Sigaudo-Roussel, D., & Fromy, B. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.003 · Cited by 83 · see citing works
Some new food for thought: The role of vitamin D in the mental health of older adults
Cherniack, E. P., Troen, B. R., Florez, H. J., Roos, B. A., & Levis, S. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0003-3 · Cited by 81 · see citing works
Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease
Landel, V., Millet, P., Baranger, K., Loriod, B., & Feron, F. P. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0087-2 · Cited by 79 · see citing works
Glia in the cytokine-mediated onset of depression: fine tuning the immune response
Jo, W. K., Zhang, Y., Emrich, H. M., & Dietrich, D. E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00268 · Cited by 77 · see citing works
Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement
Gezen‐Ak, D., Dursun, E., & Yılmazer, S. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1268-6 · Cited by 77 · see citing works
A New Mechanism for Amyloid-β Induction of iNOS: Vitamin D-VDR Pathway Disruption
Dursun, E., Gezen‐Ak, D., & Yılmazer, S. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130416 · Cited by 70 · see citing works
Vitamin D and cognitive function: The Tromsø Study
Jorde, R., Mathiesen, E. B., Rogne, S., Wilsgaard, T., Kjærgaard, M., Grimnes, G., & Schirmer, H. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.06.009 · Cited by 69 · see citing works
Serum 25-Hydroxyvitamin D Levels and Depression in Older Adults: A Dose–Response Meta-Analysis of Prospective Cohort Studies
Li, H., Sun, D., Wang, A., Pan, H., Feng, W., Ng, C. H., Ungvari, G. S., Tao, L., Li, X., Wang, W., et al. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.05.022 · Cited by 69 · see citing works
Developmental vitamin D deficiency alters learning in C57Bl/6J mice
de Abreu, D. A. F., Nivet, E., Baril, N., Khrestchatisky, M., Roman, F. S., & Feron, F. P. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.005 · Cited by 67 · see citing works
Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder
Coşkun, S., Şimşek, Ş., Camkurt, M. A., Çim, A., & Çelik, S. B. (2016) · Gene · doi:10.1016/j.gene.2016.05.004 · Cited by 67 · see citing works
Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats
Tang, H., Hua, F., Wang, J., Sayeed, I., Wang, X., Chen, Z., Yousuf, S., Atif, F., & Stein, D. G. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.06.009 · Cited by 64 · see citing works
Treatment with hormone therapy and calcitriol did not affect depression in older postmenopausal women
Yalamanchili, V., & Gallagher, J. C. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31823bcec5 · Cited by 64 · see citing works
Vitamin D and Cognition: An Update of the Current Evidence
Anastasiou, C. A., Yannakoulia, M., & Scarmeas, N. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132636 · Cited by 63 · see citing works
The peculiar role of vitamin D in the pathophysiology of cardiovascular and neurodegenerative diseases
Janjusevic, M., Gagno, G., Fluca, A. L., Padoan, L., Beltrami, A. P., Sinagra, G., Moretti, R., & Aleksova, A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120193 · Cited by 62 · see citing works
Hypovitaminosis D in the elderly: From bone to brain
Cherniack, E. P., Florez, H. J., Roos, B. A., Troen, B. R., & Levis, S. (2008) · The journal of nutrition health & aging · doi:10.1007/bf02982668 · Cited by 62 · see citing works
Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults
Beydoun, M. A., Ding, E. L., Beydoun, H. A., Tanaka, T., Ferrucci, L., & Zonderman, A. B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.017137 · Cited by 54 · see citing works
GC and VDR SNPs and Vitamin D Levels in Parkinson’s Disease: The Relevance to Clinical Features
Gezen‐Ak, D., Alaylıoğlu, M., Genç, G., Gündüz, A., Candaş, E., Bılgıç, B., Atasoy, İ. L., Apaydın, H., Kızıltan, G., Gurvit, H. I., et al. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8415-9 · Cited by 52 · see citing works
Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease
Gatto, N. M., Paul, K. C., Sinsheimer, J. S., Bronstein, J. M., Bordelon, Y. M., Rausch, R., & Ritz, B. R. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.09.013 · Cited by 50 · see citing works
Low vitamin D status is associated with more depressive symptoms in Dutch older adults
Brouwer-Brolsma, E. M., Dhonukshe-Rutten, R. A. M., van Wijngaarden, J. P., van der Zwaluw, N. L., Sohl, E., Veld, P. H. I., van Dijk, S. C., Swart, K. M. A., Enneman, A. W., Ham, A. C., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0970-6 · Cited by 49 · see citing works
Vitamin D supplementation reduces depressive symptoms in patients with chronic liver disease
Stokes, C. S., Grünhage, F., Baus, C., Volmer, D. A., Wagenpfeil, S., Riemenschneider, M. J., & Lammert, F. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.07.004 · Cited by 48 · see citing works
Vitamin D basis of Alzheimer’s disease: from genetics to biomarkers
Dursun, E., & Gezen‐Ak, D. (2018) · HORMONES · doi:10.1007/s42000-018-0086-5 · Cited by 45 · see citing works
The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression
Okereke, O. I., Reynolds, C. F., Mischoulon, D., Chang, G., Cook, N. R., Copeland, T., Friedenberg, G., Buring, J. E., & Manson, J. E. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.02.017 · Cited by 45 · see citing works
Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey
Krieg, E. F., Butler, M. A., Chang, M., Liu, T., Yesupriya, A., Lindegren, M. L., & Dowling, N. F. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.08.003 · Cited by 44 · see citing works
Predictors of recurrence of major depressive disorder
Lye, M.-S., Tey, Y.-Y., Tor, Y.-S., Shahabudin, A. F., Ibrahim, N., Ling, K.-H., Stanslas, J., Loh, S.-P., Rosli, R., Lokman, K. A., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0230363 · Cited by 43 · see citing works
Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology
Stewart, A., Wong, K., Cachat, J., Elegante, M. F., Gilder, T., Mohnot, S., Wu, N., Minasyan, A., Tuohimaa, P., & Kalueff, A. V. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833c850f · Cited by 40 · see citing works
Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling
Gómez‐Oliva, R., Geribaldi‐Doldán, N., Domínguez‐García, S., Carrascal, L., Verástegui, C., Nunez‐Abades, P., & Castro, C. (2020) · Aging · doi:10.18632/aging.103510 · Cited by 39 · see citing works
Integration of peripheral transcriptomics, genomics, and interactomics following trauma identifies causal genes for symptoms of post-traumatic stress and major depression
Wuchty, S., Myers, A., Ramirez‐Restrepo, M., Huentelman, M. J., Richolt, R., Gould, F., Harvey, P. D., Michopolous, V., Steven, J. S., Wingo, A. P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01084-3 · Cited by 39 · see citing works
Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy
Jiang, P., Zhu, W.-Y., He, X., Tang, M., Dang, R.-L., Huan-de, L., Xue, Y., Zhang, L., Wu, Y., & Cao, L.-J. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph121113913 · Cited by 37 · see citing works
The Role of Vitamin D in Alzheimer’s Disease
Lương, K. V. Q., & Nguyễn, L. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512473196 · Cited by 36 · see citing works
Resilience and Aging: Research and Practice
Lavretsky, H. (2014) · Project Muse (Johns Hopkins University) · Cited by 36 · see citing works
Vitamin D Uygulamasının Primer Hippokampal Nöronlardaki İndüklenebilir Nitrik Oksit Sentaz (İNOS) Anlatımı Üzerine Etkileri
Dursun, E., Gezen‐Ak, D., & Yılmazer, S. (2014) · Nöro Psikiyatri Arşivi · doi:10.4274/npa.y7089 · Cited by 34 · see citing works
Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer’s Disease
Jeong, S. P., Sharma, N., & An, S. S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094806 · Cited by 33 · see citing works
Beta Amyloid Suppresses the Expression of the Vitamin D Receptor Gene and Induces the Expression of the Vitamin D Catabolic Enzyme Gene in Hippocampal Neurons
Dursun, E., Gezen‐Ak, D., & Yılmazer, S. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000350319 · Cited by 33 · see citing works
Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
Somoza-Moncada, M. M., Turrubiates‐Hernández, F. J., Muñóz-Valle, J. F., Gutiérrez-Brito, J. A., Díaz-Pérez, S. A., Arelis, A. A., & Hernández‐Bello, J. (2023) · Nutrients · doi:10.3390/nu15071765 · Cited by 36 · see citing works
Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old
Glocke, M., Lang, F. J. W., Schaeffeler, E., Lang, T., Schwab, M. G., & Lang, U. E. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000350159 · Cited by 33 · see citing works
Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
Amato, R., Pinelli, M., Monticelli, A., Miele, G., & Cocozza, S. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-351 · Cited by 33 · see citing works
Vitamin D and executive functioning: Are higher levels better?
Pettersen, J. A. (2015) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1125452 · Cited by 31 · see citing works
The 25(OH)D/VDR signaling may play a role in major depression
He, Y., Wu, Z., Lan, T., Wang, Y., Tian, Y., Chen, X., Li, Y., Bai, M., Liu, J., Gong, X., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.071 · Cited by 31 · see citing works
25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice
Wang, Q., Zhou, X., Zhang, P., Zhao, P., Nie, L., Ji, N., Ding, Y., & Wang, Q. (2020) · Steroids · doi:10.1016/j.steroids.2019.108570 · Cited by 29 · see citing works
Exploring the relationship between vitamin D and basic personality traits
Ubbenhorst, A., Striebich, S., Lang, F. J. W., & Lang, U. E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2175-x · Cited by 28 · see citing works
Shift work and depressive symptoms: the mediating effect of vitamin D and sleep quality
Park, H., Suh, B.-S., & Lee, S. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1585367 · Cited by 27 · see citing works
An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition
Rantanen, L. M., Bitar, M., Lampinen, R., Stewart, R., Quek, H., Oikari, L. E., Cuní‐López, C., Sutharsan, R., Thillaiyampalam, G., Iqbal, J., et al. (2022) · Cells · doi:10.3390/cells11203258 · Cited by 26 · see citing works
Genome-scale metabolic modelling predicts biomarkers and therapeutic targets for neuropsychiatric disorders
Moolamalla, S. T. R., & Vinod, P. K. U. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.103994 · Cited by 25 · see citing works
Depression in Late-Life: A Focus on Prevention
Okereke, O. I., Lyness, J. M., Lotrich, F. E., & Reynolds, C. F. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.22 · Cited by 25 · see citing works
Role of Neural Stem Cells and Vitamin D Receptor (VDR)–Mediated Cellular Signaling in the Mitigation of Neurological Diseases
Uthaiah, C. A., Beeraka, N. M., Rajalakshmi, R., M., R. C., & Madhunapantula, S. V. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02837-z · Cited by 23 · see citing works
Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey
Krieg, E. F., Butler, M. A., Chang, M., Liu, T., Yesupriya, A., Dowling, N. F., & Lindegren, M. L. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.12.004 · Cited by 22 · see citing works
Vitamin D Receptor and Megalin Gene Polymorphisms Are Associated with Longitudinal Cognitive Change among African-American Urban Adults
Beydoun, M. A., Tajuddin, S. M., Dore, G. A., Canas, J. A., Beydoun, H. A., Evans, M. K., & Zonderman, A. B. (2017) · Journal of Nutrition · doi:10.3945/jn.116.244962 · Cited by 21 · see citing works
Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals
de Jongh, R. T., Lips, P. T. A. M., Rijs, K. J., van Schoor, N. M., Kramer, M. H. H., Vandenbroucke, J. P., & Dekkers, O. M. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0688 · Cited by 20 · see citing works
A study of cognitive functions in female elderly patients with osteoporosis: a multi-center cross-sectional study
Peng, W., Li, Z., Guan, Y., Wang, D., & Huang, S. (2015) · Aging & Mental Health · doi:10.1080/13607863.2015.1033680 · Cited by 19 · see citing works
Vitamin D (Calcifediol) Supplementation Modulates NGF and BDNF and Improves Memory Function in Postmenopausal Women: a Pilot Study
Pozzi, F., Aloe, L., Frajese, G., & Frajese, G. (2013) · Research in Endocrinology · doi:10.5171/2013.552758 · Cited by 18 · see citing works
BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline
de Oliveira, A. C. R., Magalhaes, C. A., Loures, C. M. G., Fraga, V. G., de Souza, L. C., Guimarães, H. C., Cintra, M. T. G., Bicalho, M. A. C., de Sousa, M. C. R., Silveira, J. N., et al. (2018) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20180116 · Cited by 17 · see citing works
Genetic Variants in the Vitamin D Pathway, 25(OH)D Levels, and Mortality in a Large Population-Based Cohort Study
Ordóñez-Mena, J. M., Maalmi, H., Schöttker, B., Saum, K.-U., Holleczek, B., Wang, T. J., Burwinkel, B., & Brenner, H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2468 · Cited by 17 · see citing works
Correction: Low Vitamin D Status and Suicide: A Case-Control Study of Active Duty Military Service Members
Umhau, J. C., George, D. T., Heaney, R. P., Lewis, M. D., Ursano, R. J., Heilig, M. A., Hibbeln, J. R., & Schwandt, M. L. (2013) · PLoS ONE · doi:10.1371/annotation/9af84cbe-5576-4c4b-871c-f7ab0c64b9fd · Cited by 17 · see citing works
Vitamin D3 as adjunctive therapy in the treatment of depression in tuberculosis patients: a short-term pilot randomized double-blind controlled study
Zhang, L., Wang, S., Zhu, Y., & Yang, T. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s183039 · Cited by 16 · see citing works
Impact of Vitamin D Status and Supplementation on Brain-Derived Neurotrophic Factor and Mood–Cognitive Outcomes: A Structured Narrative Review
Skoczek-Rubińska, A., Cisek-Woźniak, A., Molska, M., Heyser, M., Trocholepsza, M., Pietrzak, S., & Mruczyk, K. (2025) · Nutrients · doi:10.3390/nu17162655 · Cited by 16 · see citing works
Changes in the expression of the vitamin D receptor and LVSCC-A1C in the rat hippocampus submitted to single prolonged stress
Ji, L.-L., Tong, L., Peng, J., JIN, X.-H., Wei, D., Xu, B.-K., & Wang, Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1934 · Cited by 16 · see citing works
ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis
Kempińska‐Podhorodecka, A., Milkiewicz, M., Jabłoński, D., Milkiewicz, P., & Wunsch, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176264 · Cited by 16 · see citing works
Adjunctive Vitamin D in the treatment of non-remitted depression: Lessons from a failed clinical trial
Aucoin, M., Cooley, K., Anand, L., Furtado, M., Canzonieri, A. M., Fine, A., Fotinos, K., Chandrasena, R. D., Klassen, L. J., Epstein, I., et al. (2017) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2017.09.011 · Cited by 15 · see citing works
Association between serum vitamin D and depressive symptoms among female workers in the manufacturing industry
Kwon, S. I., Son, J. S., Kim, Y. O., Chae, C. H., Kim, J. H., Kim, C. W., Park, H. O., Lee, J. H., & Jung, J. I. (2015) · Annals of Occupational and Environmental Medicine · doi:10.1186/s40557-015-0083-y · Cited by 15 · see citing works
Vitamin D in Alzheimer’s Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum
Soares, J. Z., Valeur, J., Benth, J. Š., Knapskog, A., Selbæk, G., Arefi, G., Gilfillan, G. D., Tollisen, A., Bogdanović, N., & Pettersen, R. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215536 · Cited by 14 · see citing works
The Effects of Vitamin D Insufficiency and Seasonal Decrease on Cognition
Pettersen, J. A., Fontes, S., & Duke, C. (2014) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100018497 · Cited by 14 · see citing works
Vitamin D and Age-Related Health Outcomes: Movement, Mood, and Memory
Houston, D. K. (2015) · Current Nutrition Reports · doi:10.1007/s13668-015-0124-8 · Cited by 14 · see citing works
1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice
Leibrock, C. B., Voelkl, J. G. J., Kuro‐o, M., Lang, F. J. W., & Lang, U. E. (2016) · Scientific Reports · doi:10.1038/srep24879 · Cited by 14 · see citing works
Relationship between vitamin D receptor gene polymorphism and mild cognitive impairment in elderly Uygur people.
Keyimu, K., Zhou, X., Miao, H.-J., & Zou, T. (2014) · PubMed Central · Cited by 13 · see citing works
Vitamin D receptor ( VDR ) gene polymorphism and vascular dementia due to cerebral small vessel disease in an Asian Indian cohort
Supriya, M., Chandra, S. R., Prabhakar, P., Prasad, C., & Christopher, R. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.05.025 · Cited by 13 · see citing works
Risk of suicide, suicide attempt, and suicidal ideation among people with vitamin D deficiency: a systematic review and meta-analysis
Yu, J., Mohammad, S. N., Khachatryan, L., Mohammed, J. S., Menon, S. V., Kaur, M., Sapaev, I. B., Jabir, M. S., Husseen, B., & Azizi, H. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06613-w · Cited by 14 · see citing works
Association of vitamin D receptor with longevity and healthy aging.
Varzaneh, F. N., Sharifi, F., Hossein‐Nezhad, A., Mirarefin, M., Maghbooli, Z., Ghaderpanahi, M., Larijani, B. A., & Fakhrzadeh, H. (2013) · PubMed · Cited by 12 · see citing works
Genetic, environmental and biomarker considerations delineating the regulatory effects of vitamin D on central nervous system function
Stephenson, A., Mamo, J. C. L., Takechi, R., Hackett, M. J., & Lam, V. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900268x · Cited by 12 · see citing works
The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults
de Menezes-Júnior, L. A. A., Sabião, T. D. S., de Moura, S. S., Batista, A. P., de Menezes, M. C., Carraro, J. C. C., Machado-Coelho, G. L. L., & Meireles, A. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-58561-2 · Cited by 11 · see citing works
Vitamin D Metabolism-Related Gene Haplotypes and Their Association with Metabolic Disturbances Among African-American Urban Adults
Beydoun, M. A., Hossain, S. A., Tajuddin, S. M., Canas, J. A., Kuczmarski, M. F., Beydoun, H. A., Evans, M. K., & Zonderman, A. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-26230-w · Cited by 11 · see citing works
Mid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study
Fashanu, O. E., Zhao, D., Schneider, A. L. C., Rawlings, A. M., Sharrett, A. R., Lutsey, P. L., Gottesman, R. F., Gross, A. L., Güallar, E., Alonso, Á., et al. (2019) · BMC Neurology · doi:10.1186/s12883-019-1483-3 · Cited by 11 · see citing works
BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder
Lye, M. S., Tor, Y. S., Tey, Y.-Y., Shahabudin, A., Loh, S. P., Ibrahim, N., Stanslas, J., Rosli, R., & Ling, K. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01719-0 · Cited by 11 · see citing works
Association of vitamin D receptor gene TaqI polymorphism with Alzheimer's disease in a Southeastern European Caucasian population
Dimitrakis, E., Katsarou, M., Lagiou, M., Papastefanopoulou, V., Stanitsa, E., Spandidos, D. A., Tsatsakis, A. M., Papageorgiou, S., Moutsatsou, P., Antoniou, K., et al. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11271 · Cited by 10 · see citing works
Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort
Arévalo, N. B., Castillo-Godoy, D. P., Espinoza-Fuenzalida, I., Rogers, N. K., Farias, G. A., Delgado, C., Henríquez, M., Herrera, L., Behrens, M. I., & SanMartín, C. D. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201031 · Cited by 10 · see citing works
Serum 25-hydroxyvitamin d levels and the risk of depression: A systematic review and meta-analysis
Ju, S.-Y., Lee, Y. J., & Jeong, S. N. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0426-0 · Cited by 11 · see citing works
Vitamina D - Aspectos Fisiológicos, Nutricionais, Imunológicos, Genéticos. Ações em doenças autoimunes, tumorais, infecciosas. Funções musculoesqueléticas e cognitivas
Ruscalleda, R. M. I. (2023) · Revista de Medicina · doi:10.11606/issn.1679-9836.v102i3e-210547 · Cited by 14 · see citing works

Avaliação dos níveis plasmáticos de vitamina D e polimorfismos no gene do seu receptor em pacientes com distúrbios cognitivos
de Oliveira, A. C. R. (2017) · Americanae (AECID Library)
Vitamin D-related Nutrigenetics and Cognitive Decline in an Elderly Population
Martin, C., Yates, Z. R., Veysey, M. J., King, K., Niblett, S. H., & Lucock, M. D. (2017) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2017.00006
BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline
de Oliveira, A. C. R., Magalhaes, C. A., Loures, C. M. G., Fraga, V. G., de Souza, L. C., Guimarães, H. C., Cintra, M. T. G., Bicalho, M. A. C., de Sousa, M. C. R., Silveira, J. N., et al. (2018) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20180116 · Cited by 17 · see citing works
The Effect of Genetic Variations in the Vitamin D Receptor Gene on the Course of Depressive Symptoms
Wenzler, A. N., van de Loo, B. P. A., van der Velde, N., & van Schoor, N. M. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.04.030 · Cited by 3 · see citing works
[Association of vitamin D receptor gene polymorphisms with mild cognitive impairment among elderly ethnic Uygurs].
Zhou, X., Zhu, M., Ma, L. M., & Miao, H. (2015) · PubMed · doi:10.3760/cma.j.issn.1003-9406.2015.06.027 · Cited by 1 · see citing works

Authors: Kuningas, M., Mooijaart, S. P., Jolles, J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D.
Affiliations: Leiden University Medical Center (NL)
Maastricht University Medical Centre (NL)
ORCID: Mooijaart, Simon P.
Slagboom, P. Eline
Westendorp, Rudi G.J.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2009-03
Volume: 30
Issue: 3
Pages: 466-473
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2007.07.001
OpenAlex: W2106494040
Cited by: 149
References: 47
Citations by year: 2026: 1 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 5 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 6
FWCI: 4.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: vitamin D receptor, VDR polymorphisms, cognitive function, depressive symptoms, old age, BsmI polymorphism, TaqI polymorphism, ApaI polymorphism, FokI polymorphism, haplotypes, age-related cognitive decline, Leiden 85-plus Study, genetic susceptibility
MeSH terms: Age Factors, Aged, 80 and over, Cognition, Depression, Female, Follow-Up Studies, Genotype, Haplotypes, Humans, Male, Prospective Studies, Risk Factors, Genetic Variation, Cohort Studies, Receptors, Calcitriol

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VDR gene variants associate with cognitive function and depressive symptoms in old age

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